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1. 发明申请

WO2006105082A3 ALKANE OXIDATION BY MODIFIED HYDROXYLASES 审中-公开
公开(公告)号：WO2006105082A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/011273
申请日：2006-03-28
申请人： THE CALIFORNIA INSTITUTE OF TECHNOLOGY , ARNOLD, Frances , MEINHOLD, Peter , PETERS, Matthew, W. , FASAN, Rudi , CHEN, Mike, M., Y.
发明人： ARNOLD, Frances , MEINHOLD, Peter , PETERS, Matthew, W. , FASAN, Rudi , CHEN, Mike, M., Y.
IPC分类号： C12N9/02 , C07H21/04
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.

2. 发明申请

WO2009059254A2 METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL PRECURSOR THAT IS ALSO A BIOFUEL FROM BIOMASS 审中-公开
标题翻译：经济生产生物燃料前体的方法也是生物质的生物燃料
公开(公告)号：WO2009059254A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/082160
申请日：2008-10-31
申请人： GEVO, INC , HAWKINS, Andrew, C. , GLASSNER, David, A. , BUELTER, Thomas , WADE, James , MEINHOLD, Peter , PETERS, Matthew, W. , GRUBER, Patrick, R. , EVANKO, William, A , ARISTIDOU, Aristos, A.
发明人： HAWKINS, Andrew, C. , GLASSNER, David, A. , BUELTER, Thomas , WADE, James , MEINHOLD, Peter , PETERS, Matthew, W. , GRUBER, Patrick, R. , EVANKO, William, A , ARISTIDOU, Aristos, A.
IPC分类号： C12P7/16 , C12P7/10 , C12P7/04 , C10L1/02 , C12N15/52
CPC分类号： C12P7/16 , C07K14/245 , C10G1/04 , C10G2300/1014 , C10G2300/4025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0006 , C12N9/0036 , C12N9/2414 , C12N9/2417 , C12N9/2428 , C12N9/2434 , C12P7/04 , C12P7/24 , C12P7/62 , C12Y106/01002 , C12Y302/01001 , C12Y302/01003 , Y02E50/10 , Y02E50/16 , Y02P30/20
摘要： Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.
摘要翻译：提供生产生物燃料前体的方法。还提供了将原料转化为生物燃料前体的生物催化剂。

3. 发明申请

WO2008080124A2 BUTANOL PRODUCTION BY METABOLICALLY ENGINEERED YEAST 审中-公开
标题翻译：用代谢工程酵母生产丁醇
公开(公告)号：WO2008080124A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088705
申请日：2007-12-21
申请人： GEVO , GUNAWARDENA, Uvini , MEINHOLD, Peter , PETERS, Matthew W. , URANO, Jun , FELDMAN, Reid M. Renny
发明人： GUNAWARDENA, Uvini , MEINHOLD, Peter , PETERS, Matthew W. , URANO, Jun , FELDMAN, Reid M. Renny
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12N9/0008 , C12N9/88 , C12N9/93 , Y02E50/10
摘要： There are disclosed metabolically-engineered yeast and methods of producing n-butanol. In an embodiment, metabolically-engineered yeast is capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway capable of utilizing NADH to convert acetyl-CoA to n-butanol. In another embodiment, a method of producing n-butanol includes (a) providing metabolically-engineered yeast capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and expresses at least one enzyme for a metabolic pathway utilizing NADH to convert acetyl-CoA to n-butanol; and (b) culturing the yeast to produce n-butanol. Other embodiments are also disclosed.
摘要翻译：公开了代谢工程酵母和生产正丁醇的方法。在一个实施方案中，代谢工程化的酵母能够代谢碳源以产生正丁醇，相对于由野生型酵母产生的胞质乙酰-CoA，至少一种途径产生增加的胞质乙酰-CoA，并且至少一种异源基因编码和表达至少一种能够利用NADH将乙酰-CoA转化为正丁醇的代谢途径的酶。在另一个实施方案中，生产正丁醇的方法包括（a）提供能够代谢碳源以产生正丁醇的代谢工程化的酵母，至少一个途径产生相对于由胞质乙酰-CoA产生的胞质乙酰-CoA增加的胞质乙酰-CoA 野生型酵母，并且至少一种异源基因编码并表达至少一种用于利用NADH将乙酰-CoA转化为正丁醇的代谢途径的酶; 和（b）培养酵母以产生正丁醇。其他实施例也被公开。

