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1. 发明公开

EP0175948A3 Hollow fiber for dialysis and method for manufacture thereof 有权
标题翻译：用于透析的中空纤维及其制造方法
公开(公告)号：EP0175948A3
公开(公告)日：1988-03-16
申请号：EP85110773
申请日：1985-08-27
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Takahara, Kazuaki
IPC分类号： B01D13/04 , D01D05/24 , D01F02/04 , A61M01/18
CPC分类号： D01D5/24 , B01D69/08 , B01D71/10 , D01F2/04
摘要： Unstretched hollow fibers of cuprammonium celllulose for dialysis possessing a film structure having a porosity of 15 to 25%, a pore diameter of 25 to 40 A, and an ultrafiltration raio of 3.0 to 5.5 ml mmHg.hr.m 2 are obtained by extruding, coagulating, and regenerating a cuprammonium cellulose spinning dope having a cellulose concentration of 6.8 to 8.7% and a viscosity of 500 to 1,300 poises (at 20°C).

2. 发明公开

EP0170247A2 Hemoglobin-containing liposomes and process for preparing the same 失效
标题翻译：脂质体和它们的制备方法含有血红蛋白的。
公开(公告)号：EP0170247A2
公开(公告)日：1986-02-05
申请号：EP85109515.8
申请日：1985-07-29
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Miyauchi, Yuji
IPC分类号： A61K9/50 , A61K37/14 , A61K31/375 , A61K31/195
CPC分类号： A61K9/1277 , A61K9/127 , A61K38/42
摘要： 57 There are provided hemoglobin-containing liposomes encapsulating within liposomes having membranes comprising a lipid material hemoglobin and a methemoglobin formation-inhibiting agent.
The liposomes are used as artificial blood with high oxygen-carrying capacity. As the lipid material of the liposomes are used phospholipid materials such as, for example, lecithin, phosphatidylethanolamine, phosphatidic acid, sphingomyelin and hydrogenation products thereof. As the methemoglobin formation-inhibiting agent are used salts of ascorbic acid, glutathion and the like.
The liposomes are prepared by dissolving a liposome membrane-forming lipid material and a surface-active agent, removing the solvent from said solution, adding to the residue a hemoglobin solution to which a methemoglobin formation-inhibiting agent has beer added and subjecting the starting solution thus obtained to dialysis with a physiological saline solution containing the same methemoglobin formation-inhibiting agent to remove the surface-active agent from the starting solution.
摘要翻译：有提供含血红蛋白的脂质体具有膜包含脂质材料血红蛋白和高铁血红蛋白形成抑制剂 - 脂质体内包封。脂质体被用作人造血液具有高携氧能力。作为脂质体的脂质材料，可以使用磷脂材料：如，例如，卵磷脂，磷脂酰乙醇胺，磷脂酸，鞘磷脂和它们的氢化产物。如抗坏血酸，谷胱甘肽等的高铁血红蛋白形成抑制剂的使用的盐。脂质体是由脂质体膜形成脂质材料和表面活性剂溶解，除去从所述溶液中的溶剂来制备，加入到残余物中，以哪一个高铁血红蛋白形成的血红蛋白溶液 - 抑制剂已被添加并对该起始溶液由此获得的透析用生理盐水溶液含有相同的高铁血红蛋白形成抑制剂以从起始溶液除去表面活性剂。

3. 发明公开

EP0175948A2 Method for manufacture of hollow fibers for dialysis 有权
标题翻译：一种生产用于透析中空纤维的过程。
公开(公告)号：EP0175948A2
公开(公告)日：1986-04-02
申请号：EP85110773.0
申请日：1985-08-27
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Takahara, Kazuaki
IPC分类号： B01D67/00 , B01D71/10 , D01D5/24 , D01F2/04 , A61M1/18
CPC分类号： D01D5/24 , B01D69/08 , B01D71/10 , D01F2/04
摘要： Unstretched hollow fibers of cuprammonium celllulose for dialysis possessing a film structure having a porosity of 15 to 25%, a pore diameter of 25 to 40 A, and an ultrafiltration raio of 3.0 to 5.5 ml mmHg.hr.m 2 are obtained by extruding, coagulating, and regenerating a cuprammonium cellulose spinning dope having a cellulose concentration of 6.8 to 8.7% and a viscosity of 500 to 1,300 poises (at 20°C).

