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1. 发明专利

JP2003107072A ANIONIC ION PAIR FORMING COMPOSITION 审中-公开
公开(公告)号：JP2003107072A
公开(公告)日：2003-04-09
申请号：JP2002146442
申请日：2002-05-21
申请人： TEXAS A & M UNIV SYS
发明人： VIGH GYULA
IPC分类号： G01N27/62 , B01D15/36 , G01N1/22 , G01N21/76 , G01N30/02 , G01N30/34 , G01N31/12
摘要： PROBLEM TO BE SOLVED: To obtain a paired anionic ion forming reagent and an anionic ion pair forming reagent system which do not seriously trouble an element selective detector or a detecting device after a combustion product is burned. SOLUTION: The paired anionic forming reagent, the anionic ion pair forming reagent system, an in-plant formation paired anionic forming ions and an in- plant formation paired anionic forming ion system are constituted of at least one anion and at least one paired ion with a volatile combustion product only containing O, S, or a halogen atom or their combination as a hetero atom.

2. 发明专利

JP2002296262A BUFFER COMPOSITION HAVING VOLATILE COMBUSTION PRODUCT USED IN SPECIFICITY DETECTOR FOR GAS PHASE OR VAPOR PHASE ELEMENT 审中-公开
公开(公告)号：JP2002296262A
公开(公告)日：2002-10-09
申请号：JP2001387687
申请日：2001-12-20
申请人： TEXAS A & M UNIV SYS
发明人： VIGH GYULA
IPC分类号： G01N27/62 , C07C55/02 , C07C55/24 , C07C61/08 , C07C381/12 , G01N21/76 , G01N27/447 , G01N30/26 , G01N31/12
摘要： PROBLEM TO BE SOLVED: To provide a new buffer and a new buffer system having a volatile combustion product used in an analytical technique using an element specificity detector. SOLUTION: This composition contains a cation salt of a weak acid, contains no metal atom or no metal ion, has no heteroatom other than O or O and S, and has a volatile combustion product.

3. 发明专利

JP2003090835A ANIONIC CYCLODEXTRIN COMPOSITION 审中-公开
公开(公告)号：JP2003090835A
公开(公告)日：2003-03-28
申请号：JP2002148939
申请日：2002-05-23
申请人： TEXAS A & M UNIV SYS
发明人： VIGH GYULA
IPC分类号： G01N27/62 , C08B37/16 , C08L5/16 , G01N21/75 , G01N30/06 , G01N30/26 , G01N30/64 , G01N30/74 , G01N30/88 , G01N31/12 , G01N31/22
摘要： PROBLEM TO BE SOLVED: To provide anionic cyclodextrin and anionic cyclodextrin system that can be used for analytical techniques using an element selectivity detector. SOLUTION: These anionic cyclodextrin and anionic cyclodextrin system composition include at least one cyclodextrin anion and at least one pairing ion. The anion and the pairing ion are anion and pairing ion composition that generate volatile combustion products including O or S or halogen atom or combination of them as a sole hetero atom.

4. 发明公开

EP2609426A4 FLUORESCENCE LABELING REAGENTS AND USES THEREOF 审中-公开
标题翻译： VERWENDUNGEN荧光素酶
公开(公告)号：EP2609426A4
公开(公告)日：2016-11-02
申请号：EP11820757
申请日：2011-08-26
申请人： TEXAS A & M UNIV SYS
发明人： VIGH GYULA , ESTRADA ROY T
IPC分类号： G01N33/52 , C07C311/16 , C07D317/10 , G01N33/58
CPC分类号： C08F20/26 , C07C311/39 , C07C2603/50 , C07D317/22 , C09B57/001 , G01N33/54306 , G01N33/54393 , G01N33/582 , G01N33/6809 , Y10T436/173845
摘要： A solid phase reagent and method for simultaneously capturing and fluorescently labeling an analyte with multiple reactive sites to provide a mono-labeled analyte are disclosed. The reagent can be used in the method and comprises a plurality of analyte-reactive groups tethered to a porous solid phase, wherein each analyte-reactive group is covalently attached to a fluorescent group either directly or indirectly, wherein the distance between adjacent analyte-reactive groups is greater than the gyration radius of a captured analyte; the fluorescent group is covalently attached to a cleavable anchor group either directly or through a first spacer; and the cleavable anchor group is covalently attached to the solid phase either directly or through a second spacer, wherein the solid phase is a porous solid or a porous gel.
摘要翻译：描述了固相荧光标记试剂（SPR），同时捕获和标记分析物，然后在温和条件（SCaLER）下有效释放标记分析物。

