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1. 发明申请

WO2021046244A1 CROSS-REACTIVE EPITOPE FOR MULTIPLE SCLEROSIS 审中-公开
公开(公告)号：WO2021046244A1
公开(公告)日：2021-03-11
申请号：PCT/US2020/049242
申请日：2020-09-03
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： SALIGRAMA, Naresha , DAVIS, Mark M.
IPC分类号： C07K14/725 , C07K16/24 , C07K16/28
摘要： Provided herein are methods and compositions for diagnosis and treatment of multiple sclerosis. Compositions and methods are provided, relating to novel peptides involved in autoimmune disease. In the experiments described herein, an unbiased approach was used to screen pathogenic CD4+ T cells from patients with multiple sclerosis (MS), and to determine the antigenic specificity of the T cell receptors (TCR) expressed by these pathogenic cells.

2. 发明申请

WO2022226035A1 TOLL-LIKE RECEPTOR AGONIST-NANOPARTICLE VACCINE ADJUVANT 审中-公开
公开(公告)号：WO2022226035A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025497
申请日：2022-04-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： YIN, Qian , DAVIS, Mark M. , LUO, Wei , PULENDRAN, Bali
IPC分类号： A61K47/54 , A61K47/60 , A61K47/64
摘要： Compositions and methods are provided relating to TLR agonist nanoparticle vaccine adjuvant formulations.

3. 发明申请

WO2019023622A1 POLYMERIC NANOPARTICLES FOR ENHANCED CANCER IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2019023622A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/044165
申请日：2018-07-27
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： YIN, Qian , WONG, Yu , DAVIS, Mark M.
IPC分类号： A61K39/39 , A61K9/00 , A61K9/19
摘要： Polymeric nanoparticles comprising a defined set of biologically active agents that provide for targeted stimulation of non-responsive T cells, e.g. T cells involved in cancer, are provided.

4. 发明申请

WO2018175585A3 ANTIGEN DISCOVERY FOR T CELL RECEPTORS ISOLATED FROM PATIENT TUMORS RECOGNIZING WILD-TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES 审中-公开
公开(公告)号：WO2018175585A3
公开(公告)日：2018-09-27
申请号：PCT/US2018/023569
申请日：2018-03-21
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： GEE, Marvin , DAVIS, Mark M. , HAN, Arnold , GARCIA, Kenan Christopher
IPC分类号： C12Q1/68 , C12N15/09
摘要： Compositions and methods are provided for peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

5. 发明申请

WO2018175585A2 ANTIGEN DISCOVERY FOR T CELL RECEPTORS ISOLATED FROM PATIENT TUMORS RECOGNIZING WILD-TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES 审中-公开
公开(公告)号：WO2018175585A2
公开(公告)日：2018-09-27
申请号：PCT/US2018/023569
申请日：2018-03-21
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： GEE, Marvin , DAVIS, Mark M. , HAN, Arnold , GARCIA, Kenan Christopher
IPC分类号： A61K39/00 , C07K14/16
摘要： Compositions and methods are provided for peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

6. 发明申请

WO2022226032A1 IMMUNOSTIMULATORY TOLL-LIKE RECEPTOR AGONIST-NANOPARTICLE FOR CANCER IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2022226032A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025494
申请日：2022-04-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： YIN, Qian , DAVIS, Mark M.
IPC分类号： A61K47/54 , A61K47/60 , A61K47/64
摘要： Compositions and methods are provided relating to immunostimulatory TLR agonist nanoparticle formulations. Methods are provided for treating cancer, by stimulating an immune response to cancer cells through administering to an individual mammal an effective dose or series of doses of an immunostimulatory composition comprising an immunostimulatory TLR agonist-nanoparticle; optionally in combination with a second immune regulatory agent.

