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1. 发明申请

WO2014152643A3 MICROFLUIDIC MICROBE DETECTION AND ISOLATION 审中-公开
标题翻译：微流体微生物检测和分离
公开(公告)号：WO2014152643A3
公开(公告)日：2014-09-25
申请号：PCT/US2014/027569
申请日：2014-03-14
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE GENERAL HOSPITAL CORP
发明人： HOU, Han, Wei , HAN, Jongyoon , BHATTACHARYYA, Roby , HUNG, Deb
IPC分类号： B03B5/62 , B07B13/00 , B01D11/00
摘要： A method and microfluidic device useful for isolating microbes from a blood sample which includes introducing the blood sample into the sample inlet of a spiral microfluidic device; and introducing a second fluid into the sheath inlet of the microfluidic device, wherein the spiral channel terminates in a microbe outlet and a waste outlet, and wherein the spiral channel includes a length, height, and a width that define an aspect ratio adapted to isolate any microbes present in the sample along a first portion of the spiral channel terminating at the microbe outlet, and to isolate red blood cells and leukocytes along a second portion of the spiral channel terminating at the waste outlet; and collecting the microbes from the microbe outlet, thereby isolating the microbes.
摘要翻译：一种用于从血液样品中分离微生物的方法和微流体装置，其包括将血液样品引入到螺旋微流体装置的样品入口中; 以及将第二流体引入微流体装置的鞘入口中，其中螺旋通道终止于微生物出口和废物出口，并且其中螺旋通道包括限定适于隔离的长宽比的长度，高度和宽度沿螺旋通道的第一部分存在于样品中的任何微生物终止于微生物出口，并沿着螺旋通道的第二部分分离红细胞和白细胞，终止于废物出口; 并从微生物出口收集微生物，从而分离微生物。

2. 发明公开

EP3194560A1 MICROFLUIDIC SYSTEM AND METHOD FOR PERFUSION BIOREACTOR CELL RETENTION 审中-公开
标题翻译：用于灌注生物反应器细胞保留的微流体系统和方法
公开(公告)号：EP3194560A1
公开(公告)日：2017-07-26
申请号：EP15841214.8
申请日：2015-09-17
申请人： Massachusetts Institute of Technology , National University of Singapore
发明人： EBRAHIMI WARKIANI, Majid , HAN, Jongyoon , TAY, Kah Ping, Andy , GUAN, Guofeng
IPC分类号： C12M1/00 , C12M3/00 , C12M3/04 , C12N5/02
CPC分类号： C12M29/10 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/0848 , B01L2300/0861 , C12M23/02 , C12M23/16 , C12M29/04 , C12M47/02 , C12M47/04
摘要： A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. At least one curvilinear microchannel is in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate cells in the bioreaction mixture, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel. At least two outlets are in fluid flow connection with the at least one curvilinear microchannel. At least one outlet of the at least two outlets is configured to flow the isolated cells to be recycled to the perfusion bioreactor.
摘要翻译：提供了用于灌注生物反应器的细胞保留的微流体系统。该系统包括至少一个入口，其被配置为接收待处理的生物反应混合物。至少一个曲线微通道与所述至少一个入口流体流动连接，所述至少一个曲线微通道适于沿着所述生物反应混合物的细胞大小的横截面的至少一部分至少一个曲线微通道。至少两个出口与至少一个曲线微通道流体流动连接。所述至少两个出口中的至少一个出口被配置成使分离的细胞流回到灌注生物反应器。

3. 发明申请

WO2019147802A1 RETURN FLOW SYSTEM FOR ION CONCENTRATION POLARIZATION (ICP) DESALINATION 审中-公开
公开(公告)号：WO2019147802A1
公开(公告)日：2019-08-01
申请号：PCT/US2019/014941
申请日：2019-01-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： HAN, Jongyoon , YOON, Junghyo
IPC分类号： C02F1/469
摘要： The present invention provides return flow ICP and ED systems and methods that can be used for water desalination and/or concentration of a wide range of target brine and other aqueous and contaminated streams.

