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1. 发明授权

US07473687B2 Methods for the treatment of a traumatic central nervous system injury 有权
标题翻译：治疗创伤性中枢神经系统损伤的方法
公开(公告)号：US07473687B2
公开(公告)日：2009-01-06
申请号：US11527816
申请日：2006-09-27
申请人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
发明人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
IPC分类号： A61K33/56
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译：提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。所述方法包括包含孕酮恒定或两级给药方案的治疗。在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

2. 发明申请

US20110224181A1 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY 有权
标题翻译：治疗TRAUMATIC中枢神经系统损伤的方法
公开(公告)号：US20110224181A1
公开(公告)日：2011-09-15
申请号：US13045180
申请日：2011-03-10
申请人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
发明人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
IPC分类号： A61K31/57 , A61P25/28
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译：提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。所述方法包括包含孕酮恒定或两级给药方案的治疗。在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

3. 发明授权

US08455468B2 Methods for the treatment of a traumatic central nervous system injury 有权
公开(公告)号：US08455468B2
公开(公告)日：2013-06-04
申请号：US13045180
申请日：2011-03-10
申请人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G Stein , David W. Wright , Douglas W. Lowery-North
发明人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G Stein , David W. Wright , Douglas W. Lowery-North
IPC分类号： A61K31/56
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

4. 发明授权

US07915244B2 Methods for the treatment of a traumatic central nervous injury 有权
标题翻译：治疗创伤性中枢神经损伤的方法
公开(公告)号：US07915244B2
公开(公告)日：2011-03-29
申请号：US12117217
申请日：2008-05-08
申请人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
发明人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
IPC分类号： A61K31/56
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译：提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。所述方法包括包含孕酮恒定或两级给药方案的治疗。在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

5. 发明申请

US20080318914A1 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY 有权
标题翻译：治疗TRAUMATIC中枢神经系统损伤的方法
公开(公告)号：US20080318914A1
公开(公告)日：2008-12-25
申请号：US12117217
申请日：2008-05-08
申请人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
发明人： Stuart W. Hoffman , Arthur L. Kellermann , Donald G. Stein , David W. Wright , Douglas W. Lowery-North
IPC分类号： A61K31/57 , A61P25/00
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译：提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。所述方法包括包含孕酮恒定或两级给药方案的治疗。在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

6. 发明授权

US09695489B1 Gun barrel manufacturing methods 有权
公开(公告)号：US09695489B1
公开(公告)日：2017-07-04
申请号：US15182578
申请日：2016-06-14
申请人： David W. Wright
发明人： David W. Wright
IPC分类号： C23C24/04 , F41A21/22 , C21D9/08 , C23C30/00 , B23K31/02 , C22F1/00 , F41A21/02
CPC分类号： C21D9/08 , B21C37/153 , B23K1/0008 , B23K1/19 , B23K31/02 , B23K2101/20 , B23K2101/34 , B23K2103/04 , C22C14/00 , C22C19/03 , C22C19/07 , C22C21/00 , C22C27/06 , C22C38/00 , C22F1/00 , C23C4/02 , C23C4/08 , C23C4/10 , C23C4/129 , C23C4/18 , C23C24/04 , C23C24/106 , C23C28/322 , C23C28/345 , F41A21/02 , F41A21/22 , F41A21/482
摘要： A method of forming a gun barrel is disclosed that includes applying one or more coatings to the gun barrel such as just a top coating, or a bond coating and then a top coating. The method may also include (before applying one or more coatings): threading an outer surface of the gun barrel proximate a first end of the gun barrel; threadedly coupling the first end of the gun barrel to a gun chamber; fixedly coupling the gun barrel to the gun chamber. The method may also include heat treating the coating layer(s), contouring the outer coating layer, applying a ceramic top coating to the contoured outer coating layer of the gun barrel, and/or sealing the gun barrel with a liquid metal sealer.

7. 发明授权

US09486216B2 Fastener apparatus for tissue and methods of deployment and manufacture 有权
公开(公告)号：US09486216B2
公开(公告)日：2016-11-08
申请号：US11237132
申请日：2005-09-27
申请人： David W. Wright
发明人： David W. Wright
IPC分类号： A61B17/08 , A61B17/072 , A61B17/11 , A61B17/115 , A61B17/00
CPC分类号： A61B17/128 , A61B17/072 , A61B17/11 , A61B17/115 , A61B17/122 , A61B2017/00243 , A61B2017/1107 , A61B2017/1139
摘要： A device for connecting two tubular vessels together in a side-by-side or tangential manner is disclosed. The device has an annulus and at least one series of fingers connected to and extending away from the annulus. In the preferred embodiment there are two sets of fingers connected to and extending away from the annulus in opposite directions. Each finger is preferably biased into an arcuate shape. In use, a deployment apparatus is used to constrain the fingers of the device to be in a relatively planar configuration. The deployment apparatus containing the device is placed between and in contact with the two tubular vessels so that one tubular vessel is above the device and one tubular vessel is below the device and so that the fingers of the device come into contact with the tissue of the vessels. As the fingers penetrate the vessels the constraint on the fingers is removed so that the fingers can assume their biased arcuate shape. In this way, the fingers penetrate and grasp the tissue of the vessels so that the device grasps the vessels and pulls the vessels toward each other.

