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1. 发明申请

US20080207921A1 Organic Compounds 失效
标题翻译：有机化合物
公开(公告)号：US20080207921A1
公开(公告)日：2008-08-28
申请号：US11916875
申请日：2006-06-06
申请人： Stuart John Mickel , Gottfried Sedelmeier , Hans Hirt , Frank Schafer , Michael Foulkes , Walter Prikoszovich
发明人： Stuart John Mickel , Gottfried Sedelmeier , Hans Hirt , Frank Schafer , Michael Foulkes , Walter Prikoszovich
IPC分类号： C07D207/06
CPC分类号： C07D405/04 , C07C237/22 , C07D207/08 , C07D307/32 , C07D307/33 , Y02P20/55
摘要： The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof, said manufacture comprising (preferably consisting in) reacting a compound of the formula I,
摘要翻译：本发明涉及可用于合成药物活性化合物，特别是肾素抑制剂如阿利吉仑的新方法，新工艺步骤和新型中间体。特别地，本发明涉及制备式III化合物的方法，其中R 1，R 2，R 2，R 3， SUB>和PG如说明书中所定义，或其盐，所述制备包含（优选地）使式I化合物，

2. 发明申请

US20060199854A1 Process for the preparation of n-substituted 2-cyanopyrrolidines 失效
标题翻译： N-取代的2-氰基吡咯烷的制备方法
公开(公告)号：US20060199854A1
公开(公告)日：2006-09-07
申请号：US10552835
申请日：2004-04-15
申请人： Frank Schafer , Gottfried Sedelmeier
发明人： Frank Schafer , Gottfried Sedelmeier
IPC分类号： A61K31/401 , C07D207/277
CPC分类号： C07D207/16
摘要： The present invention relates to a process for the preparation of a N—(N′-substituted glycyl)-2-cyanopyrrolidine comprising at least (a) reacting, in the presence of dimethylformamide, a compound of formula (V) wherein, independently of each other, X1 and X3 are halogen; X2 is halogen, OH, O—C(═O)—CH2X3, —O—SO2—(C1-8)alkyl or —O—SO2-(aryl), with L-prolinamide, followed by (b) reacting the resultant compound without isolation with a dehydration agent, optionally followed by (c) reacting, in the presence of a base, the resultant compound without isolation with an appropriate amine and (d) recovering the resultant cornpound in free form or in acid addition salt form.
摘要翻译：本发明涉及一种制备N-（N'取代的甘氨酰基）-2-氰基吡咯烷的方法，该方法至少包括（a）在二甲基甲酰胺存在下使式（Ⅴ）化合物与彼此之间，X 1和X 3是卤素; X 2是卤素，OH，OC（-O）-CH 2 X 3，-O-SO 2

3. 发明申请

US20090069526A1 THERMOPLASTIC POLYURETHANES 有权
公开(公告)号：US20090069526A1
公开(公告)日：2009-03-12
申请号：US12293103
申请日：2007-04-11
申请人： Oliver Steffen Henze , Rudiger Krech , Frank Prissok , Karin Scheffer , Frank Schafer , Heinrich Niermann
发明人： Oliver Steffen Henze , Rudiger Krech , Frank Prissok , Karin Scheffer , Frank Schafer , Heinrich Niermann
IPC分类号： C08G18/32 , B29C45/00
CPC分类号： A43B1/14 , A43B5/04 , C08G18/4854 , C08G18/6674 , C08G2120/00
摘要： A process for the preparation of thermoplastic polyurethane by reacting (a) isocyanates with (b) compounds reactive toward isocyanates and having a molecular weight (Mw) of from 500 to 10 000 g/mol and (c) chain extenders having a molecular weight of from 50 to 499 g/mol, if appropriate in the presence of (d) catalysts and/or (e) conventional additives, wherein the chain extender mixture consisting of a main chain extender (c1) and one or more co-chain extenders (c2) is used and the thermoplastic polyurethane prepared has a rigid phase fraction of greater than 0.40, the rigid phase fraction being defined by the following formula: rigid   phase   fraction = { ∑ x = 1 k  [ ( m KVx / M KVx ) * M Iso + m KVx ] } / m ges with the following meanings: MKVx: molar mass of the chain extender x in g/mol mKVx: mass of the chain extender x in g MIso: molar mass of the isocyanate used in g/mol mges: total mass of all starting materials in g k: number of chain extenders.

