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    • 5. 发明授权
    • Cleaning device
    • US11285502B2
    • 2022-03-29
    • US16879699
    • 2020-05-20
    • Mark Thompson
    • Mark Thompson
    • B05B11/00B08B3/04
    • A cleaning device includes a cartridge assembly, a hose/tubing, a nozzle, and an activator. The cartridge assembly includes at least one cartridge configured to hold a liquid solution. An attachment device is coupled to the cartridge assembly and is configured to secure the position of the cartridge assembly to a user's arm adjacent the hand. A pump is located within the cleaning device and is located between cartridge and the nozzle, such that pump regulates dispensing of the liquid solution. The nozzle is in communication with the pump and acts as a diffuser to adjust the stream of the liquid solution passed through the hose from pump. The activator is in communication with the pump such that operation of the activator selectively releases a volume of the liquid solution from the cartridge so as to pass through the nozzle. A control unit and interface are permitted.
    • 7. 发明授权
    • Methods for cultivating cells, propagating and purifying viruses
    • 培养细胞,增殖和纯化病毒的方法
    • US09085753B2
    • 2015-07-21
    • US13473494
    • 2012-05-16
    • Jonathan LiuMark ThompsonLuis J. MarangaFloro CataniagSimon S. Hsu
    • Jonathan LiuMark ThompsonLuis J. MarangaFloro CataniagSimon S. Hsu
    • C12N7/02A61K39/145
    • C12N7/02A61K39/12A61K39/145C12N7/00C12N2760/16051C12N2760/16134C12N2760/16151C12N2760/16234C12N2760/16251
    • The present invention provides novel serum-free cell culture medium and methods for cultivating MDCK cells. In particular, non-tumorigenic MDCK cells. The present invention also provides methods for producing influenza viruses (e.g., particularly cold-adapted, and/or temperature sensitive, and/or attenuated influenza viruses) that eliminate the need for a cell culture medium exchange step. The novel medium and methods are useful to grow influenza viruses, in cell culture to high titer. The present invention further provides purification methods for purifying influenza viruses with high overall recovery of live virus and result in levels of host cell DNA (HCD), host cell protein (HCP) and non-specific endonuclease (e.g., Benzonase), which are below the specifications required by regulatory agencies. The immunogenic compositions can be used to actively immunize subjects or to generate antibodies for a variety of uses, including passive immunization and diagnostic immunoassays.
    • 本发明提供新型的无血清细胞培养基和培养MDCK细胞的方法。 特别是非致瘤性MDCK细胞。 本发明还提供了消除对细胞培养基交换步骤的需要的用于生产流感病毒(例如,特别冷适应的和/或温度敏感的和/或减毒的流感病毒)的方法。 新型培养基和方法可用于在细胞培养物中高效滴加流感病毒。 本发明还提供了用于纯化具有高活性病毒总体回收率的流感病毒的纯化方法,并导致宿主细胞DNA(HCD),宿主细胞蛋白(HCP)和非特异性内切核酸酶(例如,Benzonase)的水平,其低于 监管机构要求的规格。 免疫原性组合物可用于主动免疫受试者或产生用于多种用途的抗体,包括被动免疫和诊断性免疫测定。
    • 8. 发明申请
    • MULTI-USE TOOL TABLES
    • 多用工具表
    • US20140332657A1
    • 2014-11-13
    • US14444662
    • 2014-07-28
    • Mark Thompson
    • Mark Thompson
    • B25H1/14B25H1/04B25H1/02
    • B25H1/14B25H1/02B25H1/04
    • Multi-use tool tables configured to support table tools and allow selective rotation of the table tools between an upright position and an inverted position are described in the present application. The multi-use tool tables include: one or more rotatable plates having a first surface for receiving a first tool and a second opposing surface for receiving a second tool, a perimeter edge of the one or more rotatable plates being attached to a rotatable shaft; a column with a first attached to a support mechanism and a second attached to a sleeve, the sleeve being configured to receive the rotatable shaft; and a stop mechanism configured to selectively resist movement of the rotatable shaft within the sleeve. The one or more rotatable plates are rotatable between a first surface upright/second surface inverted position and a second surface upright/first surface inverted position.
    • 在本申请中描述了被配置为支撑工作台工具并允许桌子工具在直立位置和倒置位置之间的选择性旋转的多用工具台。 所述多用途工具台包括:一个或多个可旋转板,其具有用于接收第一工具的第一表面和用于接收第二工具的第二相对表面,所述一个或多个可旋转板的周边边缘附接到可旋转轴; 柱,其首先附接到支撑机构,第二连接到套筒,所述套筒构造成容纳所述可旋转轴; 以及停止机构,其构造成选择性地阻止所述可旋转轴在所述套筒内的移动。 一个或多个可旋转板可在第一表面竖立/第二表面倒置位置和第二表面竖立/第一表面倒置位置之间旋转。