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1. 发明申请

WO2010122546A1 METHOD AND DEVICE OF ESTIMATING A DOSE OF IONIZING RADIATION 审中-公开
标题翻译：估计离子辐射剂量的方法和装置
公开(公告)号：WO2010122546A1
公开(公告)日：2010-10-28
申请号：PCT/IL2010/000303
申请日：2010-04-15
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , BLANK, Aharon , TWIG, Ygal
发明人： BLANK, Aharon , TWIG, Ygal
IPC分类号： G01N24/10 , G01R33/60 , G01R33/38 , A61B5/055 , G01R33/3873
CPC分类号： G01N24/10 , A61B5/055 , A61B5/4504 , A61B5/4547 , G01R33/3808 , G01R33/383 , G01R33/3873 , G01R33/60
摘要： A device (100) of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source (101) adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator (104) mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer (106) to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.
摘要翻译：一种估计在骨内体积中吸收的电离辐射剂量的装置（100）。该装置包括适于在具有小于2立方毫米（mm 3）的体积的探测空间中产生基本静态磁场的静态磁场源（101），探测空间被放置在静磁场的远端场源，安装在远端附近的微谐振器（104）和至少一个传输线，馈送谐振器以在探测空间处产生微波磁场并传输从所述微波磁场返回的信号并且指示所述探测空间中的辐射诱导的顺磁性缺陷，以便允许光谱仪（106）根据信号的分析来计算吸收在放置在探测空间中的骨的一部分中的电离辐射的剂量。静态磁场源的尺寸和形状适于调节探测空间以与骨的骨内体积重叠。

2. 发明申请

WO2009037709A2 MRI PROBE MAGNET AND COIL CONFIGURATIONS 审中-公开
标题翻译： MRI探头磁铁和线圈配置
公开(公告)号：WO2009037709A2
公开(公告)日：2009-03-26
申请号：PCT/IL2008/001259
申请日：2008-09-21
申请人： TOPSPIN MEDICAL (ISRAEL) LTD. , TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , BLANK, Aharon , ZUR, Yuval , TAMMAM, Eric , HAREL, Amir
发明人： BLANK, Aharon , ZUR, Yuval , TAMMAM, Eric , HAREL, Amir
IPC分类号： G01R33/28 , G01R33/341 , G01R33/383 , G01R33/385 , G01R33/54 , G01R33/56 , A61B8/12
CPC分类号： G01R33/3808 , A61B8/4209 , G01R33/341 , G01R33/383 , G01R33/385 , G01R33/54 , G01R33/56 , G01R33/5608 , G01R33/5617 , G01R33/56518 , G01R33/56572
摘要： A magnet assembly for a self-contained MRI probe having a longitudinal axis in a z-direction, the probe adapted to image an imaging region located relative to the probe, in terms of a Cartesian x-y-z coordinate system, at least partly in a positive x direction, the magnet assembly comprising magnet portions which produce a static magnetic field in the imaging region, including at least: a) a first portion located at y 0, with magnetization having a positive y component and a positive x component.
摘要翻译：一种用于独立MRI探针的磁体组件，其具有在z方向上的纵向轴线，所述探针适合于以笛卡尔xyz坐标系为基础，以相对于所述探针定位的成像区域，至少部分地为正x 所述磁体组件包括在所述成像区域中产生静态磁场的磁体部分，所述磁体部分至少包括：a）位于y <0的第一部分，其磁化具有正的y分量和负的x分量; 和b）位于y> 0的第二部分，其磁化具有正的y分量和正的x分量。

3. 发明申请

WO2007144890A1 PROBE AND SYSTEM FOR ELECTRON SPIN RESONANCE IMAGING 审中-公开
标题翻译：电子自旋谐振成像的探测与系统
公开(公告)号：WO2007144890A1
公开(公告)日：2007-12-21
申请号：PCT/IL2007/000726
申请日：2007-06-14
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , BLANK, Aharon , SHTIRBERG, Lazar
发明人： BLANK, Aharon , SHTIRBERG, Lazar
IPC分类号： G01N24/10 , G01R33/60 , G01R33/38
CPC分类号： G01R33/60 , G01N24/10 , G01R33/3808 , G01R33/385
摘要： ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator (108), and one sided gradient coils (116, 118). An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to IOOA in pulses shorter than 1 μsec.
摘要翻译：描述了ESR成像探针，系统和方法。该探针是一种非原位探针，该系统包括该探头并配置用于操作该探针，该方法包括从探头的谐振器外部检测ESR。根据本发明的探针的示例性实施例包括冷却介质谐振器（108）和单侧梯度线圈（116,118）。该系统的示例性实施例包括源电流，其被配置为在短于1微秒的脉冲中以高达100A提供高达100A的电流。