4. 发明授权

US6078049A Stable isotope analyzer 失效
标题翻译：稳定同位素分析仪
公开(公告)号：US6078049A
公开(公告)日：2000-06-20
申请号：US51811
申请日：1998-08-24
申请人： Frank Schafer , Stefan Meier
发明人： Frank Schafer , Stefan Meier
IPC分类号： G01N33/497 , G01N21/3504 , G01N21/37 , G01N21/31
CPC分类号： G01N21/274 , G01N21/3504 , G01N21/37
摘要： A stable isotope analyzer is concentration calibrated by measuring relative proportions of isotopes in a measurement gas. The measurement gas is a component of a gaseous mixture consisting of the measurement gas and one other gas or a mixture of gases containing none of the measurement gas. First, a mixture is produced with a relatively high concentration of the measurement gas and known isotope proportions. The concentration of the measurement gas in the other gas is determined and the isotope proportion is measured to determine a point on a calibration curve (measured isotope proportion values vs. measured concentration values). At least one further point on the calibration curve is determined by diluting the measurement gas in the mixture by introducing a gas or gaseous mixture containing no measurement gas. The reduced concentration is determined and the isotope proportion measured to determine another point on the calibration curve. The steps of reducing the measurement gas concentration in the gaseous mixture, measuring the measurement gas concentration, and measuring the isotope proportion are preferably repeated a plurality of times to plot the calibration curve more accurately.
摘要翻译： PCT No.PCT / EP96 / 04384 Sec。 371日期：1998年8月24日 102（e）1998年8月24日PCT PCT 1996年10月9日PCT公布。第WO97 / 14952号公报日期1997年4月24日稳定同位素分析仪通过测量测量气体中同位素的相对比例进行浓度校准。测量气体是由测量气体和另一种气体组成的气体混合物的组分或不含测量气体的气体混合物。首先，产生具有较高浓度的测量气体和已知同位素比例的混合物。确定其他气体中测量气体的浓度，并测量同位素比例以确定校准曲线上的点（测量的同位素比值与测量的浓度值）。通过引入不含测量气体的气体或气体混合物来稀释混合物中的测量气体来确定校准曲线上的至少一个点。确定降低的浓度并测量同位素比例以确定校准曲线上的另一个点。优选重复多次重复减少气体混合物中的测量气体浓度，测量测量气体浓度和测量同位素比例的步骤以更准确地绘制校准曲线。

5. 发明申请

US20070161744A1 (Meth) acrylate sirup as a suspension stabilisator for colourants 审中-公开
标题翻译：（甲基）丙烯酸酯sirup作为着色剂的悬浮稳定剂
公开(公告)号：US20070161744A1
公开(公告)日：2007-07-12
申请号：US10589270
申请日：2005-01-14
申请人： Klaus Kabs , Frank Schafer , Hans Lichtenstein , Bernd Klossek
发明人： Klaus Kabs , Frank Schafer , Hans Lichtenstein , Bernd Klossek
IPC分类号： C08L31/00
CPC分类号： C09B67/0013 , C08F220/00 , C08J3/226 , C08J2433/00 , C09B67/0063 , C09B67/009
摘要： The invention relates to a polymer solvent binding agent for pigments based on methylmethacrylate. The binding agent is a polymer made of methylmethacrylate and one or several additional radical polymerisierable compounds and is used in the form of a partially polymerised sirup.
摘要翻译：本发明涉及一种基于甲基丙烯酸甲酯的颜料聚合物溶剂结合剂。结合剂是由甲基丙烯酸甲酯和一种或几种另外的自由基聚合物可固化化合物制成的聚合物，并以部分聚合的聚合物形式使用。

