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1. 发明申请

US20070286767A1 Ophthalmic Compositions Comprising a Branched, Glycerol Monoalkyl Compound and a Fatty Acid Monoester 有权
标题翻译：包含支链甘油单烷基化合物和脂肪酸单酯的眼科组合物
公开(公告)号：US20070286767A1
公开(公告)日：2007-12-13
申请号：US11691125
申请日：2007-03-26
申请人： Susan E. Burke , Eric Phillips , Fang Zhao , Vicki Barniak , Joseph C. Salamone
发明人： Susan E. Burke , Eric Phillips , Fang Zhao , Vicki Barniak , Joseph C. Salamone
IPC分类号： A61L2/18
CPC分类号： A61K9/0048 , A61L12/141 , A61L12/142 , A61L12/143 , A61L12/145 , C11D1/667 , C11D3/0026 , C11D3/0078 , C11D3/2068 , C11D3/2093 , C11D3/30 , C11D3/3427 , C11D3/48 , Y10S134/901
摘要： An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.
摘要翻译：一种含有支链甘油单烷基化合物和脂肪酸单酯的眼用组合物。脂肪酸单酯包含具有6至14个碳原子的脂族脂肪酸部分和脂族羟基部分。组合物还将具有在200mOsmol / kg至400mOsmol / kg范围内的重量摩尔渗透压浓度。本发明还涉及在包含表面活性剂的水性眼用组合物中抑制泡沫形成的方法以及提高含有脂肪酸单酯的水性眼用组合物的杀生物功效的方法。

2. 发明授权

US07670997B2 Ophthalmic compositions comprising a branched, glycerol monoalkyl compound and a fatty acid monoester 有权
标题翻译：包含支链甘油单烷基化合物和脂肪酸单酯的眼科组合物
公开(公告)号：US07670997B2
公开(公告)日：2010-03-02
申请号：US11691125
申请日：2007-03-26
申请人： Susan E. Burke , Eric Phillips , Fang Zhao , Vicki Barniak , Joseph C. Salamone
发明人： Susan E. Burke , Eric Phillips , Fang Zhao , Vicki Barniak , Joseph C. Salamone
IPC分类号： C11D3/48 , C11D3/44
CPC分类号： A61K9/0048 , A61L12/141 , A61L12/142 , A61L12/143 , A61L12/145 , C11D1/667 , C11D3/0026 , C11D3/0078 , C11D3/2068 , C11D3/2093 , C11D3/30 , C11D3/3427 , C11D3/48 , Y10S134/901
摘要： An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.
摘要翻译：一种含有支链甘油单烷基化合物和脂肪酸单酯的眼用组合物。脂肪酸单酯包含具有6至14个碳原子的脂族脂肪酸部分和脂族羟基部分。组合物还将具有在200mOsmol / kg至400mOsmol / kg范围内的重量摩尔渗透压浓度。本发明还涉及在包含表面活性剂的水性眼用组合物中抑制泡沫形成的方法以及提高含有脂肪酸单酯的水性眼用组合物的杀生物功效的方法。

3. 发明申请

US20080214421A1 CONTACT LENS CARE COMPOSITION 审中-公开
标题翻译：联系眼镜护理组合
公开(公告)号：US20080214421A1
公开(公告)日：2008-09-04
申请号：US12030987
申请日：2008-02-14
申请人： Fang Zhao , Shane Mao , Kimberly Millard , Eric Phillips , Vicki Barniak
发明人： Fang Zhao , Shane Mao , Kimberly Millard , Eric Phillips , Vicki Barniak
IPC分类号： C11D3/20
CPC分类号： C11D3/0078 , A01N37/12 , A61L12/141 , A61L12/142 , A61L12/143 , C11D1/667 , C11D3/2093 , C11D3/48 , A01N25/02 , A01N33/12 , A01N47/44 , A01N2300/00
摘要： A method of disinfecting, cleaning or packaging a contact lens by contacting the lens with an ophthalmically acceptable lens care composition. The composition comprises a fatty acid monoester and a cationic antimicrobial component. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms, and an aliphatic hydroxyl portion. The invention is also directed to an ophthalmically acceptable lens care composition comprising a fatty acid monoester and a cationic antimicrobial component.
摘要翻译：通过使镜片与眼科可接受的镜片护理组合物接触来消毒，清洁或包装隐形眼镜的方法。组合物包含脂肪酸单酯和阳离子抗微生物组分。脂肪酸单酯包含具有6至14个碳原子的脂族脂肪酸部分和脂族羟基部分。本发明还涉及包含脂肪酸单酯和阳离子抗微生物组分的眼科可接受的晶状体护理组合物。