4. 发明申请

WO2008013996A2 ENGINEERED MICROORGANISMS FOR INCREASING PRODUCT YIELD IN BIOTRANSFORMATIONS, RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于增加生物产品产量的工程微生物，相关方法和系统
公开(公告)号：WO2008013996A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/017013
申请日：2007-07-27
申请人： Gevo Inc. , PETERS, Matthew W. , MEINHOLD, Peter , BUELTER, Thomas , LANDWEHR, Marco
发明人： PETERS, Matthew W. , MEINHOLD, Peter , BUELTER, Thomas , LANDWEHR, Marco
IPC分类号： C12N1/21
CPC分类号： C12N9/0036
摘要： Recombinant microorganisms engineered to increase product yield in a biotransformation are shown. The microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in the biotransformation. Also methods and systems using such recombinant microorganisms are described.
摘要翻译：显示了在生物转化中改进产物产量的工程改造的重组微生物。工程化微生物以增加参与生物转化的NAD（P）H需氧化还原酶可用的NAD（P）H的量。还描述了使用这种重组微生物的方法和系统。

5. 发明申请

WO2009103026A1 ENGINEERED MICROORGANISMS FOR PRODUCING ISOPROPANOL 审中-公开
标题翻译：用于生产异丙酚的工程微生物
公开(公告)号：WO2009103026A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/034152
申请日：2009-02-13
申请人： GEVO, INC. , HAWKINS, Andrew, C. , PETERS, Matthew, W. , MEINHOLD, Peter , BUELTER, Thomas , GLASSNER, David, A. , GRUBER, Patrick, R. , WADE, James
发明人： HAWKINS, Andrew, C. , PETERS, Matthew, W. , MEINHOLD, Peter , BUELTER, Thomas , GLASSNER, David, A. , GRUBER, Patrick, R. , WADE, James
IPC分类号： C12P7/06 , C12P7/16
CPC分类号： C12P7/04 , C12P5/026 , C12P7/28 , Y02E50/17
摘要： Methods and compositions for the production of bio-based material precursors are provided.
摘要翻译：提供了用于生产基于生物的材料前体的方法和组合物。

6. 发明申请

WO2009059253A2 METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL FROM BIOMASS 审中-公开
标题翻译：从生物量经济生产生物燃料的方法
公开(公告)号：WO2009059253A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/082159
申请日：2008-10-31
申请人： GEVO, INC. , HAWKINS, Andrew, C. , GLASSNER, David, A. , BUELTER, Thomas , WADE, James , MEINHOLD, Peter , PETERS, Matthew, W. , GRUBER, Patrick, R. , EVANKO, William, A. , ARISTIDOU, Aristos, A.
发明人： HAWKINS, Andrew, C. , GLASSNER, David, A. , BUELTER, Thomas , WADE, James , MEINHOLD, Peter , PETERS, Matthew, W. , GRUBER, Patrick, R. , EVANKO, William, A. , ARISTIDOU, Aristos, A.
IPC分类号： C12P7/16 , C12P7/10 , C12P7/04 , C10L1/02 , C12N15/52
CPC分类号： C12P7/16 , C07K14/245 , C10G1/04 , C10G2300/1014 , C10G2300/4025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N9/0006 , C12N9/0036 , C12N9/2414 , C12N9/2417 , C12N9/2428 , C12N9/2434 , C12P7/04 , C12P7/24 , C12P7/62 , C12Y106/01002 , C12Y302/01001 , C12Y302/01003 , Y02E50/10 , Y02E50/16 , Y02P30/20
摘要： Methods for producing a biofuel are provided. Also provided are biocatalysts that convert a feedstock to a biofuel.
摘要翻译：提供生产生物燃料的方法。还提供了将原料转化为生物燃料的生物催化剂。

7. 发明申请

WO2013003545A1 TUNING OF FUSEL ALCOHOL BY-PRODUCTS DURING ISOBUTANOL PRODUCTION BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物对异丁醇生产过程中的酒精醇副产物进行调节
公开(公告)号：WO2013003545A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044563
申请日：2012-06-28
申请人： GEVO, INC. , MEINHOLD, Peter , PETERS, Matthew, W. , HAWKINS, Andrew, C. , FELDMAN, Reid, M. , URANO, Jun
发明人： MEINHOLD, Peter , PETERS, Matthew, W. , HAWKINS, Andrew, C. , FELDMAN, Reid, M. , URANO, Jun
IPC分类号： C12P7/16 , C12N1/00 , C12N15/74
CPC分类号： C12N15/52 , C12P7/16 , Y02E50/10
摘要： The disclosure relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of a 2-ketoisovalerate-derived by-product such as 3-methyl-1-butanol. The recombinant microorganisms may be microorganisms of the Saccharomyces dade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本公开涉及包含生物合成途径的重组微生物和使用所述重组微生物产生各种有益代谢物的方法。在各个方面，重组微生物可以进一步包含一种或多种修饰，导致还原或消除2-酮异戊酸酯衍生的副产物如3-甲基-1-丁醇。重组微生物可以是酵母的微生物，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，前WGD（全基因组复制）酵母微生物和非发酵酵母微生物。

