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1. 发明申请

WO2007047566A3 SYSTEM AND METHOD FOR CHARACTERIZING VASCULAR TISSUE 审中-公开
公开(公告)号：WO2007047566A3
公开(公告)日：2007-04-26
申请号：PCT/US2006/040334
申请日：2006-10-14
申请人： THE CLEVELAND CLINIC FOUNDATION , NAIR, Anuja , KUBAN, Barry, D. , VINCE, D., Geoffrey , KLINGENSMITH, Jon, David
发明人： NAIR, Anuja , KUBAN, Barry, D. , VINCE, D., Geoffrey , KLINGENSMITH, Jon, David
IPC分类号： A61B8/14
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter. In one embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire R backscattered data from a vascular structure. The backscattered ultrasound data is then used with an algorithm to estimate transfer function(s) which is used to calculate response data for the vascular tissue. In another embodiment, an IVUS console is electrically connected to a catheter and a computing device is used to acquire backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and the histology data are then used to characterize at least a portion of the vascular tissue.

2. 发明申请

WO2004017821A2 SYSTEM AND METHOD OF ACQUIRING BLOOD-VESSEL DATA 审中-公开
标题翻译：获取血管数据的系统和方法
公开(公告)号：WO2004017821A2
公开(公告)日：2004-03-04
申请号：PCT/US2003/026492
申请日：2003-08-25
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KUBAN, Barry, D. , KLINGENSMITH, Jon, D. , VINCE, D., Geoffrey , NAIR, Anuja
IPC分类号： A61B
CPC分类号： A61B8/4461 , A61B5/02007 , A61B5/0456 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/483 , A61B8/543 , G06T7/0012 , G06T7/12 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101
摘要： A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still -- i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer. In another embodiment of the present invention, the data-gathering system further includes a retraction device adapted to move the data-gathering probe though a blood vessel at a substantially steady speed.
摘要翻译：提供了一种用于将血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。具体地，数据收集装置适于分别从心脏监测装置和数据收集探针获取心跳数据和血管数据。在本发明的优选实施例中，在心跳数据的周期部分期间获取血管数据。通过在该循环部分（或在与其基本对应的间隔期间）识别心跳数据的周期性（或通常重复发生）部分并获取血管数据，可以分析血管，如同静置时一样 - 即，不扩大和放松。在本发明的一个实施例中，所述心脏监测装置包括EKG装置，所述数据收集装置包括血管内超声（IVUS）装置和计算装置，并且所述数据收集探针包括至少一个换能器。在本发明的另一个实施例中，数据收集系统还包括一个缩回装置，其适于以基本上稳定的速度移动通过血管的数据收集探针。

3. 发明申请

WO2005070300A1 SYSTEM AND METHOD FOR DETERMINING A TRANSFER FUNCTION 审中-公开
标题翻译：用于确定传递函数的系统和方法
公开(公告)号：WO2005070300A1
公开(公告)日：2005-08-04
申请号：PCT/US2004/002860
申请日：2004-02-02
申请人： THE CLEVELAND CLINIC FOUNDATION , NAIR, Anuja , VINCE, Geoffrey, D. , KLINGENSMITH, Jon, D. , KUBAN, Barry, D.
发明人： NAIR, Anuja , VINCE, Geoffrey, D. , KLINGENSMITH, Jon, D. , KUBAN, Barry, D.
IPC分类号： A61B8/14
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto -- e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device (110) is electrically connected to a catheter (120) and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data).
摘要翻译：提供了一种用于使用从血管组织反向散射的超声数据来估计导管（包括附接到其上的部件 - 例如IVUS控制台，换能器等）的传递功能的系统和方法。具体地，根据本发明的第一实施例，计算设备（110）电连接到导管（120）并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射的超声数据与算法一起用于估计传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。

4. 发明申请

WO2004069027A2 NON-INVASIVE TISSUE CHARACTERIZATION SYSTEM AND METHOD 审中-公开
标题翻译：非侵入式组织特征系统及方法
公开(公告)号：WO2004069027A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002367
申请日：2004-01-29
申请人： THE CLEVELAND CLINIC FOUNDATION , VINCE, Geoffrey, D. , NAIR, Anuja , KLINGENSMITH, Jon, D.
发明人： VINCE, Geoffrey, D. , NAIR, Anuja , KLINGENSMITH, Jon, D.
IPC分类号： A61B
CPC分类号： A61B8/00 , A61B5/02007 , A61B5/7264 , A61B8/0825
摘要： One embodiment of the present system and method is directed to the identification of tissues within a vascular object by analyzing ultrasound data collected from the vascular object by non-invasive scans. By identifying and characterizing types of tissue from ultrasound data, an assessment can be made about the health condition of a patient without an invasive procedure. Other applications of the present system will also be appreciated including identifying other types of tissues.
摘要翻译：本系统和方法的一个实施例涉及通过非侵入性扫描分析从血管对象收集的超声数据来识别血管对象内的组织。通过从超声数据中识别和表征组织的类型，可以对没有侵入性程序的患者的健康状况进行评估。还将理解本系统的其它应用，包括识别其他类型的组织。

