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1. 发明专利

AU2017316768A1 Multivalent vaccine composition 未知
公开(公告)号：AU2017316768A1
公开(公告)日：2019-04-11
申请号：AU2017316768
申请日：2017-08-24
申请人： SERUM INSTITUTE OF INDIA PVT LTD , THE CENTERS FOR DISEASE CONTROL AND PREVENTION CDC
发明人： DHERE RAJEEV MHALASAKANT , PISAL SAMBHAJI SHANKAR , ZADE JAGDISH KAMALAJI , SABALE RAJENDRA NARAYAN , KADAM RAVINDRA BAPURAO , KAMBLE ABHIJEET SANJEEV , JIANG BAOMING , GLASS ROGER
IPC分类号： A61K39/12
摘要： The present invention relates to stable, immunogenic combination vaccine(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis and Hepatitis B virus. The invention particularly provides a multivalent combination vaccine comprising of i) significantly dose reduced Salk IPV or Sabin IPV (IPV) antigens prepared by utilizing improved methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum recovery of D-antigen and ii) Injectable heat inactivated Rotavirus antigen(s) obtained from Rotavirus (CDC-9) strains that provides a broad cross-protective immunity among human rotavirus strains, iii) Hib PRP -carrier protein conjugate having improved stability and immunogenicity wherein said Hib PRP -earner protein conjugate is initially prepared by using novel conjugation process and subsequently blended at low temperature in presence of a stabilizer for minimizing free PRP release iv) whole ceil pertussis antigen with improved immunogenicity and stability obtained by addition of whole cell pertussis antigen at a later stage in a blend thereby minimizing hydrolysis based degradation v) Homogenous fractions of Diphtheria toxoid and Tetanus toxoid obtained by removal of undesirable aggregates by using Gel Permeation chromatography. The process of making such stable and immunogenic vaccine compositions by i) individually adsorbing dose reduced IPV. IRV antigens on alum hydroxide and keeping other antigen(s) unadsorbed or adsorbed on Alum Phosphate, Alum hydroxide, on a combination of Alum hydroxide and Alum phosphate and ii) using a particular order of addition of antigens during blending is also disclosed.

2. 发明专利

PH12019500404A1 MULTIVALENT VACCINE COMPOSITION 未知
公开(公告)号：PH12019500404A1
公开(公告)日：2020-01-20
申请号：PH12019500404
申请日：2019-02-26
申请人： THE CENTERS FOR DISEASE CONTROL AND PREVENTION CDC , SERUM INSTITUTE OF INDIA PVT LTD
发明人： DHERE RAJEEV MHALASAKANT , PISAL SAMBHAJI SHANKAR , ZADE JAGDISH KAMALAJI , SABALE RAJENDRA NARAYAN , KADAM RAVINDRA BAPURAO , KAMBLE ABHIJEET SANJEEV , JIANG BAOMING , GLASS ROGER
IPC分类号： A61K39/12
摘要： The present invention relates to stable, immunogenic combination vaccine(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis and Hepatitis B virus. The invention particularly provides a multivalent combination vaccine comprising of i) significantly dose reduced Salk IPV or Sabin IPV (IPV) antigens prepared by utilizing improved methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum recovery of D-antigen and ii) Injectable heat inactivated Rotavirus antigen(s) obtained from Rotavirus (CDC-9) strains that provides a broad cross-protective immunity among human rotavirus strains, iii) Hib PRP -carrier protein conjugate having improved stability and immunogenicity wherein said Hib PRP -earner protein conjugate is initially prepared by using novel conjugation process and subsequently blended at low temperature in presence of a stabilizer for minimizing free PRP release iv) whole ceil pertussis antigen with improved immunogenicity and stability obtained by addition of whole cell pertussis antigen at a later stage in a blend thereby minimizing hydrolysis based degradation v) Homogenous fractions of Diphtheria toxoid and Tetanus toxoid obtained by removal of undesirable aggregates by using Gel Permeation chromatography. The process of making such stable and immunogenic vaccine compositions by i) individually adsorbing dose reduced IPV. IRV antigens on alum hydroxide and keeping other antigen(s) unadsorbed or adsorbed on Alum Phosphate, Alum hydroxide, on a combination of Alum hydroxide and Alum phosphate and ii) using a particular order of addition of antigens during blending is also disclosed.