4. 发明申请

WO2009027973A1 EX-SITU NMR SPECTROSCOPY 审中-公开
标题翻译： EX-SITU NMR光谱
公开(公告)号：WO2009027973A1
公开(公告)日：2009-03-05
申请号：PCT/IL2008/001164
申请日：2008-08-27
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , BLANK, Aharon , KATZ, Itai
发明人： BLANK, Aharon , KATZ, Itai
IPC分类号： G01R33/38 , G01N24/08 , G01R33/46 , G01R33/383
CPC分类号： G01R33/3808 , G01N24/08 , G01R33/383 , G01R33/46
摘要： A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.
摘要翻译：公开了一种用于非原位磁共振分析的装置。该装置包括用于在静磁场单元外部产生大致圆柱形对称的静态磁场的静态磁场单元（12），以及用于在射频单元外部产生大致圆柱对称的射频场的射频单元（14）。射频场垂直于静磁场。磁场的空间不均匀性与射频场的空间不均匀性基本一致。

5. 发明公开

EP2422188A1 METHOD AND DEVICE OF ESTIMATING A DOSE OF IONIZING RADIATION 审中-公开
标题翻译：方法和设备评估IONISIERUNGSSTRAHLUNGSDOSIS的
公开(公告)号：EP2422188A1
公开(公告)日：2012-02-29
申请号：EP10726305.5
申请日：2010-04-15
申请人： Technion Research & Development Foundation Ltd.
发明人： BLANK, Aharon , TWIG, Ygal
IPC分类号： G01N24/10 , G01R33/60 , G01R33/38 , A61B5/055 , G01R33/3873
CPC分类号： G01N24/10 , A61B5/055 , A61B5/4504 , A61B5/4547 , G01R33/3808 , G01R33/383 , G01R33/3873 , G01R33/60
摘要： A device (100) of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source (101) adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator (104) mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer (106) to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.

6. 发明公开

EP2183611A1 EX-SITU NMR SPECTROSCOPY 审中-公开
标题翻译：易地NMR光谱
公开(公告)号：EP2183611A1
公开(公告)日：2010-05-12
申请号：EP08789836.7
申请日：2008-08-27
申请人： Technion Research & Development Foundation Ltd.
发明人： BLANK, Aharon , KATZ, Itai
IPC分类号： G01R33/38 , G01N24/08 , G01R33/46 , G01R33/383
CPC分类号： G01R33/3808 , G01N24/08 , G01R33/383 , G01R33/46
摘要： A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.

7. 发明公开

EP2035818A1 PROBE AND SYSTEM FOR ELECTRON SPIN RESONANCE IMAGING 审中-公开
标题翻译：探头和成像系统利用电子自旋共振
公开(公告)号：EP2035818A1
公开(公告)日：2009-03-18
申请号：EP07736465.1
申请日：2007-06-14
申请人： Technion Research & Development Foundation LTD.
发明人： BLANK, Aharon , SHTIRBERG, Lazar
IPC分类号： G01N24/10 , G01R33/60 , G01R33/38
CPC分类号： G01R33/60 , G01N24/10 , G01R33/3808 , G01R33/385
摘要： ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator (108), and one sided gradient coils (116, 118). An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to IOOA in pulses shorter than 1 μsec.