5. 发明申请

WO2004017835A1 SYSTEM AND METHOD OF CHARACTERIZING VASCULAR TISSUE 审中-公开
标题翻译：表征血管组织的系统和方法
公开(公告)号：WO2004017835A1
公开(公告)日：2004-03-04
申请号：PCT/US2003/026521
申请日：2003-08-25
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAIR, Anuja , VINCE, Geoffrey, D. , KLINGENSMITH, Jon, D. , KUBAN, Barry, D.
IPC分类号： A61B8/12
CPC分类号： A61B8/4461 , A61B5/02007 , A61B5/0456 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/483 , A61B8/543 , G06T7/0012 , G06T7/12 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device (120) is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device (130) and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device (130), or more particularly, a characterization application (132) operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database (134).
摘要翻译：提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。具体地，在本发明的一个实施例中，使用超声波装置（120）从血管获取RF背散射数据（即，IVUS数据）。然后将IVUS数据传送到计算设备（130）并用于创建IVUS图像。然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。然后，计算设备（130），或更具体地，在其上操作的特征应用（132））适于识别IVUS图像上的相应区域。然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。识别对应区域后，识别与该区域对应的IVUS数据。然后执行信号处理，并且识别至少一个参数。所识别的参数和组织类型（例如表征数据）被存储在数据库（134）中。

6. 发明申请

WO2005091885A3 SYSTEM AND METHOD FOR VASCULAR BORDER DETECTION 审中-公开
公开(公告)号：WO2005091885A3
公开(公告)日：2005-10-06
申请号：PCT/US2005/006159
申请日：2005-02-25
申请人： THE CLEVELAND CLINIC FOUNDATION , KLINGENSMITH, Jon, D. , NAIR, Anuja , KUBAN, Barry, D. , VINCE, D., Geoffrey
发明人： KLINGENSMITH, Jon, D. , NAIR, Anuja , KUBAN, Barry, D. , VINCE, D., Geoffrey
IPC分类号： A61B18/04 , A61B8/00 , A61B6/00 , A61B5/05
摘要： A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border ( e.g. , tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device ( e.g. , an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device ( e.g. , database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application ( e.g. , a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information ( e.g. , tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information ( e.g. , gradient information, other-border information, etc.), to determine at least one border on a vascular image.

7. 发明申请

WO2004017823A3 SYSTEM AND METHOD FOR IDENTIFYING A VASCULAR BORDER 审中-公开
公开(公告)号：WO2004017823A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/027075
申请日：2003-08-26
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KLINGENSMITH, Jon, D. , VINCE, Geoffrey, D. , NAIR, Anuja , KUBAN, Barry, D.
IPC分类号： A61B8/12
摘要： A system and method is provided for using a first vascular (20) image, or more particularly a plurality of control points (22) located thereon, to identify a border (64) on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device (120). In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon -- i.e., a border-detection application (122), an extrapolation application (124), and an active-contour application (126). These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.

8. 发明公开

EP1933715A2 SYSTEM AND METHOD FOR CHARACTERIZING VASCULAR TISSUE 审中-公开
标题翻译：系统和方法表征血管组织
公开(公告)号：EP1933715A2
公开(公告)日：2008-06-25
申请号：EP06826017.3
申请日：2006-10-14
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAIR, Anuja , KUBAN, Barry, D. , VINCE, D., Geoffrey , KLINGENSMITH, Jon, David
IPC分类号： A61B8/14
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/7203 , A61B5/726 , A61B8/0833 , A61B8/12 , A61B8/4461 , A61B8/4488 , A61B8/461 , A61B8/467 , A61B8/52 , A61B8/5238 , G01S7/5205 , G01S7/52087 , G01S15/8977 , G06F19/00
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. In one embodiment, a computing device and catheter acquire RF backscattered data from a vascular structure. The backscattered ultrasound data is then used to estimate at least one transfer function. The transfer function(s) can then be used to calculate response data for the vascular tissue. Another embodiment includes an IVUS console connected to a catheter and a computing device that acquires RF backscattered data from a vascular structure. Based on the backscattered data, the computing device estimates the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue.

9. 发明授权

EP1534139B1 SYSTEM AND METHOD OF CHARACTERIZING VASCULAR TISSUE 有权
公开(公告)号：EP1534139B1
公开(公告)日：2018-12-19
申请号：EP03793365.2
申请日：2003-08-25
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAIR, Anuja , VINCE, Geoffrey, D. , KLINGENSMITH, Jon, D. , KUBAN, Barry, D.
IPC分类号： A61B8/12 , A61B8/00 , A61B5/02 , A61B5/0456 , G06T7/00 , G06T7/12 , A61B8/08
CPC分类号： A61B8/4461 , A61B5/02007 , A61B5/0456 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/483 , A61B8/543 , G06T7/0012 , G06T7/12 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device (120) is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device (130) and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device (130), or more particularly, a characterization application (132) operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database (134).

10. 发明授权

EP1534137B1 SYSTEM AND METHOD FOR IDENTIFYING A VASCULAR BORDER 有权
标题翻译：用于识别血管边界的系统和方法
公开(公告)号：EP1534137B1
公开(公告)日：2017-10-11
申请号：EP03749207.1
申请日：2003-08-26
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KLINGENSMITH, Jon, D. , VINCE, Geoffrey, D. , NAIR, Anuja , KUBAN, Barry, D.
IPC分类号： A61B8/12
CPC分类号： A61B8/4461 , A61B5/02007 , A61B5/0456 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/483 , A61B8/543 , G06T7/0012 , G06T7/12 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101

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