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1. 发明授权

US06996951B2 Flexible multi-compartment container with peelable seals and method for making same 失效
公开(公告)号：US06996951B2
公开(公告)日：2006-02-14
申请号：US10664643
申请日：2003-09-17
申请人： Steven L. Smith , Ward Barney , Noel Gharbian , Douglas G. Harvey , Mark R. Mclonis , Christopher D. Peara , Scott L. Pool , Giuseppe Sacca , Thomas R. Sakaguchi , Sharilyn J. Sandberg , William V. Walter , Nicholas Chung-Hui Wu , Walter A. York , H. Theodore Young , William A. Sperko , Robert E. Turner , William B. Ray
发明人： Steven L. Smith , Ward Barney , Noel Gharbian , Douglas G. Harvey , Mark R. Mclonis , Christopher D. Peara , Scott L. Pool , Giuseppe Sacca , Thomas R. Sakaguchi , Sharilyn J. Sandberg , William V. Walter , Nicholas Chung-Hui Wu , Walter A. York , H. Theodore Young , William A. Sperko , Robert E. Turner , William B. Ray
IPC分类号： B65B55/02
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1475 , A61J1/2024 , A61M2207/00 , B29C49/0005 , B29C49/0047 , B29C65/02 , B29C65/08 , B29C65/18 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/133 , B29C66/242 , B29C66/53262 , B29C66/71 , B29C66/72321 , B29C66/72341 , B29K2705/02 , B29L2009/00 , B29L2031/7148 , B31B2241/00 , B32B27/08 , B65D75/5861 , B65D81/3266 , C08L23/0815 , C08L23/16 , C08L53/00 , C08L53/02 , C08L53/025 , C08L2666/06 , C08L2666/04 , C08L2666/24 , C08L2666/02 , B29C65/00 , B29K2025/08 , B29K2023/16 , B29K2021/003 , B29K2009/06
摘要： A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient.

2. 发明授权

US5910138A Flexible medical container with selectively enlargeable compartments and method for making same 失效
公开(公告)号：US5910138A
公开(公告)日：1999-06-08
申请号：US967692
申请日：1997-11-12
申请人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
发明人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
IPC分类号： A61J1/05 , A61J1/00 , A61J1/10 , A61J1/20 , B29C49/00 , B29C65/02 , B31B3/00 , B31B41/00 , B32B27/08 , B65D33/38 , B65D75/58 , B65D81/32 , C08L23/08 , C08L23/16 , C08L53/00 , C08L53/02 , A61B19/00
CPC分类号： A61J1/2093 , A61J1/10 , B29C49/0005 , B29C49/0047 , B29C65/02 , B29C65/18 , B29C66/53262 , B31B1/00 , B31B41/00 , B32B27/08 , B65D81/3266 , C08L23/0815 , C08L23/16 , C08L53/025 , A61J1/1475 , A61J1/2024 , A61M2207/00 , B29C65/08 , B29C66/71 , B29K2705/02 , B29L2009/00 , B29L2031/7148 , B31B2241/00 , B65D75/5861 , C08L53/00 , C08L53/02
摘要： A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient.

3. 发明授权

US06468377B1 Flexible medical container with selectively enlargeable compartments and method for making same 有权
标题翻译：具有选择性扩大隔间的灵活医疗容器及其制造方法
公开(公告)号：US06468377B1
公开(公告)日：2002-10-22
申请号：US09247997
申请日：1999-02-10
申请人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
发明人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
IPC分类号： B32B3100
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1475 , A61J1/16 , A61J1/2024 , A61M2207/00 , B29C49/0005 , B29C49/0047 , B29C65/02 , B29C65/18 , B29C65/76 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/133 , B29C66/242 , B29C66/53262 , B29C66/71 , B29C66/72321 , B29C66/7234 , B29C66/72341 , B29C66/72343 , B29C66/80 , B29C66/8322 , B29C2793/0027 , B29C2793/009 , B29K2023/06 , B29K2023/0641 , B29K2023/083 , B29K2023/086 , B29K2023/12 , B29K2101/12 , B29K2105/0085 , B29K2105/0088 , B29K2305/02 , B29K2705/02 , B29L2009/00 , B29L2009/003 , B29L2031/7148 , B31B70/844 , B31B2155/00 , B31B2170/20 , B31B2241/00 , B32B15/08 , B32B27/08 , B32B27/32 , B65B55/16 , B65D75/5861 , B65D81/3266 , C08L23/0815 , C08L23/142 , C08L23/16 , C08L53/00 , C08L53/02 , C08L53/025 , C08L2666/06 , C08L2666/24 , C08L2666/04 , C08L2666/02 , B29C65/00 , B29K2067/003 , B29K2067/00 , B29K2027/12 , B29K2027/08 , B29K2025/08 , B29K2023/10 , B29K2023/08 , B29K2023/065 , B29K2009/06
摘要： A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient.
摘要翻译：提供了一种用于医疗解决方案的存储和管理的柔性容器。容器包含由聚合物的平面层和相对的后片制成的透明前片。后片由平面层压层制成。前后片沿着共同的外围边缘密封在一起以形成体积的外壳。体积外壳由具有高氧气和湿气阻隔性能的材料构成，其允许容器热塑性塑料长时间储存，而不会降低内容物。然后用加压气体使体积外壳膨胀，以使前后片材向外伸展，从而增加容器的容积。容器的替代实施例包含由可剥离密封件分隔的多个隔室，用于容纳稀释剂和药物。密封件通过操纵容器而破裂，从而将内容物混合在一起，以通过标准的IV装置输送到患者身上。

