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1. 发明申请

WO1994015534A1 VASOOCCLUSION DEVICE CONTAINING RADIOPAQUE FIBERS 审中-公开
标题翻译：包含放射性纤维的血管扩张装置
公开(公告)号：WO1994015534A1
公开(公告)日：1994-07-21
申请号：PCT/US1993012515
申请日：1993-12-22
申请人： TARGET THERAPEUTICS, INC. , ENGELSON, Erik, T. , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/12177 , A61B90/39 , A61M25/0043 , A61M25/0108
摘要： This invention relates to a vaso-occlusive device (110) to be surgically implanted within a patient vessel (102) in order to block the flow of blood through the vessel (102) or to form a clot within an aneurysm stemming from the vessel (102). The vaso-occlusive device (110) is formed of a woven tubular braid (126) having at least one radiopaque fiber (128) so that the braid location may be observed. The braid (126) may also be partially woven from radio-lucent fibers (130). Optionally, the device may contain a fibrous center (156) or wick in its interior. The device may be continuous or segmented and a fibrous covering or element (152) may be attached.
摘要翻译：本发明涉及一种通过外科手术植入患者血管（102）内的血管闭塞装置（110），以阻止血液通过血管（102）的流动或在血管内形成血栓 102）。血管闭塞装置（110）由具有至少一个不透射线纤维（128）的织造管状编织物（126）形成，使得可以观察到编织物位置。编织物（126）也可以由无线电透明纤维（130）部分地编织。可选地，该装置可以在其内部包含纤维中心（156）或芯。该装置可以是连续的或分段的，并且纤维覆盖物或元件（152）可以附接。

2. 发明申请

WO1994026341A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO1994026341A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005312
申请日：1994-05-13
申请人： TARGET THERAPEUTICS, INC. , SAMSON, Gene , ENGELSON, Erik, T. , CHEE, Uriel, Hiram , WOODARD, Robert, E.
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M25/00
CPC分类号： A61M25/008 , A61M25/0043 , A61M25/0053 , A61M25/0068 , A61M25/09 , A61M2025/0057 , A61M2025/0073
摘要： The invention is a surgical instrument and specifically is a catheter (100) for treating a target site by delivering a controlled amount of therapeutic or diagnostic agent (the target site being accessible by a tortuous path through the vasculature), the perfusion tip (110) assembly on first catheter, and a process of using that catheter to deliver fluids to the selected vascular site.
摘要翻译：本发明是一种手术器械，特别是用于通过输送受控量的治疗或诊断剂（目标部位可通过脉管系统的曲折路径访问）来治疗靶部位的导管（100），灌注尖端（110）组装在第一导管上，以及使用该导管将流体输送到所选择的血管部位的过程。

3. 发明申请

WO1994026336A1 LUBRICIOUS CATHETERS 审中-公开
标题翻译：润滑杆
公开(公告)号：WO1994026336A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005343
申请日：1994-05-12
申请人： TARGET THERAPEUTICS, INC. , ENGELSON, Erik, T. , HERGENROTHER, Robert , EDER, Joseph
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M05/32
CPC分类号： A61L29/085 , A61L29/14 , A61M25/0045 , A61M2025/0046
摘要： This invention is in the general field of surgical instruments. It relates specifically to catheters (100) which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vaso-occlusive agents to a target site within a human or animal body which is accessible by a system of natural passageways within that body. The catheters are coated in such a way that they are exceptionally slippery and the coating is very durable. The invention also relates to methods of coating the catheters and to methods of applying lubricious coatings.
摘要翻译：本发明在外科器械的一般领域。它具体涉及导管（100），其可用于心血管和血管内程序以将诊断性，治疗性或血管闭塞性药物递送到人或动物体内的目标部位，该体内可由该体内的天然通道系统接近。导管以这样的方式涂覆，使得它们非常滑，并且涂层非常耐用。本发明还涉及涂覆导管的方法和应用润滑涂层的方法。

4. 发明申请

WO1998015311A1 GUIDE CATHETER WITH ENHANCED GUIDEWIRE TRACKING 审中-公开
标题翻译：导轨与增强导轨跟踪
公开(公告)号：WO1998015311A1
公开(公告)日：1998-04-16
申请号：PCT/US1997015850
申请日：1997-10-07
申请人： TARGET THERAPEUTICS, INC. , ENGELSON, Erik, T. , MILLS, Timothy, C. , NITA, Henry , SANTOS, Rhoda, M.
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M25/00
CPC分类号： A61M25/0054
摘要： This is a guide catheter assembly. The guide catheter assembly is used to cooperate with a micro-catheter in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, situated within the catheter body in such a way to create a catheter section having an exceptionally thin wall, controlled stiffness, and high resistance to kinking. The catheter has a terminal segment which is not supported by a braid and the polymer making up that terminal segment is either the same hardness as is the polymer making up the outer covering of next more adjacent section or, preferably, the polymer is harder than is the polymer making up the segment located just proximally of that terminal segment. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided reinforcing member typically is embedded in a flexible outer tubing member. An inner tubing member is lubricious.
摘要翻译：这是导管组件。引导导管组件用于与微导管配合以进入身体内的组织靶，通常是通过血管系统可接近的靶。本发明的中心是使用编织金属加强构件，其以这样的方式设置在导管主体内，以形成具有特别薄的壁，受控刚度和高耐扭结的导管部分。导管具有不由编织物支撑的端子段，并且构成该端子段的聚合物与组成下一个相邻区段的外覆层的聚合物的硬度相同，或者优选地，聚合物比构成该段的聚合物位于该末端段的近侧。编织物可以具有单个节距，或者可以沿导管或导管部分的轴线变化。编织加强构件通常嵌入在柔性外管构件中。内管件是润滑的。