5. 发明公开

EP1333910A4 ELECTROPHORESIS APPARATUS AND METHOD 审中-公开
标题翻译：电泳和程序
公开(公告)号：EP1333910A4
公开(公告)日：2006-11-29
申请号：EP01971492
申请日：2001-09-24
申请人： TEXAS A & M UNIV SYS , GRADIPORE LTD
发明人： VIGH GYULA , OGLE DAVID , RYLATT DENNIS BRIAN
IPC分类号： G01N27/26 , B01D57/02 , B01D61/46 , B03C5/00 , C12M1/00 , C12M1/34 , G01N27/447
CPC分类号： G01N27/44795 , B01D57/02 , G01N27/44769
摘要： An electrophoresis apparatus comprising a separation unit with a first electrolyte chamber and a second electrolyte chamber, a first sample chamber and a second sample chamber, a first ion permeable barrier positioned between the first sample chamber and second sample chamber which prevents substantial convective mixing between the contents of the first and second sample chamber, a second ion permeable barrier positioned between the first electrolyte chamber and the first sample chamber which prevents substantial convective mixing of the contents of the first electrolyte chamber and the first sample chamber, a third ion permeable barrier positioned between the second sample chamber and the second electrolyte chamber which prevents substantial convective mixing of the contents of the second electrolyte chamber and the second sample chamber.

6. 发明公开

EP1341596A4 MULTI-PORT SEPARATION APPARATUS AND METHOD 有权
标题翻译： MULTI-PORT-分离器和程序
公开(公告)号：EP1341596A4
公开(公告)日：2004-07-21
申请号：EP01973847
申请日：2001-10-05
申请人： GRADIPORE LTD , TEXAS A & M UNIV SYS
发明人： OGLE DAVID , VIGH GYULA , RYLATT DENNIS BRIAN
IPC分类号： B01D57/02 , B03C5/00 , G01N27/447 , B01D61/42
CPC分类号： G01N27/44795 , B01D57/02 , G01N27/44769
摘要： Multi-port electrophoresis apparatus comprising: (a) cathode chamber with inlet and outlet means defining an anolyte flow path; (b) anode chamber with inlet and outlet means defining an anolyte flow path, to generate an electric field; (c) at least one electrolyte reservoir in fluid communication with the cathode and anode chambers; (d) means adapted for communicating electrolyte between the lectrolyte reservoir and the cathode and the anode chambers; (e) at least three separation chambers adjacently disposed between the cathode and the anode chambers, the separation chambers formed by a plurality of ion-permeable barriers, adapted to impede convective mixing of contents of adjacent chambers; (f) inlet and outlet means for communicating liquid into and out of the separation chambers; (g) at least one sample reservoir, wherein each sample reservoir is connected with at least one separation chamber; and (h) means for communicating fluids between a sample reservoir and at least one separation chamber.

7. 发明申请

WO2013033046A3 FLUORESCENT pI MARKERS FOR ISOELECTRIC FOCUSING SEPARATIONS AND FLUORESCENT LABELING 审中-公开
标题翻译：荧光分光光度法和荧光标记荧光标记
公开(公告)号：WO2013033046A3
公开(公告)日：2013-08-01
申请号：PCT/US2012052579
申请日：2012-08-27
申请人： TEXAS A & M UNIV SYS , VIGH GYULA , LI MING-CHIEN
发明人： VIGH GYULA , LI MING-CHIEN
IPC分类号： C09K11/06 , C07C311/21 , G01N27/447
CPC分类号： G01N27/44795 , C07C311/32 , C07C311/37 , C07C311/42 , C07C2603/50 , C07D233/64 , C07D295/088 , C07D295/13 , C07D295/26 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1033 , C09K2211/1044 , G01N27/447 , G01N33/582 , Y10T436/143333
摘要： UV-Absorbing and fluorescent pl markers for isoelectric focusing separations and fluorescent labeling, and methods for making and using the markers.
摘要翻译：用于等电聚焦分离和荧光标记的UV吸收和荧光标记，以及用于制备和使用标记的方法。

