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1. 发明申请

US20110123574A1 INHALABLE SUSTAINED THERAPEUTIC FORMULATIONS 审中-公开
标题翻译：可持续的持续治疗方案
公开(公告)号：US20110123574A1
公开(公告)日：2011-05-26
申请号：US12907584
申请日：2010-10-19
申请人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
发明人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
IPC分类号： A61K9/00 , A61K31/137 , A61K31/46 , A61P11/08 , A61P11/00
CPC分类号： A61K31/46 , A61K9/0075 , A61K9/1617 , A61K31/137 , A61K31/40 , A61M11/00 , A61M15/003 , A61M15/0045 , A61M15/009 , A61M15/0091 , A61M2202/064
摘要： The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.
摘要翻译：本发明部分地基于意想不到的发现，即用于肺部递送包含磷脂和足够量的亮氨酸的治疗性，预防性或诊断剂的颗粒可以产生药剂的持久作用。具体地，用于肺部递送含有磷脂或磷脂组合的治疗性预防或诊断剂的颗粒，其中磷脂或磷脂组合以约1至46重量％的量存在于颗粒中; 和亮氨酸，其中亮氨酸以至少46重量％的量存在于颗粒中，可有助于药剂的持续作用。包含至少46重量百分比的亮氨酸但不含磷脂的颗粒不具有这些相同的持续作用特性。

2. 发明授权

US07754242B2 Inhalable sustained therapeutic formulations 有权
标题翻译：可吸入的持续治疗配方
公开(公告)号：US07754242B2
公开(公告)日：2010-07-13
申请号：US10392333
申请日：2003-03-19
申请人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
发明人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
IPC分类号： A61K9/16 , A61K9/12
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/1617 , A61K31/40 , A61K31/438 , A61K31/46 , A61K45/06
摘要： The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.
摘要翻译：本发明部分地基于意想不到的发现，即用于肺部递送包含磷脂和足够量的亮氨酸的治疗性，预防性或诊断剂的颗粒可以产生药剂的持久作用。具体地，用于肺部递送含有磷脂或磷脂组合的治疗性预防或诊断剂的颗粒，其中磷脂或磷脂组合以约1至46重量％的量存在于颗粒中; 和亮氨酸，其中亮氨酸以至少46重量％的量存在于颗粒中，可有助于药剂的持续作用。包含至少46重量百分比的亮氨酸但不含磷脂的颗粒不具有这些相同的持续作用特性。

3. 发明授权

US07297437B2 Battery with gelled electrolyte 有权
标题翻译：电池用凝胶电解液
公开(公告)号：US07297437B2
公开(公告)日：2007-11-20
申请号：US10483953
申请日：2002-02-12
申请人： Robert Clarke , Brian Dougherty , Stephen Harrison , J. Peter Millington , Samaresh Mohanta
发明人： Robert Clarke , Brian Dougherty , Stephen Harrison , J. Peter Millington , Samaresh Mohanta
IPC分类号： H01M4/36
CPC分类号： H01M6/182 , H01M6/22 , H01M2300/008 , H01M2300/0085 , H01M2300/0091
摘要： An electric device comprises a gelled acid electrolyte (142A) in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries and especially primary batteries, while preferred acid electrolytes (124A) have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte (142A) in which with a lanthanide forms a redox pair with zinc.
摘要翻译：电气装置包括与与第二元素形成氧化还原对的镧系元素复合的凝胶酸电解质（142A）。优选的电气装置包括电池，特别是初级电池，而优选的酸性电解质（124A）具有磺酸基。考虑的镧系元素特别包括铈，优选的第二元素尤其包括锌。或者，预期的电气装置可以包括凝胶电解质（142A），其中镧系元素与锌形成氧化还原对。

