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1. 发明申请

WO2009085823A1 MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-R-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚R-羟基丁酸酯和共聚物的熔融非织造物的医疗装置
公开(公告)号：WO2009085823A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087159
申请日：2008-12-17
申请人： TEPHA, INC. , HO, Kicherl , WILLIAMS, Simon, F. , RIZK, Said , MARTIN, David, P.
发明人： HO, Kicherl , WILLIAMS, Simon, F. , RIZK, Said , MARTIN, David, P.
IPC分类号： D04H1/56 , A61L17/10
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non- wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4- hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly- 4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non- woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和厚度为10μm至50mm。通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。无纺布可以用于各种目的，包括制造医疗装置。

2. 发明申请

WO2007092417A1 TOUGHENED POLYLACTIC ACID POLYMERS AND COPOLYMERS 审中-公开
标题翻译：增韧聚酰胺聚合物和共聚物
公开(公告)号：WO2007092417A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/003100
申请日：2007-02-06
申请人： TEPHA, INC. , RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
IPC分类号： A61L15/22 , A61L17/12 , A61L27/26 , A61L29/04 , A61L31/04 , C08L67/04
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Toughened compositions of PLA and PLA copolymers are disclosed, which also have low tensile modulus values and greater elongation to break. These toughened compositions are prepared by blending PLA and PLA copolymers with poly-4-hydroxybutyrate, and copolymers thereof. Blending of ρoly-4-hydroxybutyrate with PLA and its copolymers has been found to impart advantageous properties to the resulting blend. These compositions, and objects formed from these compositions, have improved toughness and lower stiffness than polylactic acid polymers or copolymers alone.
摘要翻译：公开了PLA和PLA共聚物的增韧组合物，其也具有低拉伸模量值和较大的断裂伸长率。这些增韧的组合物通过将PLA和PLA共聚物与聚-4-羟基丁酸酯及其共聚物共混来制备。已经发现丙烯酸4-羟基丁酸酯与PLA及其共聚物的混合赋予所得共混物有利的性质。这些组合物和由这些组合物形成的物体比单独的聚乳酸聚合物或共聚物具有改善的韧性和较低的刚度。

3. 发明申请

WO2008070428A2 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：WO2008070428A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/084991
申请日：2007-11-16
申请人： TEPHA, INC. , RIZK, Said , MARTIN, David, P. , HO, Kicherl , WILLIAMS, Simon, F.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm 2 , tensile modulus less than 181 kgf/mm 2 , and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2， 2℃，断裂伸长率为10-500％，其中该膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个膜中定向至超过膜的原始长度的25％方向。这些可以用于各种目的，包括制造医疗器械。

4. 发明申请

WO2004101002A2 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 审中-公开
标题翻译：聚羟基烷基酯医用纺织品和纤维
公开(公告)号：WO2004101002A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/013475
申请日：2004-04-30
申请人： TEPHA, INC. , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
发明人： MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
IPC分类号： A61L
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和手术网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。这些装置提供比目前可获得的更广泛的体内强度保持性能，并且可以提供额外的益处，例如抗粘附性质，降低的感染风险或由于吸收和最终消除装置而导致的其他手术后问题，以及有竞争力的成本。该装置还可以特别适用于儿科人群，其吸收不应妨碍生长，并且在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合以提供具有改进的机械，生物和处理性质的植入物。

5. 发明申请

WO2007092464A2 METHODS AND DEVICES FOR ROTATOR CUFF REPAIR 审中-公开
标题翻译： ROTATOR CUFF维修的方法和设备
公开(公告)号：WO2007092464A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003185
申请日：2007-02-05
申请人： TEPHA, INC. , COLEMAN, Struan , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
发明人： COLEMAN, Struan , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
IPC分类号： A61L27/00 , A61F2/08
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti- adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于腱和韧带修复的包括肩袖修复的插入和增强装置以及使用关节镜方法进行输送的方法。该装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以关节镜地传送，并且提供额外的益处，例如支持手术修复，高初始强度，体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拉出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，有竞争力的成本，长期的机械稳定性。这些装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

