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1. 发明申请

WO2008154207A9 METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS 审中-公开
公开(公告)号：WO2008154207A9
公开(公告)日：2008-12-18
申请号：PCT/US2008/065567
申请日：2008-06-02
申请人： THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH , REED, John, C. , YIP, Kenneth , SERGIENKO, Eduard , SU, Ying
发明人： REED, John, C. , YIP, Kenneth , SERGIENKO, Eduard , SU, Ying
IPC分类号： G01N33/53 , G01N33/00
摘要： An assay for determining compounds that inhibit activity of a BC1-2 protein, or affect conversion of Bc1-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bc1-2 and related Bc1-2 family members are identified.

2. 发明申请

WO2008157003A2 CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS 审中-公开
标题翻译： BFL-1化学抑制剂及相关方法
公开(公告)号：WO2008157003A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/065422
申请日：2008-05-30
申请人： THE BURNHAM INSTITUTE , REED, John, C. , ZHAI, Dayong , KITADA, Shinichi , SERGIENKO, Eduard
发明人： REED, John, C. , ZHAI, Dayong , KITADA, Shinichi , SERGIENKO, Eduard
IPC分类号： A61K31/5377 , A61K31/496 , G01N33/53 , A61P35/00
CPC分类号： A61K31/496 , A61K31/5377 , G01N2500/02
摘要： Compounds that bind to BfI-1 as well as conjugates of such compounds are provided. Various embodiments additionally provide methods of using such compounds to identify additional anti-apoptotic BfI- 1 binding compounds. Methods of using such compounds to increase apoptosis in a cell are also provided.
摘要翻译：提供了结合BfI-1的化合物以及这些化合物的缀合物。各种实施方案另外提供使用这些化合物鉴定另外的抗凋亡BfI-1结合化合物的方法。还提供了使用这些化合物增加细胞凋亡的方法。

3. 发明公开

EP1865977A2 METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE 审中-公开
标题翻译：方法和组合物去抑制IAP-抑制胱天蛋白酶
公开(公告)号：EP1865977A2
公开(公告)日：2007-12-19
申请号：EP06738724.1
申请日：2006-03-17
申请人： The Burnham Institute for Medical Research , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
发明人： REED, John, C. , HOUGHTEN, Rihcard, A. , NEFZI, Adel , OSTRESH, John, M. , PINILLA, Clemencia , WELSH, Kate
IPC分类号： A61K38/08 , A61K38/06
CPC分类号： A61K38/07 , A61K38/08
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.

4. 发明申请

WO2008036244A1 USE OF CYCLOSPORIN A TO SENSITIZE RESISTANT CANCER CELLS TO DEATH RECEPTOR LIGANDS 审中-公开
标题翻译： CYPOSPORIN A将耐药性癌细胞用于死亡受体配体
公开(公告)号：WO2008036244A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/020157
申请日：2007-09-17
申请人： THE BURHAM INSTITUTE FOR MEDICAL RESEARCH , REED, John, C. , THOMAS, Michael, Paul
发明人： REED, John, C. , THOMAS, Michael, Paul
IPC分类号： A61K38/00
CPC分类号： A61K38/13 , A61K38/1709 , A61K38/1761 , A61K38/185 , A61K38/191 , A61K2300/00
摘要： Cyclosporin A has been discovered to sensitize cancers resistant to TNF-family death receptors such as TRAIL and Fas to ligand-mediated apoptosis. Therefore, compositions that include cyclosporin A are useful in treating such cancers.
摘要翻译：已经发现环孢菌素A使对TNF-家族死亡受体（例如TRAIL和Fas）的抗癌剂对配体介导的凋亡敏感。因此，包含环孢菌素A的组合物可用于治疗这种癌症。

