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1. 发明申请

WO2010090737A1 PYRIDAZINONE COMPOUNDS 审中-公开
标题翻译：吡咯烷酮化合物
公开(公告)号：WO2010090737A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/000307
申请日：2010-02-04
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TANIGUCHI, Takahiko , KAWADA, Akira , KONDO, Mitsuyo , QUINN, John, F. , KUNITOMO, Jun , YOSHIKAWA, Masato , FUSHIMI, Makoto
发明人： TANIGUCHI, Takahiko , KAWADA, Akira , KONDO, Mitsuyo , QUINN, John, F. , KUNITOMO, Jun , YOSHIKAWA, Masato , FUSHIMI, Makoto
IPC分类号： A01N43/58 , A61K31/50
CPC分类号： C07D403/04 , A61K9/2059 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted,or a salt thereof.
摘要翻译：本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。式（I0）的化合物，其中R1表示取代基; R2表示氢原子或取代基; R3表示氢原子或取代基; 环A表示可被取代的芳环，环B表示可被取代的5元杂芳环或其盐。

2. 发明申请

WO2012018909A1 FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：熔融杂环化合物
公开(公告)号：WO2012018909A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046417
申请日：2011-08-03
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , RAKER, Joseph , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , HASUI, Tomoaki , KUNITOMO, Jun
发明人： RAKER, Joseph , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , HASUI, Tomoaki , KUNITOMO, Jun
IPC分类号： C07D471/04 , C07D471/14 , C07D519/00 , A61K31/437 , A61P25/18
CPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound represented by the formula (1'): wherein, Ring A' represents an optionally substituted pyridine ring, an optionally substituted pyridazine ring, a pyrimidine ring, or 10 a pyrazine ring, R1' represents (1) wherein, R 1a' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B2 represents a bond, -S-, -0-, -CO-, an optionally substituted methylene group, or -NR a' - (R a' represents a hydrogen atom, or an optionally substituted C 1-6 alkyl group), and Ring B 1' represents an optionally further substituted 6- to 10- membered aromatic hydrocarbon ring, or an optionally further substituted 5- to 10-membered aromatic heterocyclic ring, or alternatively, L' and R 1a' may be taken together to form an optionally substituted bicyclic or tricyclic fused heterocyclic group, or (2), wherein, R 1b' represents an optionally substituted phenyl group, or an optionally substituted 5- to 10-membered heterocyclic group, Ring B 2' represents an optionally substituted benzene ring, an optionally substituted pyridine ring, an optionally substituted pyrimidine ring, an optionally substituted pyrazine ring, or an optionally substituted pyridazine ring, Ring D' represents an optionally further substituted 5- or 6- membered ring, R 2' represents a hydrogen atom, or a substituent, X' represents =N- or =CR b' - (R b' represents a hydrogen atom, or a substituent), _ _ _ _ _ represents that R b' and R 2' may form, taken together with the carbon atom and the nitrogen atom to which they are each adjacent, an optionally substituted 5- to 7-membered ring when.X' is =CR b' -, or a salt thereof.
摘要翻译：本发明提供了具有PDE 10A抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。由式（1'）表示的化合物：其中环A'表示任选取代的吡啶环，任选取代的哒嗪环，嘧啶环或吡嗪环，R1'表示（1）其中R1a'表示任选取代的苯基或任选取代的5至10元杂环基，环B2表示键，-S - ， - O-，-CO-，任选取代的亚甲基或-NR a' “表示氢原子或任选取代的C 1-6烷基），并且环B1'表示任选进一步取代的6-至10-元芳族烃环，或任选进一步取代的5至10元芳族杂环，或者可选地，L'和R 1a'可以一起形成任选取代的双环或三环稠合杂环基，或（2），其中，R 1b'表示任选取代的苯基，或任选取代的5-至10- 环B2'代表任选取代的苯环，任选取代的吡啶环，任选取代的嘧啶环，任选取代的吡嗪环或任选取代的哒嗪环，环D'表示任选进一步取代的5-或6-元环，R 2' 表示氢原子或取代基，X'表示= N-或= CRb'-（Rb'表示氢原子或取代基），表示Rb'和R2'可以一起形成与它们各自相邻的碳原子和氮原子，当X'= CRb'-时，任选取代的5-至7-元环，或其盐。

