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1. 发明授权

US09161903B2 Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权
标题翻译：可流动的组合物在皮肤递送至目标组织部位时变硬
公开(公告)号：US09161903B2
公开(公告)日：2015-10-20
申请号：US12262705
申请日：2008-10-31
申请人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
发明人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
IPC分类号： A61K51/00 , A61K9/00 , A61K9/14 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/16 , A61K31/573 , A61K47/10 , A61K47/34 , A61K51/1213
摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.
摘要翻译：提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。

2. 发明授权

US09757476B2 Compositions and methods for diagnosis of axial pain with or without radiculopathy 有权
公开(公告)号：US09757476B2
公开(公告)日：2017-09-12
申请号：US11449309
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.

3. 发明授权

US09364582B2 Malleable implants containing demineralized bone matrix 有权
标题翻译：含有脱钙骨基质的韧性植入物
公开(公告)号：US09364582B2
公开(公告)日：2016-06-14
申请号：US13238844
申请日：2011-09-21
申请人： Susan J. Drapeau , Kathy L. Remsen , William F. McKay , Nelson L. Scarborough
发明人： Susan J. Drapeau , Kathy L. Remsen , William F. McKay , Nelson L. Scarborough
IPC分类号： A61F2/28 , A61L27/20 , A61L27/48 , A61L27/24 , A61L27/36
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions.
摘要翻译：描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。固体可以包括颗粒胶原和颗粒脱矿质骨基质。液体载体包括含有一种或多种多糖的水性介质。还描述了制备和使用这种医药组合物的方法。

4. 发明授权

US08012139B2 Devices and methods for delivering medical agents 有权
标题翻译：用于递送医疗药剂的装置和方法
公开(公告)号：US08012139B2
公开(公告)日：2011-09-06
申请号：US12859391
申请日：2010-08-19
申请人： William F. McKay , Susan J. Drapeau
发明人： William F. McKay , Susan J. Drapeau
IPC分类号： A61M1/00 , A61M31/00 , A61M5/00
CPC分类号： A61M5/3148 , A61B17/3478 , A61B2017/00247 , A61B2017/00261 , A61B2018/00392 , A61M5/32 , A61M5/3291 , A61M5/3298 , A61M2005/341
摘要： Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.
摘要翻译：描述了用于将医疗剂递送到患者组织体积（例如脊椎盘的内部空间）内的多个位置的新方法，并且还用于在医疗剂递送期间从其中移除材料以增强输送。还描述了医疗输送装置，例如构造成便于将医疗药剂区域递送到患者组织的针组件。

5. 发明申请

US20100312173A1 Devices and Methods for Delivering Medical Agents 有权
标题翻译：提供医疗代理的设备和方法
公开(公告)号：US20100312173A1
公开(公告)日：2010-12-09
申请号：US12859391
申请日：2010-08-19
申请人： William F. McKay , Susan J. Drapeau
发明人： William F. McKay , Susan J. Drapeau
IPC分类号： A61M5/31 , A61M1/00
CPC分类号： A61M5/3148 , A61B17/3478 , A61B2017/00247 , A61B2017/00261 , A61B2018/00392 , A61M5/32 , A61M5/3291 , A61M5/3298 , A61M2005/341
摘要： Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.
摘要翻译：描述了用于将医疗剂递送到患者组织体积（例如脊椎盘的内部空间）内的多个位置的新方法，并且还用于在医疗剂递送期间从其中移除材料以增强输送。还描述了医疗输送装置，例如构造成便于将医疗药剂区域递送到患者组织的针组件。

6. 发明授权

US07850656B2 Devices and methods for delivering medical agents 有权
标题翻译：用于递送医疗药剂的装置和方法
公开(公告)号：US07850656B2
公开(公告)日：2010-12-14
申请号：US11118125
申请日：2005-04-29
申请人： William F. McKay , Susan J. Drapeau
发明人： William F. McKay , Susan J. Drapeau
IPC分类号： A61M5/00
CPC分类号： A61M5/3148 , A61B17/3478 , A61B2017/00247 , A61B2017/00261 , A61B2018/00392 , A61M5/32 , A61M5/3291 , A61M5/3298 , A61M2005/341
摘要： Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.
摘要翻译：描述了用于将医疗剂递送到患者组织体积（例如脊椎盘的内部空间）内的多个位置的新方法，并且还用于在医疗剂递送期间从其中移除材料以增强输送。还描述了医疗输送装置，例如构造成便于将医疗药剂区域递送到患者组织的针组件。

7. 发明授权

US07838022B2 Malleable implants containing demineralized bone matrix 有权
标题翻译：含有脱钙骨基质的韧性植入物
公开(公告)号：US07838022B2
公开(公告)日：2010-11-23
申请号：US11415037
申请日：2006-05-01
申请人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
发明人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
IPC分类号： A61F2/28 , A61K35/32
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.
摘要翻译：描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。固体包括颗粒状胶原和颗粒脱矿质骨基质。液体载体包括含有多糖的水性介质。还描述了制备和使用这种医药组合物的方法。

8. 发明申请

US20080177218A1 Method for treating facet pain 有权
标题翻译：治疗面疼痛的方法
公开(公告)号：US20080177218A1
公开(公告)日：2008-07-24
申请号：US11589410
申请日：2006-10-30
申请人： William F. McKay , Susan J. Drapeau
发明人： William F. McKay , Susan J. Drapeau
IPC分类号： A61N1/30
CPC分类号： A61B17/56 , A61B2017/564
摘要： A method for treating a facet pain in a subject by providing an effective amount of therapeutic agent in manner that by a biological repair effect on the facet is produced as compared to a temporary anti-inflammatory effect.
摘要翻译：与临时抗炎作用相比，产生通过以方面的生物修复作用提供有效量的治疗剂来治疗受试者的小平面疼痛的方法。

9. 发明授权

US08252738B2 Method for changing cell phenotype using LIM mineralization proteins 有权
标题翻译：使用LIM矿化蛋白改变细胞表型的方法
公开(公告)号：US08252738B2
公开(公告)日：2012-08-28
申请号：US11875267
申请日：2007-10-19
申请人： Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
发明人： Jeffrey C. Marx , William F. McKay , Susan J. Drapeau
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C12N15/00 , C12N15/12
CPC分类号： A61L27/54 , A61F2002/2817 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K38/1875 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C12N5/0602 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/60 , C12N2501/998 , C12N2510/00 , A61K2300/00
摘要： Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo.
摘要翻译：提供改变细胞表型的方法。所述方法包括增加与细胞中编码LMP蛋白或其片段的氨基酸序列至少70％相同的氨基酸序列的量。细胞可以由包含编码与编码LMP或其片段的氨基酸序列至少70％相同的氨基酸序列的核酸序列或包含至少70％的酸序列的组合物的组合物接触，与编码LMP或其片段的氨基酸序列或其任何组合相同。细胞可以在体内或体外接触。

10. 发明申请

US20100297255A1 MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX 有权
标题翻译：包含骨质疏松基质的可植入植入物
公开(公告)号：US20100297255A1
公开(公告)日：2010-11-25
申请号：US12850673
申请日：2010-08-05
申请人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
发明人： Susan J. Drapeau , Kathy L. Chamness , William F. McKay
IPC分类号： A61K38/39 , A61K35/28 , A61K38/18 , A61P19/08 , A61P35/00 , A61P31/00 , A61P31/10 , A61P29/00 , A61P7/02 , A61P41/00
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.
摘要翻译：描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。固体包括颗粒状胶原和颗粒脱矿质骨基质。液体载体包括含有多糖的水性介质。还描述了制备和使用这种医药组合物的方法。

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