3. 发明专利

CU20190013A7 COMPOSICIONES DE VACUNAS MULTIVALENTES 未知
公开(公告)号：CU20190013A7
公开(公告)日：2019-10-04
申请号：CU20190013
申请日：2017-08-24
申请人： SERUM INSTITUTE OF INDIA PVT LTD , THE CENTERS FOR DISEASE CONTROL AND PREVENTION CDC
发明人： DHERE RAJEEV MHALASAKANT , GLASS ROGER , JIANG BAOMING , KADAM RAVINDRA BAPURAO , KAMBLE ABHIJEET SANJEEV , PISAL SAMBHAJI SHANKAR , SABALE RAJENDRA NARAYAN , ZADE JAGDISH KAMALAJI
IPC分类号： A61K39/12
摘要： La presente invención se refiere a composiciones de vacunas multivalentes que comprenden una mezcla de antígenos para Ia prevención y profilaxis de infecciones causadas por rotavirus, poliovirus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis y Hepatitis B virus, así como el proceso de fabricación de las mismas. La invención, en particular, se refiere a una vacuna de combinación multivalente estable que comprende antígenos de Salk IPV o Sabin IPV (IPV) significativamente reducidos y antígeno (s) inyectable de Rotavirus, inactivado por calor, obtenido de cepas de Rotavirus (CDC -9).

4. 发明专利

CA3032901A1 MULTIVALENT VACCINE COMPOSITION 未知
公开(公告)号：CA3032901A1
公开(公告)日：2018-03-01
申请号：CA3032901
申请日：2017-08-24
申请人： SERUM INSTITUTE OF INDIA PVT LTD , THE CENTERS FOR DISEASE CONTROL AND PREVENTION CDC
发明人： DHERE RAJEEV MHALASAKANT , PISAL SAMBHAJI SHANKAR , ZADE JAGDISH KAMALAJI , SABALE RAJENDRA NARAYAN , KADAM RAVINDRA BAPURAO , KAMBLE ABHIJEET SANJEEV , JIANG BAOMING , GLASS ROGER
IPC分类号： A61K39/12
摘要： The present invention relates to stable, immunogenic combination vaccine(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis and Hepatitis B virus. The invention particularly provides a multivalent combination vaccine comprising of i) significantly dose reduced Salk IPV or Sabin IPV (IPV) antigens prepared by utilizing improved methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum recovery of D-antigen and ii) Injectable heat inactivated Rotavirus antigen(s) obtained from Rotavirus (CDC-9) strains that provides a broad cross-protective immunity among human rotavirus strains, iii) Hib PRP -carrier protein conjugate having improved stability and immunogenicity wherein said Hib PRP -earner protein conjugate is initially prepared by using novel conjugation process and subsequently blended at low temperature in presence of a stabilizer for minimizing free PRP release iv) whole ceil pertussis antigen with improved immunogenicity and stability obtained by addition of whole cell pertussis antigen at a later stage in a blend thereby minimizing hydrolysis based degradation v) Homogenous fractions of Diphtheria toxoid and Tetanus toxoid obtained by removal of undesirable aggregates by using Gel Permeation chromatography. The process of making such stable and immunogenic vaccine compositions by i) individually adsorbing dose reduced IPV. IRV antigens on alum hydroxide and keeping other antigen(s) unadsorbed or adsorbed on Alum Phosphate, Alum hydroxide, on a combination of Alum hydroxide and Alum phosphate and ii) using a particular order of addition of antigens during blending is also disclosed.

5. 发明专利

PE20200004A1 COMPOSICION DE VACUNA MULTIVALENTE NOVEDOSA 未知
公开(公告)号：PE20200004A1
公开(公告)日：2020-01-06
申请号：PE2019000409
申请日：2017-08-24
申请人： SERUM INSTITUTE OF INDIA PVT LTD , US HEALTH
发明人： PISAL SAMBHAJI SHANKAR , ZADE JAGDISH KAMALAJI , SABALE RAJENDRA NARAYAN , KADAM RAVINDRA BAPURAO , KAMBLE ABHIJEET SANJEEV , JIANG BAOMING , GLASS ROGER , DHERE RAJEEV MHALASAKANT
IPC分类号： A61K39/12
摘要： La presente invencion se refiere a una vacuna de combinacion bivalente que comprende: i) antigeno de virus de polio inactivado seleccionado entre cepa Salk o Sabin en dosis reducidas ; ii) antigeno de rotavirus inactivado por calor inyectable seleccionado entre CDC-9,CDC-66 o cualquier otra cepa de rotavirus inactivada; iii) opcionalmente uno o mas antigenos seleccionados entre el grupo de toxoide de difteria, toxoide tetanico, pertussis de celula entera, HBsAg, conjugados de PRP Hib- proteina transportadora, entre otros y iv) uno o mas adyuvantes seleccionados de sal de aluminio como hidroxido de aluminio o fosfato de aluminio. Dicha vacuna tiene estabilidad e inmunogenicidad mejorada, siendo util para la prevencion y profilaxis de infecciones causadas por el rotavirus, el virus de la poliomielitis, Haemophilus influenzae, Corynebacterium diptheriae, Clostridium tetani, Bordetella pertussis y el virus de la Hepatitis B. Tambien se refiere a un proceso de fabricacion de dicha vacuna de combinacion.

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