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1. 发明申请

US20050148008A1 Compositions and methods relating to ovarian specific genes and proteins 审中-公开
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050148008A1
公开(公告)日：2005-07-07
申请号：US11057516
申请日：2005-02-14
申请人： Susana Salceda , Roberto Macina , Ping Hu , Herve Recipon , Kalpana Karra , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Ping Hu , Herve Recipon , Kalpana Karra , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68 , A61K48/00 , C07H21/04 , C07K14/72 , C07K16/30
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

2. 发明申请

US20050048559A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050048559A1
公开(公告)日：2005-03-03
申请号：US10958863
申请日：2004-10-05
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , G01N33/574 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

3. 发明申请

US20050084899A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
公开(公告)号：US20050084899A1
公开(公告)日：2005-04-21
申请号：US11005609
申请日：2004-12-06
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu , Leah Turner
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , C12Q1/6886 , G01N33/574 , C07H21/04 , C07K14/72
CPC分类号： G01N33/57415 , A61K2039/505 , C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

4. 发明申请

US20050181413A1 Compositions and methods relating to ovary specific genes and proteins 审中-公开
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20050181413A1
公开(公告)日：2005-08-18
申请号：US11057447
申请日：2005-02-14
申请人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve Recipon , Robert Cafferkey , Yongming Sun , Chenghua Liu
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/68 , C07H21/04 , C07K14/72
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/57449 , G01N33/68
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

5. 发明授权

US07208267B2 Compositions and methods relating to breast specific genes and proteins 失效
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US07208267B2
公开(公告)日：2007-04-24
申请号：US09989890
申请日：2001-11-21
申请人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Herve E. Recipon , Jason Pluta , Yongming Sun , Chenghua Liu
IPC分类号： C12Q1/68 , C12N15/00 , C12N5/00 , C12N15/11 , C12N15/12 , C12P21/02 , A61K31/711 , A61K31/713
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/505 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

6. 发明申请

US20060199180A1 Compositions and methods relating to ovarian specific genes and proteins 失效
标题翻译：与卵巢特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20060199180A1
公开(公告)日：2006-09-07
申请号：US10523834
申请日：2003-08-06
申请人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
发明人： Roberto Macina , Susana Salceda , Chenghua Liu , Yongming Sun , Leah Turner
IPC分类号： C12Q1/68
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

7. 发明申请

US20060051759A1 Compositions and methods relating to breast specific genes and proteins 审中-公开
标题翻译：与乳腺特异性基因和蛋白质有关的组成和方法
公开(公告)号：US20060051759A1
公开(公告)日：2006-03-09
申请号：US10517696
申请日：2003-06-16
申请人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
发明人： Susana Salceda , Roberto Macina , Leah Turner , Yongming Sun , Chenghua Liu
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , A61K38/00 , A61K39/00 , C07K14/4748 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

8. 发明申请

US20050266483A1 Novel method of diagnosing, monitoring, staging, imaging and treating colon cancer 审中-公开
标题翻译：诊断，监测，分期，成像和治疗结肠癌的新方法
公开(公告)号：US20050266483A1
公开(公告)日：2005-12-01
申请号：US11158378
申请日：2005-06-22
申请人： Yongming Sun , Herve Recipon , Roberto Macina
发明人： Yongming Sun , Herve Recipon , Roberto Macina
IPC分类号： G01N33/53 , A61K39/395 , A61K49/16 , A61K51/00 , A61K51/10 , A61P35/00 , C07K14/47 , C12N15/09 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , A61K49/16 , A61K51/10 , C07K14/47
摘要： The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating colon cancer.
摘要翻译：本发明提供了检测，诊断，监测，分期，预后，成像和治疗结肠癌的新方法。

9. 发明申请

US20050153332A1 Method of diagnosing, monitoring, staging, imaging and treating colon cancer 审中-公开
标题翻译：诊断，监测，分期，成像和治疗结肠癌的方法
公开(公告)号：US20050153332A1
公开(公告)日：2005-07-14
申请号：US11000263
申请日：2004-11-30
申请人： Roberto Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve Recipon
发明人： Roberto Macina , Sei-Yu Chen , Jason Pluta , Yongming Sun , Herve Recipon
IPC分类号： G01N33/53 , A61K39/00 , A61K45/00 , A61K48/00 , A61K49/00 , A61K51/00 , A61P35/00 , C07K16/18 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , C12Q1/6886 , G01N33/574 , G01N33/58 , C07K14/705
CPC分类号： G01N33/57419 , A61K49/0008 , C12Q1/6886 , C12Q2600/136
摘要： The invention relates to CSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及CSG多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

10. 发明申请

US20050026211A1 Compositions and methods relating to lung specific genes 审中-公开
标题翻译：与肺特异性基因有关的组成和方法
公开(公告)号：US20050026211A1
公开(公告)日：2005-02-03
申请号：US10933058
申请日：2004-09-02
申请人： Sei-Yu Chen , Roberto Macina , Yongming Sun , Herve Recipon
发明人： Sei-Yu Chen , Roberto Macina , Yongming Sun , Herve Recipon
IPC分类号： G21H5/02 , A61K39/00 , A61K45/00 , A61K49/00 , A61K51/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K14/47 , C07K16/32 , C12N15/09 , C12N15/12 , C12Q1/68 , G01T1/161 , C07H21/04 , G01N33/574
CPC分类号： C07K14/47 , A61K39/00
摘要： The invention relates to LSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及LSG多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

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