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1. 发明申请

WO1986005784A1 ANTIBIOTICS AND PREPARATION CONTAINING SAME 审中-公开
标题翻译：抗生素及其制备方法
公开(公告)号：WO1986005784A1
公开(公告)日：1986-10-09
申请号：PCT/JP1985000160
申请日：1985-04-03
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SHIMADZU, Hiroshi , SHINAGAWA, Susumu , MINAMIDA, Isao
IPC分类号： C07D225/08
CPC分类号： C07D491/08 , C07D225/08 , C07D513/08
摘要： Compounds represented by general formula (I) (wherein R and R , which may be the same or different, each represents hydrogen or an organic residue via a carbon atom or -SO2-, X represents (II), (III), (IV), (V), (wherein R represents hydrogen, hydroxy, halogen or an organic residue via a carbon, nitrogen, oxygen, or sulfur atom, R represents a divalent group via two carbon atoms which may optionally be substituted, - is bound to the p-position of the benzene ring with respect to R O-, and - is bound to the m-position with respect to R O-), R represents carboxy, a group derived from carboxy, or a delta -lactone together with -OH in position 7 or 13, and Y represents -CO- or (VI) (wherein R forms a 5-membered ring together with -OR when R represents an organic residue via a carbon atom), provided that X does not represent (VII), when R and R each represents H, R represents methoxycarbonyl, and Y represents -CO-, and that X does not represent (VIII) when R represents methyl, R is hydrogen, R is methoxycarbonyl, and Y is -CO-) and salts thereof have excellent antibacterial activity, and can be used as antibacterial agent.
摘要翻译：由通式（I）表示的化合物（其中R 1和R 2可以相同或不同，各自表示氢或有机残基经由碳原子或-SO 2 - ，X表示（II），（III），（IV），（V），（其中R 4表示氢，羟基，卤素或有机残基经碳，氮，氧或硫原子，R 5表示二价基团，经二可以任选被取代的碳原子，相对于R 1 O-与苯环的对位相结合，并且相对于R 1 O-键连接在m-位上， R 1表示羧基，衍生自羧基的基团，或δ-内酯与位置7或13中的-OH，Y表示-CO-或（VI）（其中R 7）当R 1通过碳原子代表有机残基时，与-OR 1一起形成5元环），条件是X不表示（Ⅶ），当R 1和R 2各自表示 H，R 6表示甲氧基羰基，Y表示-CO-，并且X不表示当R表示甲基，R 2为氢，R 6为甲氧基羰基，Y为-CO-时，其为（VIII），其盐具有优异的抗菌活性，可用作抗菌剂。

2. 发明申请

WO1984001574A1 PROCESS FOR PREPARING PHYSIOLOGICALLY ACTIVE SUBSTANCE FA-5859 AND ITS DERIVATIVES 审中-公开
标题翻译：制备生理活性物质FA-5859及其衍生物的方法
公开(公告)号：WO1984001574A1
公开(公告)日：1984-04-26
申请号：PCT/JP1982000409
申请日：1982-10-15
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SHINAGAWA, Susumu , KANAMARU, Tsuneo , ASAI, Mitsuko
IPC分类号： C07C101/24
CPC分类号： C12R1/645 , C12P13/04 , C12R1/66
摘要： Novel physiologically active substances, deacetyl FA-5859 and FA-5859, represented by the formula (I), wherein R1 represents hydrogen or an acetyl group, and the salts thereof can be chemically synthesized. These compounds show an excellent fatty acid decomposition-inhibiting effect, and are utilized as diuretics for mammals and as a biochemical reagent for clarifying the mechanism of fatty acid metabolism.
摘要翻译：由式（I）表示的新型生理活性物质脱乙酰基FA-5859和FA-5859，其中R1表示氢或乙酰基，其盐可以化学合成。这些化合物显示优异的脂肪酸分解抑制作用，并且用作哺乳动物的利尿剂和用作澄清脂肪酸代谢机制的生化试剂。

