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1. 发明申请

WO2008002833A2 ADJUVANT-MEDIATED REACTIVITY ENHANCEMENT OF POLYMERIZABLE POLYACETYLENIC MATERIALS 审中-公开
标题翻译：可聚合聚乙烯材料的添加剂介导的反应活性增强
公开(公告)号：WO2008002833A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/071868
申请日：2007-06-22
申请人： TEMPTIME CORPORATION , PRUSIK, Thaddeus , SMITH, Dawn , BAUGHMAN, Ray, H.
发明人： PRUSIK, Thaddeus , SMITH, Dawn , BAUGHMAN, Ray, H.
IPC分类号： C09D11/00
CPC分类号： C09D11/50
摘要： Indicator inks, indicators formed by printing or otherwise utilizing the inks and host products utilizing the indicators are disclosed. Reactivity-enhancing adjuvants stimulate enhanced thermal reactivity of diacetylenic or other indicator agents capable of responding to ambient thermal conditions with a visual change signaling an end point. The diacetylenic or other agents may be sensitive or relatively insensitive to ambient temperatures. Use of a reactivity-enhancing adjuvant provides a useful means for adapting the reactivities of indicator agents to the response characteristics of prospective host products, for example perishables such as vaccines or fresh fish and maturables such as fruit, cheese and wine. Some exemplary adjuvants include low- temperature polymerization initiators, for example methyl ethyl ketone peroxide and polymerization accelerators, for example cobalt compounds. Such initiators and accelerators can also be used in combination.
摘要翻译：公开了指示剂油墨，通过使用指示剂印刷或以其它方式利用油墨和主体产品形成的指示剂。反应性增强佐剂刺激能够响应于环境热条件的二乙炔或其他指示剂的增强的热反应性，其中以指示终点的视觉改变。二乙炔或其它试剂可能对环境温度敏感或相对不敏感。使用反应性增强佐剂提供了一种有用的方法，用于使指示剂的反应性适应于预期宿主产物的反应特性，例如易腐食物例如疫苗或鲜鱼以及可食用如水果，奶酪和葡萄酒。一些示例性的助剂包括低温聚合引发剂，例如甲基乙基酮过氧化物和聚合促进剂，例如钴化合物。这样的引发剂和促进剂也可以组合使用。

2. 发明申请

WO2007056727A2 FREEZE INDICATORS SUITABLE FOR MASS PRODUCTION 审中-公开
标题翻译：冷冻指示剂适用于大量生产
公开(公告)号：WO2007056727A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/060613
申请日：2006-11-07
申请人： TEMPTIME CORPORATION , TAYLOR, Dene, H. , PRUSIK, Thaddeus , SMITH, Dawn
发明人： TAYLOR, Dene, H. , PRUSIK, Thaddeus , SMITH, Dawn
IPC分类号： G01K1/02
CPC分类号： G01K1/02 , G01K3/005 , G01K11/06 , G01K11/12 , G01K2207/04 , Y10S252/962
摘要： A freeze indicator employs, as active indicator element, dispersion of solid particles in a liquid medium which can be water or aqueous and which coagulates to provide an irreversible appearance change when subject to freezing. The liquid dispersion can be contained in an indicator volume around which extends a vapor block layer. The vapor block layer can prevent loss of liquid vapor from the dispersion and consequent drying out and dysfunctionality of the freeze indicator. For containing an aqueous medium, bilayer and trilayer laminate materials can be used which have a low water vapor transmission rate. The active indicator element can be a dilute colloidal dispersion of a metal such as gold or silver or other inorganic pigment material in water or an aqueous medium. Some embodiments avoid use of dispersants and the like and employ an active indicator element consisting of inorganic pigment particles, water and optionally an ice nucleating agent. Heavy water, or deuterated water can be components of the water, if desired.
摘要翻译：冷冻指示器使用固体颗粒在液体介质中的分散体作为活性指示剂元素，液体介质可以是水或水，并在凝固时提供不可逆的外观变化。液体分散体可以包含在延伸蒸气阻挡层的指示体积中。蒸气阻挡层可以防止液体蒸气从分散体中的损失，从而导致冷冻指示器的干燥和功能失调。为了含有水性介质，可以使用具有低水蒸汽透过率的双层和三层层压材料。活性指示剂元素可以是诸如金或银之类的金属或其它无机颜料材料在水或水介质中的稀释胶体分散体。一些实施方案避免使用分散剂等并且使用由无机颜料颗粒，水和任选的冰核成核剂组成的活性指示剂元件。如果需要，重水或氘代水可以是水的组分。