8. 发明授权

US08805803B2 Index extraction from documents 有权
标题翻译：从文件索引提取
公开(公告)号：US08805803B2
公开(公告)日：2014-08-12
申请号：US10916877
申请日：2004-08-12
申请人： Steven J. Simske , David W. Wright
发明人： Steven J. Simske , David W. Wright
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30613 , G06F17/30705
摘要： Systems, methods, and programs embodied in a computer readable medium are provided for index extraction. Stored in a database are ground truth documents that are organized according to a plurality of classifications, each classification having a group of predefined indices. A document to be indexed is classified by drawing an association between the document and one of the classifications. An attempt is made to extract from the document at least a subset of the group of predefined indices associated with the one of the classifications. Upon a failure to extract the subset of the group of predefined indices, attempts are made to find and correct at least one text recognition error in the document based upon a salient dictionary associated with the one of the classifications.
摘要翻译：提供体现在计算机可读介质中的系统，方法和程序用于索引提取。存储在数据库中的是根据多个分类组织的地面真实文档，每个分类具有一组预定义的索引。要索引的文档通过绘制文档和其中一个分类之间的关联来分类。尝试从文档中提取与该分类之一相关联的预定义索引组的至少一个子集。当未能提取预定义索引组的子集时，尝试基于与所述分类之一相关联的显着词典尝试在文档中查找和校正至少一个文本识别错误。

9. 发明授权

US08568311B2 Display enhanced testing for concussions and mild traumatic brain injury 有权
标题翻译：显示脑震荡和轻度创伤性脑损伤的增强测试
公开(公告)号：US08568311B2
公开(公告)日：2013-10-29
申请号：US11503579
申请日：2006-08-10
申请人： Michelle C. LaPlaca , David W. Wright
发明人： Michelle C. LaPlaca , David W. Wright
IPC分类号： G09B19/00 , A61B5/16 , G06Q50/22
CPC分类号： A61B5/16 , A61B5/4076 , A61B5/4088 , A61B5/6814 , G09B7/00
摘要： Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list learning and recall, along with variations of these tasks. Immersive and non-immersive systems and methods are disclosed. Testing and results feedback using the present invention may be completed in real time, typically in less than 15 minutes.
摘要翻译：认知评估系统和方法为评估认知障碍的存在或不存在提供综合解决方案。本发明用于测试个体的认知功能，包括信息处理速度，工作记忆，工作列表学习和召回，以及这些任务的变化。公开了沉浸式和非沉浸式的系统和方法。使用本发明的测试和结果反馈可以实时完成，通常在不到15分钟内完成。

10. 发明授权

US08382785B2 Apparatus and method for performing cystotomy procedures 有权
标题翻译：用于执行膀胱切开术的装置和方法
公开(公告)号：US08382785B2
公开(公告)日：2013-02-26
申请号：US12790313
申请日：2010-05-28
申请人： Ronald E. Zook , Laurence K. Sampson , Timothy E. Braun , Kenneth A. High , Steve W. Jackinsky , Pete W. Kroehl , Davey B. Palmer , David W. Wright , Paul P. Burek
发明人： Ronald E. Zook , Laurence K. Sampson , Timothy E. Braun , Kenneth A. High , Steve W. Jackinsky , Pete W. Kroehl , Davey B. Palmer , David W. Wright , Paul P. Burek
IPC分类号： A61B17/34 , A61B17/32 , A61M29/00
CPC分类号： A61M29/00 , A61B17/3403 , A61B17/3415 , A61B17/3462 , A61B2017/00278 , A61B2017/00473 , A61B2017/00477 , A61B2017/3484 , A61B2090/062
摘要： A cystotomy apparatus includes a sound from which an advancement device having a cutting tip creates a surgical pathway from the bladder through abdominal tissue to the external abdomen along a predetermined path. The cutting tip is captured and removed from the advancement device in a capture cup located in the predetermined path by an alignment structure. The cutting tip is removed from the advancement device while within the capture cup, to allow a dilator, cannula or catheter to be drawn through the surgical pathway into the bladder.
摘要翻译：囊状切开装置包括声音，具有切割尖端的前进装置从该声音沿着预定路径产生从膀胱通过腹部组织到外部腹部的外科路径。通过对准结构，在位于预定路径中的捕获杯中从切割装置捕获并移除切割尖端。切割尖端在推进装置的同时在捕获杯内被移除，以允许扩张器，插管或导管通过手术通道进入膀胱。

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