3. 发明申请

WO2011163355A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS 审中-公开
标题翻译：熔融杂环化合物作为磷酸二氢钾（PDES）抑制剂
公开(公告)号：WO2011163355A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041443
申请日：2011-06-22
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TANIGUCHI, Takahiko , YOSHIKAWA, Masato , MIURA, Kasei , HASUI, Tomoaki , HONDA, Eiji , IMAMURA, Keisuke , KAMATA, Makoto , KAMISAKI, Haruhi , QUINN, John, F. , RAKER, Joseph , CAMARA, Fatoumata , WANG, Yi
发明人： TANIGUCHI, Takahiko , YOSHIKAWA, Masato , MIURA, Kasei , HASUI, Tomoaki , HONDA, Eiji , IMAMURA, Keisuke , KAMATA, Makoto , KAMISAKI, Haruhi , QUINN, John, F. , RAKER, Joseph , CAMARA, Fatoumata , WANG, Yi
IPC分类号： C07D471/04 , C07D473/28 , C07D487/04 , C07D498/04 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52 , A61P25/18
CPC分类号： A61K31/4353 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/551 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/28 , C07D487/04 , C07D495/04 , C07D498/04 , C07D498/08 , C07D519/00 , C07F7/10
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I) :
摘要翻译：本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗由式（I）表示的精神分裂症等的药剂：

4. 发明申请

WO2018100558A8 CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS 审中-公开
公开(公告)号：WO2018100558A8
公开(公告)日：2018-06-07
申请号：PCT/IB2017/057588
申请日：2017-12-01
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： YOSHIKAWA, Masato , SAITOH, Morihisa , KATO, Taisuke , YOSHITOMI, Yayoi , SEKI, Tomohiro , NAKAGAWA, Yasuo , TOMINARI, Yusuke , SETO, Masaki , SASAKI, Yusuke , OKANIWA, Masanori , ODA, Tsuneo , SHIBUYA, Akito , HIDAKA, Kosuke , SHIOKAWA, Zenyu , MURATA, Shumpei , OKABE, Atsutoshi , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , FREEZE, Brian Scott , TAWARAISHI, Taisuke , WADA, Yasufumi , GREENSPAN, Paul D.
IPC分类号： C07H21/00 , C07H21/02 , A61K31/7084 , A61P35/00
摘要： The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

5. 发明申请

WO2018100558A2 CYCLIC DINUCLEOTIDE 审中-公开
公开(公告)号：WO2018100558A2
公开(公告)日：2018-06-07
申请号：PCT/IB2017/057588
申请日：2017-12-01
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： YOSHIKAWA, Masato , SAITOH, Morihisa , KATO, Taisuke , YOSHITOMI, Yayoi , SEKI, Tomohiro , NAKAGAWA, Yasuo , TOMINARI, Yusuke , SETO, Masaki , SASAKI, Yusuke , OKANIWA, Masanori , ODA, Tsuneo , SHIBUYA, Akito , HIDAKA, Kosuke , SHIOKAWA, Zenyu , MURATA, Shumpei , OKABE, Atsutoshi , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , FREEZE, Brian Scott , TAWARAISHI, Taisuke , WADA, Yasufumi , GREENSPAN, Paul D.
IPC分类号： C07H21/00 , C07H21/02 , A61K31/7084 , A61P35/00
CPC分类号： C07H21/02 , A61P35/00 , C07H21/00
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I), wherein each symbol is as defined in the description, or a salt thereof.