3. 发明申请

WO2007056752A2 COMBINATION FREEZE INDICATORS 审中-公开
标题翻译：组合冻结指示器
公开(公告)号：WO2007056752A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/060681
申请日：2006-11-08
申请人： TEMPTIME CORPORATION , TAYLOR, Dene, H. , PRUSIK, Thaddeus , SMITH, Dawn
发明人： TAYLOR, Dene, H. , PRUSIK, Thaddeus , SMITH, Dawn
IPC分类号： G01K1/02
CPC分类号： G01K3/04 , G01K3/005 , G01K2207/04
摘要： A combination temperature exposure indicator suitable for attachment to, or association with, a host product has a substrate, a freeze indicator supported by the substrate and a cumulative ambient time-temperature indicator also supported by the substrate. The freeze indicator can provide a visual indication of exposure of the freeze indicator to a freezing or near- freezing temperature and the cumulative time-temperature indicator can provide a visual indication of exposure of the cumulative time-temperature indicator to a predetermined cumulative time-temperature value. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.
摘要翻译：组合温度曝光指示剂适于附着于主体产品或与主产品相关联，具有底物，由基底支撑的结冰指示剂和也由基底支持的累积环境时间温度指示剂。冷冻指示器可以提供冷冻指示器暴露于冷冻或接近冷冻温度的可视指示，并且累积时间 - 温度指示器可以提供累积时间 - 温度指示器暴露于预定累积时间温度的视觉指示值。还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

4. 发明申请

WO2006060602A2 PARTICLE SIZE CONTROL FOR ACETYLENIC AGENTS USEFUL IN CONDITION MONITORING SYSTEMS 审中-公开
标题翻译：在条件监测系统中有用的乙酰化剂的颗粒尺寸控制
公开(公告)号：WO2006060602A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/043520
申请日：2005-12-01
申请人： TEMPTIME CORPORATION , PRUSIK, Thaddeus , SMITH, Dawn , LEUBNER, Ingo
发明人： PRUSIK, Thaddeus , SMITH, Dawn , LEUBNER, Ingo
IPC分类号： C07C273/16
CPC分类号： C07C273/189 , C07C275/20
摘要： Precipitation of polyacetylenic agents can be effected with control of a particle size parameter such as mean size or spread, by mixing a warm solution of the acetylenic agent with a cold precipitation fluid and appropriate selection of a constituent of the cold precipitation fluid and/or of the temperature conditions and collecting the precipitated acetylenic agent. Precipitation additives such as nitrocellulose or gelatin can usefully be employed. Solvents such as aqueous methanol and ethyl 3-ethoxypropionate can be useful. Polyacetylenic agents, e.g. substituted diacetylenics are useful to provide visual changes in condition-monitoring indicators such as time-temperature indicators, "TTIs", useful as freshness indicators for radiation exposure monitoring and for other purposes. Controlled, small and/or consistent particle sizes of such polyacetylenic agents are helpful in providing consistent commercial properties, especially in inks in which they may be formulated.
摘要翻译：通过将炔属试剂的温溶液与冷沉淀流体混合并适当选择冷沉淀液和/或冷沉淀液的组分，可以通过控制粒径参数如平均尺寸或扩展来实现聚乙炔化剂的沉淀温度条件并收集沉淀的炔属剂。可以有效地使用沉淀添加剂如硝酸纤维素或明胶。溶剂如甲醇水溶液和3-乙氧基丙酸乙酯是有用的。聚乙炔化剂，例如取代的二乙酰基可用于提供条件监测指标的视觉变化，例如时间 - 温度指标“TTI”，作为辐射暴露监测的新鲜度指标和用于其他目的。这种聚乙炔化剂的受控的，小的和/或一致的粒度有助于提供一致的商业性质，特别是在它们可以配制的油墨中。

5. 发明申请

WO2005015237A1 OPHTHALMIC SENSOR 审中-公开
标题翻译：眼科传感器
公开(公告)号：WO2005015237A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008825
申请日：2004-08-06
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CHAPOY, Lawrence, L. , DOMSCHKE, Angelika, Maria , SMITH, Dawn
发明人： CHAPOY, Lawrence, L. , DOMSCHKE, Angelika, Maria , SMITH, Dawn
IPC分类号： G01N33/66
CPC分类号： G02C7/04 , G01N33/582 , G01N33/66
摘要： This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.
摘要翻译：本发明通常涉及用于以非侵入性或微创方式检测/测量眼液中的糖，特别是葡萄糖的生物相容性传感器，以及使用生物相容性传感器的方法。本发明的生物相容性传感器包括，基本上由...组成或由包括与糖相互作用或与糖反应的分子感测部分的眼科装置组成，以提供指示眼液中糖水平的光学信号。

