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1. 发明申请

WO2020118251A3 HYPOXIA TARGETING COMPOSITIONS AND COMBINATIONS THEREOF WITH A PARP INHIBITOR AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020118251A3
公开(公告)日：2020-06-11
申请号：PCT/US2019/065065
申请日：2019-12-06
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： MEHIBEL, Manal , GIACCIA, Amato, J.
IPC分类号： A61K31/519 , A61K45/06 , A61K31/517
摘要： Methods for treating a cancer are provided, the methods comprising administering to an individual an effective amount of a hypoxia targeting composition, such as a hypoxia-activated drug or a prodrug thereof, and combinations thereof with an effective amount of a poly (ADP-rib ose) polymerase (PARP) inhibitor. In some instances, one or more of a homology recombination (HR) efficiency status, an IDH mutation status, and a hypoxia status of a cancer is used as a basis for selecting an individual for a treatment disclosed herein. Also provided are compositions (such as pharmaceutical formulations), medicine, kits, and unit dosages useful for the methods described herein.

2. 发明申请

WO2003102169A1 ANAEROBE TARGETED ENZYME-MEDIATED PRODRUG THERAPY 审中-公开
标题翻译： ANAEROBE目标ENZYME介导的PRODRUG治疗
公开(公告)号：WO2003102169A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017291
申请日：2003-05-30
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CENTRE FOR APPLIED MICROBIOLOGY & RESEARCH
发明人： BROWN, John, M. , LIU, Shie-Chau , GIACCIA, Amato, J. , MINTON, Nigel, P.
IPC分类号： C12N1/20
CPC分类号： A61K48/0058 , A61K35/742 , A61K38/50 , C12N1/20 , C12N9/0004 , C12N15/74 , C12R1/145
摘要： Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described.
摘要翻译：描述了在固体肿瘤中存在于厌氧条件下产生能够催化前体药物转化为其细胞毒性产物的酶的酶的重组厌氧细菌组合物。还描述了使用该组合物治疗肿瘤的方法。

3. 发明申请

WO2020118251A2 HYPOXIA TARGETING COMPOSITIONS AND COMBINATIONS THEREOF WITH A PARP INHIBITOR AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020118251A2
公开(公告)日：2020-06-11
申请号：PCT/US2019/065065
申请日：2019-12-06
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： MEHIBEL, Manal , GIACCIA, Amato, J.
IPC分类号： A61K31/4196
摘要： Methods for treating a cancer are provided, the methods comprising administering to an individual an effective amount of a hypoxia targeting composition, such as a hypoxia-activated drug or a prodrug thereof, and combinations thereof with an effective amount of a poly (ADP-rib ose) polymerase (PARP) inhibitor. In some instances, one or more of a homology recombination (HR) efficiency status, an IDH mutation status, and a hypoxia status of a cancer is used as a basis for selecting an individual for a treatment disclosed herein. Also provided are compositions (such as pharmaceutical formulations), medicine, kits, and unit dosages useful for the methods described herein.

4. 发明申请

WO2014035828A2 INHIBITION OF AXL SIGNALING IN ANTI-METASTATIC THERAPY 审中-公开
标题翻译： AXI信号在抗生素治疗中的抑制作用
公开(公告)号：WO2014035828A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/056435
申请日：2013-08-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： GIACCIA, Amato, J. , RANKIN, Erinn, Bruno , COCHRAN, Jennifer, R. , JONES, Douglas , KARIOLIS, Mihalis , FUH, Katherine , MIAO, Yu
IPC分类号： C12N9/12 , A61K38/45 , C07K16/22 , A61K45/06
CPC分类号： C07K14/705 , A61K38/00 , A61K45/06 , C07K14/82
摘要： Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.
摘要翻译：提供了通过施用治疗剂量的抑制AXL蛋白活性的药物组合物来减轻哺乳动物癌症的组合物和方法，例如通过竞争性或非竞争性地抑制AXL与其配体GAS6之间的结合相互作用。

5. 发明申请

WO1995010273A1 USE OF PROTEIN KINASE C ACTIVATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR KILLING HYPOXIC TUMOR CELLS 审中-公开
标题翻译：蛋白激酶C激活剂用于制造杀伤性高血压肿瘤细胞的药物的应用
公开(公告)号：WO1995010273A1
公开(公告)日：1995-04-20
申请号：PCT/US1994011653
申请日：1994-10-14
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GIACCIA, Amato, J. , KOONG, Albert, C.
IPC分类号： A61K31/215
CPC分类号： C07K14/525 , A61K31/00 , A61K31/215 , A61K31/22 , A61K31/23 , A61K31/34 , A61K38/191 , A61K38/39 , A61K48/00 , A61K2300/00 , C07K14/4703
摘要： Disclosed is a method of treating a solid tumor, where the tumor contains regions of hypoxic cells, either because of poor vascularization in the tumor or because of vasoconstrictive or vaso-occlusive measures brought to bear on the tumor. The method includes administering to a subject a compound effective to activate protein kinase C activity in the cells of the tumor, via a route effective to direct the compound to such regions of hypoxia in the tumor. Preferred compounds include phorbol esters, diacylglycerols, and thapsigargin. Also disclosed is a vaso-occlusive composition containing a protein kinase C activator, for use in the treatment method.
摘要翻译：公开了一种治疗实体肿瘤的方法，其中肿瘤含有缺氧细胞的区域，这是由于肿瘤中的血管形成不良或由于血管收缩或血管收缩措施对肿瘤造成的。所述方法包括通过有效地将化合物引导到肿瘤中的这种缺氧区域的途径向受试者施用有效激活肿瘤细胞中的蛋白激酶C活性的化合物。优选的化合物包括佛波酯，二酰基甘油和毒胡萝卜素。还公开了用于治疗方法的含有蛋白激酶C激活剂的血管闭塞组合物。