5. 发明申请

WO1994027668A1 VARIABLE STIFFNESS BALLOON CATHETER 审中-公开
标题翻译：可变刚度气球导管
公开(公告)号：WO1994027668A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005679
申请日：1994-05-20
申请人： TARGET THERAPEUTICS, INC. , ENGELSON, Erik, T.
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61M25/0045 , A61M25/0054 , A61M2025/0079 , A61M2025/1063
摘要： This invention is a single-lumen balloon catheter (12) and assembly having a variable stiffness shaft that allows for greater guidewire (13) trackability and proximal pushability than previous designs. The catheter (12) has an elongate tubular body that is made of inner (19, 20) and outer (18) coaxial tubes, the inner tube (19, 20) being made of proximal and distal sections, the proximal section (19) being stiffer than the distal section (20) and the distal section (20) being stiffer than the outer tube (18).
摘要翻译：本发明是一种具有可变刚度轴的单腔气囊导管（12）和组件，其允许比以前的设计更大的导丝（13）跟踪性和近端推挤性。所述导管（12）具有由内部（19,20）和外部（18）同轴管制成的细长管状体，所述内部管（19,20）由近端和远端部分制成，所述近端部分（19）比所述远端部分（20）更硬，并且所述远端部分（20）比所述外管（18）更硬。

6. 发明申请

WO1995031149A1 DUAL COIL MEDICAL RETRIEVAL DEVICE 审中-公开
标题翻译：双线圈医疗检索装置
公开(公告)号：WO1995031149A1
公开(公告)日：1995-11-23
申请号：PCT/US1995005872
申请日：1995-05-09
申请人： TARGET THERAPEUTICS, INC. , GRAVES, Virgil, B. , RAPPE, Alan , SEPETKA, Ivan , GIA, Son , PHAM, Pete, Phong , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61B19/00
CPC分类号： A61B17/221 , A61B17/12022 , A61B90/39 , A61B2017/22035 , A61B2017/2212
摘要： A device for retrieving foreign bodies, such as a vaso-occlusive coil or other articles from within vessels such as those of the cardiovascular system. Two small snare coils (60, 62) are joined at their distal ends (68, 70) to form a loop. The proximal ends of the coils are attached to one or more elongated actuator members (20, 22). The loop size is adjusted by manipulation of one or more of the proximal ends (26, 44) of the elongated actuator members. This retrieval device may be used to ensnare and either reposition or remove foreign bodies within a vessel lumen.
摘要翻译：一种用于从诸如心血管系统的血管内的血管中检索诸如血管闭塞线圈或其他物品的异物的装置。两个小的圈套线圈（60,62）在其远端（68,70）处连接以形成环。线圈的近端附接到一个或多个细长致动器构件（20,22）。通过操纵细长致动器构件的一个或多个近端（26,44）来调节环尺寸。这种检索装置可用于捕获并重新定位或移除血管腔内的异物。

7. 发明申请

WO1996000101A1 KINK-FREE SPIRAL-WOUND CATHETER 审中-公开
标题翻译：无闪烁的螺旋式导管
公开(公告)号：WO1996000101A1
公开(公告)日：1996-01-04
申请号：PCT/US1995008083
申请日：1995-06-26
申请人： TARGET THERAPEUTICS, INC. , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M25/00
CPC分类号： A61L29/08 , A61L29/041 , A61L29/049 , A61L29/06 , A61M25/005 , A61M25/0053 , C08L23/06 , C08L23/12 , C08L27/06 , C08L27/12 , C08L77/00 , C08L79/08 , C08L81/06
摘要： This invention is a surgical device. In particular, it is a catheter (210) suitable for treating a tissue target within the body, which target is accessible through the vascular system. Central to the invention is the use of stiffener ribbons (218), typically metallic, wound within the catheter body in such a way as to create a catheter having controllable stiffness.
摘要翻译：本发明是一种手术装置。特别地，它是适合于治疗身体内的组织靶的导管（210），该靶可通过血管系统接近。本发明的中心是使用通常金属的加强筋（218）以导致具有可控刚度的导管的方式缠绕在导管体内。