4. 发明授权

US06764567B2 Flexible medical container with selectively enlargeable compartments and method for making same 有权
标题翻译：具有选择性扩大隔间的灵活医疗容器及其制造方法
公开(公告)号：US06764567B2
公开(公告)日：2004-07-20
申请号：US10233213
申请日：2002-08-28
申请人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
发明人： William A. Sperko , Robert E. Turner , Steven L. Smith , William B. Ray
IPC分类号： B32B3100
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1475 , A61J1/2024 , A61M2207/00 , B29C49/0005 , B29C49/0047 , B29C65/02 , B29C65/08 , B29C65/18 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/133 , B29C66/242 , B29C66/53262 , B29C66/71 , B29C66/72321 , B29C66/72341 , B29K2705/02 , B29L2009/00 , B29L2031/7148 , B31B2241/00 , B32B27/08 , B65D75/5861 , B65D81/3266 , C08L23/0815 , C08L23/16 , C08L53/00 , C08L53/02 , C08L53/025 , C08L2666/06 , C08L2666/04 , C08L2666/24 , C08L2666/02 , B29C65/00 , B29K2025/08 , B29K2023/16 , B29K2021/003 , B29K2009/06
摘要： A flexible container is provided for the storage and administration of medical solutions. The container incorporates a transparent front sheet made from a planar layer of a polymer and an opposing rear sheet. The rear sheet is made from a planar laminate layer. The front and rear sheets are sealed together along a common peripheral edge to form a volume enclosure. The volume enclosure is constructed of materials having high oxygen and moisture barrier properties which allows the container thermoplastic to be stored for extended periods of time without degrading the contents. The volume enclosure is then inflated with a pressurized gas to permanently stretch the front and rear sheets outwardly and to thereby increase the volume capacity of the container. An alternative embodiment of the container incorporates multiple compartments, separated by peelable seals, for containing a diluent and a medicament. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient.
摘要翻译：提供了一种用于医疗解决方案的存储和管理的柔性容器。容器包含由聚合物的平面层和相对的后片制成的透明前片。后片由平面层压层制成。前后片沿着共同的外围边缘密封在一起以形成体积的外壳。体积外壳由具有高氧气和湿气阻隔性能的材料构成，其允许容器热塑性塑料长时间储存，而不会降低内容物。然后用加压气体使体积外壳膨胀，以使前后片材向外伸展，从而增加容器的容积。容器的替代实施例包含由可剥离密封件分隔的多个隔室，用于容纳稀释剂和药物。密封件通过操纵容器而破裂，从而将内容物混合在一起，以通过标准的IV装置输送到患者身上。

5. 发明授权

US4223278A High energy, rapid discharge device for the excitation of gas discharge lasers 失效
标题翻译：高能量，快速放电装置用于气体放电激光器的激发
公开(公告)号：US4223278A
公开(公告)日：1980-09-16
申请号：US764479
申请日：1977-01-31
申请人： Steven D. Colson , Paul C. Engelking , Robert E. Turner
发明人： Steven D. Colson , Paul C. Engelking , Robert E. Turner
IPC分类号： H01S3/0973 , H01S3/09
CPC分类号： H01S3/0973
摘要： A new method and apparatus for storing and delivering the electrical energy used to drive high powered, gas discharge laser devices which require transverse electrical excitation utilizes high voltage commercial storage capacitors and the optimum electrical characteristics and cost advantages of planar electrical transmission lines.
摘要翻译：用于存储和传送用于驱动需要横向电激励的大功率气体放电激光器件的电能的新方法和装置利用高压商业存储电容器以及平面电传输线路的最佳电特性和成本优点。

