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1. 发明申请

WO1995005389A1 SEQUENCE-SPECIFIC GLYCOCONJUGATE TRANSCRIPTIONAL ANTAGONISTS 审中-公开
标题翻译：序列特异性糖蛋白转录拮抗剂
公开(公告)号：WO1995005389A1
公开(公告)日：1995-02-23
申请号：PCT/US1994009123
申请日：1994-08-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , YALE UNIVERSITY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , YALE UNIVERSITY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HO, Steffan, N. , SCHREIBER, Stuart, L. , DANISHEFSKY, Samuel, J. , CRABTREE, Gerald, R.
IPC分类号： C07H13/12
CPC分类号： A61K31/70 , C07H3/06 , C07H11/00 , C12Q1/6897
摘要： The invention provides glycoconjugates which bind polynucleotides in a sequence-selective manner and/or preferentially displace or inhibit binding of transcription factors to their recognition sites on DNA. The DNA-binding glycoconjugates of the invention, exemplified by calicheamicin-MG (as shown in the figure), are used as selective transcriptional antagonists, among other uses.
摘要翻译：本发明提供了以序列选择性方式结合多核苷酸和/或优先置换或抑制转录因子与其在DNA上的识别位点的结合的糖缀合物。使用本发明的DNA结合糖缀合物，例如加利车霉素-MG（如图所示），用作选择性转录拮抗剂等。

2. 发明申请

WO1995008554A1 NF-AT POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译： NF-AT多肽和多核苷酸
公开(公告)号：WO1995008554A1
公开(公告)日：1995-03-30
申请号：PCT/US1994010724
申请日：1994-09-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CRABTREE, Gerald, R. , NORTHROP, Jeffrey, P. , HO, Steffan, N.
IPC分类号： C07H17/00
CPC分类号： A61K31/70 , A61K38/1709 , C07K14/4702 , C07K14/4705 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158 , G01N33/6872 , G01N2500/02 , A61K2300/00
摘要： The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides. The invention also provides methods for detecting T cells (including activated T cells) in a cellular sample, methods for treating hyperactive or hypoactive T cell conditions, methods for screening for immunomodulatory agents, methods for diagnostic staging of lymphocyte differentiation, methods for producing NF-AT proteins for use as research or diagnostic reagents, methods for producing antibodies reactive with the novel polypeptides, and methods for producing transgenic nonhuman animals.
摘要翻译：本发明提供与转录复合体NF-AT相关的新型多肽，编码这些多肽的多核苷酸，与这些多肽反应的抗体，用于检测编码这种多肽的多核苷酸的多核苷酸杂交探针和PCR扩增探针，编码这些多肽的转基因，编码此类多肽的同源靶向构建体和/或同源地整合编码此类多肽的内源基因或其附近，包含通常编码该多肽的功能性破坏性内源基因的非人类转基因动物以及包含编码此类多肽的转基因的转基因非人动物。本发明还提供了用于检测细胞样品中T细胞（包括活化T细胞）的检测方法，用于治疗多动症或低反应性T细胞病症的方法，免疫调节剂筛选方法，淋巴细胞分化诊断分期方法，用作研究或诊断试剂的AT蛋白，用于产生与新多肽反应的抗体的方法，以及用于产生转基因非人动物的方法。

3. 发明公开

EP0722452A1 NF-AT POLYPEPTIDES AND POLYNUCLEOTIDES 失效
标题翻译： NF-AT多肽和多核苷酸
公开(公告)号：EP0722452A1
公开(公告)日：1996-07-24
申请号：EP94929297.0
申请日：1994-09-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： CRABTREE, Gerald, R. , NORTHROP, Jeffrey, P. , HO, Steffan, N.
IPC分类号： G01N33 , A61K38 , A61K48 , A61P37 , C07H21 , C07K14 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： A61K31/70 , A61K38/1709 , C07K14/4702 , C07K14/4705 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158 , G01N33/6872 , G01N2500/02 , A61K2300/00
摘要： The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides. The invention also provides methods for detecting T cells (including activated T cells) in a cellular sample, methods for treating hyperactive or hypoactive T cell conditions, methods for screening for immunomodulatory agents, methods for diagnostic staging of lymphocyte differentiation, methods for producing NF-AT proteins for use as research or diagnostic reagents, methods for producing antibodies reactive with the novel polypeptides, and methods for producing transgenic nonhuman animals.

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