4. 发明公开

EP0186211A1 Polymerizable liposome-forming lipid, method for production thereof, and use thereof 有权
标题翻译：其制备方法及其使用的聚合脂质体形成脂质，过程。
公开(公告)号：EP0186211A1
公开(公告)日：1986-07-02
申请号：EP85116607.4
申请日：1985-12-27
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Yoshioka, Hiroshi
IPC分类号： C07F9/10 , A61K9/50
CPC分类号： A61K9/1273 , C07F9/10
摘要： A polymerizable liposome-forming lipid represented by the following general formula I:
wherein R stands for -(CH 2 )- 2 N ⊕ (CH 3 ) 3 , -(CH 2 )- 2 N ⊕ H 3 , or- CH 2 CH(N ⊕ H 3 )-COO ⊖ .

5. 发明授权

EP0175948B1 Method for manufacture of hollow fibers for dialysis 有权
标题翻译：用于制造用于透析的中空纤维的方法
公开(公告)号：EP0175948B1
公开(公告)日：1990-06-27
申请号：EP85110773.0
申请日：1985-08-27
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Takahara, Kazuaki
IPC分类号： B01D67/00 , B01D71/10 , D01D5/24 , D01F2/04 , A61M1/18
CPC分类号： D01D5/24 , B01D69/08 , B01D71/10 , D01F2/04

6. 发明授权

EP0186211B1 Polymerizable liposome-forming lipid, method for production thereof, and use thereof 有权
标题翻译：可聚合的脂质体脂肪，其生产方法及其用途
公开(公告)号：EP0186211B1
公开(公告)日：1989-03-01
申请号：EP85116607.4
申请日：1985-12-27
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Yoshioka, Hiroshi
IPC分类号： C07F9/10 , A61K9/50
CPC分类号： A61K9/1273 , C07F9/10

7. 发明授权

EP0170247B1 Hemoglobin-containing liposomes and process for preparing the same 失效
标题翻译：含血球蛋白的含脂质体及其制备方法
公开(公告)号：EP0170247B1
公开(公告)日：1990-09-26
申请号：EP85109515.8
申请日：1985-07-29
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Miyauchi, Yuji
IPC分类号： A61K9/50 , A61K37/14 , A61K31/375 , A61K31/195
CPC分类号： A61K9/1277 , A61K9/127 , A61K38/42

8. 发明公开

EP0170247A3 Hemoglobin-containing liposomes and process for preparing the same 失效
标题翻译：含血球蛋白的含脂质体及其制备方法
公开(公告)号：EP0170247A3
公开(公告)日：1986-05-14
申请号：EP85109515
申请日：1985-07-29
申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
发明人： Suzuki, Kazuhiko , Miyauchi, Yuji
IPC分类号： A61K09/50 , A61K37/14 , A61K31/375 , A61K31/195
CPC分类号： A61K9/1277 , A61K9/127 , A61K38/42
摘要： 57 There are provided hemoglobin-containing liposomes encapsulating within liposomes having membranes comprising a lipid material hemoglobin and a methemoglobin formation-inhibiting agent. The liposomes are used as artificial blood with high oxygen-carrying capacity. As the lipid material of the liposomes are used phospholipid materials such as, for example, lecithin, phosphatidylethanolamine, phosphatidic acid, sphingomyelin and hydrogenation products thereof. As the methemoglobin formation-inhibiting agent are used salts of ascorbic acid, glutathion and the like. The liposomes are prepared by dissolving a liposome membrane-forming lipid material and a surface-active agent, removing the solvent from said solution, adding to the residue a hemoglobin solution to which a methemoglobin formation-inhibiting agent has beer added and subjecting the starting solution thus obtained to dialysis with a physiological saline solution containing the same methemoglobin formation-inhibiting agent to remove the surface-active agent from the starting solution.

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