4. 发明申请

US20110144329A1 Amorphous Besifloxacin Solid 失效
标题翻译：无定形贝西沙星固体
公开(公告)号：US20110144329A1
公开(公告)日：2011-06-16
申请号：US12956009
申请日：2010-11-30
申请人： Mohannad Shawer , Eric Phillips , Harry M. King, JR.
发明人： Mohannad Shawer , Eric Phillips , Harry M. King, JR.
IPC分类号： C07D223/12
CPC分类号： C07D401/04 , C07D223/12
摘要： Amorphous solid-state form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 6.9-7.1, 9.4, 10.6-10.7, and 13.4-13.7°±0.2°, and a diffuse halo pattern at 11-30°; and (b) a DSC (differential scanning calorimetry) melting peak at about 267-272° C. The amorphous solid is prepared by rapid precipitation from a saturated or supersaturated solution of besifloxacin free base in a solvent comprising at least benzyl alcohol.
摘要翻译：（R） - （+） - 7-（3-氨基-2,3,4,5,6,7-六氢-1H-吖庚因-1-基）-1,4-二氢 - 4-氧代喹啉-3-羧酸的特征在于以下中的至少一种：（a）包含在2θ处的峰的X射线粉末衍射（“XRPD”）光谱; 角度为6.9-7.1,9.4,10.6-10.7和13.4-13.7°±0.2°，扩散晕图案为11-30°; 在约267-272℃下的DSC（差示扫描量热法）熔融峰。（b）在约267-272℃下的DSC（差示扫描量热法）熔融峰。通过在至少含有苄醇的溶剂中从饱和或过饱和的贝沙沙星游离碱溶液快速沉淀制备无定形固体。

5. 发明申请

US20100087550A1 Formulations with a Tertiary Amine Oxide 审中-公开
标题翻译：具有叔胺氧化物的配方
公开(公告)号：US20100087550A1
公开(公告)日：2010-04-08
申请号：US12542739
申请日：2009-08-18
申请人： Zora Marlowe , Paramita Bandyopadhyay , Hongna Wang , Eric Phillips
发明人： Zora Marlowe , Paramita Bandyopadhyay , Hongna Wang , Eric Phillips
IPC分类号： A61K47/18 , A61P27/00 , A61K47/36 , A61K47/38
CPC分类号： A61K9/0048 , A61K47/18 , A61K47/36 , A61K47/38
摘要： A topical pharmaceutical formulation comprising 0.5 ppm to 1000 ppm of a tertiary amine oxide of general formula I wherein R1 is a C8-C18alkyl, and R2 and R3 are independently selected from a C1-C4alkyl or C1-C4hydroxyalkyl. The tertiary amine oxide functions as a preservative or enhances the preservative efficacy in such formulations developed for topical administration. In particular, the topical formulation is an ophthalmic composition.
摘要翻译：包含0.5ppm至1000ppm的通式I的叔胺氧化物的局部药物制剂，其中R 1是C 8 -C 18烷基，R 2和R 3独立地选自C 1 -C 4烷基或C 1 -C 4羟烷基。叔胺氧化物起防腐剂的作用，或增强了在用于局部给药的这些制剂中的防腐功效。特别地，局部制剂是眼用组合物。

6. 发明授权

US08882894B2 Vaporisation injector 有权
标题翻译：蒸发注射器
公开(公告)号：US08882894B2
公开(公告)日：2014-11-11
申请号：US13518761
申请日：2010-02-01
申请人： Stefano Pelagatti , Eric Phillips , Paolo Magni
发明人： Stefano Pelagatti , Eric Phillips , Paolo Magni
IPC分类号： B01D53/02 , G01N30/12 , G01N30/10 , G01N30/04 , G01N30/16 , G01N30/18
CPC分类号： G01N30/12 , G01N30/04 , G01N30/10 , G01N30/16 , G01N30/18 , G01N2030/167 , G01N2030/185
摘要： The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
摘要翻译：本发明涉及一种用于气相色谱仪的蒸发注射器，所述注射器包括以可拆卸的方式安装在气相色谱仪主体上的结构（11），包括样品引入装置，蒸发室和用于将载气供给到蒸发室和隔膜吹扫装置，以及用于抽空分离的样品和载气的气动连接。

