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1. 发明授权

EP3132675B1 METHOD AND SYSTEM OF CULTIVATING OPHIOCORDYCEPS SINENSIS 有权转让
公开(公告)号：EP3132675B1
公开(公告)日：2019-03-13
申请号：EP16200380.0
申请日：2016-11-24
申请人： Sunshine Lake Pharma Co., Ltd. , Yichang Shanchenshuidu Cordyceps Co., Ltd.
发明人： LI, Wenjia , ZHANG, Zongyao , LI, Quanping , LV, Yanhua , QIAN, Zhengming
IPC分类号： A01G18/00 , A01M1/04 , A01K67/033 , C12N1/14

2. 发明公开

EP3132675A3 METHOD AND SYSTEM OF CULTIVATING OPHIOCORDYCEPS SINENSIS 有权转让
标题翻译：方法和系统的培养目标中华眼镜蛇
公开(公告)号：EP3132675A3
公开(公告)日：2017-08-23
申请号：EP16200380.0
申请日：2016-11-24
申请人： Sunshine Lake Pharma Co., Ltd. , Yichang Shanchenshuidu Cordyceps Co., Ltd.
发明人： LI, Wenjia , ZHANG, Zongyao , LI, Quanping , LV, Yanhua , QIAN, Zhengming
IPC分类号： A01G1/04 , A01M1/04 , A01M1/10
CPC分类号： A01K67/033 , A01G18/00 , A01M1/04 , A01M1/106 , C12M1/00 , C12N1/14 , F21V23/003 , F21Y2113/10 , F21Y2115/10
摘要： The present invention relates to a system and method of cultivating Cordyceps, specifically, provided herein is a system of cultivating Cordyceps comprising: a Hepialus moth trapping device (100); a Hepialus moth eggs screening device, wherein the device is connected with the Hepialus moth trapping device; an ascospores-collecting device; a mycelia-preparing device; a conidia-preparing device; an infection device, wherein the device is connected with the ascospores-collecting device, the mycelia-preparing device and the conidia-preparing device; and a feeding device, wherein the device is connected with the Hepialus moth eggs screening device and the infection device. And also provided is a method of using the system to cultivate Cordyceps. The system and method have advantages in less manpower, suitable for industrial-scale production of Cordyceps, harvesting Cordyceps with steady production and high quality.
摘要翻译：本发明涉及一种培育冬虫夏草的系统和方法，具体地说，本文提供了一种培养冬虫夏草的系统，包括：姬松蛾捕捉装置（100）; Hepialus蛾卵筛选装置，其中所述装置与Hepialus蛾捕获装置连接; 子囊孢子收集装置; 菌丝体制备装置; 分生孢子制备装置; 感染装置，所述装置与子囊孢子采集装置，菌丝体制备装置和分生孢子制备装置连接; 以及喂食装置，所述装置与蝎蛾卵卵筛选装置和感染装置连接。还提供了使用该系统培育冬虫夏草的方法。该系统和方法具有人力少的优点，适合工业化生产冬虫夏草，收获冬虫夏草生产稳定，质量优良。

3. 发明公开

EP3132675A2 METHOD AND SYSTEM OF CULTIVATING OPHIOCORDYCEPS SINENSIS 有权转让
标题翻译： VERFAHREN UND SYSTEM ZUR KULTIVIERUNG VON OPHIOCORDYCEPS SINENSIS
公开(公告)号：EP3132675A2
公开(公告)日：2017-02-22
申请号：EP16200380.0
申请日：2016-11-24
申请人： Sunshine Lake Pharma Co., Ltd. , Yichang Shanchenshuidu Cordyceps Co., Ltd.
发明人： LI, Wenjia , ZHANG, Zongyao , LI, Quanping , LV, Yanhua , QIAN, Zhengming
IPC分类号： A01G1/04 , A01M1/04
CPC分类号： A01K67/033 , A01G18/00 , A01M1/04 , A01M1/106 , C12M1/00 , C12N1/14 , F21V23/003 , F21Y2113/10 , F21Y2115/10
摘要： The present invention relates to a system and method of cultivating Cordyceps, specifically, provided herein is a system of cultivating Cordyceps comprising: a Hepialus moth trapping device (100); a Hepialus moth eggs screening device, wherein the device is connected with the Hepialus moth trapping device; an ascospores-collecting device; a mycelia-preparing device; a conidia-preparing device; an infection device, wherein the device is connected with the ascospores-collecting device, the mycelia-preparing device and the conidia-preparing device; and a feeding device, wherein the device is connected with the Hepialus moth eggs screening device and the infection device. And also provided is a method of using the system to cultivate Cordyceps. The system and method have advantages in less manpower, suitable for industrial-scale production of Cordyceps, harvesting Cordyceps with steady production and high quality.
摘要翻译：本发明涉及一种栽培冬虫夏草的系统和方法，具体地说，本发明提供了一种栽培冬虫夏草的系统，其特征在于，包括：肝蛾诱捕装置（100）; 一种Hepialus蛾卵筛选装置，其中该装置与Hepialus蛾诱捕装置连接; 子囊孢子收集装置; 菌丝体制备装置; 分生孢子准备装置; 感染装置，其中所述装置与子囊孢子收集装置，菌丝体制备装置和分生孢子制备装置连接; 以及饲养装置，其中所述装置与Hepialus蛾卵筛选装置和感染装置连接。还提供了一种使用该系统培养冬虫夏草的方法。该系统和方法人力较少，适用于冬虫夏草的工业规模生产，收获稳定，质量好的冬虫夏草。