4. 发明申请

US20050145743A1 Method and apparatus for transporting a sheet from a dryer to a reel 有权
标题翻译：将片材从干燥器输送到卷轴的方法和装置
公开(公告)号：US20050145743A1
公开(公告)日：2005-07-07
申请号：US11054026
申请日：2005-02-09
申请人： Robert Clarke , Thomas Neal
发明人： Robert Clarke , Thomas Neal
IPC分类号： D21F7/00 , B65H20/06 , D21G9/00 , B65H20/10
CPC分类号： B65H20/12 , B65H20/06 , B65H2301/511 , B65H2301/517 , B65H2301/522 , B65H2406/323 , B65H2801/84 , D21G9/0063
摘要： A system and method for transferring a continuously advancing paper web from a dryer to a reel section is provided. The system includes a first fabric defining a first moving conveyor. The first fabric may be a permeable fabric, which is positioned downstream from the dryer. A second fabric, which may also be permeable and defines a second moving conveyor, is also included. The first moving conveyor overlaps the second moving conveyor for a predetermined distance, and the first and second moving conveyors are configured to receive the paper web between the conveyors. A vacuum device is rotatably disposed against the first moving conveyor, and the dryer and the vacuum device are disposed relative to each other to form an open draw. The vacuum device is configured to produce a vacuum to attract the web to the first fabric for transferring the advancing web into the predetermined distance where the first and second conveyors overlap.
摘要翻译：提供了一种用于将连续推进的纸幅从干燥器转移到卷轴部分的系统和方法。该系统包括限定第一移动输送机的第一织物。第一织物可以是位于干燥器下游的可渗透织物。还可以包括也可渗透并限定第二移动输送机的第二织物。第一移动输送机与第二移动输送机重叠预定距离，并且第一和第二移动输送机构造成在输送机之间接收纸幅。真空装置可旋转地设置在第一移动输送机上，并且干燥器和真空装置相对于彼此设置以形成开放式抽出。真空装置被配置为产生真空以将幅材吸引到第一织物，以将前进幅材传送到第一和第二输送机重叠的预定距离。

5. 发明授权

US5625767A Method and system for two-dimensional visualization of an information taxonomy and of text documents based on topical content of the documents 失效
标题翻译：基于文献专题内容的信息分类法和文本文档的二维可视化方法和系统
公开(公告)号：US5625767A
公开(公告)日：1997-04-29
申请号：US402839
申请日：1995-03-13
申请人： Brian Bartell , Robert Clarke
发明人： Brian Bartell , Robert Clarke
IPC分类号： G06F17/30 , G06T11/00
CPC分类号： G06F17/30572 , Y10S707/99935
摘要： A method and system for aiding users in visualizing the relatedness of retrieved text documents and the topics to which they relate comprises training a classifier by semantically analyzing an initial group of manually-classified documents, positioning the classes and documents in two-dimensional space in response to semantic associations between the classes, and displaying the classes and documents. The displayed documents may be retrieved by an information storage and retrieval subsystem in any suitable manner.
摘要翻译：用于帮助用户可视化所检索的文本文档及其相关主题的相关性的方法和系统包括：通过语义分析手动分类文档的初始组来对分类器进行训练，将类和文档定位在二维空间中以作出响应到类之间的语义关联，并显示类和文档。显示的文件可以以任何合适的方式由信息存储和检索子系统检索。

6. 发明授权

US5549675A Method for implanting tissue in a host 失效
标题翻译：在组织中植入组织的方法
公开(公告)号：US5549675A
公开(公告)日：1996-08-27
申请号：US180018
申请日：1994-01-11
申请人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
发明人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
IPC分类号： C12M1/00 , A61F2/02 , A61K9/00 , A61L27/00 , A61L27/38 , C12N5/06
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38 , Y10S623/902
摘要： A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.
摘要翻译：提供了将细胞植入宿主组织的方法。该方法包括以下步骤：创建用于保持细胞的植入物组件，其包括用于在所述装置中的宿主组织和植入细胞之间形成多孔边界的壁装置，边界的孔径足以将植入的细胞与免疫响应; 将没有细胞的组件植入宿主组织中; 以及访问组件的内部以将单元格添加到其中。

7. 发明申请

US20140088148A1 SMALL MOLECULE INHIBITORS OF XBP1 SPLICING 有权
标题翻译： XBP1分离小分子抑制剂
公开(公告)号：US20140088148A1
公开(公告)日：2014-03-27
申请号：US14009969
申请日：2012-04-04
申请人： Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shahjahan , Jaqueline Smith
发明人： Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shahjahan , Jaqueline Smith
IPC分类号： C07D213/32 , A61K31/4439 , A61K45/06 , C07D417/14 , C07D401/14 , C07D405/14 , A61K31/444 , C07D401/04 , C07D417/04
CPC分类号： A61K31/4439 , A61K31/41 , A61K31/426 , A61K31/427 , A61K31/444 , A61K45/06 , C07D213/32 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/14
摘要： Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
摘要翻译：提供了通过IRE1剪接XBP1的小分子抑制剂，以及它们用于治疗或预防癌症（例如内分泌耐药性乳腺癌），糖尿病和肥胖症的方法。