7. 发明申请

US20110237605A1 Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative 审中-公开
标题翻译：（4-（1,8-萘啶-2-基）哌啶-1-基）嘧啶衍生物的分子结晶
公开(公告)号：US20110237605A1
公开(公告)日：2011-09-29
申请号：US13018896
申请日：2011-02-01
申请人： Eric Phillips , Mohannad Shawer
发明人： Eric Phillips , Mohannad Shawer
IPC分类号： A61K31/506 , C07D471/04 , A61P27/02 , A61P35/00
CPC分类号： C07D471/04
摘要： A molecular crystal form of (S)-3-(2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4-ylamino)-2-(4-methoxyphenylsulfonamido)propanoic acid is characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°. The molecular crystal can be formulated into pharmaceutical composition for treating or controlling diseases resulting from pathological angiogenesis.
摘要翻译：分子晶形式的（S）-3-（2,5-二甲基-6-（4-（5,6,7,8-四氢-1,8-二氮杂萘-2-基）哌啶-1-基）嘧啶-4-基氨基）-2-（4-甲氧基苯基磺酰氨基）丙酸的特征在于包含在2θ处的峰的X射线粉末衍射（“XRPD”）光谱; 角度为7.44,14.80,16.64和23.04±0.2°。分子晶体可以配制成药物组合物，用于治疗或控制由病理性血管生成引起的疾病。

8. 发明授权

US08518935B2 Amorphous besifloxacin solid 失效
标题翻译：无定形塞米沙星固体
公开(公告)号：US08518935B2
公开(公告)日：2013-08-27
申请号：US12956009
申请日：2010-11-30
申请人： Mohannad Shawer , Eric Phillips , Harry M. King, Jr.
发明人： Mohannad Shawer , Eric Phillips , Harry M. King, Jr.
IPC分类号： A61K31/55 , A61P31/04 , C07D401/04
CPC分类号： C07D401/04 , C07D223/12
摘要： Amorphous solid-state form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 6.9-7.1, 9.4, 10.6-10.7, and 13.4-13.7°±0.2°, and a diffuse halo pattern at 11-30°; and (b) a DSC (differential scanning calorimetry) melting peak at about 267-272° C. The amorphous solid is prepared by rapid precipitation from a saturated or supersaturated solution of besifloxacin free base in a solvent comprising at least benzyl alcohol.
摘要翻译：（R） - （+） - 7-（3-氨基-2,3,4,5,6,7-六氢-1H-吖庚因-1-基）-1,4-二氢 - 4-氧代喹啉-3-羧酸的特征在于以下至少一个：（a）X射线粉末衍射（“XRPD”）谱，其包括在2θ角为6.9-7.1,9.4,10.6-10.7和13.4的峰 -13.7°±0.2°，扩散晕图案在11-30°; 在约267-272℃下的DSC（差示扫描量热法）熔融峰。（b）在约267-272℃下的DSC（差示扫描量热法）熔融峰。通过在至少含有苄醇的溶剂中从饱和或过饱和的贝沙沙星游离碱溶液快速沉淀制备无定形固体。

9. 发明申请

US20120280061A1 VAPORISATION INJECTOR 有权
标题翻译：蒸汽喷射器
公开(公告)号：US20120280061A1
公开(公告)日：2012-11-08
申请号：US13518761
申请日：2010-02-01
申请人： Stefano Pelagatti , Eric Phillips , Paolo Magni
发明人： Stefano Pelagatti , Eric Phillips , Paolo Magni
IPC分类号： B05B1/28
CPC分类号： G01N30/12 , G01N30/04 , G01N30/10 , G01N30/16 , G01N30/18 , G01N2030/167 , G01N2030/185
摘要： The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
摘要翻译：本发明涉及一种用于气相色谱仪的蒸发注射器，所述注射器包括以可拆卸的方式安装在气相色谱仪主体上的结构（11），包括样品引入装置，蒸发室和用于将载气供给到蒸发室和隔膜吹扫装置，以及用于抽空分离的样品和载气的气动连接。

10. 发明授权

US11484831B1 Direct air capture system removing carbon dioxide 有权
公开(公告)号：US11484831B1
公开(公告)日：2022-11-01
申请号：US17405950
申请日：2021-08-18
申请人： Eric Phillips
发明人： Eric Phillips
IPC分类号： B01D53/62 , B01D53/78
摘要： A direct air capture (DAC) system for removal of carbon dioxide from ambient air has a reaction chamber having an air intake opening and an air exhaust opening, an air movement mechanism positioned to move air from outside through the reaction chamber, utilizing the air intake and the air exhaust openings, and a mechanism introducing sodium hydroxide into the reaction chamber. Carbon dioxide in the air moved through the reaction chamber interacts chemically with the sodium hydroxide, producing sodium carbonate and water.

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