5. 发明申请

WO2003045974A2 METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE 审中-公开
标题翻译：用于抑制IAP抑制CASPASE的方法和组合物
公开(公告)号：WO2003045974A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/037577
申请日：2002-11-21
申请人： THE BURNHAM INSTITUTE , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES , REED, John, C. , HOUGHTEN, Richard, A. , NEFZI, Adel , OSTRESH, John, M. , PINILLA, Clemencia , WELSH, Kate
发明人： REED, John, C. , HOUGHTEN, Richard, A. , NEFZI, Adel , OSTRESH, John, M. , PINILLA, Clemencia , WELSH, Kate
IPC分类号： C07K
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K5/1027
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in Figures 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882,TPI914 or TPI927. The methods of the invention also can be used for promoting apoptosis in a cell and for reducing the severity of a pathology characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂减阻IAP抑制的半胱天冬酶。还提供了具有选自图5，图9，图10，图14B和图21-24所示的任何结构的核心结构的分离剂，其中所述试剂去抑制IAP-抑制的半胱天冬酶。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。该方法包括使IAP抑制的半胱天冬酶与有效量的试剂接触以对抑制IAP-抑制的半胱天冬酶进行脱保护，该试剂具有选自核心肽的核心基序，所述核心基序具有核心肽 4至39和42至55，以及选自TPI759，TPI882，TPI914或TPI927的核心结构。本发明的方法还可用于促进细胞凋亡和降低以凋亡水平降低为特征的病理学的严重性。还提供了用于鉴定抑制IAP抑制的半胱天冬酶的药剂的方法。

6. 发明申请

WO2002090931A2 METHODS FOR DETERMINING THE PROGNOSIS FOR CANCER PATIENTS USING TUCAN 审中-公开
标题翻译：使用TUCAN确定癌症患者预后的方法
公开(公告)号：WO2002090931A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014487
申请日：2002-05-07
申请人： THE BURNHAM INSTITUTE , REED, John, C.
发明人： REED, John, C.
IPC分类号： G01N
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/158 , G01N2510/00 , G01N2800/52
摘要： This invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a reference level of TUCAN, wherein a low level of TUCAN in the sample correlates with increased survival of the patient. Another method involves (a) measuring a level of TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) classifying the patient as belonging to either a first or second group of patients, wherein the first group of patients having low levels of TUCAN is classified as having an increased likelihood of survival compared to the second group of patients having high level of TUCAN.
摘要翻译：本发明提供了确定癌症患者的存活预后的方法。一种方法包括（a）测量来自癌症患者的含赘生瘤细胞的样品中TUCAN的水平，和（b）将样品中TUCAN的水平与TUCAN的参考水平进行比较，其中TUCAN的水平低样本与患者的生存率增加相关。另一种方法包括（a）测量来自癌症患者的含赘生瘤细胞的样品中TUCAN的水平，和（b）将患者归类为属于第一组或第二组患者，其中第一组患者具有低与第二组具有高水平TUCAN的患者相比，TUCAN的水平被归类为具有增加的存活可能性。

7. 发明申请

WO2009120874A2 INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-кB ACTIVATION 审中-公开
标题翻译：抗原受体诱导的NF-κB激活的抑制剂
公开(公告)号：WO2009120874A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038419
申请日：2009-03-26
申请人： BURNHAM INSTITUTE FOR MEDICAL RESEARCH , HUMAN BIOMOLECULAR RESEARCH INSTITUTE , REED, John, C. , SHI, Ranxin , RE, Daniel , CASHMAN, John, R. , OKOLOTOWICZ, Karl, J.
发明人： REED, John, C. , SHI, Ranxin , RE, Daniel , CASHMAN, John, R. , OKOLOTOWICZ, Karl, J.
IPC分类号： A61K31/4184 , C07D413/04 , C07D235/04 , A61K31/5377 , A61P43/00
CPC分类号： C07D235/04 , C07D413/04
摘要： A method to identify selective inhibitors of antigen receptor-mediated NF-кB activation is provided, as well as compositions having one or more of those inhibitors and methods of using those inhibitors.
摘要翻译：提供了鉴定抗原受体介导的NF-κB激活的选择性抑制剂的方法，以及具有一种或多种这些抑制剂的组合物和使用这些抑制剂的方法。

