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1. 发明申请

US20090264445A1 PYRROLIDINONE GLUCOKINASE ACTIVATORS 有权
标题翻译：吡咯烷酮GLUCOKINASE激活剂
公开(公告)号：US20090264445A1
公开(公告)日：2009-10-22
申请号：US12400065
申请日：2009-03-09
申请人： Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号： A61K31/497 , C07D403/12 , A61K31/4155
CPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

2. 发明申请

US20120328565A1 ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：有害化合物
公开(公告)号：US20120328565A1
公开(公告)日：2012-12-27
申请号：US13528920
申请日：2012-06-21
申请人： John A. Brinkman , Andrew F. Donnell , Robert Francis Kester , Yimin Qian , Ramakanth Sarabu , Sung-Sau So
发明人： John A. Brinkman , Andrew F. Donnell , Robert Francis Kester , Yimin Qian , Ramakanth Sarabu , Sung-Sau So
IPC分类号： A61K31/4178 , C07D417/14 , C07D401/14 , C07D487/04 , C12N5/071 , A61K31/4439 , A61K31/551 , A61K38/21 , A61P31/14 , C07D403/14 , A61K31/428
CPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , C07D417/14
摘要： The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the treatment of HCV infection.
摘要翻译：本发明公开了式I的化合物，其中式I中的变量如本文所述定义。还公开了含有这些化合物的药物组合物和使用式I化合物治疗HCV感染的方法。

3. 发明授权

US07947692B2 Substituted thiazolo[5,4-d]pyrimidine urea derivatives 有权
标题翻译：取代的噻唑并[5,4-d]嘧啶脲衍生物
公开(公告)号：US07947692B2
公开(公告)日：2011-05-24
申请号：US11801972
申请日：2007-05-11
申请人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
发明人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
IPC分类号： C07D487/04 , C07D513/04 , A61K31/519 , A61P3/10 , A61P11/06 , A61K31/4353 , A61K31/496 , A61K31/5355 , A61K31/45
CPC分类号： C07D513/04 , C07D521/00
摘要： There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
摘要翻译：呈现下式的化合物或其药学上可接受的盐，它们是活性腺苷A2B受体拮抗剂，可用于治疗糖尿病，糖尿病性视网膜病变，哮喘和腹泻。

4. 发明申请

US20070270433A1 Thiazolo-pyrimidine/pyridine urea derivatives 有权
标题翻译：噻唑并嘧啶/吡啶脲衍生物
公开(公告)号：US20070270433A1
公开(公告)日：2007-11-22
申请号：US11801972
申请日：2007-05-11
申请人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
发明人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
IPC分类号： A61K31/519 , A61K31/496 , C07D498/02
CPC分类号： C07D513/04 , C07D521/00
摘要： There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
摘要翻译：呈现下式的化合物或其药学上可接受的盐，它们是活性腺苷A2B受体拮抗剂，可用于治疗糖尿病，糖尿病性视网膜病变，哮喘和腹泻。

5. 发明申请

US20120230951A1 ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：有害化合物
公开(公告)号：US20120230951A1
公开(公告)日：2012-09-13
申请号：US13414854
申请日：2012-03-08
申请人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
发明人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
IPC分类号： A61K31/55 , A61P37/02 , A61P31/14 , A61K38/21 , C07D487/06 , A61K31/551
CPC分类号： C07D487/06 , A61K31/55 , A61K31/551 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译：本发明提供用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

6. 发明授权

US5375528A Container for a large spherical explosive charge 失效
标题翻译：集装箱用于大型球形炸药
公开(公告)号：US5375528A
公开(公告)日：1994-12-27
申请号：US19371
申请日：1993-02-18
申请人： John A. Brinkman , Leon Shenfil , Donald N. Thatcher
发明人： John A. Brinkman , Leon Shenfil , Donald N. Thatcher
IPC分类号： F42B3/00
CPC分类号： F42B3/00
摘要： A light weight explosive mass for a spherical charge of high explosives used to simulate nuclear bursts at ground or above ground level or underwater wherein the sphericity of the loaded explosive mass must be maintained within tight tolerance, exemplary of which are particulate ammonium nitrate/fuel oil (ANFO) explosive and liquid nitromethane explosive, contained in a flexible fabric shell that becomes spheroidal by reason of being filled with the explosive, is disclosed.
摘要翻译：用于模拟地面或地面以上或水下的核爆炸的高爆炸物的轻质爆炸物质，其中装载的爆炸物质的球形度必须保持在严格的公差范围内，其示例是颗粒状硝酸铵/燃料油（ANFO）爆炸性和液体硝基甲烷爆炸物，包含在由于充满炸药而变成球形的柔性织物外壳中。

7. 发明授权

US4223557A Flowmeter 失效
标题翻译：流量计
公开(公告)号：US4223557A
公开(公告)日：1980-09-23
申请号：US23810
申请日：1979-03-26
申请人： John A. Brinkman
发明人： John A. Brinkman
IPC分类号： G01F1/22 , G01F1/24 , G01F1/36
CPC分类号： G01F1/24 , G01F1/22
摘要： The flowmeter is basically a curved rotameter, having a tapered conduit which is curved in the vertical plane. Inlet and outlet plenum chambers are provided for passing the fluid through the curved rotameter. A ball is positioned within the curved rotameter so that it can move up the conduit under the influence of the stream of fluid. A differential pressure sensor (which may be mounted on a partition separating the plenum chambers) determines the pressure differential between both sides of the ball. This pressure differential is an indication of the rate of flow of fluid through the meter. In a preferred embodiment, two conduits with opposed curves are used to compensate for variations in vertical alignment of the flowmeter.
摘要翻译：流量计基本上是一个弯曲的转子流量计，具有在垂直平面上弯曲的锥形导管。提供入口和出口增压室，用于使流体通过弯曲的转子流量计。一个球定位在弯曲的转子流量计内，使得它可以在流体流的影响下向上移动导管。差压传感器（其可以安装在分隔压力室的隔板上）确定球的两侧之间的压力差。该压力差表示流经仪表的流速。在优选实施例中，使用具有相对曲线的两个管道来补偿流量计的垂直对准的变化。

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