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1. 发明授权

US06322805B1 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof 有权
标题翻译：可生物降解聚合胶束型药物组合物及其制备方法
公开(公告)号：US06322805B1
公开(公告)日：2001-11-27
申请号：US09547545
申请日：2000-04-12
申请人： Sung-Chul Kim , Eun-Ok Chang , In-Suk Song , Chaul-Min Pai
发明人： Sung-Chul Kim , Eun-Ok Chang , In-Suk Song , Chaul-Min Pai
IPC分类号： A61F200
CPC分类号： A61K47/34 , A61K9/1075
摘要： A biodegradable polymeric drug carrier micelle composition capable of solubilizing a hydrophobic drug in a hydrophilic environment comprises a biodegradable polymeric drug carrier micelle and a hydrophobic drug wherein the drug is physically trapped within and not covalently bonded to the polymeric drug carrier micelle. The drug carrying micelle is capable of dissolving in water to form a solution thereof, and the drug carrier comprises an amphiphilic block copolymer having a hydrophilic poly(alkylene oxide) component, and a biodegradable hydrophobic polymer component selected from the group consisting of poly(lactic acid), poly(glycoloc acid), poly(lactic-co-glycolic acid), poly(&egr;-caprolactone), a derivative thereof and a mixture thereof. Preferably the amphiphilic block copolymer has a molecular weight in a range of about 1430 to about 6000 Daltons and the hydrophilic component content is in a range of about 50 wt % to about 70 wt % based on the total weight of the block copolymer.
摘要翻译：能够将疏水性药物溶解在亲水环境中的可生物降解的聚合物药物载体胶束组合物包括可生物降解的聚合物药物载体胶束和疏水性药物，其中所述药物被物理地俘获并且不共价键合到聚合物药物载体胶束上。载药胶束能够溶解在水中以形成其溶液，药物载体包括具有亲水性聚（环氧烷）组分的两亲性嵌段共聚物和选自聚（乳酸）的生物可降解的疏水性聚合物组分酸），聚（糖醇酸），聚（乳酸 - 共 - 乙醇酸），聚（ε-己内酯），其衍生物及其混合物。优选地，两亲性嵌段共聚物的分子量在约1430至约6000道尔顿范围内，并且基于嵌段共聚物的总重量，亲水组分含量在约50重量％至约70重量％的范围内。

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