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1. 发明专利

JP2014147842A Container impregnated with medicine 有权
标题翻译：容纳人用药物
公开(公告)号：JP2014147842A
公开(公告)日：2014-08-21
申请号：JP2014102203
申请日：2014-05-16
申请人： Synthes Gmbh , シンセスゲーエムベーハー
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
IPC分类号： A61L27/00 , A61F2/28 , A61M31/00
CPC分类号： A61M31/002 , A61B17/68 , A61B17/70 , A61B17/72 , A61B17/8028 , A61B2017/00004 , A61B2017/00893 , A61C8/0013 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067 , A61J3/00 , A61J2200/00 , A61L27/54 , A61L31/148 , A61L31/16 , A61M37/00 , A61M2205/04 , Y10T156/1051
摘要： PROBLEM TO BE SOLVED: To provide an improved sleeve impregnated with medicine.SOLUTION: The sleeve impregnated with medicine wraps a medical implant. The sleeve defines an inner cavity for receiving medical implant, and includes a body made of biocompatible material. The biocompatible material has bioresorbability. The body may include a plurality of openings such as holes and bores extending from the cavity through the body. The sleeve may further include a first end, a second end, and a resorbable sheet impregnated with medicine. The first end of the sleeve may be open for reception of a medical implant therethrough, and the second end may be closed. The implant is wrapped in the sleeve so as to be embedded in a patient. With passing of time, the medicine is dosed from the embedded sleeve to the tissues around the embedded portion in vivo.
摘要翻译：要解决的问题：提供用药物浸渍的改进的套管。解决方案：浸渍有药物的套管包裹医用植入物。套筒限定用于接收医疗植入物的内腔，并且包括由生物相容性材料制成的身体。生物相容性材料具有生物可再吸收性。主体可以包括多个开口，例如从空腔穿过主体延伸的孔和孔。套筒还可包括第一端，第二端和浸渍有药物的可再吸收片。套筒的第一端可以打开以接收医疗植入物，并且第二端可以是封闭的。将植入物包裹在套筒中以嵌入患者体内。随着时间的推移，药物从嵌入式套管中向嵌入部分周围的组织体内施用。

2. 发明专利

JP2012250084A Drug-impregnated encasement 有权
标题翻译：药物滥用
公开(公告)号：JP2012250084A
公开(公告)日：2012-12-20
申请号：JP2012209414
申请日：2012-09-24
申请人： Synthes Gmbh , シンセスゲーエムベーハー
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
IPC分类号： A61L27/00 , A61F2/02 , A61K6/00 , A61L31/00
CPC分类号： A61M31/002 , A61B17/68 , A61B17/70 , A61B17/72 , A61B17/8028 , A61B2017/00004 , A61B2017/00893 , A61C8/0013 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067 , A61J3/00 , A61J2200/00 , A61L27/54 , A61L31/148 , A61L31/16 , A61M37/00 , A61M2205/04 , Y10T156/1051
摘要： PROBLEM TO BE SOLVED: To provide an improved drug-impregnated sleeve.SOLUTION: The drug-impregnated sleeve for encasing a medical implant is provided. The sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. The biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. The first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site.
摘要翻译：要解决的问题：提供改进的药物浸渍套管。提供了用于封装医用植入物的药物浸渍套筒。套筒可以包括由生物相容的材料制成的主体，该主体限定了构造成接收医疗植入物的内部空腔。生物相容的材料是生物可再吸收的。主体可以包括从空腔穿过主体延伸的多个孔，例如穿孔或孔。套筒还可以包括第一端，第二端和浸渍在可再吸收片中的药物。套筒的第一端可以是敞开的，用于接收通过其中的医疗植入物，并且第二端可以是封闭的。植入物可以被封装在套筒中并且植入患者体内，药物在体内随着时间被分配到围绕植入部位的组织。版权所有（C）2013，JPO＆INPIT

3. 发明申请

WO2007047420A8 DRUG-IMPREGNATED ENCASEMENT 审中-公开
标题翻译：药物滥用
公开(公告)号：WO2007047420A8
公开(公告)日：2008-03-13
申请号：PCT/US2006040038
申请日：2006-10-12
申请人： SYNTHES USA , SYNTHES GMBH , FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
IPC分类号： A61N1/30
CPC分类号： A61M31/002 , A61B17/68 , A61B17/70 , A61B17/72 , A61B17/8028 , A61B2017/00004 , A61B2017/00893 , A61C8/0013 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067 , A61J3/00 , A61J2200/00 , A61L27/54 , A61L31/148 , A61L31/16 , A61M37/00 , A61M2205/04 , Y10T156/1051
摘要： A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.
摘要翻译：提供了用于封装医疗植入物的药物浸渍套管。在一个实施例中，套筒可以包括由生物相容的材料制成的主体，该主体限定了构造成接收医疗植入物的内部空腔。在一个实施方案中，生物相容性材料是生物可再吸收的。主体可以包括从空腔穿过主体延伸的多个孔，例如穿孔或孔。套筒还可以包括第一端，第二端和浸渍在可再吸收片中的药物。在一个可能的实施例中，套筒的第一端可以是敞开的，用于接收通过其中的医疗植入物，并且第二端可以是封闭的。植入物可以被封装在套筒中并且植入患者体内，药物在体内随着时间被分配到围绕植入部位的组织。在一个实施方案中，主体由至少一片生物相容性材料制成。在一个实施方案中，套筒可以至少部分地由己内酯制成以向套筒增加拉伸性。

4. 发明专利

BRPI0617325A2 未知
公开(公告)号：BRPI0617325A2
公开(公告)日：2011-07-19
申请号：BRPI0617325
申请日：2006-10-12
申请人： SYNTHES GMBH
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOTT A , KERR SEAN HAMILTON
IPC分类号： A61N1/30
摘要： A drug-impregnated sleeve (10) for encasing a medical implant is provided. In one embodiment, the sleeve may include a body (20) made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet (12) of a biologically-compatible material, in one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.