4. 发明申请

WO2016044555A1 SYSTEM AND METHOD FOR INERTIAL FOCUSING MICROFILTRATION FOR INTRA-OPERATIVE BLOOD SALVAGE AUTOTRANSFUSION 审中-公开
标题翻译：用于手术中血管造影术的手术聚焦的系统和方法
公开(公告)号：WO2016044555A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050628
申请日：2015-09-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： EBRAHIMI WARKIANI, Majid , GUAN, Guofeng , TAY, Kah Ping Andy , WU, Lidan , HAN, Jongyoon , LIM, Chwee Teck
IPC分类号： G01N33/49
CPC分类号： A61M1/36 , A61M1/0281 , A61M2202/09 , A61M2202/20 , A61M2205/0244 , A61M2206/10
摘要： A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
摘要翻译：提供了一种手术内救助自体输血系统。所述系统包括至少一个入口，其构造成接收患者的全血; 至少一个与所述至少一个入口流体连通的曲线微通道，所述至少一个曲线微通道适于基于细胞大小，沿着所述至少一个入口的横截面的至少一部分来分离全血中的循环肿瘤细胞所述至少一个曲线微通道; 以及至少两个与所述至少一个曲线微通道流体流动连接的出口，所述至少两个出口的至少一个出口构造成流过从全血分离的循环肿瘤细胞，以及至少一个其它出口至少两个出口配置成流过全血的剩余部分的至少一部分，清洁分离的循环肿瘤细胞，以返回给患者。

5. 发明申请

WO2013052793A1 MICROFABRICATED ION-SELECTIVE ELECTRODES FOR FUNCTIONAL ELECTRICAL STIMULATION AND NEURAL BLOCKING 审中-公开
标题翻译：用于功能电刺激和神经阻滞的微波离子选择性电极
公开(公告)号：WO2013052793A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/058941
申请日：2012-10-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER INC.
发明人： HAN, Jongyoon , IBRAHIM, Ahmed , LIN, Samuel, J. , MELIK, Rohat , RABIE, Amr , SONG, Yong-Ak , SARPESHKAR, Rahul
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0551 , A61B5/0488 , A61B5/224 , A61N1/0553 , A61N1/3605 , A61N1/36071 , A61N1/36075 , A61N1/361 , A61N1/37205
摘要： A neural prosthetic device is provided that includes one or more ion-selective membranes enabled by electrically-controlled local modulation of ion concentrations around a nerve so as to achieve different excitability states of the nerve for electrical stimulation or inhibition of nerve signal propagation. The local modulation is achieved by positioning the nerve in a bipolar perpendicular arrangement so as to modulate the ion concentrations of the one or more ion-selective membranes in situ to change the nerve excitability locally at the site of electrical stimulation or along the nerve for on-demand suppression of nerve propagation.
摘要翻译：提供了神经修复装置，其包括一个或多个离子选择性膜，其通过对神经周围的离子浓度进行电控局部调制而实现，以实现用于电刺激或抑制神经信号传播的神经的不同兴奋性状态。通过将神经置于双极垂直布置中来实现局部调制，以便原位调节一种或多种离子选择性膜的离子浓度，以在电刺激部位或沿神经位置局部改变神经兴奋性抑制神经传播。

6. 发明申请

WO2007022281A3 MICROFLUIDIC PI-BASED MOLECULAR SORTING 审中-公开
公开(公告)号：WO2007022281A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032001
申请日：2006-08-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HAN, Jongyoon , SONG, Yong-Ak
发明人： HAN, Jongyoon , SONG, Yong-Ak
IPC分类号： C02F1/40 , G01N27/00 , G01N33/558
摘要： This invention is directed to methods and devices for separating molecules in a sample, based on differences in their isoelectric point (pI). The methods and devices make use of a diffusion potential created in a microfluidic chamber when a buffered solution comprising molecules, which differ in terms of their isoelectric point (pI) values and a second buffer, which differs from the buffered solution in terms of its pH or salt concentration are introduced in the chamber. The diffusion potential, in turn, enables charge-based separation of the molecules. Applications and permutations of the methods and devices are described.

7. 发明申请

WO2023076447A1 MICRO MAGNETIC RESONANCE RELAXOMETRY (ΜMRR) FOR RAPID AND NON-INVASIVE DETECTION OF SENESCENCE IN MESENCHYMAL STEM CELLS 审中-公开
公开(公告)号：WO2023076447A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/047982
申请日：2022-10-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： HAN, Jongyoon , BOYER, Laurie , THAMARATH, Smitha Surendran , NEO, Shu Hui , TEE, Ching Ann
IPC分类号： G01R33/48 , A61B5/055 , G01N24/08 , G01R33/50
摘要： Senescent cells can be detected using magnetic resonance relaxometry.