6. 发明申请

WO2018100558A9 CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTEFERON GENES) AGONISTS 审中-公开
公开(公告)号：WO2018100558A9
公开(公告)日：2018-06-07
申请号：PCT/IB2017/057588
申请日：2017-12-01
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： YOSHIKAWA, Masato , SAITOH, Morihisa , KATO, Taisuke , YOSHITOMI, Yayoi , SEKI, Tomohiro , NAKAGAWA, Yasuo , TOMINARI, Yusuke , SETO, Masaki , SASAKI, Yusuke , OKANIWA, Masanori , ODA, Tsuneo , SHIBUYA, Akito , HIDAKA, Kosuke , SHIOKAWA, Zenyu , MURATA, Shumpei , OKABE, Atsutoshi , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , FREEZE, Brian Scott , TAWARAISHI, Taisuke , WADA, Yasufumi , GREENSPAN, Paul D.
IPC分类号： C07H21/00 , C07H21/02 , A61K31/7084 , A61P35/00
摘要： The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

7. 发明申请

WO2018100558A3 CYCLIC PURINE DINUCLEOTIDES AS STING (STIMULATOR OF INTEFERON GENES) AGONISTS 审中-公开
公开(公告)号：WO2018100558A3
公开(公告)日：2018-06-07
申请号：PCT/IB2017/057588
申请日：2017-12-01
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： YOSHIKAWA, Masato , SAITOH, Morihisa , KATO, Taisuke , YOSHITOMI, Yayoi , SEKI, Tomohiro , NAKAGAWA, Yasuo , TOMINARI, Yusuke , SETO, Masaki , SASAKI, Yusuke , OKANIWA, Masanori , ODA, Tsuneo , SHIBUYA, Akito , HIDAKA, Kosuke , SHIOKAWA, Zenyu , MURATA, Shumpei , OKABE, Atsutoshi , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , FREEZE, Brian Scott , TAWARAISHI, Taisuke , WADA, Yasufumi , GREENSPAN, Paul D.
IPC分类号： C07H21/00 , C07H21/02 , A61K31/7084 , A61P35/00
摘要： The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

8. 发明申请

WO2017014321A1 OXADIAZOLE DERIVATIVES USEFUL AS HDAC INHIBITORS 审中-公开
标题翻译：用作HDAC抑制剂的奥沙利多衍生物
公开(公告)号：WO2017014321A1
公开(公告)日：2017-01-26
申请号：PCT/JP2016/071655
申请日：2016-07-15
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： KAIEDA, Akira , TOYOFUKU, Masashi , DAINI, Masaki , NARA, Hiroshi , YOSHIKAWA, Masato , ISHII, Naoki , HIDAKA, Kousuke
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D491/107 , C07D498/08 , A61K31/4245 , A61P37/00
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound. The present invention relates to a compound represented by the formula (I) : wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供具有HDAC抑制作用的杂环化合物，可用于治疗自身免疫疾病和/或炎性疾病，移植物抗宿主病，癌症，包括神经变性疾病的中枢神经疾病，Charcot-Marie-Tooth病等和包含该化合物的药物组合物。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

9. 发明申请

WO2013054822A1 1 - ARYLCARBONYL - 4 - OXY - PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： 1 - ARYLCARBONYL - 4 - OXY - 用于治疗神经病变性疾病的哌啶化合物
公开(公告)号：WO2013054822A1
公开(公告)日：2013-04-18
申请号：PCT/JP2012/076257
申请日：2012-10-03
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： KOIKE, Tatsuki , YOSHIKAWA, Masato , KAMISAKI, Haruhi , FARNABY, William John
IPC分类号： C07D401/10 , C07D401/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D498/08 , A61K31/506 , A61K31/444 , A61P25/28
CPC分类号： C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。本发明涉及由式（I）表示的化合物，其中每个符号如说明书中所定义，或其盐。

10. 发明申请

WO2021060567A1 2-ISOINDOL-1,3,4-OXADIAZOLE DERIVATIVES USEFUL AS HDAC6 INHIBITORS 审中-公开
公开(公告)号：WO2021060567A1
公开(公告)日：2021-04-01
申请号：PCT/JP2020/037386
申请日：2020-09-24
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： ITO, Masahiro , SUGIYAMA, Hideyuki , YAMAMOTO, Takeshi , KAKEGAWA, Keiko , LI, Jinxing , WANG, Junsi , KASAHARA, Takahito , YOSHIKAWA, Masato
IPC分类号： C07D413/04 , A61P25/28 , A61K31/4245 , C07D413/14
摘要： The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

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