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1. 发明申请

WO1995011248A1 AMYLOID 'beta'-PROTEIN AGGLUTINATION AND/OR DEPOSITION INHIBITOR 审中-公开
标题翻译： AMYLOIDβ-PROTEIN AGGLUTINATION和/或沉积抑制剂
公开(公告)号：WO1995011248A1
公开(公告)日：1995-04-27
申请号：PCT/JP1994001770
申请日：1994-10-20
申请人： TEIJIN LIMITED , TOMIYAMA, Takami , SUWA, Yorimasa , ASANO, Satoshi , KATAOKA, Kenichiro , MORITA, Takuya , ENDO, Noriaki
发明人： TEIJIN LIMITED
IPC分类号： C07D498/18
CPC分类号： C07D498/08
摘要： An amyloid beta -protein agglutination and/or deposition inhibitor containing rifamycin represented by formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient; and a drug containing the same for treating or preventing senile dementia of Alzheimer type.
摘要翻译：含有由式（I）表示的利福霉素或其药学上可接受的盐作为活性成分的淀粉样蛋白β-蛋白凝集和/或沉积抑制剂; 以及含有该药物用于治疗或预防老年痴呆型老年痴呆症的药物。

2. 发明申请

WO1997001534A1 PROSTAGLANDINS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译： PROSTAGLANDINS及其生产方法
公开(公告)号：WO1997001534A1
公开(公告)日：1997-01-16
申请号：PCT/JP1996001662
申请日：1996-06-17
申请人： TEIJIN LIMITED , KATAOKA, Kenichiro , MINOSHIMA, Toru , SHIOTA, Tatsuki , TSUTSUMI, Takaharu , HADA, Takahiko , TANAKA, Hiroko , MORITA, Takuya , ENDO, Noriaki
发明人： TEIJIN LIMITED
IPC分类号： C07C405/00
CPC分类号： C07C405/0033 , C07C405/00 , C07C405/0016
摘要： Prostaglandins represented by general formula (I), (II) or (III) and inhibitors of cell migration induced by a chemokine which comprise the compound (I) or (II) as the active ingredient, wherein R represents C1-10 alkyl, C3-8 cycloalkyl, cyano, formyl, carboxy, (C1-5 alkyl)oxycarbonyl, C2-7 alkanoyl or C1-5 alkyl substituted by halogeno or phenyl; Z represents hydrogen or OR ; R and R represent each hydrogen, tri(C1-7 hydrocarbyl)-silyl or a group forming an acetal bond together with the oxygen atom of the hydroxyl group; R represents C1-8 alkyl, C2-8 alkenyl, C2-8 alkylnyl, phenyl or C3-8 cycloalkyl; Y represents C1-5 alkyl or CO2R wherein R represents hydrogen, C1-10 alkyl, C2-10 alkenyl or a cation; X represents methylene or oxygen, W represents sulfur, sulfinyl or methylene; V represents sulfur or sulfinyl; W represents sulfur or methylene; and - - - represents a double or single bond.
摘要翻译：由通式（I），（II）或（III）表示的前列腺素和由包含化合物（I）或（II）作为活性成分的趋化因子诱导的细胞迁移抑制剂，其中R 1表示C1-10 烷基，C 3-8环烷基，氰基，甲酰基，羧基，（C 1-5烷基）氧羰基，C 2-7烷酰基或被卤素或苯基取代的C 1-5烷基; Z表示氢或OR 2; R 2和R 3各自表示氢，三（C 1-7烃基） - 甲硅烷基或与羟基的氧原子一起形成缩醛键的基团; R 4表示C 1-8烷基，C 2-8烯基，C 2-8烷基，苯基或C 3-8环烷基; Y表示C 1-5烷基或CO 2 R 5，其中R 5表示氢，C 1-10烷基，C 2-10烯基或阳离子; X表示亚甲基或氧，W表示硫，亚磺酰基或亚甲基; V表示硫或亚磺酰基; W 1表示硫或亚甲基; 而 - - - 表示双键或单键。