6. 发明申请

WO2022036009A1 SBCMA VARIANTS AND FC FUSION PROTEINS THEREOF 审中-公开
公开(公告)号：WO2022036009A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045615
申请日：2021-08-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： GIACCIA, Amato, J. , MIAO, Yu , THAKKAR, Kaushik , MIZUNO, Kazue
IPC分类号： A61K39/395 , C07K14/47
摘要： The invention is directed to novel sBCMA variants and sBCMA variant - Fc fusion proteins, polynucleotides encoding the sBCMA variants and/or sBCMA variant - Fc fusion proteins, methods of making the sBCMA variants and/or sBCMA variant - Fc fusion proteins, and methods of using compositions comprising the sBCMA variants and/or sBCMA variant - Fc fusion proteins, for example, in treating diseases such as tumors/cancers, immunoregulatory disorders, etc.

7. 发明申请

WO2009114552A1 HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT 审中-公开
标题翻译： HETEROARYL化合物，组合物和使用癌症治疗方法
公开(公告)号：WO2009114552A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036696
申请日：2009-03-10
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , AUCKLAND UNISERVICES LIMITED , TURCOTTE, Sandra , CHAN, Denise, A. , SUTPHIN, Patrick, D. , GIACCIA, Amato, J. , HAY, Michael, P. , DENNY, William, A. , BONNET, Muriel, Marie
发明人： TURCOTTE, Sandra , CHAN, Denise, A. , SUTPHIN, Patrick, D. , GIACCIA, Amato, J. , HAY, Michael, P. , DENNY, William, A. , BONNET, Muriel, Marie
IPC分类号： C07D401/04 , C07D417/04 , A61K31/4436 , A61K31/4439
CPC分类号： C07D417/04 , C07D401/04
摘要： Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.
摘要翻译：本文提供了新颖的杂芳基化合物，包含该化合物的组合物，以及治疗或预防方法，包括施用化合物。这些化合物在靶向von Hippel-Lindau基因中缺陷的细胞和诱导自噬细胞死亡中是有效的。该方法涉及治疗或预防诸如癌症的疾病，特别是由冯·希波尔 - 林多病引起的癌症。本发明的化合物可以与另一种治疗剂组合施用。

8. 发明申请

WO2003072064A9 METHODS AND COMPOSITIONS FOR REGULATING ADIPOGENESIS 审中-公开
公开(公告)号：WO2003072064A9
公开(公告)日：2003-09-04
申请号：PCT/US2003/006360
申请日：2003-02-28
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GIACCIA, Amato, J. , YUN, Zhong
发明人： GIACCIA, Amato, J. , YUN, Zhong
IPC分类号： C12N9/20 , A61K39/00 , C07H21/02

9. 发明申请

WO2003072064A2 METHODS AND COMPOSITIONS FOR REGULATING ADIPOGENESIS 审中-公开
标题翻译：用于调节ADIPOGENESISIS的方法和组合物
公开(公告)号：WO2003072064A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/006360
申请日：2003-02-28
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GIACCIA, Amato, J. , YUN, Zhong
发明人： GIACCIA, Amato, J. , YUN, Zhong
IPC分类号： A61K
CPC分类号： C07K14/4703
摘要： According to the disclosure hypoxia-mediated adipogenic inhibition involves the repression of PPARγ2 expression and its activity is a common mechanism for adipogenic inhibition by a variety of stimuli. The present disclosure relates to methods and compositions for regulating adipogenesis. The disclosure provides compositions comprising one or more DECI/Stra13 fragments of capable of inhibiting PPARγ2 promoter activity. These fragments, e.g. the basic helix loop helix domain or amino acids 1-141, have substantially the same PPARγ2 promoter repressing activity as the full length polypeptide. The present disclosure provides methods of inhibiting adipogenesis comprising contacting a cell with a fragment of DEC1/Stra13. The invention further relates to methods and compositions of inhibiting angiogenesis in a tumor comprising contacting a tumor or tumor cell with a DEC1/Stra13 agonist.
摘要翻译：根据该公开内容，缺氧介导的脂肪形成抑制涉及PPARgamma2表达的抑制，其活性是通过各种刺激造成脂肪形成抑制的常见机制。本公开涉及用于调节脂肪形成的方法和组合物。本公开提供了包含一种或多种能抑制PPARγ2启动子活性的DECI / Stra13片段的组合物。这些片段，例如碱性螺旋环螺旋结构域或氨基酸1-141具有与全长多肽基本上相同的PPARγ启动子抑制活性。本公开提供了抑制脂肪形成的方法，包括使细胞与DEC1 / Stra13的片段接触。本发明还涉及抑制肿瘤中血管生成的方法和组合物，包括使肿瘤或肿瘤细胞与DEC1 / Stra13激动剂接触。

10. 发明公开

EP4196164A1 SBCMA VARIANTS AND FC FUSION PROTEINS THEREOF 审中-实审
公开(公告)号：EP4196164A1
公开(公告)日：2023-06-21
申请号：EP21856674.3
申请日：2021-08-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： GIACCIA, Amato, J. , MIAO, Yu , THAKKAR, Kaushik , MIZUNO, Kazue
IPC分类号： A61K39/395 , C07K14/47

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