7. 发明申请

WO2022133347A2 DISPLAY OF PEPTIDE-MHC (PMHC) ON MULTIMERIC PROTEIN SCAFFOLDS AND USES THEREOF 审中-公开
公开(公告)号：WO2022133347A2
公开(公告)日：2022-06-23
申请号：PCT/US2021/064378
申请日：2021-12-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： DAVIS, Mark M. , MALLAJOSYULA, Venkata Vamsee Aditya
IPC分类号： A61K9/16 , A61K38/17 , A61K39/00 , B82B1/00
摘要： An antigen-specific T cell binding agent is provided, where a multivalent 'spheromer' system utilizes a scaffold of a self-assembling polypeptide nanoparticle, for example using selfassembling ferritin polypeptides. The system is compatible with current pMHC reagents, including both MHC-I and MHC-II molecules, and streptavidin reagents that allow ease-of-use. The spheromer assembly pipeline provides a consistent reagent across multiple batches of synthesis with ease of production. The defined geometry of the scaffold allows precise site-directed conjugation of pMHC, leading to a homogenous reagent. The spheromer binds cognate TCRs with a significantly higher avidity than a tetrameric reagent.

8. 发明申请

WO2019152108A1 SYSTEMS AND METHODS FOR MULTIPLEXED MEASUREMENTS IN SINGLE AND ENSEMBLE CELLS 审中-公开
公开(公告)号：WO2019152108A1
公开(公告)日：2019-08-08
申请号：PCT/US2018/066592
申请日：2018-12-19
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： SALIGRAMA, Naresha , SATPATHY, Ansuman , CHANG, Howard Y. , DAVIS, Mark M.
IPC分类号： C12M1/00 , C12N15/09 , C12P19/34
摘要： Provided are systems and methods that can combine T cell receptor sequencing (TCRseq) and Assay for Transposase Accessible Chromatin using sequencing (ATAC-seq), and/or respective aspects thereof. Further provided are systems and methods that can combine ATAC-seq and perturbation sequencing (Perturb-seq), and/or respective aspects thereof.

9. 发明申请

WO2017015064A1 DETECTION PHENOTYPING AND QUANTITATION OF CELLS WITH MULTIMERIC BINDING REAGENT 审中-公开
标题翻译：用多种结合试剂检测细胞的定位和定量
公开(公告)号：WO2017015064A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/042341
申请日：2016-07-14
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： DAVIS, Mark M. , HUANG, Jun
IPC分类号： A61K38/00 , C12N15/09
CPC分类号： G01N33/56972 , C07K14/00 , C07K14/36 , G01N2333/70539
摘要： Methods and compositions are provided for labeling cells according to the specificity of a receptor of interes by contacting with a multimeric binding reagent. The multimeric binding reagent is based on a "tetrameric scaffold protein", which tetrameric scaffold protein has little or no affinity for biotin, and which comprises a C-terminal cysteine residue on one or more, usually all four of the polypeptides in the tetramer. The scaffold protein is modified by biotinylation at the terminal cysteines, to provide the central portion of the multimeric binding reagent. The biotinylated tetramer is combined with a high affinity biotin-binding protein tetramer. The complex thus generated has unfilled biotin-binding sites that can accommodate up to twelve biotin-tagged specific binding reagents, and is useful in various affinity selection and detection formats.
摘要翻译：提供方法和组合物，以通过与多聚体结合试剂接触，根据内在受体的特异性标记细胞。多聚体结合试剂基于“四聚体支架蛋白”，其四聚体支架蛋白对生物素几乎没有或没有亲和力，并且其在四聚体中的一个或多个，通常全部四个多肽中包含C末端半胱氨酸残基。通过在末端半胱氨酸的生物素化修饰支架蛋白，以提供多聚体结合试剂的中心部分。生物素化四聚体与高亲和力生物素结合蛋白四聚体组合。由此产生的复合物具有可以容纳多达12个生物素标记的特异性结合试剂的未填充的生物素结合位点，并且可用于各种亲和力选择和检测形式。

10. 发明申请

WO2022187367A1 POLYPEPTIDE CONSTRUCTS WITH NOVEL BINDING AFFINITY AND USES THEREOF 审中-公开
公开(公告)号：WO2022187367A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018529
申请日：2022-03-02
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： CHIOU, Shin-Heng , TSENG, Diane , MACKALL, Crystal L. , DAVIS, Mark M.
IPC分类号： C07K14/725 , C07K16/28 , C07K7/08 , A61P35/00 , A61K38/03
摘要： The present disclosure relates generally to polypeptide constructs, and particularly relate to T-cell receptor (TCR) constructs having binding affinity for a specific cognate antigen. The disclosure also provides compositions and methods useful for producing such constructs as well as methods for the diagnosis, prevention, and/or treatment of conditions associated with cells expressing the cognate antigen recognized by the polypeptide constructs.

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