3. 发明申请

WO1997044329A1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为化学受体拮抗剂的二元醇循环二胺衍生物
公开(公告)号：WO1997044329A1
公开(公告)日：1997-11-27
申请号：PCT/US1997008577
申请日：1997-05-20
申请人： TEIJIN LIMITED , SHIOTA, Tatsuki , YAMAGAMI, Shinsuke , KATAOKA, Kenichiro , ENDO, Noriaki , TANAKA, Hiroko , BARNUM, Doug , GREENE, Jonathan , MOREE, Wilna , RAMIREZ-WEINHOUSE, Michelle , TARBY, Christine
发明人： TEIJIN LIMITED
IPC分类号： C07D243/08
CPC分类号： C07D417/06 , A61K31/495 , A61K31/496 , A61K31/551 , C07D213/38 , C07D243/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/06
摘要： Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as MIP-la and/or MCP-l on target cells, and are useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
摘要翻译：描述式（I）的环状二胺或其药理学上可接受的酸加成盐及其医疗应用。这些化合物抑制趋化因子如MIP-1a和/或MCP-1对靶细胞的作用，并且可用作疾病中的治疗药物和/或预防药物，例如动脉粥样硬化，类风湿性关节炎等，其中血液单核细胞淋巴细胞浸润到组织中。

4. 发明申请

WO1992002619A1 PLASMID FOR USE IN PRODUCING INFLAMED REGION DERIVED PHOSPHOLIPASE A2 INHIBITORY PROTEIN, MICROBIAL CELL, AND PRODUCTION AND USE OF SAID PROTEIN 审中-公开
标题翻译：用于生产炎症区域衍生的磷脂酶A2抑制性蛋白质，微生物细胞以及生产和使用合适蛋白质的PLASMID
公开(公告)号：WO1992002619A1
公开(公告)日：1992-02-20
申请号：PCT/JP1991001040
申请日：1991-08-03
申请人： TEIJIN LIMITED , SUWA, Yorimasa , IMAIZUMI, Atsushi , OKADA, Masahiro , SUZUKI, Yoji , KUDO, Ichiro , INOUE, Keizo , AZUMA, Chieko , MURAKAMI, Makoto
发明人： TEIJIN LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A61K38/00
摘要： A plasmid for use in producing an inflamed region derived phospholipase A2 inhibitory protein; a microbial cell transformed with the plasmid; a process for producing the protein by culturing the cell; and the protein thus produced and an allergic reaction suppresor containing it as the active ingredient. The plasmid contains a DNA sequence coding for a rat or human inflamed region derived phospholipase A2 inhibitory protein and a DNA sequence having a promoter function of regulating the expression of the protein. Escherichia coli is mainly used as the host cell.

5. 发明申请

WO1989005851A1 NOVEL HUMAN PHOSPHOLIPASE A2 AND ITS FRAGMENT PEPTIDE 审中-公开
标题翻译：新型人类磷酸酶A2及其片段肽
公开(公告)号：WO1989005851A1
公开(公告)日：1989-06-29
申请号：PCT/JP1988001311
申请日：1988-12-23
申请人： TEIJIN LIMITED , IMAIZUMI, Atsushi , SUWA, Yorimasa , OKADA, Masahiro , SUZUKI, Yoji , KUDO, Ichiro , INOUE, Keizo , HARA, Shuntaro , MATSUTA, Kunio , MIYAMOTO, Terumasa
发明人： TEIJIN LIMITED
IPC分类号： C12N09/16
CPC分类号： C12N9/18
摘要： A protein comprising phospholipase A2 which has an N-terminal amino acid sequence of NH2-Asn-Leu-Val-Asn-Phe-X-X-Met-Ile-X-Leu-Thr-Thr-Gly-Lys-Glu-Ala-Ala-Leu-X-Tyr-Gly-Phe-Tyr-Gly-, for example, a protein having a molecular weight of about 137,000 and originating in the human inflamed region, and a polypeptide or a fragment thereof having the above-described amino acid sequence participate in inflammation and act as an inflammation inducer, thus being useful as antigens for diagnosis of diseases such as inflammation, infection, immunological diseases, etc.

6. 发明申请

WO1988007552A1 PROTEIN HAVING ACTIVITY OF INHIBITING INFLAMMATION-INDUCING PHOSPHOLIPASE A2 审中-公开
标题翻译：具有抑制炎症诱导磷脂酶A2活性的蛋白
公开(公告)号：WO1988007552A1
公开(公告)日：1988-10-06
申请号：PCT/JP1988000318
申请日：1988-03-30
申请人： TEIJIN LIMITED , INOUE, Keizo , IMAIZUMI, Atsushi , KAMIMURA, Takashi , SUWA, Yorimasa , OKADA, Masahiro , SUZUKI, Yoji , KUDO, Ichiro
发明人： TEIJIN LIMITED
IPC分类号： C07K15/06
CPC分类号： C07K14/4703 , A61K38/00
摘要： A protein having an activity of inhibiting inflammation-inducing phospholipase A2, which is induced from cells by administering glucocorticoid thereto and which has a molecular weight of, for example, 40 K and has an N-terminal amino acid sequence of N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp.