8. 发明申请

WO1996000104A1 DETACHABLE MICROCOIL DELIVERY CATHETER 审中-公开
标题翻译：可拆卸微型麦克风输送管
公开(公告)号：WO1996000104A1
公开(公告)日：1996-01-04
申请号：PCT/US1995008016
申请日：1995-06-20
申请人： TARGET THERAPEUTICS, INC. , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12095 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0091 , A61M25/09
摘要： This invention is a surgical instrument, and specifically is a device for delivering embolic coils (102) to a selected site within the vasculature of the human body. The instrument uses, and may include, a catheter (110) used to place the embolic coil. In particular, the device is comprised of a pusher wire (108) having a distal tip (106) which is configured to engage the proximal end of the embolic coil (102). The device may also include a cylindrical pusher (112) which coaxially surrounds at least a portion of the pusher wire and cooperates in the disengagement of the coil from the pusher wire and the ejection of the vasoocclusive coil into the selected vascular site. The pusher wire's engagement tip (106) may be of any selected and convenient shape and may be grooved, if so desired, to enhance the engagement joint strength.
摘要翻译：本发明是一种手术器械，特别是用于将栓塞线圈（102）输送到人体脉管系统内的选定部位的装置。仪器使用并且可以包括用于放置栓塞线圈的导管（110）。特别地，该装置由具有远端尖端（106）的推进线（108）构成，该远端构造成接合栓塞线圈（102）的近端。该装置还可以包括圆柱形推动器（112），其同轴地围绕推进线的至少一部分并且在线圈与推进线的分离以及将血管收缩性线圈排出到所选择的血管部位中配合。推杆的接合尖端（106）可以是任何选择和方便的形状，并且如果需要，可以是开槽的，以增强接合接合强度。

9. 发明申请

WO1994026206A1 TEMPORARY INFLATABLE INTRAVASCULAR PROSTHESIS 审中-公开
标题翻译：临床可激活的血管内皮生长因子
公开(公告)号：WO1994026206A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005216
申请日：1994-05-11
申请人： TARGET THERAPEUTICS, INC. , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61F02/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2250/0003 , A61F2250/0059 , A61F2250/0098 , A61M25/1002
摘要： This invention is in the general field of surgical instruments and relates specifically to an inflatable prosthetic device (100) suitable for use in cardiovascular or endo-vascular procedures, such as angioplasty, to restore normal blood flow through the vessel. The device is generally a helically wound balloon having a false lumen through its center which is inflatable through its integral inflation lumen (110).
摘要翻译：本发明在外科器械的一般领域中，具体涉及适用于心血管或内血管手术（例如血管成形术）的可充气假体装置（100），以恢复通过血管的正常血流。该装置通常是具有穿过其中心的假腔的螺旋形缠绕球囊，其通过其整体的充气腔（110）可充气。

10. 发明申请

WO1994011047A1 SINGLE-LUMEN BALLOON CATHETER HAVING A DIRECTIONAL VALVE 审中-公开
标题翻译：具有方向阀的单壁气泡导管
公开(公告)号：WO1994011047A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010638
申请日：1993-11-04
申请人： TARGET THERAPEUTICS, INC. , SAMSON, Gene
发明人： TARGET THERAPEUTICS, INC.
IPC分类号： A61M25/00
CPC分类号： A61M25/104 , A61M25/0045 , A61M25/0075 , A61M29/02 , A61M2025/0076 , A61M2025/1093
摘要： This invention is a single lumen balloon catheter (100) having a valve seat (124) on the distal end of the catheter, distal of the balloon (112), which may be operated by a control wire (102) having a valve plug (104) disposed on the wire. The valve seat (106) may be engaged by the valve plug (104) from either direction, depending on the installation of the control wire (102). In either event, if the valve plug (104) is installed distally of the valve seat (124) in the catheter lumen, the valve (106) is closed by pulling on the control wire (102) (or moving the control wire (102) in a proximal direction) and introducing fluid through the catheter lumen through the balloon (112). Alternatively, the guide wire (102), with its integral valve plug (104) may be introduced from the proximal end of the catheter (100) and may traverse the body of the balloon (112) to engage the valve seat (122) in the distal end of the catheter (100). Pushing on the control wire (102) will seat the valve, allowing fluid to inflate the balloon (112).
摘要翻译：本发明是一种单腔气囊导管（100），其在导管的远端上具有阀座（124），该气囊导管远离球囊（112），其可以由具有阀塞的控制线（102）操作 104）。取决于控制线（102）的安装，阀座（106）可以由阀芯（104）从任一方向接合。在任一情况下，如果阀塞（104）安装在导管内腔中的阀座（124）的远侧，则阀（106）通过拉动控制线（102）而关闭（或移动控制线102 ），并且通过所述气囊（112）将流体引导通过所述导管内腔。或者，具有其一体式阀塞（104）的导丝（102）可以从导管（100）的近端引入并且可以横过球囊（112）的主体以与阀座（122）接合导管（100）的远端。推动控制线（102）将座阀，允许流体使球囊（112）膨胀。

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