6. 发明申请

WO2008021349A1 TEMPORAL PHOTO-BLEACHING OF COLORED LENS CARE SOLUTIONS AND USE THEREOF 审中-公开
标题翻译：彩色镜片护理溶液的时间照相漂白及其用途
公开(公告)号：WO2008021349A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/017963
申请日：2007-08-14
申请人： NOVARTIS AG , LANE, Jennifer Dawn , SMITH, Dawn
发明人： LANE, Jennifer Dawn , SMITH, Dawn
IPC分类号： A61L12/12 , A61L12/14 , A61L12/08 , C11D3/00 , C11D3/40
CPC分类号： A61L12/124 , A61L12/086 , A61L12/142 , C11D3/0078 , Y10S134/901
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change, due to temporally photo-bleaching of a colored lens care solution, to indicate the readiness of disinfection and cleaning of contact lenses.
摘要翻译：本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。本发明的镜片护理套件允许客户在视觉上识别镜片何时消毒，清洁并准备穿戴。由于彩色透镜护理溶液的暂时照相漂白，本发明依赖于颜色变化，以指示隐形眼镜的消毒和清洁的准备状态。

7. 发明申请

WO2007098040A1 METHOD FOR STERILIZATION OF HYDROGEL CONTACT LENSES 审中-公开
标题翻译：水凝胶接触镜的灭菌方法
公开(公告)号：WO2007098040A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/004155
申请日：2007-02-15
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
发明人： VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
IPC分类号： A61L12/14 , A61L12/08 , A61L12/04 , A61L101/36 , A61L101/16
CPC分类号： A61L12/04 , A61L12/08 , A61L12/14 , C11D1/722 , C11D3/0078 , C11D7/10 , C11D7/263 , C11D7/265 , C11D7/3218 , C11D7/34 , C11D7/36
摘要： The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.
摘要翻译：本发明提供一种水溶液，用于消毒和储存由水凝胶材料，优选含有（含氧化烯）的水凝胶材料制成的眼科装置，优选隐形眼镜。溶液包含一种或多种有机缓冲剂，例如Good缓冲液或双 - 氨基多元醇; 具有多个羟基的有机张力调节剂，其量足以提供约200至约450 mosm / l的渗透压，其中所述水溶液的pH为约5.5至约8.5，条件是所述水溶液包括浓度为约15mM或更低和约5000ppm氯化钠的磷酸盐缓冲液。本发明还提供了使用本发明的水溶液对眼科装置进行消毒和储存的方法。

8. 发明申请

WO2007020010A1 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2007020010A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/007924
申请日：2006-08-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
发明人： WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
IPC分类号： G02B1/04
CPC分类号： B29C33/60 , B29C33/62 , B29D11/00134 , B29D11/00192 , G02B1/043
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.
摘要翻译：本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。本发明的方法包括将不可交联的亲水性聚合物添加到包含透镜形成材料的流体组合物中，该透镜形成材料的量足以将平均的模具分离力减小至少约40％，与不使用不可交联的亲水性并且在模具分离力中提供约10N或更小的差异。不可交联的亲水性聚合物与透镜形成材料的混溶性有限，足够低以在模具和其中的流体组合物之间的界面处成功地及时地形成具有足够厚度的完整界面膜，并且具有最小化缠结的结构的界面膜中的不可交联的亲水聚合物与形成的透镜的聚合物基体。

9. 发明申请

WO2005031442A1 OPHTHALMIC DEVICE COMPRISING A HOLOGRAPHIC SENSOR 审中-公开
标题翻译：包含全息传感器的透明设备
公开(公告)号：WO2005031442A1
公开(公告)日：2005-04-07
申请号：PCT/GB2004/004093
申请日：2004-09-27
申请人： SMART HOLOGRAMS LIMITED , CIBA VISION CORPORATION , CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. , LOWE, Christopher, Robin , KABILAN, Satyamoorthy , BLYTH, Jeffrey , DOMSCHKE, Angelika , SMITH, Dawn , KARANGU, Njeri
发明人： LOWE, Christopher, Robin , KABILAN, Satyamoorthy , BLYTH, Jeffrey , DOMSCHKE, Angelika , SMITH, Dawn , KARANGU, Njeri
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , G01N21/75 , G01N21/77 , G01N21/78 , G01N2021/758 , G01N2021/7723 , G01N2021/7773 , G02C7/04
摘要： An ophthalmic device comprises a holographic element comprising a medium and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid. The device may be used for the detection of analytes such as glucose.
摘要翻译：眼科装置包括全息元件，其包括介质，并且在其中设置有全息图，其中该元件的光学特性由于介质的物理性质的变化而改变，并且其中作为相互作用的结果产生变化介于介质和存在于眼液中的分析物之间。该装置可用于检测分析物如葡萄糖。

10. 发明授权

EP1946056B1 FREEZE INDICATORS SUITABLE FOR MASS PRODUCTION 有权
标题翻译：面向大规模生产出适合FROST指标
公开(公告)号：EP1946056B1
公开(公告)日：2016-07-27
申请号：EP06839742.1
申请日：2006-11-07
申请人： Temptime Corporation
发明人： TAYLOR, Dene, H. , PRUSIK, Thaddeus , SMITH, Dawn
IPC分类号： G01K1/02 , G01K3/00 , G01K11/06 , G01K11/12
CPC分类号： G01K1/02 , G01K3/005 , G01K11/06 , G01K11/12 , G01K2207/04 , Y10S252/962

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