8. 发明申请

US20070041912A1 Trospium containing compositions 审中-公开
标题翻译：含有Trospium的组合物
公开(公告)号：US20070041912A1
公开(公告)日：2007-02-22
申请号：US10550471
申请日：2003-09-04
申请人： Elliot Ehrich , Daniel Deaver , Robert Clarke , Michael Lipp
发明人： Elliot Ehrich , Daniel Deaver , Robert Clarke , Michael Lipp
IPC分类号： A61K31/4747 , A61L9/04
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/1617 , A61K31/40 , A61K31/438 , A61K31/46 , A61K45/06
摘要： The invention relates to a method for treating a disease characterized by a constrictive airway comprising administering to a patient in need thereof via inhalation a pharmaceutical composition comprising trospium, wherein said patient achieves an effective therapy for at least 10 hours. The trospium composition is preferably a particulate formulation useful for administration via a dry powder inhaler. In a preferred embodiment, the composition further comprises a second active agent, such as a beta-2 agonist. A particularly preferred second active agent is formoterol, wherein the trospium, formoterol composition is manufactured by spray drying a mixture comprising trospium and formoterol.
摘要翻译：本发明涉及用于治疗特征在于缩窄性气道的疾病的方法，其包括通过吸入给予有需要的患者包含trospium的药物组合物，其中所述患者达到有效治疗至少10小时。 ium组合物优选是可用于通过干粉吸入器施用的颗粒制剂。在优选的实施方案中，组合物还包含第二活性剂，例如β-2激动剂。特别优选的第二活性剂是福莫特罗，其中通过将包含trospium和福莫特罗的混合物喷雾干燥来制备tro石福莫特罗组合物。

9. 发明申请

US20060205112A1 Semiconductor package fabrication 有权
标题翻译：半导体封装制造
公开(公告)号：US20060205112A1
公开(公告)日：2006-09-14
申请号：US11367725
申请日：2006-03-03
申请人： Martin Standing , Mark Pavier , Robert Clarke , Andrew Sawle , Kenneth McCartney
发明人： Martin Standing , Mark Pavier , Robert Clarke , Andrew Sawle , Kenneth McCartney
IPC分类号： H01L21/00
CPC分类号： H01L21/4825 , H01L21/4867 , H01L23/544 , H01L24/06 , H01L24/13 , H01L24/14 , H01L24/27 , H01L24/29 , H01L24/33 , H01L24/40 , H01L24/743 , H01L24/83 , H01L25/16 , H01L25/50 , H01L2223/54433 , H01L2223/54486 , H01L2224/0401 , H01L2224/05553 , H01L2224/05554 , H01L2224/0603 , H01L2224/13099 , H01L2224/16 , H01L2224/274 , H01L2224/29 , H01L2224/29101 , H01L2224/29111 , H01L2224/2919 , H01L2224/2929 , H01L2224/29339 , H01L2224/743 , H01L2224/83192 , H01L2224/83194 , H01L2224/838 , H01L2924/00013 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01022 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01042 , H01L2924/01046 , H01L2924/01047 , H01L2924/0105 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0133 , H01L2924/014 , H01L2924/0665 , H01L2924/0781 , H01L2924/1033 , H01L2924/1305 , H01L2924/13055 , H01L2924/13062 , H01L2924/13064 , H01L2924/13091 , H01L2924/14 , H01L2924/157 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H05K1/0266 , H05K3/1241 , H05K3/245 , H01L2924/00 , H01L2924/00014 , H01L2224/29099
摘要： A semiconductor package fabrication method in which drop on demand deposition of a drop on demand depositable material is used to prepare one component or a plurality of components of a semiconductor package or multi-chip module.
摘要翻译：一种半导体封装制造方法，其中使用按需存放材料的按需投入沉积来制备半导体封装或多芯片模块的一个组件或多个组件。

10. 发明申请

US20060201648A1 Method and apparatus for transporting a sheet from a dryer to a reel 有权
公开(公告)号：US20060201648A1
公开(公告)日：2006-09-14
申请号：US11417848
申请日：2006-05-04
申请人： Robert Clarke , Thomas Neal
发明人： Robert Clarke , Thomas Neal
IPC分类号： D21F7/00
CPC分类号： B65H20/12 , B65H20/06 , B65H2301/511 , B65H2301/517 , B65H2301/522 , B65H2406/323 , B65H2801/84 , D21G9/0063
摘要： A system and method for transferring a continuously advancing paper web from a dryer to a reel section is provided. The system includes a first fabric defining a first moving conveyor. The first fabric may be a permeable fabric, which is positioned downstream from the dryer. A second fabric, which may also be permeable and defines a second moving conveyor, is also included. The first moving conveyor overlaps the second moving conveyor for a predetermined distance, and the first and second moving conveyors are configured to receive the paper web between the conveyors. A vacuum device is rotatably disposed against the first moving conveyor, and the dryer and the vacuum device are disposed relative to each other to form an open draw. The vacuum device is configured to produce a vacuum to attract the web to the first fabric for transferring the advancing web into the predetermined distance where the first and second conveyors overlap.

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