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1. 发明申请

WO2005062967A2 NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：新型抗IL 13抗体及其用途
公开(公告)号：WO2005062967A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043501
申请日：2004-12-23
申请人： TANOX, INC. , FUNG, Sek, Chung , MOYLE, Matthew , LU, Mason , YAN, Changning , SINGH, Sanjaya , HUANG, Dan
发明人： FUNG, Sek, Chung , MOYLE, Matthew , LU, Mason , YAN, Changning , SINGH, Sanjaya , HUANG, Dan
IPC分类号： A61K39/395 , C07K16/00 , C07K16/24 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
摘要翻译：本发明涉及与糖基化和非糖基化的人IL13两者特异性结合并具有高亲和力的抗IL13抗体，不结合小鼠IL13，并以约1:2的摩尔比（MAb：IL13）中和人IL13活性）。本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

2. 发明申请

WO2008140455A1 TREATMENT OF RADIATION AND CHEMO-THERAPY INDUCED FIBROSIS USING NOVEL ANTI-IL 13 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：使用新型抗IL 13单克隆抗体治疗放射治疗和化疗疗法诱导性纤维化
公开(公告)号：WO2008140455A1
公开(公告)日：2008-11-20
申请号：PCT/US2007/011559
申请日：2007-05-15
申请人： TANOX, INC. , FUNG, Sek, Chung , MOYLE, Matthew
发明人： FUNG, Sek, Chung , MOYLE, Matthew
IPC分类号： C12N5/06 , C12N5/16
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24
摘要： The present application relates to the treatment of fibrosis using novel anti-IL13 monoclonal antibodies. The antibodies useful in the present invention comprise anti-ILl 3 antibodies that bind specifically and with high affinity to ILl 3. In particular, such treatment may be in subjects undergoing radiotherapy and/or chemotherapy. Examples of anti-IL13 antibodies are 228B/C-1, 228A-4, 227-26, and 227-43.
摘要翻译：本申请涉及使用新的抗IL13单克隆抗体治疗纤维化。可用于本发明的抗体包含特异性结合并以高亲和力结合IL11的抗IL11抗体。特别地，这种治疗可以是进行放射治疗和/或化疗的受试者。抗IL13抗体的实例是228B / C-1,228A-4,227-26和227-43。

3. 发明申请

WO2005062972A2 TREATMENT OF CANCER WITH NOVEL ANTI-IL 13 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：治疗癌症与新型抗IL 13单克隆抗体
公开(公告)号：WO2005062972A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043541
申请日：2004-12-23
申请人： TANOX, INC. , FUNG, Sek, Chung , MOYLE, Matthew
发明人： FUNG, Sek, Chung , MOYLE, Matthew
IPC分类号： A61K39/395 , C07K16/00 , C07K16/24 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the treatment of IL13 dependent neoplastic disorders comprising the administration of novel anti-IL13 antibodies, The invention aiso includes diagnosing such tumors or cancer using the antibodies of the present invention to detect overexpression of IL13 in the patient.
摘要翻译：本发明涉及IL13依赖性肿瘤疾病的治疗，其包括施用新的抗IL13抗体。本发明还包括使用本发明的抗体诊断此类肿瘤或癌症以检测患者中IL13的过度表达。

4. 发明申请

WO2011019932A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开
公开(公告)号：WO2011019932A3
公开(公告)日：2011-02-17
申请号：PCT/US2010/045346
申请日：2010-08-12
申请人： THERACLONE SCIENCES, INC. , GRANDEA, Andres G., III , KING, Gordon , COX, Thomas C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
发明人： GRANDEA, Andres G., III , KING, Gordon , COX, Thomas C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： A61K39/42 , C07K16/10 , A61P37/02 , A61P31/16 , G01N33/53
摘要： The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.

5. 发明申请

WO2011031833A2 HUMAN ANTI-CANCER ANTIBODIES 审中-公开
标题翻译：人类抗癌抗体
公开(公告)号：WO2011031833A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048234
申请日：2010-09-09
申请人： THERACLONE SCIENCES, INC. , HAMMOND, Phillip, W. , VAN DER VUURST DE VRIES, Anne-Renee , TJOELKER, Larry, W. , MOYLE, Matthew
发明人： HAMMOND, Phillip, W. , VAN DER VUURST DE VRIES, Anne-Renee , TJOELKER, Larry, W. , MOYLE, Matthew
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , G01N33/574
CPC分类号： G01N33/57407 , C07K16/3015 , C07K16/3069 , C07K2317/515 , C07K2317/732 , C07K2317/92
摘要： The present invention provides novel human anti-cancer antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of cancer.
摘要翻译：本发明提供了新的人类抗癌抗体及相关组合物和方法。这些抗体用于癌症的诊断和治疗。

6. 发明申请

WO2010135521A2 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开
标题翻译：用于治疗和诊断流感病毒的组合物和方法
公开(公告)号：WO2010135521A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035559
申请日：2010-05-20
申请人： THERACLONE SCIENCES, INC. , GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N33/56983
摘要： The present invention provides novel human anti- influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译：本发明提供新型人类抗流感抗体及相关组合物和方法。这些抗体用于流感感染的诊断和治疗。