7. 发明申请

WO1992006997A1 PEPTIDE WITH ACTIVITY OF INHIBITING PHOSPHOLIPASE A2 ORIGINATING IN INFLAMED PART 审中-公开
标题翻译：抑制磷脂酶A2活化的肽在炎症部分中起作用
公开(公告)号：WO1992006997A1
公开(公告)日：1992-04-30
申请号：PCT/JP1991001424
申请日：1991-10-17
申请人： TEIJIN LIMITED , SUWA, Yorimasa , IMAIZUMI, Atsushi , OKADA, Masahiro , AZUMA, Chieko , KUDO, Ichiro , INOUE, Keizo
发明人： TEIJIN LIMITED
IPC分类号： C07K07/10
CPC分类号： C07K14/4703 , A61K38/00
摘要： A peptide with an activity of inhibiting phospholipase A2 originating in inflamed parts, which has an amino acid sequence represented by formula (I).

8. 发明申请

WO1991001999A1 PHOSPHOLIPASE A2 INHIBITING PROTEIN ORIGINATING IN INFLAMED REGION, PRODUCTION THEREOF, AND GENE THEREFOR 审中-公开
标题翻译：磷脂酶A2抑制蛋白质在炎症区域中的产生，其生产及其基因
公开(公告)号：WO1991001999A1
公开(公告)日：1991-02-21
申请号：PCT/JP1990000996
申请日：1990-08-03
申请人： TEIJIN LIMITED , SUWA, Yorimasa , IMAIZUMI, Atsushi , OKADA, Masahiro , KUDO, Ichiro , INOUE, Keizo , SUZUKI, Yoji
发明人： TEIJIN LIMITED
IPC分类号： C07K13/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： A phospholipase A2 inhibiting protein originating in inflamed regions and having a sequence of 334 amino acids as shown or a physiologically equivalent amino acid sequence, a method of producing said protein by enzymatically treating the serum of a mammal, and a gene which codes for said protein.

9. 发明申请

WO1991016448A1 HUMAN MONOCLONAL ANTIBODY AGAINST GLYCOPROTEIN GP III OF VARICELLA ZOSTER VIRUS 审中-公开
标题翻译：人类单克隆抗体对大肠杆菌病毒的糖蛋白GP III
公开(公告)号：WO1991016448A1
公开(公告)日：1991-10-31
申请号：PCT/JP1991000519
申请日：1991-04-19
申请人： TEIJIN LIMITED , MASUHO, Yasuhiko , SUGANO, Toru , TOMIYAMA, Takami , SASAKI, Satoshi , KIMURA, Tsuyoshi , KAWAMURA, Takashi , MATSUMOTO, Yoh-ichi
发明人： TEIJIN LIMITED
IPC分类号： C12P21/08
CPC分类号： C07K16/088 , A61K38/00 , C07K2317/732
摘要： A human monoclonal antibody against glycoprotein gp III of varicella zoster virus (VZV) and a hybridoma which produces the same. This hybridoma is obtained by sensitizing a human lymphocyte with a gp III antigen in the presence of a mitogen, fusing the sensitized lymphocyte with a mouse myeloma cell, and selecting a cell line which produces a monoclonal antibody which reacts in an ELISA with a cell monolayer plate but substantially not in an ELISA with a cell homogenate plate.

10. 发明申请

WO1995019340A1 7-THIAPROSTAGLANDINS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译： 7-THIAPROSTAGLANDINS及其生产方法
公开(公告)号：WO1995019340A1
公开(公告)日：1995-07-20
申请号：PCT/JP1995000042
申请日：1995-01-18
申请人： TEIJIN LIMITED , MINOSHIMA, Toru , KATAOKA, Kenichiro , TANAKA, Hiroko , ISHII, Koji , ENDO, Noriaka
发明人： TEIJIN LIMITED
IPC分类号： C07C405/00
CPC分类号： C07C405/0033
摘要： 7-Thiaprostaglandins represented by general formula (I), enantiomers thereof, and mixtures thereof, inhibiting cell migration caused by chemokives such as monocyte migration factor MCP-1/MCAF and serving as a remedy for arteriosclerosis, diabetic angiopathy, and the like.
摘要翻译：由通式（I）表示的7-硫代前列腺素，其对映异构体及其混合物，抑制由诸如单核细胞迁移因子MCP-1 / MCAF的化学试剂引起的细胞迁移并用作动脉硬化，糖尿病性血管病等的补救剂。

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