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1. 发明申请

WO2005037832B1 AZABICYCYCLIC COMPOUNDS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于缓解疼痛和治疗中枢神经系统疾病的化学化合物
公开(公告)号：WO2005037832B1
公开(公告)日：2005-09-15
申请号：PCT/US2004034051
申请日：2004-10-15
申请人： TARGACEPT INC , BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
发明人： BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
IPC分类号： A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04 , A61K31/403 , A61P25/00
CPC分类号： C07D221/22 , C07D401/04
摘要： Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
摘要翻译：特征在于正常神经递质释放（如多巴胺释放（如帕金森综合征，帕金森氏病，图雷特氏综合征，注意缺陷障碍或精神分裂症））改变的中枢神经系统疾病易患或患有疾病的患者是通过施用如本文所述的式（1或2）化合物进行治疗。式（1和2）的化合物也可用于治疗疼痛，治疗药物成瘾，尼古丁成瘾和/或肥胖症。该化合物可作为单独的立体异构体，外消旋混合物，非对映异构体等存在。

2. 发明申请

WO2005037832A2 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：药物组合物和消除疼痛和治疗中枢神经系统疾病的方法
公开(公告)号：WO2005037832A2
公开(公告)日：2005-04-28
申请号：PCT/US2004034051
申请日：2004-10-15
申请人： TARGACEPT INC , BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
发明人： BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
IPC分类号： A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04 , C07D471/00
CPC分类号： C07D221/22 , C07D401/04
摘要： Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
摘要翻译：特征在于正常神经递质释放（如多巴胺释放（如帕金森综合征，帕金森氏病，图雷特氏综合征，注意缺陷障碍或精神分裂症））改变的中枢神经系统疾病易患或患有疾病的患者是通过施用如本文所述的式（1或2）化合物进行治疗。式（1和2）的化合物也可用于治疗疼痛，治疗药物成瘾，尼古丁成瘾和/或肥胖症。该化合物可作为单独的立体异构体，外消旋混合物，非对映异构体等存在。

3. 发明申请

WO2004108668A3 ALPHA-7 NEURONAL NICOTINIC RECEPTOR LIGANDS: COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： ALPHA-7神经细胞受体配体：组合物和使用方法
公开(公告)号：WO2004108668A3
公开(公告)日：2006-07-20
申请号：PCT/US2004017516
申请日：2004-06-03
申请人： TARGACEPT INC , BENCHERIF MEROUANE , MILLER CRAIG HARRISON , HAWKINS GREGORY D , BHATTI BALWINDER S
发明人： BENCHERIF MEROUANE , MILLER CRAIG HARRISON , HAWKINS GREGORY D , BHATTI BALWINDER S
IPC分类号： A61K31/64 , C07D20060101 , C07D453/02 , C07D487/08
CPC分类号： A61K31/64 , C07D453/02 , C07D487/08
摘要： Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptane, a 1-aza-2-(3-pyridyl)bicyclo [2.2.2] octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.1]octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.2]nonane, a 1-aza-7-(3-pyridyl) bicyclo[2.2.1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3.2.2]nonane, or a 1-aza-7-(3-pyridyl)bicyclo[3.2.2]nonane. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
摘要翻译：特征在于正常神经递质释放（如多巴胺释放（如帕金森综合征，帕金森氏病，图雷特氏综合征，注意缺陷障碍或精神分裂症））改变的中枢神经系统疾病易患或患有疾病的患者是通过施用1-氮杂-2-（3-吡啶基）双环[2.2.1]庚烷，1-氮杂-2-（3-吡啶基）双环[2.2.2]辛烷，1-氮杂-2- （3-吡啶基）双环[3.2.1]辛烷，1-氮杂-2-（3-吡啶基）双环[3.2.2]壬烷，1-氮杂-7-（3-吡啶基）双环[2.2.1 ]庚烷，1-氮杂-3-（3-吡啶基）双环[3.2.2]壬烷或1-氮杂-7-（3-吡啶基）双环[3.2.2]壬烷。该化合物可作为单独的立体异构体，外消旋混合物，非对映异构体等存在。

4. 发明专利

AT451368T 未知
公开(公告)号：AT451368T
公开(公告)日：2009-12-15
申请号：AT04795238
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04

5. 发明专利

SI1678172T1 AzabicikliŽŤne spojine za lajĹˇanje boleŽŤine in zdravljenje motenj centralnega ĹľivŽŤnega sistema 未知
公开(公告)号：SI1678172T1
公开(公告)日：2010-04-30
申请号：SI200431352
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04

6. 发明专利

PT1678172E COMPOSIÇÕES FARMACÊUTICAS E MÉTODOS PARA ALÍVIO DA DOR E TRATAMENTO DE PERTURBAÇÕES DO SISTEMA NERVOSO CENTRAL 未知
公开(公告)号：PT1678172E
公开(公告)日：2010-03-03
申请号：PT04795238
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： MIAO LAN , MILLER CRAIG H , BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MAZUROV ANATOLY , PHILLIPS TERESA Y
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04

