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1. 发明申请

US20140227267A1 BOVINE FUSION ANTIBODIES 有权
标题翻译： BOVINE融合抗体
公开(公告)号：US20140227267A1
公开(公告)日：2014-08-14
申请号：US14152441
申请日：2014-01-10
申请人： The California Institute for Biomedical Research
发明人： Feng WANG , Yong ZHANG , Peter G. Schultz
IPC分类号： C07K16/28
CPC分类号： C07K16/00 , C07K7/08 , C07K14/575 , C07K14/5759 , C07K14/605 , C07K14/61 , C07K14/635 , C07K14/64 , C07K14/811 , C07K16/2869 , C07K2317/565 , C07K2318/10 , C07K2319/00 , C07K2319/30
摘要： Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
摘要翻译：本文公开了包含至少一个免疫球蛋白结构域或其片段的免疫球蛋白构建体; 以及连接到或插入所述免疫球蛋白结构域的治疗性多肽或其衍生物或变体。还提供了包含哺乳动物免疫球蛋白重链的免疫球蛋白构建体，其包含互补决定区3（CDR3H）或其片段中的至少一部分旋钮结构域; 以及连接到CDR3H的所述旋钮结构域或插入CDR3H的所述旋钮结构域中的治疗性多肽。还提供了包含哺乳动物免疫球蛋白重链的免疫球蛋白构建体，其包含互补决定区3（CDR3H）或其片段中的至少一部分茎结构域; 以及与CDR3H的所述茎结构域连接或插入的治疗性多肽。本文还描述了包含本文所述的用于治疗和预防受试者的疾病或病症的免疫球蛋白构建体的方法和组合物。

2. 发明授权

US10336735B2 Small molecule inhibitors of fibrosis 有权
公开(公告)号：US10336735B2
公开(公告)日：2019-07-02
申请号：US15534225
申请日：2015-12-09
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
发明人： Luke Lairson , Arnab K. Chatterjee , Michael Bollong , Baiyuan Yang , Peter G. Schultz
IPC分类号： A01N57/00 , C07D403/10 , C07D405/12 , C07D405/14 , C07D495/04
摘要： Described herein are compounds and compositions for the treatment of a fibrotic disease.

3. 发明申请

US20180344812A1 MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：US20180344812A1
公开(公告)日：2018-12-06
申请号：US16000829
申请日：2018-06-05
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
IPC分类号： A61K38/22 , A61K45/06 , A61K38/26 , A61K9/00 , A61K47/54 , A61K47/60 , A61K9/70
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0021 , A61K9/703 , A61K38/2278 , A61K38/26 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K47/60
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

4. 发明授权

US09663499B2 Small molecule inhibitors of fibrosis 有权
公开(公告)号：US09663499B2
公开(公告)日：2017-05-30
申请号：US14895813
申请日：2014-06-05
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
发明人： Luke Lairson , Michael Bollong , Peter G. Schultz , Arnab K. Chatterjee , Baiyuan Yang , Puneet Kumar , Kaveri Urkalan
IPC分类号： A61K31/496 , C07D405/14 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D417/14
CPC分类号： C07D405/14 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D417/14
摘要： Described herein are compounds and compositions for the treatment of a fibrotic disease.

5. 发明授权

US09656972B2 Compounds for treatment of cystic fibrosis 有权
公开(公告)号：US09656972B2
公开(公告)日：2017-05-23
申请号：US14900355
申请日：2014-07-02
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： Peter G. Schultz , Arnab K. Chatterjee , Manoj Kumar , Gustav Welzel
IPC分类号： A61K31/497 , C07D241/28 , C07D241/32 , C07D403/12 , C07D241/34 , C07C279/18
CPC分类号： C07D241/32 , C07C279/18 , C07D241/28 , C07D241/34 , C07D403/12
摘要： Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.

7. 发明授权

US10351626B2 Targeting agent antibody conjugates and uses thereof 有权
公开(公告)号：US10351626B2
公开(公告)日：2019-07-16
申请号：US14774647
申请日：2014-03-14
申请人： The California Institute for Biomedical Research , The Scripps Research Institute
发明人： Chanhyuk Kim , Jun Y. Axup , Hwayoung Yun , Peter G. Schultz , Jennifer Ma , Jiayin Shen , Pengyu Yang
IPC分类号： A61K47/68 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/395 , C07C275/16 , C07C275/24 , C07D249/04 , C07K16/30 , A61K47/54 , A61K39/00
摘要： Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.

8. 发明授权

US10501546B2 Insulin immunoglobulin fusion proteins 有权
公开(公告)号：US10501546B2
公开(公告)日：2019-12-10
申请号：US15756296
申请日：2016-09-02
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： Feng Wang , Matthew S. Tremblay , Travis Young , Nicole Alvarez , Yan Liu , Juanjuan Du , Peter G. Schultz
IPC分类号： C07K16/28 , C07K14/62 , A61P3/10
CPC分类号： C07K16/2851 , A61P3/10 , C07K14/62 , C07K16/2854 , C07K2317/24 , C07K2319/00
摘要： Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions.

9. 发明授权

US10286078B2 Modified therapeutic agents and compositions thereof 有权
公开(公告)号：US10286078B2
公开(公告)日：2019-05-14
申请号：US14917689
申请日：2014-09-12
申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
发明人： Weijun Shen , Peter G. Schultz , Avinash Muppidi , Insha Ahmad , Pengyu Yang
IPC分类号： A61K38/22 , A61K9/00 , A61K47/48 , A61K38/26 , A61K38/28 , A61K38/17 , A61K38/18 , A61K45/06 , A61K47/54
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.

10. 发明授权

US09624276B2 Peptidic chimeric antigen receptor T cell switches and uses thereof 有权
公开(公告)号：US09624276B2
公开(公告)日：2017-04-18
申请号：US14688894
申请日：2015-04-16
申请人： The California Institute for Biomedical Research
发明人： Travis Young , Chanhyuk Kim , Peter G. Schultz
IPC分类号： C07K14/395 , C07K14/00 , C07K16/00 , A61K39/00 , C12N5/10 , C07K19/00 , C12N5/0783 , A61K38/00
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/3955 , A61K2039/505 , A61K2039/515 , A61K2039/572 , A61K2039/70 , C07K14/395 , C07K16/2803 , C07K16/2887 , C07K2319/01 , C07K2319/30 , C12N5/0636
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

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