6. 发明授权

US5540913A Formulations and uses thereof in the prevention and treatment of oral lesions 失效
标题翻译：预防和治疗口腔损伤的制剂及其用途
公开(公告)号：US5540913A
公开(公告)日：1996-07-30
申请号：US233918
申请日：1994-04-26
申请人： Robert E. Turner
发明人： Robert E. Turner
IPC分类号： A61K8/19 , A61K8/22 , A61K33/40 , A61Q11/00 , A61K7/16 , A61K7/20 , A61K33/10
CPC分类号： A61K8/19 , A61K33/40 , A61K8/22 , A61Q11/00 , Y10S514/901 , Y10S514/902 , Y10S514/906
摘要： The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.
摘要翻译：本发明提供了适于预防和治疗口腔损伤的溶液，片剂和凝胶形式的组合物。该组合物适合用作口腔冲洗液，并且包含水，制剂混合物中预混水溶液中的过氧化物（优选过氧化氢），约0.1％至约0.4％的碳酸氢盐（优选碳酸氢钠）。为了制备适于预防和治疗口腔损伤的组合物，最优选包括将过氧化物和碳酸氢盐溶解在水溶液中以产生预混合的制剂。此外，本发明包括预防和治疗入选使用化学治疗剂的口腔损伤的方法。

7. 发明授权

US5162658A Thermal detection arrangement having a plurality of optical filter devices 失效
标题翻译：具有大量光学滤波器件的热检测装置
公开(公告)号：US5162658A
公开(公告)日：1992-11-10
申请号：US688175
申请日：1991-04-22
申请人： Robert E. Turner , Richard A. Ford
发明人： Robert E. Turner , Richard A. Ford
IPC分类号： G01J5/02 , G01J5/08 , G01J5/12 , G01J5/14 , G01J5/60 , G01N21/35 , G08B17/12
CPC分类号： G01J5/12 , G01J5/08 , G01J5/0862 , G01J5/602 , G08B17/12 , G01J5/026
摘要： A thermal detector arrangement includes a number of channels, each including a collimator for collimating incident radiation to a respective optical filter. Each optical filter has a respective radiation passband characteristic with one having a passband spanning the passbands of all of the other optical filters. The radiation passed by each optical filter is passed to a thermal detector, which preferably is in the form of a thermally isolating membrane acting as a radiation absorbent cavity and supported by a semiconductor substrate. The output signals from the thermal detectors are multiplexed, amplified by an amplifier having voltage offset compensation and digitally processed to provide an indication of a fire to be sensed.

8. 发明授权

US4723254A Recycling apparatus for an excimer laser 失效
标题翻译：准分子激光的回收设备
公开(公告)号：US4723254A
公开(公告)日：1988-02-02
申请号：US736870
申请日：1985-05-22
申请人： Robert E. Turner
发明人： Robert E. Turner
IPC分类号： H01S3/036 , H01S3/225 , H01S3/22
CPC分类号： H01S3/036 , H01S3/225
摘要： For an excimer laser system utilizing in a laser chamber a lasing material and a mixture of a diluent rare gas and a heavy rare gas and halogen rare gas in given percentages, there is disclosed a method and apparatus for reducing the expenditure of the rare gases by continuously evacuating the laser mixture from the laser chamber removing from the evacuated laser mixture any gaseous impurities to provide a cleaned laser mixture and thereafter feeding the cleaned laser mixture back into the laser chamber. Along with the cleaned laser mixture there is fed in a supplemental halogen gas. The gaseous impurities along with the halogen are removed by passing the gas through an elongated tube having calcium particles therein with a void fraction for a given length of tube in the range 0.30 to 0.60. Some of the ratio is obtained by providing alternate layers of calcium particles and inert, refractory spacers, such as stainless steel wool.
摘要翻译：对于在激光室中以给定百分比在激光室中使用激光材料和稀有稀有气体和重稀有气体和卤素稀有气体的混合物的准分子激光系统，公开了一种通过以下方式减少稀有气体的消耗的方法和装置：从激光室连续排出激光混合物，从真空的激光混合物中除去任何气态杂质，以提供清洁的激光混合物，然后将清洁的激光混合物送回激光室。随着清洁的激光混合物，补充卤素气体。通过使气体通过其中具有钙颗粒的细长管，其中具有给定长度的管的空隙率在0.30至0.60的范围内来除去气态杂质以及卤素。一些比例是通过提供交替的钙颗粒层和惰性的耐火间隔物，例如不锈钢羊毛来获得的。