7. 发明专利

DE602004024565D1 未知
公开(公告)号：DE602004024565D1
公开(公告)日：2010-01-21
申请号：DE602004024565
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： BREINING SCOTT R , BHATTI BALWINDER S , HAWKINS GREGORY D , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04

8. 发明专利

DK1678172T3 Azabicykliske forbindelser til lindring af smerte og behandling af sygdomme i centralnervesystemet 未知
公开(公告)号：DK1678172T3
公开(公告)日：2010-04-06
申请号：DK04795238
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： BREINING SCOTT R , BHATTI BALWINDER S , MIAO LAN , MAZUROV ANATOLY , PHILLIPS TERESA Y , MILLER CRAIG H , HAWKINS GREGORY D
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04

9. 发明专利

CA2539811A1 AZABICYCYCLIC COMPOUNDS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS 未知
公开(公告)号：CA2539811A1
公开(公告)日：2005-04-28
申请号：CA2539811
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： MIAO LAN , HAWKINS GREGORY D , MAZUROV ANATOLY , BHATTI BALWINDER S , MILLER CRAIG H , BREINING SCOTT R , PHILLIPS TERESA Y
IPC分类号： C07D401/04 , A61K31/403 , A61K31/46 , A61K31/506 , A61P25/00 , C07D221/22

10. 发明专利

ES2356356T3 COMPUESTOS AZABICICLICOS PARA ALIVIAR EL DOLOR Y TRATAR LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL. 未知
公开(公告)号：ES2356356T3
公开(公告)日：2011-04-07
申请号：ES04795238
申请日：2004-10-15
申请人： TARGACEPT INC
发明人： MIAO LAN , MILLER CRAIG H , BHATTI BALWINDER S , PHILLIPS TERESA Y , HAWKINS GREGORY D , MAZUROV ANATOLY , BREINING SCOTT R
IPC分类号： C07D471/00 , A61K31/46 , A61K31/506 , C07D221/22 , C07D401/04
摘要： Un compuesto de la fórmula general: **(Ver fórmula)** donde k, m, n, y p son individuos 0, 1, 2 o 3, siempre que, cuando k + p=1, m o n o ambos deben ser mayores que 0, donde la suma de k + p -2 y la suma de m + n =1, o la suma de k + p=2 y la suma de m + n=0, o la suma de k + p=1 y la suma de m + n=1;Ar es un anillo heteroaril monocíclico o policíclico, opcionalmente sustituido en cualquier posición con un sustituyente Z como se define abajo, con la condición que en los compuestos de la fórmula 2, cuando el anillo azabicíclico es un 6-azabiciclo[3.2.1]octano, Ar no es piridina y donde cuando los componentes son azabiciclo [3.2.1]octanos, el anillo Ar es seleccionado de piridinil, pirimidinil, pirazinil, piridazinil, pirrolil, pirazolil, thiazoiyl, isothiazolil, triazolil, oxazolil o isoxazoyl; donde Zj se refiere a j como el número de sustituyentes Z, donde los sustituyentes pueden estar presentes en cualquier átomo de carbón en el anillo azabicíclico, J es 0, 1, o 2, cada Z es, individualmente, una especie sustituyente seleccionada del grupo consistente en alquil, alquil sustituido, alquenil, alquenil sustituidol, heterociclilo, heterocíclico sustituido, cicloalquil, doalquil sustituido, aril (incluyendo heteroaril), aril sustituido (incluyendo heteroaril), alquilaril, alquilaril sustituido, arilalquil, aralquil sustituido, halógeno (e.g., F, Cl, Br, o I). -OR', -NR'R'', -CF3, -CN, -NO2, -C2R', -SR', -N3, -C(=O)NR'R'', -NRC(=O)R'', -C(=O)R', -C(=O)OR', -OC(=O)R', -O(CR'R''), C(=O)R', -O(CR,R'')rNR''C(=O)R', -O(CR,R'')rNR''SO2R', -OC(=O)NR'R'', -NR,C(=O)OR'', -SO2R', -SO2NR'R'', y -NR'SO2R'', donde R' y R'' son hidrógenos individuales, alquilos menores (p.e, alquil de cadena lineal o ramificada incluyendo C1-C8, preferiblemente C1-C5, tal como metil, etil, o isopropilo), ddoalquil, heterocidil, aril, o arilalquil, (tal como benzil), y r es un entero de 1 a 6, R' y R'' pueden combinar para formar una funcionalidad cíclica, el término "sustituido" como se aplica a alquil, aril, (incluyendo heteroaril), cicloalquil y similares se refiere a los sustituyentes descritos anteriormente, empezando con los halógenos y terminando en -NR'SO2R''; R es hidrógeno, alquil menor, arilalquil (incluyendo heteroarilalquil), acil, alcoxicarbonil o ariloxicarbonil, en la forma de un estereoisómero o una mezcla de esteroisómeros.

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