5. 发明专利

AU2006304229A1 Drug-impregnated encasement 未知
公开(公告)号：AU2006304229A1
公开(公告)日：2007-04-26
申请号：AU2006304229
申请日：2006-10-12
申请人： SYNTHES GMBH
发明人： KERR SEAN HAMILTON , GRUSKIN ELLIOT A , FULMER MARK THOMAS , FRIGG ROBERT , ARMBRUSTER DAVID A
IPC分类号： A61N1/30
摘要： A drug-impregnated sleeve (10) for encasing a medical implant is provided. In one embodiment, the sleeve may include a body (20) made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet (12) of a biologically-compatible material, in one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.

6. 发明专利

ZA200803822B Drug impregnated encasement 未知
公开(公告)号：ZA200803822B
公开(公告)日：2010-01-27
申请号：ZA200803822
申请日：2008-05-05
申请人： SYNTHES GMBH
发明人： FULMER MARK THOMAS , FRIGG ROBERT , KERR SEAN HAMILTON , ARMBRUSTER DAVID A , GRUSKIN ELLIOT A
IPC分类号： A61N20100101
摘要： A drug-impregnated sleeve (10) for encasing a medical implant is provided. In one embodiment, the sleeve may include a body (20) made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet (12) of a biologically-compatible material, in one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.

7. 发明专利

CO6190540A2 COMPUESTO CERAMICO POLIMERO Y METODO 未知
公开(公告)号：CO6190540A2
公开(公告)日：2010-08-19
申请号：CO09054994
申请日：2009-05-28
申请人： SYNTHES GMBH
发明人： LIU XINYIN , FULMER MARK THOMAS , GRUSKIN ELLIOT , LEPRE MILVIA
IPC分类号： A61L31/12
摘要： 1.- Un material de compuesto, que comprende: una fase de polímero que incluye un poli(alfa-hidroxi éster) mezclado con un disolvente para mantener la fase de polímero en un estado no sólido; y una fase de cerámica bioabsorbible mezclada con la fase de polímero; en el cual, cuando el disolvente está en presencia de agua, éste se difunde de la fase de polímero para producir la solidificación de la fase de polímero y curar el material de compuesto. 2.- El material de compuesto de la reivindicación 1, en donde el disolvente se escoge de un grupo que consiste en n-metil-2-pirrolidona, 2-pirrolidona y sulfóxido de dimetilo. 3.- El material de compuesto de la reivindicación 1, en donde el poli(alfa-hidroxi éster) incluye uno o más de polilactida, policaprolactona, un copolímero que incluye poli(lactida-co-glicólido), un copolímero que incluye policaprolactona y poliactida, un copolímero que incluye polietilenglicol y uno o más poli (alfahidroxi ésteres) seleccionados del grupo consistente en policaprolactona, polilactida y poliglicólido. 4.- El material de compuesto de la reivindicación 1, en donde la fase de polímero incluye un copolímero. 5.- El material de compuesto de la reivindicación 1, en donde la fase de polímero incluye una mezcla física de un poli (alfa-hidroxi éster) y uno o más agentes hidrófilos. 6.- El material de compuesto de la reivindicación 1, en donde la cerámica bioabsorbible incluye uno o más de fosfato de calcio, sulfato de calcio y una mezcla de fosfato de calcio y sulfato de calcio. 7.- El material de compuesto de la reivindicación 1, en donde el material de compuesto está contenido en un estado no sólido en una cámara de almacenamiento dentro de un dispositivo de suministro. 8.- El material de compuesto de la reivindicación 7, en donde el dispositivo de suministro incluye una jeringa para mantener el material de compuesto en el estado no sólido antes de suministro.

8. 发明公开

EP1933936A4 DRUG-IMPREGNATED ENCASEMENT 有权转让
标题翻译：麻省理工学院埃里克斯
公开(公告)号：EP1933936A4
公开(公告)日：2010-05-12
申请号：EP06816850
申请日：2006-10-12
申请人： SYNTHES GMBH , SYNTHES USA
发明人： FULMER MARK THOMAS , ARMBRUSTER DAVID A , FRIGG ROBERT , GRUSKIN ELLIOT A , KERR SEAN HAMILTON
IPC分类号： A61N1/30
CPC分类号： A61M31/002 , A61B17/68 , A61B17/70 , A61B17/72 , A61B17/8028 , A61B2017/00004 , A61B2017/00893 , A61C8/0013 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067 , A61J3/00 , A61J2200/00 , A61L27/54 , A61L31/148 , A61L31/16 , A61M37/00 , A61M2205/04 , Y10T156/1051
摘要： A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.
摘要翻译：提供了用于封装医用植入物的药物浸渍套管。在一个实施例中，套筒可以包括由生物相容性材料制成的主体，该主体限定了构造成接收医疗植入物的内部空腔。在一个实施方案中，生物相容性材料是生物可再吸收的。主体可以包括从空腔延伸穿过主体的多个孔，例如穿孔或孔。套筒还可以包括第一端，第二端和浸入可再吸收片中的药物。在一个可能的实施例中，套筒的第一端可以是敞开的，用于接收通过其中的医疗植入物，并且第二端可以是封闭的。植入物可以封装在套管中并植入患者体内，药物在体内随时间分配到围绕植入部位的组织。在一个实施例中，身体由至少一片生物相容性材料制成。

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