7. 发明申请

WO2010011337A1 METHODS AND COMPOSITIONS FOR DISCOVERY OF TARGET-SPECIFIC ANTIBODIES USING ANTIBODY REPERTOIRE ARRAY (ARA) 审中-公开
标题翻译：使用抗体代码阵列（ARA）发现靶向特异性抗体的方法和组合
公开(公告)号：WO2010011337A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/004303
申请日：2009-07-24
申请人： THERACLONE SCIENCES , MOYLE, Matthew
发明人： MOYLE, Matthew
IPC分类号： C07K16/00 , G01N33/50 , G01N33/543
CPC分类号： C07K16/00 , C07K16/005 , C07K16/28 , C07K2317/21 , G01N33/6845 , G01N33/6854
摘要： The invention provides antibody arrays specific for target antigens. Methods for discovery and compositions comprising native human antibodies, arrays comprising such antibodies, immortalized B cells expressing such antibodies and non-immortalized B cell libraries comprising B cells expressing such antibodies are provided. The invention provides a method for screening monoclonal antibodies for functional effects on cell surface molecules such as receptors using antibody repertoire arrays specific for target cell surface molecules. Functional antibodies directed to a target and therapeutics derived from such antibodies are also provided. High throughput and parallel screening for potentially therapeutic antibodies are provided. Antibodies directed to functional epitope clusters corresponding to a target and vaccines and therapeutics derived from such antibodies are also provided.
摘要翻译：本发明提供了针对靶抗原特异性的抗体阵列。提供了发现的方法和包含天然人抗体的组合物，包含这种抗体的阵列，表达这种抗体的永生化B细胞和包含表达这种抗体的B细胞的非永生化B细胞文库。本发明提供一种筛选单克隆抗体的方法，用于对细胞表面分子例如受体使用针对靶细胞表面分子特异的抗体库序列的功能效应。还提供了针对靶标的功能性抗体和源自这些抗体的治疗剂。提供了高通量和平行筛选潜在的治疗性抗体。还提供了针对对应于靶标和疫苗的功能性表位簇的抗体和源自这些抗体的治疗剂。

8. 发明申请

WO2012125614A1 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开
标题翻译：用于治疗和诊断流感病毒的组合物和方法
公开(公告)号：WO2012125614A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028883
申请日：2012-03-13
申请人： THERACLONE SCIENCES, INC. , GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： A61K31/00 , C07K16/00 , C07K16/42 , A61P31/16
CPC分类号： A61K31/215 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K16/1018 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92 , A61K2300/00
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译：本发明提供新的人类抗流感抗体及相关组合物和方法。这些抗体用于流感感染的诊断和治疗。

9. 发明申请

WO2012112489A2 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开
标题翻译：用于治疗和诊断流感病毒的组合物和方法
公开(公告)号：WO2012112489A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/024971
申请日：2012-02-14
申请人： THERACLONE SCIENCES, INC. , GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas, C. , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , HAMMOND, Phil
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17 , A61P31/16 , A61P31/00
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/76 , G01N33/54306 , G01N33/56983 , G01N2333/11
摘要： The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
摘要翻译：本发明提供使用针对流感血凝素和基质2胞外域多肽产生的抗体的组合来诊断，治疗和预防流感感染的组合物，疫苗和方法。

10. 发明申请

WO2010107939A2 HUMAN IMMUNODEFICIENCY VIRUS (HIV) -NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：人类免疫缺陷病毒（HIV） - 抗精神病药物
公开(公告)号：WO2010107939A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/027695
申请日：2010-03-17
申请人： THERACLONE SCIENCES, INC. , CHAN-HUI, Po-Ying , MITCHAM, Jennifer , OLSEN, Ole , FREY, Steven , MOYLE, Matthew , PHOGAT, Sanjay, K. , BURTON, Dennis, R. , WALKER, Laura, Marjorie , POIGNARD, Pascal, Raymond, Georges
发明人： CHAN-HUI, Po-Ying , MITCHAM, Jennifer , OLSEN, Ole , FREY, Steven , MOYLE, Matthew , PHOGAT, Sanjay, K. , BURTON, Dennis, R. , WALKER, Laura, Marjorie , POIGNARD, Pascal, Raymond, Georges
IPC分类号： A61K39/00
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-I species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-I species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gpl20 are provided. Immunogens for generating anti-HIV 1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译：本发明提供了一种获得广泛中和抗体（bNab）的方法，包括从供体PBMC样品中筛选记忆B细胞培养物以对多种HIV-1物质进行中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制多个进化枝中HIV-1物质的感染。提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。提供了通过使用来自gp120可变环内的保守区域的表位的免疫来产生这种抗体的方法。还提供了产生抗艾滋病毒1疫苗的免疫原。此外，提供了使用合适表位的疫苗接种方法。

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