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1. 发明专利

JP2011105747A Method and composition for the prevention and treatment of sepsis 审中-公开
标题翻译：预防和治疗食欲的方法和组合
公开(公告)号：JP2011105747A
公开(公告)日：2011-06-02
申请号：JP2011014797
申请日：2011-01-27
申请人： Medinnova As , Tanox Inc , タノックスインコーポレーテッド , メディノバエー.エス
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61K45/06 , A01N37/18 , A61K20060101 , A61K38/00 , A61K39/395 , A61P31/04 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18 , C07K16/2896
摘要： PROBLEM TO BE SOLVED: To provide a method and a composition for the prevention and treatment of sepsis.
SOLUTION: The method for preventing or treating sepsis by administering in combination of a sepsis preventing or treating amount of one or more complement inhibitors and a sepsis preventing or treating amount of one or more CD14 pathway inhibitors to a patient. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins such as C5a, and the CD14 pathway inhibitors are preferably antibodies that bind to and inhibit CD14 pathway components such as CD14 and LPS.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于预防和治疗败血症的方法和组合物。解决方案：通过将败血症预防或治疗量的一种或多种补体抑制剂和防止或治疗量的一种或多种CD14途径抑制剂的组合施用于患者的方法。补体抑制剂优选结合并抑制补体蛋白如C5a的抗体，并且CD14途径抑制剂优选结合并抑制CD14途径成分如CD14和LPS的抗体。版权所有（C）2011，JPO＆INPIT

2. 发明公开

EP1628530A4 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF SEPSIS 有权
标题翻译：方法和组合物进行预防和败血症的治疗
公开(公告)号：EP1628530A4
公开(公告)日：2007-08-29
申请号：EP04752211
申请日：2004-05-14
申请人： TANOX INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61K39/395 , A01N37/18 , A61K20060101 , A61K38/00 , A61P31/00 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18 , C07K16/2896

3. 发明专利

CA2524534C METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF SEPSIS 未知
公开(公告)号：CA2524534C
公开(公告)日：2012-12-11
申请号：CA2524534
申请日：2004-05-14
申请人： TANOX INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61K39/395 , A01N37/18 , A61K20060101 , A61K38/00 , A61P31/04 , C07K16/18 , C07K16/28
摘要： A method for preventing or treating sepsis by administering in conjunction a sepsis preventing or treating amount of one or more complement inhibitors and a sepsis preventing or treating amount of one or more CD14 pathway inhibitors to a patient. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins such as C5a and the CD14 pathway inhibitors are preferably antibodies that bind to and inhibit CD14 pathway components such as CD14 and LPS.

4. 发明专利

ES2387275T3 Métodos y composiciones para la prevención y el tratamiento de la sepsis 未知
公开(公告)号：ES2387275T3
公开(公告)日：2012-09-19
申请号：ES04752211
申请日：2004-05-14
申请人： TANOX INC , MEDINNOVA AS , GENENTECH INC
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61K39/395 , A01N37/18 , A61K20060101 , A61K38/00 , A61P31/00 , C07K16/18 , C07K16/28
摘要： Composición que comprende un inhibidor de complemento y un inhibidor de la vía de CD14, en la que: (i)dicho inhibidor de complemento comprende un anticuerpo anti-C5a o un fragmento funcionalmente equivalentedel mismo; y (ii) dicho inhibidor de la vía de CD14 comprende nucleótidos antisentido de CD14, un siARN deCD14, un ARNi de CD14 o un anticuerpo anti-CD14 o un fragmento funcionalmente equivalente del mismo.

5. 发明专利

JP2007161724A New anti-il13 antibody and use thereof 审中-公开
标题翻译：新抗IL13抗体及其用途
公开(公告)号：JP2007161724A
公开(公告)日：2007-06-28
申请号：JP2007015642
申请日：2007-01-25
申请人： Tanox Inc , タノックスインコーポレイテッド
发明人： FUNG SEK CHUNG , MOYLE MATTHEW , LU MASON , YAN CHANGNING , SINGH SANJAYA , HUANG DAN
IPC分类号： C07K16/24 , A61K39/395 , A61P11/06 , A61P37/00 , A61P37/08 , C07K16/00 , C07K16/46 , C12N15/02 , C12P21/08 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide an inhibitor strong and specific to IL13, with its activity remained intact after put to long-term administration to the airway with asthma. SOLUTION: The inhibitor is an anti-IL13 antibody that binds specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralizes human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The use of these antibodies in the treatment of IL13-mediated diseases, such as asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and allergic diseases including osteoporosis, is also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供对IL13强烈和特异性的抑制剂，其在长期给予哮喘气道后保持完整。解决方案：抑制剂是一种特异性结合并且对糖基化和非糖基化的人IL13具有高亲和力的抗IL13抗体，不结合小鼠IL13，并以约1:2的近似摩尔比中和人IL13活性（单抗：IL13）。使用这些抗体治疗IL13介导的疾病，如哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺病，还提供溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和包括骨质疏松症在内的过敏性疾病。版权所有（C）2007，JPO＆INPIT