6. 发明申请

US20080093694A1 Method for manufacturing a semcoductor component and a semiconductor component, in particular a diaphragm sensor 有权
标题翻译：用于制造半导体元件和半导体元件的方法，特别是光阑传感器
公开(公告)号：US20080093694A1
公开(公告)日：2008-04-24
申请号：US12001289
申请日：2007-12-10
申请人： Hubert Benzel , Heribert Weber , Hans Artmann , Thorsten Pannek , Frank Schafer
发明人： Hubert Benzel , Heribert Weber , Hans Artmann , Thorsten Pannek , Frank Schafer
IPC分类号： H01L29/02 , H01L21/02
CPC分类号： B81C1/00182 , B81B2203/0127 , B81B2203/0315 , B81C2201/0115 , B81C2201/0136 , G01L9/0042
摘要： In a method for manufacturing a semiconductor component having a semiconductor substrate, a flat, porous diaphragm layer and a cavity underneath the porous diaphragm layer are produced to form unsupported structures for a component. In a first approach, the semiconductor substrate may receive a doping in the diaphragm region that is different from that of the cavity. This permits different pore sizes and/or porosities to be produced, which is used in producing the cavity for improved etching gas transport. Also, mesopores may be produced in the diaphragm region and nanopores may be produced as an auxiliary structure in what is to become the cavity region.
摘要翻译：在制造具有半导体衬底的半导体部件的方法中，制造平坦的多孔隔膜层和多孔隔膜层下方的空腔，以形成用于部件的无支撑结构。在第一种方法中，半导体衬底可以在膜片区域中接收不同于空腔的掺杂。这允许产生不同的孔径和/或孔隙率，其用于制造用于改善蚀刻气体输送的空腔。此外，可以在隔膜区域中产生中孔，并且可以在将要成为空腔区域的地方制造纳米孔作为辅助结构。

7. 发明申请

US20050226217A1 Data sink/data source, data transmission device and data terminal device for a circuit-switched and packet-switched network 有权
标题翻译：用于电路交换和分组交换网络的数据宿/数据源，数据传输设备和数据终端设备
公开(公告)号：US20050226217A1
公开(公告)日：2005-10-13
申请号：US10514226
申请日：2004-02-26
申请人： Gunter Logemann , Hasan Palandoken , Frank Schafer
发明人： Gunter Logemann , Hasan Palandoken , Frank Schafer
IPC分类号： H04L5/00 , H04L12/00 , H04L12/28 , H04L12/54 , H04L12/64 , H04M7/00
CPC分类号： H04L12/6418 , H04L12/5692 , H04L2012/6472 , H04L2012/6475 , H04M7/0057 , H04M2207/206
摘要： The present invention is directed toward, a data sink/data source data transmission device and data terminal device for a circuit-switched and packet-switched network, the ability to eliminate the logical separation between applications, which are based on the circuit-switched network (e.g., PSTN, ISDN), and applications, which are based on the packet-switched network, (e.g., Internet). To this end, a data transmission device for transmitting and receiving data into/from the circuit-switched network includes controllable switchover parts. This data transmission device is or can be assigned to a universally useable unit for automatically processing data and for transmitting and receiving data to/from the packet-switched network and is assigned or can be assigned to the at least one data terminal device for transmitting and receiving data into/from the circuit-switched network. The switch-over parts can be controlled in such a manner that the data terminal device which, in a first operating mode is connected to the circuit-switched device, can be switched from the first operating mode into a second operating mode, during which the data terminal device is connected to the packet-switched network via the data transmission device and the data processing device, and from the second operating mode into the first operating mode.
摘要翻译：本发明涉及用于电路交换和分组交换网络的数据宿/数据源数据传输设备和数据终端设备，消除基于电路交换网络的应用之间的逻辑分离的能力（例如，PSTN，ISDN）和基于分组交换网络（例如，因特网）的应用。为此，用于向/从电路交换网络发送和接收数据的数据传输装置包括可控切换部分。该数据传输设备是或可以被分配给通用的单元，用于自动处理数据以及从分组交换网络发送和接收数据，并被分配或者可以被分配给至少一个数据终端设备进行传输和从电路交换网络接收数据。可以以使第一操作模式中连接到电路交换设备的数据终端设备从第一操作模式切换到第二操作模式的方式来控制切换部分，在此期间，数据终端设备经由数据传输设备和数据处理设备连接到分组交换网络，并从第二操作模式连接到第一操作模式。

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