8. 发明公开

EP3316912A1 METHOD FOR PREPARATION OF HIGHLY POLARIZED NUCLEAR SPINS CONTAINING SAMPLES AND USES THEREOF FOR NMR AND MRI 有权
标题翻译：制备含有样品的高度偏振的核自旋的方法及其用于NMR和MRI的用途
公开(公告)号：EP3316912A1
公开(公告)日：2018-05-09
申请号：EP16817376.3
申请日：2016-06-26
申请人： Technion Research & Development Foundation Ltd. , Yeda Research and Development Co. Ltd
发明人： BLANK, Aharon , KATZ, Itai , FEINTUCH, Akiva
IPC分类号： A61K49/20 , G01R33/28 , G01R33/56 , H01J37/00
CPC分类号： G01R33/5601 , A61B5/055 , A61K49/20 , A61M5/007 , A61M2005/006 , G01R33/282 , G01R33/4806 , G01R33/62 , H01J37/00
摘要： A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

9. 发明申请

WO2005067392A2 MRI PROBE FOR PROSTATE IMAGING 审中-公开
标题翻译：用于前瞻性成像的MRI探测
公开(公告)号：WO2005067392A2
公开(公告)日：2005-07-28
申请号：PCT/IL2005/000074
申请日：2005-01-20
申请人： TOPSPIN MEDICAL (ISRAEL) LTD. , TIDHAR, Gil , BLANK, Aharon
发明人： TIDHAR, Gil , BLANK, Aharon
IPC分类号： G01R33/28 , G01R33/383
CPC分类号： G01R33/285 , G01R33/3808 , G01R33/383 , G01R33/4814 , G01R33/56509
摘要： ABSRACT A rectal probe adapted for ultrasound and magnetic resonance imaging of the prostate, comprising: a) an ultrasound imaging probe; b) an MRI probe comprising a first magnetic field source for creating a static magnetic field in an MRI imaging region outside the rectal probe, a second magnetic field source for creating a time-varying magnetic field which excites nuclei in the MRI imaging region, and a receiver for receiving NMR signals from the excited nuclei and generating MRI imaging data indicative thereof; and c) a link joining the ultrasound probe and the MRI probe.
摘要翻译： ABSRACT适用于前列腺的超声和磁共振成像的直肠探针，包括：a）超声成像探针; b）MRI探针，其包括用于在直肠探针外部的MRI成像区域中产生静态磁场的第一磁场源，用于产生在MRI成像区域激发核的时变磁场的第二磁场源，以及用于从激发的核接收NMR信号并产生指示其的MRI成像数据的接收器; 和c）连接超声探针和MRI探针的连接。

10. 发明申请

WO2006043275A2 MAGNET AND COIL CONFIGURATIONS FOR MRI PROBES 审中-公开
标题翻译： MRI探针的磁铁和线圈配置
公开(公告)号：WO2006043275A2
公开(公告)日：2006-04-27
申请号：PCT/IL2005/001100
申请日：2005-10-17
申请人： TOPSPIN MEDICAL (ISRAEL) LTD. , BLANK, Aharon , LEWKONYA, Gadi , ZUR, Yuval , FRIEDMAN, Hanna , TIDHAR, Gil
发明人： BLANK, Aharon , LEWKONYA, Gadi , ZUR, Yuval , FRIEDMAN, Hanna , TIDHAR, Gil
CPC分类号： G01R33/285 , A61B5/02007 , A61B5/055 , G01R33/287 , G01R33/3808 , G01R33/383
摘要： A probe, with a longitudinal axis, for use in an NMR system, the probe comprising: (a) a plurality of static magnetic field sources which create a static magnetic field that is non-axisymmetric about the longitudinal axis, in a region outside the probe; and (b) at least one antenna, compromising one or more antennas together capable of creating a time-varying magnetic field which is capable of at least one of exciting nuclei in a sub-region of the region, receiving NMR signals from said excited nuclei and generating NMR electrical signals therefrom; wherein the plurality of magnetic field sources comprise adjacent static magnetic field sources that are magnetized in directions that differ by more than 10 degrees and less than 170 degrees.
摘要翻译：具有纵向轴线的用于NMR系统的探针，所述探针包括：（a）多个静态磁场源，其产生围绕所述纵向轴线非轴对称的静态磁场，探测; 并且（b）至少一个天线，将一个或多个天线一起折合起来能够产生能够在该区域的子区域中激励核中的至少一个的时变磁场，从所述激发的核接收NMR信号并从其中产生NMR电信号; 其中所述多个磁场源包括在相差大于10度且小于170度的方向上磁化的相邻静磁场源。

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