6. 发明专利

AU2010249190A1 Methods and compositions for the prevention and treatment of sepsis 未知
公开(公告)号：AU2010249190A1
公开(公告)日：2011-01-06
申请号：AU2010249190
申请日：2010-12-06
申请人： GENENTECH INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： C07K16/18 , A01N37/18 , A61K20060101 , A61K38/00 , C07K16/28

7. 发明专利

ES2522525T3 Métodos y composiciones para la prevención y el tratamiento de la sepsis 未知
公开(公告)号：ES2522525T3
公开(公告)日：2014-11-14
申请号：ES10179747
申请日：2004-05-14
申请人： GENENTECH INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： A61P31/00 , A01N37/18 , A61K20060101 , A61K38/00 , A61K39/395 , C07K16/18 , C07K16/28
摘要： Composición que comprende uno más inhibidores de complemento y uno o más inhibidores del mecanismo de CD14, en la que: (i) dicho uno o más inhibidores de complemento comprende un anticuerpo anti-C4a o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-C5a o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-receptor de C5a o un fragmento funcionalmente equivalente del mismo, o un anticuerpo anti-C3a o un fragmento funcionalmente equivalente del mismo; y (ii) dicho uno o más inhibidores del mecanismo de CD14 comprende nucleótidos antisentido de CD14, un siARN de CD14, un ARNi de CD14, un anticuerpo anti-LPS o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-LBP o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-CD14 o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-TLR4 o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-MD2 o un fragmento funcionalmente equivalente del mismo, un anticuerpo anti-TLR2 o un fragmento funcionalmente equivalente del mismo, o un anticuerpo anti-TLR6 o un fragmento funcionalmente equivalente del mismo; en la que el fragmento funcionalmente equivalente de un anticuerpo se une al mismo componente del sistema de complementos o el mecanismo de CD14 e inhibe la activación del complemento o la función del mecanismo de CD14 sustancialmente de la misma manera que el anticuerpo completo.

8. 发明专利

AU2004241069B2 Methods and compositions for the prevention and treatment of sepsis 未知
公开(公告)号：AU2004241069B2
公开(公告)日：2010-09-09
申请号：AU2004241069
申请日：2004-05-14
申请人： GENENTECH INC , MEDINNOVA AS
发明人： MOLLNES TOM EIRIK , FUNG SEK CHUNG
IPC分类号： C07K16/18 , A01N37/18 , A61K20060101 , A61K38/00 , C07K16/28

9. 发明专利

AU2010249190B2 Methods and compositions for the prevention and treatment of sepsis 未知
公开(公告)号：AU2010249190B2
公开(公告)日：2013-02-28
申请号：AU2010249190
申请日：2010-12-06
申请人： GENENTECH INC , MEDINNOVA AS
发明人： FUNG SEK CHUNG , MOLLNES TOM EIRIK
IPC分类号： C07K16/18 , A01N37/18 , A61K20060101 , A61K38/00 , C07K16/28
摘要： METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF SEPSIS Abstract A method and composition for preventing or treating sepsis by administering in conjunction a sepsis preventing or treating amount of one or more complement inhibitors and a sepsis preventing or treating amount of one or more CD14 pathway inhibitors to a patient. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins such as C5a and the CD14 pathway inhibitors are preferably antibodies that bind to and inhibit CD14 pathway components such as CD14 and LPS. 3193680_1 CGH

10. 发明专利

DK1628530T3 FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL FOREBYGGELSE OG BEHANDLING AF SEPSIS 未知
公开(公告)号：DK1628530T3
公开(公告)日：2012-07-23
申请号：DK04752211
申请日：2004-05-14
申请人： GENENTECH INC , MEDINNOVA AS
发明人： MOLLNES TOM EIRIK , FUNG SEK CHUNG
IPC分类号： A61K39/395 , A01N37/18 , A61K20060101 , A61K38/00 , A61P31/00 , C07K16/18 , C07K16/28

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