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1. 发明申请

WO2005098099A1 EMULSION-BASED CONTROL OF ELECTROSPUN FIBER MORPHOLOGY 审中-公开
标题翻译：电纺纤维形态的基于乳液的控制
公开(公告)号：WO2005098099A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/009048
申请日：2005-03-17
申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SHASTRI, Venkatram, P. , SY, Jay, C. , CHEN, I-Wei
发明人： SHASTRI, Venkatram, P. , SY, Jay, C. , CHEN, I-Wei
IPC分类号： D01D5/04
CPC分类号： D01D5/0038 , D01D5/0015 , D01D5/247 , D01F1/10 , D01F6/50 , D01F6/625 , D01F6/92 , Y10T428/2933
摘要： The invention provides a fiber having different morphology and a method of making such fiber in a predictable manner. The method includes providing a first component including water, wherein the first component has a first evaporation rate, providing a second component including a polymer, wherein the second component has a second evaporation rate, provided that the second evaporation rate is higher than the first evaporation rate, combining the first component and the second component to make an emulsion, applying a force to the emulsion, and extruding the emulsion to make the fiber, wherein the fiber has an outer surface, an internal cavity and a diameter of at most 10 micrometers.
摘要翻译：本发明提供了具有不同形态的纤维和以可预测的方式制备这种纤维的方法。该方法包括提供包括水的第一组分，其中第一组分具有第一蒸发速率，提供包括聚合物的第二组分，其中第二组分具有第二蒸发速率，条件是第二蒸发速率高于第一蒸发速率速率，组合第一组分和第二组分以制备乳液，向乳液施加力并挤出乳液以制备纤维，其中纤维具有外表面，内腔和至多10微米的直径。

2. 发明申请

WO2004085998A2 BIOMIMETIC HIERARCHIES USING FUNCTIONALIZED NANOPARTICLES AS BUILDING BLOCKS 审中-公开
标题翻译：使用功能化纳米颗粒作为建筑块的生物分层
公开(公告)号：WO2004085998A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/009192
申请日：2004-03-26
申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SHASTRI, Venkatram, P. , CHEN, I-Wei , ZNIDARSIC, William
发明人： SHASTRI, Venkatram, P. , CHEN, I-Wei , ZNIDARSIC, William
IPC分类号： G01N
CPC分类号： A61K33/00 , A61K9/06 , A61K9/5115 , A61K9/5138 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1875 , A61K38/30
摘要： The invention provides a three-dimensional construct including a polymeric matrix and a nanoparticle as shown in Fig. 1 having a diameter of about 5 nm to about 10 microns, wherein the nanoparticle is (a) coated with at least two monomolecular layers each carrying biological information and (b) dispersed in the polymeric matrix at a density of at least 0.01 vol%. The invention further provides a method of presenting biological information to a cell or a tissue and thereby affecting at least one parameter of the cell or the tissue, the method involves providing the three-dimensional construct and contacting it with the cell or the tissue to present the biological information and thereby affecting at least one characteristic of the cell or the tissue. In certain embodiments, the diameter, the biological information and the density are selected to affect at least one characteristic of the cell or the tissue.
摘要翻译：本发明提供了包括如图1所示的聚合物基质和纳米颗粒的三维结构。 1，其直径为约5nm至约10微米，其中所述纳米颗粒（a）涂覆有至少两个携带生物信息的单分子层，和（b）以至少0.01vol％的密度分散在所述聚合物基质中。本发明还提供了向细胞或组织呈递生物学信息从而影响细胞或组织的至少一个参数的方法，所述方法包括提供三维构建体并使其与细胞或组织接触以呈现生物信息，从而影响细胞或组织的至少一种特征。在某些实施方案中，选择直径，生物信息和密度以影响细胞或组织的至少一种特征。

3. 发明申请

WO2004027385A2 ENGINEERING OF MATERIAL SURFACES 审中-公开
标题翻译：材料表面工程
公开(公告)号：WO2004027385A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029587
申请日：2003-09-22
申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SHASTRI, Venkatram, P. , CHEN, I-Wei , CHOI, Hoon , LIPSKI, Anna, Marie
发明人： SHASTRI, Venkatram, P. , CHEN, I-Wei , CHOI, Hoon , LIPSKI, Anna, Marie
IPC分类号： G01N
CPC分类号： A61L27/34 , A61L27/28 , A61L27/50 , A61L2400/18
摘要： The invention provides a device having a surface and a functional layer associated with the surface, where the functional layer includes particles having a structure substituted with a functional group, where the functional group is adapted to modify a property of the device, the device is sufficiently biocompatible for application to a multicellular organism and the particles have an average diameter of about 5 nm to about 10 microns.
摘要翻译：本发明提供具有表面和与表面相关的功能层的装置，其中功能层包括具有被官能团取代的结构的颗粒，其中官能团适于改变性质该装置对于施用于多细胞生物体具有足够的生物相容性，并且该颗粒具有约5nm至约10微米的平均直径。

