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1. 发明授权

US10188823B2 Continuous high pressure delivery system 有权
公开(公告)号：US10188823B2
公开(公告)日：2019-01-29
申请号：US13555810
申请日：2012-07-23
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
IPC分类号： A61M11/04 , A61M16/14 , A61M15/00 , A61M16/10 , A61M11/00 , A61M15/02 , A61M16/00 , A61M16/08
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.

2. 发明授权

US08251055B2 Continuous high pressure delivery system 有权
标题翻译：连续高压输送系统
公开(公告)号：US08251055B2
公开(公告)日：2012-08-28
申请号：US11866283
申请日：2007-10-02
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, Jr. , Douglas D. McRae
IPC分类号： A61M11/04
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分挥发。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺部提供通气气体。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热的空气或通风气体混合并将混合的气溶胶引导到流道的入口端。

3. 发明申请

US20130068224A1 CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM 审中-公开
标题翻译：连续高压输送系统
公开(公告)号：US20130068224A1
公开(公告)日：2013-03-21
申请号：US13555810
申请日：2012-07-23
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, JR. , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel, JR. , Douglas D. McRae
IPC分类号： A61M16/14 , A61M16/10
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分汽化。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺提供通气。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热空气混合，并将混合气溶胶引导到流路。

4. 发明申请

US20080110458A1 CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM 有权
标题翻译：连续高压输送系统
公开(公告)号：US20080110458A1
公开(公告)日：2008-05-15
申请号：US11866283
申请日：2007-10-02
申请人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel , Douglas D. McRae
发明人： Sudarsan Srinivasan , David Ammann , Donald Brookman , Niranjan Maharajh , Gary Grollimund , F. Murphy Sprinkel , Douglas D. McRae
IPC分类号： A61M16/00 , A61M11/06 , A61B19/00
CPC分类号： A61M16/14 , A61M11/001 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/00 , A61M15/025 , A61M16/024 , A61M16/0808 , A61M16/1065 , A61M16/1075 , A61M2205/128 , A61M2205/3368 , A61M2205/505
摘要： A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.
摘要翻译：药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。气溶胶发生器从液体制剂形成气溶胶，其被部分汽化。泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺提供通气。该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热空气混合，并将混合气溶胶引导到流路。

5. 发明申请

US20050132879A1 Piston pump useful for aerosol generation 有权
标题翻译：活塞泵可用于气溶胶产生
公开(公告)号：US20050132879A1
公开(公告)日：2005-06-23
申请号：US10790753
申请日：2004-03-03
申请人： Gary Grollimund , Donald Brookman , Kenneth Cox , Walter Nichols , Edwin Waldbusser
发明人： Gary Grollimund , Donald Brookman , Kenneth Cox , Walter Nichols , Edwin Waldbusser
IPC分类号： F04B1/04 , F04B7/06 , F04B27/08 , F04B39/00 , F01B3/00
CPC分类号： F04B7/06 , F04B1/0408 , F04B27/0878 , F04B39/0005
摘要： A piston pump delivers precise and repeatable volumes of a fluid from a reservoir to a downstream component, and includes a piston that is rotatably and reciprocally mounted within a cylinder. The outer periphery of the piston forms an interference fit with the inner periphery of the cylinder. At least one groove is formed in the outer periphery of the piston, with the groove defining a precise volume between the piston and the cylinder, and extending in an axial direction of the piston. The cylinder includes an inlet port for providing fluid communication between a reservoir and the at least one groove when the piston is in a first position, and an exit port circumferentially spaced from the inlet port for providing fluid communication between the at least one groove and a downstream component when the first piston is rotated to a second position where the at least one groove is aligned with the exit port.
摘要翻译：活塞泵将精确和可重复的体积的液体从储存器提供到下游部件，并且包括可旋转并且往复地安装在气缸内的活塞。活塞的外周与气缸的内周形成过盈配合。在活塞的外周形成至少一个凹槽，其中凹槽在活塞和气缸之间限定精确的体积，并沿活塞的轴向方向延伸。气缸包括入口端口，用于当活塞处于第一位置时在储存器和至少一个凹槽之间提供流体连通，以及与入口端口周向间隔开的出口，用于提供至少一个凹槽与一个凹槽之间的流体连通当所述第一活塞旋转到第二位置时，所述至少一个凹槽与所述出口对准。

6. 发明授权

US5432600A Systems for optically inspecting cylindrical surfaces 失效
标题翻译：用于光学检查圆柱面的系统
公开(公告)号：US5432600A
公开(公告)日：1995-07-11
申请号：US218041
申请日：1994-03-24
申请人： Gary Grollimund , H. Cary Longest, Jr. , Barry S. Smith
发明人： Gary Grollimund , H. Cary Longest, Jr. , Barry S. Smith
IPC分类号： A24C5/34 , B07C5/342 , G01N21/952 , G01N21/88
CPC分类号： G01N21/952 , A24C5/3412 , B07C5/3422 , B07C5/365 , G01N2021/8887 , G01N2201/102
摘要： The entire cylindrical surface of a cylindrical object such as a cigarette is optically inspected by first inspecting at least 180.degree. of the circumference of a first side of the surface, and then inspecting at least 180.degree. of the circumference of the other side. Each of the inspection stations illuminates more than 180.degree. of the circumference and images the surface from two angularly spaced directions to ensure that at least 180.degree. of the circumference is seen at each station. Any object having a defective image is automatically rejected from the apparatus, and the images and other statistical information regarding the performance of the system are displayed by the system. The images are formed in such a way as to greatly increase the speed at which the inspection system operates so that it can keep up with the very high rates at which objects such as cigarettes are made in modern machinery (e.g., approximately 10,000 cigarettes per minute). The images are analyzed using techniques which make possible the detection of very small defects and also compensate for possible nonuniform illumination of the objects in the circumferential direction.
摘要翻译：通过首先检查表面的第一侧的圆周的至少180°，然后检查另一侧的至少180°的圆周，对诸如香烟的圆柱形物体的整个圆柱形表面进行光学检查。每个检查站照亮超过180°的圆周，并从两个角度间隔的方向对表面进行成像，以确保在每个站点看到至少180°的圆周。具有缺陷图像的任何物体被自动地从装置中拒绝，并且关于系统性能的图像和其他统计信息由系统显示。图像的形成方式大大增加了检查系统运行的速度，以便能够跟上在现代机械中制造诸如香烟的物体的非常高的速率（例如，每分钟约10,000支香烟）。使用能够检测非常小的缺陷并且还可以补偿在圆周方向上物体的可能的不均匀照明的技术来分析图像。

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