8. 发明申请

WO2012027717A2 FLOURESCENCE LABELING REAGENTS AND USES THEREOF 审中-公开
标题翻译：荧光标记试剂及其用途
公开(公告)号：WO2012027717A2
公开(公告)日：2012-03-01
申请号：PCT/US2011049433
申请日：2011-08-26
申请人： TEXAS A & M UNIV SYS , VIGH GYULA , ESTRADA ROY T
发明人： VIGH GYULA , ESTRADA ROY T
IPC分类号： G01N33/52 , C07C311/16 , C07D317/10 , G01N33/58
CPC分类号： C08F20/26 , C07C311/39 , C07C2603/50 , C07D317/22 , C09B57/001 , G01N33/54306 , G01N33/54393 , G01N33/582 , G01N33/6809 , Y10T436/173845
摘要： Solid phase fluorescent labeling reagents (SPR) are described that simultaneously capture and label analytes, and then efficiently release the labeled-analytes under mild conditions (SCaLER).
摘要翻译：描述固相荧光标记试剂（SPR），同时捕获和标记分析物，然后在温和条件下（SCaLER）有效释放标记的分析物。

9. 发明申请

WO2005105910A3 WATER-SOLUBLE, UV-ABSORBING AND/OR FLUORESCENT COMPONENTS WITH VERY HIGH ISOELECTRIC POINTS 审中-公开
标题翻译：具有非常高的电压点的水溶性紫外线吸收和/或荧光成分
公开(公告)号：WO2005105910A3
公开(公告)日：2006-06-15
申请号：PCT/US2005014031
申请日：2005-04-22
申请人： TEXAS A & M UNIV SYS , VIGH GYULA , LALWANI SANJIV K , BUSBY BRENT , NZEADIBE KINGSLEY , FLEISHER HELEN C , SHAVE EVAN E
发明人： VIGH GYULA , LALWANI SANJIV K , BUSBY BRENT , NZEADIBE KINGSLEY , FLEISHER HELEN C , SHAVE EVAN E
IPC分类号： C07K17/00 , A61K35/14 , C08K5/19 , C08K5/34 , C12N9/74
CPC分类号： G01N27/44747 , C07H1/00 , C08K5/19
摘要： Water-soluble, UV-absorbing and/or fluorescing compound having an isoelectric point greater than 10, can be obtained using molecules chosen from the group of molecules consisting of those containing at least one secondary alcohol OH group with a pK a value greater than 10 and at least one amino group with a pK b value smaller than 5, those containing at least one primary alcohol OH group and at least one secondary alcohol OH group with respective pK a values greater than 10 and at least one amino group with a pK b value smaller than 5 or a quaternary ammonium group, and those containing at least two secondary alcohol OH groups with respective pK a values greater than 10 and at least one amno group with a pK b value smaller than 5 or a quaternary ammonium group; and having at least one UV absorbing group or at least one fluorescing group or a combination thereof. The invention includes methods for producing such compounds.
摘要翻译：具有等电点大于10的水溶性，紫外线吸收和/或发荧光化合物可以使用选自由含有至少一个仲醇OH基团的分子组成的分子组成的分子，pK / SUB>值大于10，并且至少一个pK 小于5的氨基，含有至少一个伯醇OH基团和至少一个仲醇OH基团的相应pK < 其中大于10的值和至少一个pK 小于5或季铵基团的氨基，以及含有至少两个仲醇OH基团的氨基， pK 大于10的值和至少一个pK 小于5的氨基或季铵基; 并具有至少一个UV吸收基团或至少一个荧光基团或其组合。本发明包括生产这种化合物的方法。

10. 发明专利

AT473040T 未知
公开(公告)号：AT473040T
公开(公告)日：2010-07-15
申请号：AT01973847
申请日：2001-10-05
申请人： ARTURUS CAPITAL LTD , TEXAS A & M UNIV SYS
发明人： OGLE DAVID , VIGH GYULA , RYLATT DENNIS
IPC分类号： B01D57/02 , B01D61/42 , B03C5/00 , G01N27/447
摘要： A multi-port electrophoresis system comprising: first and second electrode chambers containing a cathode and an anode respectively, wherein the electrode chambers are disposed relative to one another so that the electrodes are adapted to generate an electric field upon application of a selected electric potential therebetween; at least three adjacently disposed separation chambers disposed between the electrode chambers and separated from adjacent separation chambers and the electrode chambers by ion-permeable barriers adapted to impede convective mixing of the contents of adjacent chambers; a first electrolyte reservoir in fluid communication with at least one of the electrode chambers; at least one sample reservoir in fluid communication with at least one of the separation chambers; means adapted for communicating fluids to the first and second electrode chambers and to the at least three separation chambers; means adapted for communicating an electrolyte between the electrolyte reservoir and at least one of the first and second electrode chambers; and means adapted for communicating at least one fluid between at least one separation chamber and the at least one sample reservoir; wherein application of the selected electric potential causes migration of at least one component through at least one of the ion-permeable barriers.

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