6. 发明申请

WO2006081517A3 EMBOLIZATION USING POLY-4-HYDROXYBUTYRATE PARTICLES 审中-公开
公开(公告)号：WO2006081517A3
公开(公告)日：2006-08-03
申请号：PCT/US2006/003128
申请日：2006-01-27
申请人： TEPHA, INC. , MARTIN, David, P. , CRABTREE, Donald , WILLIAMS, Simon, F.
发明人： MARTIN, David, P. , CRABTREE, Donald , WILLIAMS, Simon, F.
IPC分类号： A61K9/16 , A61P7/00 , A61P9/00
摘要： Absorbable particles which comprises poly-4-hydroxybutyrate and/or its copolymers are formulated in injectable suspension suitable for prophylactic or therapeutic embolization, which comprises administering to a human or animal the injectable suspension process for producing particles of the poly-4-hydroxybutyrate and/or its copolymer.

7. 发明申请

WO2010017014A3 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
公开(公告)号：WO2010017014A3
公开(公告)日：2010-02-11
申请号：PCT/US2009/051024
申请日：2009-07-17
申请人： TEPHA, INC. , SCHMITZ, Klaus-Peter , BEHREND, Detlef , STERNBERG, Katrin , GRABOW, Niels , MARTIN, David, P. , WILLIAMS, Simon, F.
发明人： SCHMITZ, Klaus-Peter , BEHREND, Detlef , STERNBERG, Katrin , GRABOW, Niels , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61L31/10 , A61L31/16
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L- lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.

8. 发明申请

WO2007092418A2 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
标题翻译：聚合，可降解药水和涂层
公开(公告)号：WO2007092418A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003101
申请日：2007-02-06
申请人： TEPHA, INC. , SCHMITZ, Klaus-Peter , BEHREND, Detlef , STERNBERG, Katrin , GRABOW, Niels , MARTIN, David, P. , WILLIAMS, Simon, F.
发明人： SCHMITZ, Klaus-Peter , BEHREND, Detlef , STERNBERG, Katrin , GRABOW, Niels , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61L27/26 , A61L31/04
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo . Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。

9. 发明申请

WO2016094669A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
标题翻译：聚-4-羟基丁酸酯及其共聚物的多元纤维和单体的定向方法
公开(公告)号：WO2016094669A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065015
申请日：2015-12-10
申请人： TEPHA, INC.
发明人： GANATRA, Amit , FELIX, Fabio , SHAH, Bhavin , BERNASCONI, Matthew , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： D01F6/62
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yams and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yams and fibers are produced by cold drawing the multifilament yams and monofilament fibers before hot drawing the yams and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yams and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yams have tenacities higher than 8.1 grams per denier, and in vivo , retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo . The monofilament fibers have tensile strengths higher than 500 MPa. These yams and fibers may be used to make various medical devices for various applications.
摘要翻译：已经开发了可再吸收的复丝纱线和包括聚-4-羟基丁酸酯的单丝纤维及其具有高强度或高拉伸强度的共聚物。在高于聚合物或共聚物的熔融温度的温度下，在拉伸纱线和纤维的拉伸下，通过冷拉丝复丝纱线和单丝纤维来生产纱线和纤维。这些纱线和纤维在体内具有延长的强度保持性，使得它们适用于需要高强度和强度保持性的软组织修复。复丝纱具有高于8.1克/旦尼尔的强度，并且体内在2周时保持其初始强度的至少65％。单丝纤维在体内4周时保持其初始强度的至少50％。单丝纤维的拉伸强度高于500MPa。这些纱线和纤维可用于制造用于各种应用的各种医疗装置。

10. 发明申请

WO2022240725A1 NIPPLE RECONSTRUCTION IMPLANT 审中-公开
公开(公告)号：WO2022240725A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028284
申请日：2022-05-09
申请人： TEPHA, INC.
发明人： LIMEM, Skander , SARIIBRAHIMOGLU, Kemal , SCOTT, Jeffrey Robert , WILLIAMS, Simon, F.
IPC分类号： A61F2/12 , A61F2/00 , A61L27/14 , A61F2/0059 , A61F2/0063 , A61F2210/0004 , A61F2230/0093 , A61F2240/001 , A61F2250/0023 , A61F2250/0067 , A61L2430/04 , A61L27/18 , A61L27/56
摘要： Absorbable implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the nipple following total mastectomy and breast reconstruction. The implants may be formed from absorbable mesh and/or dry spun sheet.

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