8. 发明申请

WO2018093475A1 LIQUID BIOPSY DETECTION OF LEUKEMIA USING CLOSED-LOOP MICROFLUIDICS 审中-公开
公开(公告)号：WO2018093475A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/055508
申请日：2017-10-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： KHOO, Bee, Luan , HAN, Jongyoon , CHOI, Kyungyong , RYU, Hyunryul
IPC分类号： B01F5/06 , B03B5/62 , B03C5/02 , G01N27/447 , G01N27/27 , G01N1/40 , G01N33/49 , G01N33/574
CPC分类号： G01N33/574 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2300/0627 , B01L2300/0864 , B01L2300/088 , B01L2300/0883 , B01L2400/0409 , G01N33/5073 , G01N33/56966 , G01N33/57488
摘要： This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies. The technique is highly effective for samples which cannot be purified in a single run. The application of detecting rare blast cells for monitoring minimal residual disease in leukemia patients is demonstrated. The sensitivity of the invention promotes the detection of blast cells in blood samples of early-stage patients.

9. 发明申请

WO2016065239A1 PURIFICATION OF ULTRA-HIGH SALINE AND CONTAMINATED WATER BY MULTI-STAGE ION CONCENTRATION POLARIZATION (ICP) DESALINATION 审中-公开
标题翻译：通过多级离子浓缩（ICP）脱盐来净化超高盐度和污染水
公开(公告)号：WO2016065239A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057080
申请日：2015-10-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： KIM, Bumjoo , HAN, Jongyoon , KWAK, Rhokyun
IPC分类号： C02F1/469 , C02F1/42 , C02F1/48
CPC分类号： C02F1/4695 , B01D61/42 , C02F1/4604 , C02F1/469 , C02F1/4698 , C02F2101/10 , C02F2101/30 , C02F2101/32 , C02F2103/08 , C02F2201/46115 , C02F2301/04 , C02F2301/08
摘要： A water stream is passed between two juxtaposed similar ion exchange membranes (AEMs or CEMs), forming an ion depletion and ion enrichment zones when an electric field is applied. As cations are selectively transferred through the CEMs, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. Trifurcation of the output channel allows collection of concentrated, dilute and intermediate streams, with the intermediate stream serving as input to the next stage of a serialized implementation.
摘要翻译：在两相并列的相似的离子交换膜（AEM或CEM）之间通过水流，当施加电场时形成离子耗尽和离子富集区。当阳离子选择性地通过CEM转移时，例如，阴离子被重新定位以实现电中性，导致离子耗尽（富集）区域的浓度下降（增加）。输出通道的分流允许收集浓缩的稀释和中间流，中间流用作序列化实施的下一阶段的输入。

10. 发明申请

WO2012170818A1 SYSTEMS AND METHODS FOR DELIVERING SUBSTANCES INTO NANOPOROUS MINERALIZED TISSUES 审中-公开
标题翻译：将物质输送到纳米矿物组织的系统和方法
公开(公告)号：WO2012170818A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041555
申请日：2012-06-08
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSIDADE FEDERAL DA PARAIBA , GAN, Hiongyap , HAN, Jongyoon , DE SOUSA, Frederico, Barbosa
发明人： GAN, Hiongyap , HAN, Jongyoon , DE SOUSA, Frederico, Barbosa
IPC分类号： A61C19/06 , A61N1/30
CPC分类号： A61C19/066 , A61N1/0548 , A61N1/306
摘要： Methods and systems are provided for transporting a therapeutic or cosmetic substance into nanoporous mineralized tissue structures, such as teeth. The method includes contacting the nanoporous mineralized tissue structure with an ionic solution including the therapeutic or cosmetic substance; and simultaneously applying to the nanoporous mineralized tissue structure an electrical potential effective to transport the therapeutic or cosmetic substance into the nanopores of the nanoporous mineralized tissue structure. The system includes at least one pair of electrodes which includes a first electrode configured for contacting the nanoporous mineralized tissue structure and a second electrode; and a power source and control circuitry for generating an electrical potential between the first electrode and the second electrode effective to transport a therapeutic or cosmetic substance, in an ionic solution in contact with a surface of the nanoporous mineralized tissue structure, into the nanopores of the nanoporous mineralized tissue structure.
摘要翻译：提供了用于将治疗或化妆物质运输到纳米多孔矿化组织结构（如牙齿）中的方法和系统。该方法包括使纳米多孔矿化组织结构与包含治疗或化妆物质的离子溶液接触; 并且同时向纳米多孔矿化组织结构施加有效地将治疗或化妆物质输送到纳米多孔矿化组织结构的纳米孔中的电势。该系统包括至少一对电极，其包括构造成用于接触纳米多孔矿化组织结构和第二电极的第一电极; 以及用于在第一电极和第二电极之间产生电势的电源和控制电路，其有效地将治疗或化妆品物质在与纳米多孔矿化组织结构的表面接触的离子溶液中输送到纳米孔的纳米孔中纳米多孔矿化组织结构。

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