9. 发明授权

US5306509A Prevention and treatment of oral lesions 失效
标题翻译：预防和治疗口腔病变
公开(公告)号：US5306509A
公开(公告)日：1994-04-26
申请号：US423500
申请日：1989-10-12
申请人： Robert E. Turner
发明人： Robert E. Turner
IPC分类号： A61K8/19 , A61K8/22 , A61K33/40 , A61Q11/00 , A61K33/00
CPC分类号： A61K8/19 , A61K33/40 , A61K8/22 , A61Q11/00
摘要： The present invention involves a preparation adapted for prophylaxis and treatment of oral lesions, The preparation comprises water, between about 0.1% and about 0.8% hydrogen peroxide and between about 0.1% and about 0.4% sodium bicarbonate. In more preferable embodiments of the present invention, the hydrogen peroxide is about 0.4% and the sodium bicarbonate is about 0.2%.Additionally, a method for prophylaxis and treatment of oral lesions is included in the present invention. This method involves the step of initially providing a preparation preferably comprising water, between about 0.1% and about 0.8% hydrogen peroxide and between about 0.1% and about 0.4% sodium bicarbonate. Oral rinsing with said preparation, particularly multiple daily oral rinsing, enhances healing of oral lesions and impedes or prevents the development of oral lesions such as, for example, those frequently incident to cancer chemotherapy.SOL also appears to be dental plaque retardant. The clinical crowns of the patients teeth appear to be free of debris during the periods of significant myelosuppression when dental flossing and toothbrushing should not and were not performed.
摘要翻译：本发明涉及适于预防和治疗口腔损伤的制剂。该制剂包含水，约0.1％至约0.8％过氧化氢和约0.1％至约0.4％碳酸氢钠。在本发明的更优选实施方案中，过氧化氢为约0.4％，碳酸氢钠为约0.2％。此外，本发明包括预防和治疗口腔损伤的方法。该方法包括首先提供优选包含约0.1％至约0.8％过氧化氢和约0.1％至约0.4％碳酸氢钠之间的水的制剂的步骤。用所述制剂进行口腔清洗，特别是多次每日口服清洗，可增强口腔损伤的愈合，并阻止或阻止口腔损伤的发展，例如经常发生癌症化学疗法的口腔损伤。 SOL也似乎是牙菌斑阻滞剂。患牙齿的临床牙冠在牙髓损伤和牙刷不应该被执行时，在显着的骨髓抑制期间似乎没有碎屑。

10. 发明授权

US5906810A Formulations and uses thereof in the prevention and treatment of oral lesions 失效
公开(公告)号：US5906810A
公开(公告)日：1999-05-25
申请号：US688610
申请日：1996-07-30
申请人： Robert E. Turner
发明人： Robert E. Turner
IPC分类号： A61K8/19 , A61K8/22 , A61K33/40 , A61Q11/00 , A61K7/16 , A61K7/20 , A61K33/10
CPC分类号： A61Q11/00 , A61K33/40 , A61K8/19 , A61K8/22
摘要： The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. In preferred embodiments, the aqueous solution has between about 0.01% and about 0.8% hydrogen or benzoyl peroxide and between about 0.01% and about 0.4% sodium bicarbonate. In more preferable embodiments of the present invention, the oral lavage (formulation) includes hydrogen peroxide at a concentration of about 0.4% and sodium bicarbonate at a concentration of about 0.2%. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention. This method involves the step of initially providing a premixed preparation comprising water, between about 0.01% and about 0.08% of a peroxide (preferably hydrogen peroxide) and between about 0.01% and about 0.4% bicarbonate (preferably sodium bicarbonate). Oral rinsing with said preparation, particularly multiple daily oral rinsing, is shown to enhance healing of oral lesions and impedes or prevents the development of oral lesions, particularly those oral lesions incident to cancer chemotherapy. SOL may also be used as a dental plaque retardant. The preparation may also serve to maintain the clinical crowns of patients' teeth free of debris during periods of significant myelosuppression, when dental flossing and tooth brushing is not feasible.

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