3. 发明申请

WO1984000539A1 DEACETYL FA-5859 AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译： DEACETYL FA-5859及其制备方法
公开(公告)号：WO1984000539A1
公开(公告)日：1984-02-16
申请号：PCT/JP1982000291
申请日：1982-07-28
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , KANAMARU, Tsuneo , SHINAGAWA, Susumu , ASAI, Mitsuko
IPC分类号： C07C101/12
CPC分类号： C12R1/645 , C12P13/04 , C12R1/66
摘要： A novel substance, deacetyl FA-5859, represented by the formula: and its salts show an excellent fatty acid decomposition-inhibiting effect and are utilized as antidiabetic agents for mammels and as biochemical reagents for studying fatty acid metabolism.
摘要翻译：一种新型物质，由以下化学式表示的脱乙酰基FA-5859及其盐显示优异的脂肪酸分解抑制作用，并用作哺乳动物的抗糖尿病剂和用作研究脂肪酸代谢的生化试剂。

4. 发明申请

WO1983001952A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：生理活性物质及其制备方法
公开(公告)号：WO1983001952A1
公开(公告)日：1983-06-09
申请号：PCT/JP1981000355
申请日：1981-11-26
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , KANAMARU, Tsuneo , SHINAGAWA, Susumu , ASAI, Mitsuko
IPC分类号： C07G17/00
CPC分类号： C12R1/645 , C12P13/04 , C12R1/66
摘要： A novel physiologically active substance FA-5859 produced by bacteria of genus Emericella or Aspergillus and salt thereof have an excellent effect of inhibiting fatty acid decomposition, and are utilized as agents for treating diabetes of mammalian animals or as biochemical reagents for clarifying fatty acid metabolism.
摘要翻译：由Emericella或曲霉属细菌产生的新型生理活性物质FA-5859及其盐具有优异的抑制脂肪酸分解的效果，可用作治疗哺乳动物的糖尿病或用作澄清脂肪酸代谢的生物化学试剂。

5. 发明公开

EP0083375A1 ANTIBACTERIAL EFFECT-ENHANCING SUBSTANCE AND PROCESS FOR ITS PREPARATION 失效
标题翻译： LEISTUNGSSTEIGERNDES ANTIBAKTERIELLES MITTEL SOWIE DESSEN HERSTELLUNGSVERFAHREN。
公开(公告)号：EP0083375A1
公开(公告)日：1983-07-13
申请号：EP82902088.2
申请日：1982-07-07
申请人： Takeda Chemical Industries, Ltd.
发明人： IMADA, Akira , KINTAKA, Kazuhiko , SHINAGAWA, Susumu
IPC分类号： C07G11/00 , C12P1/04 , A61K35/74
CPC分类号： C12R1/38 , A61K35/74 , C12P1/04
摘要： Antibacterial effect-enhancing substance F2 yielded by pseudomonad and its salt have the effect of enhancing antibacterial effect of β-lactam antibiotics, and can be used for treating bacterial diseases of mammals, fowl, etc.
摘要翻译：从假单胞菌培养的新型物质F2或其盐提高β-内酰胺抗生素对革兰氏阴性菌的抗菌作用，可用于治疗狗，人或其他哺乳动物的细菌性疾病以及家禽如鸡或鸭。用于培养的假单胞菌是例如。 US4229436中的嗜酸假单胞菌G-630或US4225586中的上消化假单胞菌SB-72310。

6. 发明授权

EP0083375B1 ANTIBACTERIAL EFFECT-ENHANCING SUBSTANCE AND PROCESS FOR ITS PREPARATION 失效
标题翻译：抗生素效应 - 增强物质及其制备方法
公开(公告)号：EP0083375B1
公开(公告)日：1987-05-20
申请号：EP82902088.2
申请日：1982-07-07
申请人： Takeda Chemical Industries, Ltd.
发明人： IMADA, Akira , KINTAKA, Kazuhiko , SHINAGAWA, Susumu
IPC分类号： C07G11/00 , C12P1/04 , A61K35/74
CPC分类号： C12R1/38 , A61K35/74 , C12P1/04
摘要： Novel substance F2, or its salt, cultured from pseudomonads enhances antibacterial action of beta-lactam antibiotics against Gram-negative bacteria and is useful in treatment of bacterial diseases of dogs, humans or other mammals and domestic fowl such as chickens or ducks. The pseudomonads used for culturing are e.g. Pseudomonas acidophila G-630 as in US4229436 or Pseudomonas mesoacidophila SB-72310 as in US4225586.

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