8. 发明申请

WO2007047551A2 METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE 审中-公开
标题翻译：用于抑制IAP抑制的CASPASE的方法和组合物
公开(公告)号：WO2007047551A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040301
申请日：2006-10-13
申请人： THE BURNHAM INSTITUTE , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES , REED, John, C. , HOUGHTEN, Richard, A. , NEFZI, Adel , OSTRESH, John, M. , PINILLA, Clemencia , WELSH, Kate
发明人： REED, John, C. , HOUGHTEN, Richard, A. , NEFZI, Adel , OSTRESH, John, M. , PINILLA, Clemencia , WELSH, Kate
IPC分类号： A61K38/54
CPC分类号： A61K31/337 , A61K31/17 , A61K31/704 , A61K31/7048 , A61K38/1761 , A61K45/06 , G01N33/573 , G01N2333/95 , G01N2500/02 , G01N2510/00 , A61K2300/00
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in Figures 5, 9, 10, 14B, 21-24 and 48, a core structure selected from the group of TPI 759, TPI 882, TPI 914 or TPI 927; and a core structure from a library selected from TPI 1391, TPI 1349, TPI 1396, TPI 1509, TPI 1540, TPI 1400, TPI 792, TPI 1332, TPI 1567, TPI 1576 and TPI 1577, wherein the agent derepresses an IAPinhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂解吸抑制IAP抑制的半胱天冬酶。还提供了分离的试剂，其具有选自图5,9,10,14B，21-24和48中所示的任何结构的核心结构，选自TPI 759，TPI 882，TPI 914或 TPI 927; 以及选自TPI 1391，TPI 1349，TPI 1396，TPI 1509，TPI 1540，TPI 1400，TPI 792，TPI 1332，TPI 1567，TPI 1576和TPI 1577的文库的核心结构，其中所述药剂解吸IAP抑制的半胱天冬酶。本发明进一步提供了去抑制IAP抑制的胱天蛋白酶的方法。

9. 发明申请

WO2009134897A1 E3-INDEPENDENT UBIQUITINYLATION ASSAY 审中-公开
标题翻译： E3独立UBIQUITINY测定
公开(公告)号：WO2009134897A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042129
申请日：2009-04-29
申请人： BURNHAM INSTITUTE FOR MEDICAL RESEARCH , REED, John, C.
发明人： REED, John, C.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/566
CPC分类号： G01N33/542 , G01N2500/02 , G01N2500/04
摘要： Disclosed herein are compositions and methods for assaying ubiquitination independent of ubiquitin ligase (E3) or a target protein.
摘要翻译：本文公开了独立于泛素连接酶（E3）或靶蛋白的泛素化测定的组合物和方法。

10. 发明申请

WO2003078598A3 METHODS FOR USING BAG EXPRESSION AS A CELL DIFFERENTIATION AGENT AND MARKER 审中-公开
公开(公告)号：WO2003078598A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/008119
申请日：2003-03-14
申请人： THE BURNHAM INSTITUTE , REED, John, C. , KERMER, Pawel , KRAJEWSKI, Stanislaw
发明人： REED, John, C. , KERMER, Pawel , KRAJEWSKI, Stanislaw
IPC分类号： C07H21/04
摘要： The invention provides a method for promoting cell differentiation, which involves modifying a cell to increase expression of a BAG polypeptide that promotes differentiation of a cell, such as a neuronal cell, stem cell or neural progenitor cell. The invention provides another method for promoting cell differentiation, which involves modifying a cell to increase the amount of a nuclear localized BAG polypeptide, when the nuclear localized BAG polypeptide promotes differentiation of the cell. The invention also provides methods for reducing the rate of cell proliferation and suppressing apoptosis. The methods involve modifying a cell to increase the amount of a nuclear localized BAG polypeptide, when the nuclear localized BAG polypeptide inhibits proliferation, or suppresses apoptosis, respectively.

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