4. 发明申请

WO2005015160A3 FUNCTIONALIZED POLYMERIC COLLOIDS 审中-公开
公开(公告)号：WO2005015160A3
公开(公告)日：2005-02-17
申请号：PCT/US2004/025500
申请日：2004-08-06
申请人： THE CHILDREN'S HOSPITAL OF PHILADELPHIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SHASTRI, Venkatram, Prasad , SUSSMAN, Eric, M. , CHEN, I-Wei
发明人： SHASTRI, Venkatram, Prasad , SUSSMAN, Eric, M. , CHEN, I-Wei
IPC分类号： B01F3/12 , A61K47/34
摘要： A process for providing a polymeric colloid, includes: dissolving a polymer in a first solvent to form a first solution; adding a second solvent to the first solution to form a second solution; adding a third solvent to the second solution to provide the polymeric colloid, wherein: the first solvent is miscible with the third solvent; and the third solvent predominantly comprises water. Polymeric colloids prepared by the process are also disclosed. The graph shows the polymeric colloid surface charge (i.e., zeta potential) as a of pH for poly(dl-lactide-co-glycolide), PLGA, and blends thereof.

5. 发明申请

WO2005007802A2 FIBROUS COMPOSITE FOR TISSUE ENGINEERING 审中-公开
标题翻译：纤维复合材料组织工程
公开(公告)号：WO2005007802A2
公开(公告)日：2005-01-27
申请号：PCT/US2003/008128
申请日：2003-03-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , CHOI, Hoon , CHEN, I-Wei
发明人： CHOI, Hoon , CHEN, I-Wei
IPC分类号： C12N
CPC分类号： A61L27/56 , A61L27/025 , A61L27/18 , A61L27/446 , A61L27/58 , C08L67/04
摘要： Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous / macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds.
摘要翻译：提供了通过本发明的方法制备的纤维复合材料，其包括氧化物和可生物降解的聚合物，其中纤维由具有纳米尺寸孔的气凝胶状氧化物材料制成。纤维组合物有利地至少具有以下特征：（i）非常高的纳米孔表面积，其也允许微晶成核; （ii）纤维之间的介孔/大孔间隙网络，提供高生物活性和高传输速率; （iii）天然骨样组织生长的大孔; （iv）用于处理和植入支持的良好的机械性能; 和（v）植入物溶解和时变机械性能的生物降解性。还提供了使用生物活性生物可降解纤维复合材料作为用于组织工程，组织再生长，骨植入物和骨修复，和/或递送药物或治疗化合物的成骨复合材料的方法。

6. 发明申请

WO2010080512A1 NON-VOLATILE RESISTANCE-SWITCHING THIN FILM DEVICES 审中-公开
标题翻译：非易失性电阻切换薄膜器件
公开(公告)号：WO2010080512A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/068518
申请日：2009-12-17
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , CHEN, I-Wei , KIM, Soo Gil , CHEN, Albert , WANG, Yudi
发明人： CHEN, I-Wei , KIM, Soo Gil , CHEN, Albert , WANG, Yudi
IPC分类号： G11C11/21
CPC分类号： G11C13/0002 , G11C13/0009 , G11C2213/33 , H01L45/10 , H01L45/1226 , H01L45/1233 , H01L45/14
摘要： Disclosed herein is a resistive switching device having an amorphous layer comprised of an insulating silicon-containing material and a conducting material. The amorphous layer may be disposed between two or more electrodes and be capable of switching between at least two resistance states. Circuits and memory devices including resistive switching devices are also disclosed, and a composition of matter involving an insulating silicon-containing material and a conducting material comprising between 5 and 40 percent by molar percentage of the composition is disclosed herein as well. Also disclosed herein are methods for switching the resistance of an amorphous material.
摘要翻译：本文公开了一种具有由绝缘含硅材料和导电材料构成的非晶层的电阻式开关器件。非晶层可以设置在两个或更多个电极之间并且能够在至少两个电阻状态之间切换。还公开了包括电阻开关器件的电路和存储器件，并且还公开了包含绝缘含硅材料和包含组合物的5-40％摩尔百分数的导电材料的物质组合物。本文还公开了用于切换无定形材料的电阻的方法。

7. 发明申请

WO2015031059A1 PH-SENSITIVE PEPTIDES AND THEIR NANOPARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：敏感性肽及其用于药物递送的纳米颗粒
公开(公告)号：WO2015031059A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/050881
申请日：2014-08-13
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： CHEN, I-Wei , CHOI, Hoon , ZHOU, Rong
IPC分类号： A61K47/48
CPC分类号： A61K47/6929 , A61K9/0019 , A61K9/5169 , A61K31/337 , A61K31/416 , A61K31/433 , A61K31/713 , A61K45/06 , A61K47/48884 , A61K47/60 , A61K47/64 , A61K47/645 , A61K47/6909 , A61K47/6935 , C07K7/06 , C07K7/08 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32 , C12N2320/51 , A61K2300/00
摘要： A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH- sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as near a tumor site (pH~6.5-6.9), the peptides may dissolve, releasing the biological substance. Also provided are the delivery methods and related kits.
摘要翻译：提供由一种或多种pH敏感肽制成的新的纳米级载体用于递送生物活性物质。肽在主链中由pH敏感的亲水和疏水性氨基酸组成。当pH环境从生理pH值变化到弱酸性环境（如肿瘤位置附近（pH〜6.5-6.9））时，肽会溶解，释放生物物质。还提供了交付方法和相关工具包。

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