8. 发明申请

WO2011142865A3 YEAST MICROORGANISMS WITH REDUCED BY-PRODUCT ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开
公开(公告)号：WO2011142865A3
公开(公告)日：2011-11-17
申请号：PCT/US2011/024482
申请日：2011-02-11
申请人： GEVO, INC. , CALIFORNIA INSTITUTE OF TECHNOLOGY , BUELTER, Thomas , HAWKINS, Andrew , PORTER-SCHEINMAN, Stephanie , MEINHOLD, Peter , DUNDON, Catherine, Asleson , ARISTIDOU, Aristos , URANO, Jun , LIES, Doug , PETERS, Matthew , DEY, Melissa , JANCAUSKAS, Justas , EVANS, Kent , KELLY, Julie , BERRY, Ruth , BASTIAN, Sabine , ARNOLD, Frances
发明人： BUELTER, Thomas , HAWKINS, Andrew , PORTER-SCHEINMAN, Stephanie , MEINHOLD, Peter , DUNDON, Catherine, Asleson , ARISTIDOU, Aristos , URANO, Jun , LIES, Doug , PETERS, Matthew , DEY, Melissa , JANCAUSKAS, Justas , EVANS, Kent , KELLY, Julie , BERRY, Ruth , BASTIAN, Sabine , ARNOLD, Frances
IPC分类号： C12N1/00 , C12N15/74
摘要： Recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites are provided. The recombinant microorganisms provided may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g.. acelolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived byproducts. Further, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

9. 发明申请

WO2010051527A2 ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS 审中-公开
标题翻译：在无机条件下生产目标化合物的工程微生物
公开(公告)号：WO2010051527A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/062952
申请日：2009-11-02
申请人： GEVO, INC. , CALIFORNIA INSTITUTE OF TECHNOLOGY , BUELTER, Thomas , MEINHOLD, Peter , FELDMAN, Reid M. Renny , ECKL, Eva , HAWKINS, Andrew , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , LIES, Doug , BASTIAN, Sabine , ARNOLD, Frances , URANO, Jun
发明人： BUELTER, Thomas , MEINHOLD, Peter , FELDMAN, Reid M. Renny , ECKL, Eva , HAWKINS, Andrew , ARISTIDOU, Aristos , DUNDON, Catherine Asleson , LIES, Doug , BASTIAN, Sabine , ARNOLD, Frances , URANO, Jun
IPC分类号： C12P7/16 , C12N9/02 , C12N1/21 , C12N1/15 , C12N1/19
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0036 , Y02E50/10 , Y02E50/17
摘要： The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.
摘要翻译：本发明通常提供重组微生物，其包含能够在需氧和厌氧条件下生产C3-C5醇的工程化代谢途径。本发明还提供已被突变或修饰以提高其NADH依赖性活性或将辅因子偏好从NADPH转变为NADH并在修饰的微生物中表达的酮酸酸还原异构酶。此外，本发明提供了以修饰微生物表达的异丁醛脱氢酶。还提供了在需氧和厌氧条件下通过使合适的底物与本发明的改性微生物接触来生产有益代谢物的方法。

10. 发明申请

WO2005017105A3 REGIO- AND ENANTIOSELECTIVE ALKANE HYDROXYLATION WITH MODIFIED CYTOCHROME P450 审中-公开
公开(公告)号：WO2005017105A3
公开(公告)日：2005-02-24
申请号：PCT/US2004/018832
申请日：2004-06-15
申请人： CALIFORNIA UNIVERSITY OF TECHNOLOGY , ARNOLD, Frances, H. , PETERS, Mathew, W. , MEINHOLD, Peter
发明人： ARNOLD, Frances, H. , PETERS, Mathew, W. , MEINHOLD, Peter
IPC分类号： C12N9/00 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00 , C07K16/00
摘要： Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydroxylates octane primarily at the 2-positio to form S -2-octanol (40% ee). Another mutant, 1-12G, hydroxylates alkanes larger than hexane primarily at the 2-position, but forms R -2-alcohols (40-55% ee). These biocatalysts are highly active for alkane substrates and support thousands of product turnovers. These regio-and enantio-selectivities are retained in whole-cell biotransformations with E. coli , where the engineered P450s can be expressed at high levels and the expensive cofactor is supplied endogenously.

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