4. 发明申请

WO2021253733A1 CONSTRUCT AND USE THEREOF 审中-公开
公开(公告)号：WO2021253733A1
公开(公告)日：2021-12-23
申请号：PCT/CN2020/133242
申请日：2020-12-02
申请人： DONGGUAN HEC BIOPHARMACEUTICAL R&D CO., LTD. , SUNSHINE LAKE PHARMA CO., LTD.
发明人： ZHANG, Xuhui , NING, Weiyu , HE, Liangliang , LUO, Xianlin , HONG, Qiang , ZHAO, Guanghui , YAN, Qingqing , TANG, Ruihua , FENG, Cuijuan , LI, Xiaoping , GUO, Linfeng , CHEN, Chao , YE, Qunrui , CHEN, Xiaofeng , LI, Wenjia
IPC分类号： C12N15/869 , C12N15/19 , C12N7/01 , C12N5/10 , A61K48/00 , A61P35/00 , A61K48/0008 , A61K48/0058 , A61P35/02 , C07K14/521 , C12N15/86 , C12N2710/16621 , C12N2710/16643 , C12N7/00
摘要： Provided are a construct and use thereof, the vector of the construct is derived from HSV, and the construct carring a chemokine coding frame, which is set at the position of UL23 gene and is operably linked to a promoter. The construct can sustainably express chemokines highly.

5. 发明申请

WO2018024162A1 GLP-1 FUSION PROTEIN COMPRISING MUTATED IMMUNOGLOBULIN FC PORTION 审中-公开
标题翻译：包含突变的免疫球蛋白FC部分的GLP-1融合蛋白
公开(公告)号：WO2018024162A1
公开(公告)日：2018-02-08
申请号：PCT/CN2017/094916
申请日：2017-07-28
申请人： SUNSHINE LAKE PHARMA CO., LTD.
发明人： ZHANG, Yubo , LI, Lijia , HE, Tiefan , XU, Linghua , LIU, Liang , CHEN, Xiaofeng , LI, Wenjia
IPC分类号： C07K19/00 , C12N15/62 , C12N5/10
摘要： Provided a fusion protein comprising GLP-1 or an analog thereof, a peptide linker, and a mutated immunoglobulin Fc portion, which fusion protein has an increased half-life. Also provided a method for producing the fusion protein and the use of the fusion protein in the preparation of medicines.
摘要翻译：提供包含GLP-1或其类似物，肽接头和突变的免疫球蛋白Fc部分的融合蛋白，该融合蛋白具有增加的半衰期。还提供了制备融合蛋白的方法和融合蛋白在药物制备中的用途。

6. 发明申请

WO2022135357A1 A hIL7/hCCL19 DOUBLE GENE RECOMBINANT ONCOLYTIC VIRUS AND ITS PREPARATION METHOD AND USE 审中-公开
公开(公告)号：WO2022135357A1
公开(公告)日：2022-06-30
申请号：PCT/CN2021/139843
申请日：2021-12-21
申请人： SUNSHINE LAKE PHARMA CO., LTD.
发明人： ZHANG, Xuhui , LUO, Xianlin , CHEN, Xiaofeng , LI, Wenjia
IPC分类号： C12N7/01 , C12N15/19 , C12N15/24 , C12N15/85 , A61K38/19 , A61K38/20 , A61P35/00
摘要： Provided are hIL7/hCCL19 double gene recombinant oncolytic virus and its preparation method and use. Also provided is a recombinant oncolytic virus, the genome of which integrates two genes IL7 and CCL19 with a strong synergistic effect, thereby enhancing the effect of the oncolytic virus. Compared with the oncolytic virus whose sensitivity usually decreases after modification, the double gene carrier type virus constructed maintains the sensitivity to tumor cells, while the virus replication ability does not decrease.

