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1. 发明申请

WO1994015943A1 ANTISENSE MOLECULES DIRECTED AGAINST A PLATELET DERIVED GROWTH FACTOR RECEPTOR RELATED GENE 审中-公开
标题翻译：抗体生成因子受体相关基因的抗原分子
公开(公告)号：WO1994015943A1
公开(公告)日：1994-07-21
申请号：PCT/US1993012602
申请日：1993-12-28
申请人： TEXAS BIOTECHNOLOGY CORPORATION
发明人： TEXAS BIOTECHNOLOGY CORPORATION , DENNER, Larry, A. , REGE, Ajay, A. , DIXON, Richard, A., F.
IPC分类号： C07H17/00
CPC分类号： C12N15/1138 , C07H21/00 , C12N2310/315
摘要： The present invention is directed to a polynucleotide of about 10 to about 50 nucleic acid bases in length, which polynucleotide hybridizes to the platelet derived growth factor receptor related gene. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation and to a process for treating vascular smooth muscle cell proliferation that comprises contacting the vascular smooth muscle cells with, or administering to a host mammal in need of such treatment an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the platelet derived growth factor receptor related gene.
摘要翻译：本发明涉及长度为约10至约50个核酸碱基的多核苷酸，该多核苷酸与血小板衍生的生长因子受体相关基因杂交。本发明还涉及包含溶解或分散在生理上可耐受的稀释剂中的上述多核苷酸的药物组合物。本发明进一步涉及一种抑制血管平滑肌细胞增殖的方法和治疗血管平滑肌细胞增殖的方法，该方法包括使血管平滑肌细胞与需要这种治疗的宿主哺乳动物接触有效量的长度为约10至约50个核酸碱基的多核苷酸，所述多核苷酸与血小板衍生生长因子受体相关基因杂交。

2. 发明申请

WO1994015945A1 ANTISENSE MOLECULES DIRECTED AGAINST A FIBROFLAST GROWTH FACTOR RECEPTOR GENE FAMILY 审中-公开
标题翻译：针对纤维母细胞生长因子受体基因家族的抗原分子
公开(公告)号：WO1994015945A1
公开(公告)日：1994-07-21
申请号：PCT/US1993012600
申请日：1993-12-28
申请人： TEXAS BIOTECHNOLOGY CORPORATION
发明人： TEXAS BIOTECHNOLOGY CORPORATION , DENNER, Larry, A. , REGE, Ajay, A. , DIXON, Richard, A., F.
IPC分类号： C07H21/00
CPC分类号： A61K31/70 , C07H21/00 , C12N15/1138 , C12N2310/31 , C12N2310/315
摘要： The present invention is directed to a polynucleotide of about 10 to about 50 nucleic acid bases in length, which polynucleotide hybridizes to the gene encoding fibroblast growth factor receptor. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation (figs. 1 and 2), a process for treating vascular smooth muscle cell proliferation (figs. 3 and 4), and a process for treating a disease state involving vascular smooth muscle cell proliferation (figs. 3 and 4), all of which processes comprise contacting vascular smooth muscle cells or administering an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the gene for fibroblast growth factor receptor.
摘要翻译：本发明涉及长度为约10至约50个核酸碱基的多核苷酸，该多核苷酸与编码成纤维细胞生长因子受体的基因杂交。本发明还涉及包含溶解或分散在生理上可耐受的稀释剂中的上述多核苷酸的药物组合物。本发明进一步涉及一种抑制血管平滑肌细胞增殖的方法（图1和2），一种治疗血管平滑肌细胞增殖的方法（图3和4），以及一种治疗涉及血管平滑肌细胞增殖（图3和图4），所有这些过程包括接触血管平滑肌细胞或施用有效量的长度为约10至约50个核酸碱基的多核苷酸，所述多核苷酸与成纤维细胞生长因子受体。

3. 发明申请

WO1994015645A1 ANTISENSE MOLECULES DIRECTED AGAINST GENES OF THE RAF ONCOGENE FAMILY 审中-公开
标题翻译：针对RAF ONCOGENE FAMILY的基因的抗原分子
公开(公告)号：WO1994015645A1
公开(公告)日：1994-07-21
申请号：PCT/US1993012603
申请日：1993-12-28
申请人： TEXAS BIOTECHNOLOGY CORPORATION
发明人： TEXAS BIOTECHNOLOGY CORPORATION , DENNER, Larry, A. , REGE, Ajay, A. , DIXON, Richard, A., F.
IPC分类号： A61K48/00
CPC分类号： C12N15/1135 , C07H21/00 , C12N2310/315 , C12N2310/321
摘要： The present invention is directed to a polynucleotide, of about 10 to about 50 nucleic acid bases in length, which hybridizes to the gene encoding raf. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation, a process for treating vascular smooth muscle cell proliferation, and process for treating a disease state involving smooth muscle cell proliferation. These processes comprise contacting the vascular smooth muscle cells or administering to a host mammal in need of such treatment, an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the gene for raf.
摘要翻译：本发明涉及长度为约10至约50个核酸碱基的多核苷酸，其与编码raf的基因杂交。本发明还涉及包含溶解或分散在生理上可耐受的稀释剂中的上述多核苷酸的药物组合物。本发明还涉及抑制血管平滑肌细胞增殖的方法，治疗血管平滑肌细胞增殖的方法，以及治疗涉及平滑肌细胞增殖的疾病状态的方法。这些方法包括使血管平滑肌细胞接触或施用于需要这种治疗的宿主哺乳动物，有效量的长度为约10至约50个核酸碱基的多核苷酸，所述多核苷酸与raf基因杂交。

4. 发明公开

EP0677055A1 ANTISENSE MOLECULES DIRECTED AGAINST A FIBROFLAST GROWTH FACTOR RECEPTOR GENE FAMILY 失效
标题翻译：针对成纤维细胞生长因子受体家族GEN-LOOKING反义分子。
公开(公告)号：EP0677055A1
公开(公告)日：1995-10-18
申请号：EP94907109.0
申请日：1993-12-28
申请人： TEXAS BIOTECHNOLOGY CORPORATION
发明人： DENNER, Larry, A. , REGE, Ajay, A. , DIXON, Richard, A., F.
IPC分类号： C07H21 , C12N15
CPC分类号： A61K31/70 , C07H21/00 , C12N15/1138 , C12N2310/31 , C12N2310/315
摘要： The present invention is directed to a polynucleotide of about 10 to about 50 nucleic acid bases in length, which polynucleotide hybridizes to the gene encoding fibroblast growth factor receptor. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation (figs. 1 and 2), a process for treating vascular smooth muscle cell proliferation (figs. 3 and 4), and a process for treating a disease state involving vascular smooth muscle cell proliferation (figs. 3 and 4), all of which processes comprise contacting vascular smooth muscle cells or administering an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the gene for fibroblast growth factor receptor.

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