7. 发明申请

WO2020177712A1 A POLYPEPTIDE MOLECULE AND APPLICATION THEREOF 审中-公开
公开(公告)号：WO2020177712A1
公开(公告)日：2020-09-10
申请号：PCT/CN2020/077750
申请日：2020-03-04
申请人： DONGGUAN HEC BIOPHARMACEUTICAL R&D CO., LTD. , SUNSHINE LAKE PHARMA CO., LTD.
发明人： CHEN, Chao , LIN, Shushan , LI, Yu , LI, Xiaoping , CHEN, Xiaofeng , LI, Wenjia , LIU, Liang , FU, Zheng
IPC分类号： C07K14/50 , C07K19/00 , C12N15/62 , C12N15/63 , A61K38/18 , A61P3/04 , A61P3/10
摘要： The present application provides an FGF21 polypeptide, which has one or more of the following properties: stable structure, long half-life, low immunogenicity, high biological activity, and enhanced glucose-lowering and lipid-lowering activities. The present application also provides a fusion protein or immunoconjugate comprising the FGF21 polypeptide described herein.

8. 发明申请

WO2023072170A1 A METHOD FOR PROMOTING THE DIFFERENTIATION OF STEM CELLS INTO FUNCTIONALLY MATURE ISLET β CELLS AND USE THEREOF 审中-公开
公开(公告)号：WO2023072170A1
公开(公告)日：2023-05-04
申请号：PCT/CN2022/127805
申请日：2022-10-27
申请人： SUNSHINE LAKE PHARMA CO., LTD.
发明人： SONG, Yizhe , LI, Jingqiu , OU, Zhensheng , GUO, Leilei , TANG, Tingting , XING, Peiwen , LIU, Jing , ZHAO, Huifang , ZHANG, Shidu , YE, Qunrui , CHEN, Xiaofeng , LI, Wenjia , FENG, Shanshan , LI, Jing
IPC分类号： C12N5/071 , C12N5/0735 , A61K31/221 , A61K35/39
摘要： Provided is a method for promoting the differentiation of pluripotent stem cells into functionally mature islet β cells. The method comprises: coculturing endocrine progenitor cells with medium containing an M3 muscarinic acetylcholine receptor agonist, so as to facilitate the differentiation of endocrine progenitor cells into islet β cells; wherein, the endocrine progenitor cells are generated from primitive gut tube cells through in vitro differentiation. During differentiation process from primitive gut tube cells to endocrine progenitor cells, the cells are not cocultured with medium containing the M3 muscarinic acetylcholine receptor agonist.

9. 发明申请

WO2022105814A1 HUMANIZED ANTI-TRKA ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2022105814A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/131343
申请日：2021-11-18
申请人： SUNSHINE LAKE PHARMA CO., LTD.
发明人： REN, Zhiheng , DONG, Junji , HE, Zhuandi , WANG, Kezhu , LU, Jielian , LIN, Shushan , LIU, Liang , LI, Xiang , ZHANG, Kuo , JIANG, Yan , LI, Xiaoping , CHEN, Xiaofeng , LI, Wenjia
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61P19/08 , A61P13/12 , A61P19/02 , C12N15/62 , C12N15/63
摘要： Provided is a humanized antibody or antigen-binding fragment thereof capable of specifically recognizing TrkA and uses thereof. The antibody comprises a heavy chain variable region with an amino acid sequence shown in any one of SEQ ID NO: 2-8, and a light chain variable region with an amino acid sequence shown in any one of SEQ ID NO: 10-13. The above-mentioned antibody according to the embodiments can specifically target and bind to the TrkA receptor and block the binding of NGF and TrkA.

10. 发明申请

WO2021027795A1 CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF 审中-公开
公开(公告)号：WO2021027795A1
公开(公告)日：2021-02-18
申请号：PCT/CN2020/108327
申请日：2020-08-11
申请人： SUNSHINE LAKE PHARMA CO., LTD.
发明人： CHEN, Chao , DONG, Junji , YU, Tingting , ZENG, Yi , XU, Le , WANG, Xufang , LI, Zhiguang , LI, Shaoyan , YE, Qunrui , CHEN, Xiaofeng , LI, Wenjia
IPC分类号： C07K19/00 , C12N15/85 , C12N5/10 , C07K16/28 , A61K39/00
摘要： Provide is a chimeric antigen receptor. The chimeric antigen receptor comprises an extracellular domain including a heavy chain variable region, a light chain variable region of a single chain antibody fragment and CD8 hinge region; a transmembrane domain including an immune co-stimulator transmembrane domain; and an intracellular domain including an immune co-stimulator intracellular segment and CD3ζ chain. The chimeric antigen receptor can specifically recognize the tumor cells expressing the specific antigen and achieve the specific killing effect against the tumor cells expressing the high specific antigen.

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