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1. 发明申请

US20130189675A1 Assay to Capture and Detect Circulating Multiple Myeloma Cells from Blood 有权
标题翻译：测定从血液中捕获和检测循环多发性骨髓瘤细胞
公开(公告)号：US20130189675A1
公开(公告)日：2013-07-25
申请号：US13554623
申请日：2012-07-20
申请人： Steven Gross , Mark Carle Connelly , Galla Chandra Rao , Marielena Mata , Carrie Morano
发明人： Steven Gross , Mark Carle Connelly , Galla Chandra Rao , Marielena Mata , Carrie Morano
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , B03C1/01 , B03C1/28 , B03C2201/26 , G01N33/57426
摘要： The invention includes methods for isolating circulating multiple myeloma cells as well as method of treating patients suspected of having diseases of abnormal plasma cells.
摘要翻译：本发明包括分离循环多发性骨髓瘤细胞的方法以及治疗怀疑患有异常浆细胞疾病的患者的方法。

2. 发明授权

US09618515B2 Assay to capture and detect circulating multiple myeloma cells from blood 有权
公开(公告)号：US09618515B2
公开(公告)日：2017-04-11
申请号：US13554623
申请日：2012-07-20
申请人： Steven Gross , Mark Carle Connelly , Galla Chandra Rao , Marielena Mata , Carrie Morano
发明人： Steven Gross , Mark Carle Connelly , Galla Chandra Rao , Marielena Mata , Carrie Morano
IPC分类号： G01N33/551 , G01N33/566 , G01N33/574 , B03C1/01 , B03C1/28
CPC分类号： G01N33/57492 , B03C1/01 , B03C1/28 , B03C2201/26 , G01N33/57426
摘要： The invention includes methods for isolating circulating multiple myeloma cells as well as method of treating patients suspected of having diseases of abnormal plasma cells.

3. 发明授权

US07863012B2 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US07863012B2
公开(公告)日：2011-01-04
申请号：US10780399
申请日：2004-02-17
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： A01N1/02 , G01N33/574 , G01N33/553 , G01N33/00
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

4. 发明授权

US08329422B2 Analysis of circulating tumor cells, fragments, and debris 有权
标题翻译：分析循环肿瘤细胞，碎片和碎片
公开(公告)号：US08329422B2
公开(公告)日：2012-12-11
申请号：US12917630
申请日：2010-11-02
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W. M. M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： G01N33/574 , G01N33/553 , G01N1/18
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTER® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CELLSPOTTER®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

5. 发明申请

US20110104718A1 Analysis of Circulating Tumor Cells, Fragments, and Debris 有权
标题翻译：循环肿瘤细胞，片段和碎片的分析
公开(公告)号：US20110104718A1
公开(公告)日：2011-05-05
申请号：US12917630
申请日：2010-11-02
申请人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W.M.M. Terstappen , Shawn Mark O'Hara , Steven Gross
发明人： Galla Chandra Rao , Christopher Larson , Madeline Repollet , Herman Rutner , Leon W.M.M. Terstappen , Shawn Mark O'Hara , Steven Gross
IPC分类号： G01N33/574 , G01N33/566
CPC分类号： G01N33/574 , G01N33/54326 , Y10S436/813 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
摘要翻译：本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。使用许多平台进行分析，包括流式细胞术和CellSpotter®荧光显微镜成像系统。分析损伤的细胞已被证明是重要的。然而，有两个损害来源：体内和体外。体内损伤是通过细胞凋亡，坏死或免疫应答发生的。在样品采集，处理，运输，加工或分析过程中发生体外损伤。因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。还提供了使用这些方法测定生物样品的试剂盒。

6. 发明申请

US20050160531A1 HEAD SUPPORT WITH BED EXTENSION 失效
标题翻译：头部支撑与床扩展
公开(公告)号：US20050160531A1
公开(公告)日：2005-07-28
申请号：US10764671
申请日：2004-01-26
申请人： Steven Gross
发明人： Steven Gross
IPC分类号： A47C20/00 , A47C20/02 , A47C20/08 , A47G9/10 , A61H37/00
CPC分类号： A47C20/026 , A47G9/1054 , A61H37/00
摘要： A first and second substantially crescent shaped rigid support are provided with substantially crescent shaped pads mounted thereon. A strap is mounted at each end of the supports for holding the supports together at a preselected distance. The supports may be used on a flat surface such as a floor or may be mounted on an independently positioned pair of rails for mounting between a mattress and a box spring by means of posts which are removably received in an opening in the crescent shaped supports and adjustably locked in an opening in each rail. The head support may be utilized on a flat surface such as a floor or beach, or as an extension for a bed for use in the giving of massages. The head support of the present invention may be used on a penetrable surface such as a sandy beach with use of the posts.
摘要翻译：第一和第二基本上新月形的刚性支撑件设置有安装在其上的基本上新月形的垫。带子安装在支撑件的每个端部，以预选的距离将支撑件保持在一起。支撑件可以用在诸如地板的平坦表面上，或者可以安装在独立定位的一对轨道上，用于通过可拆卸地容纳在新月形支撑件的开口中的柱子安装在床垫和箱形弹簧之间;以及可调节地锁定在每个轨道的开口中。头部支撑件可以在诸如地板或沙滩的平坦表面上使用，或者用作用于给予按摩的床的延伸部。本发明的头部支撑件可以用在可穿透的表面上，例如使用柱子的沙滩。

7. 发明授权

US5028627A Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor 失效
标题翻译：使用精氨酸衍生物抑制与一氧化氮产生或内皮衍生松弛因子相关的全身性低血压的方法
公开(公告)号：US5028627A
公开(公告)日：1991-07-02
申请号：US406909
申请日：1989-09-13
申请人： Robert G. Kilbourn , Steven Gross , Roberto Levi , Owen W. Griffith
发明人： Robert G. Kilbourn , Steven Gross , Roberto Levi , Owen W. Griffith
IPC分类号： A61K31/00 , A61K31/195 , A61K31/198 , A61K31/223 , A61K38/00 , A61K38/21 , A61K45/00 , A61P9/02 , A61P43/00
CPC分类号： A61K31/00 , A61K31/195 , A61K31/198 , A61K31/223 , Y10S514/93
摘要： A method for prophylaxis of treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide formation from arginine. Preferaby N.sup.G -substituted arginine or an N.sup.G,N.sup.G -disubstituted arginine (having at least one hydrogen on a terminal guanidino amino group replaced by another atomic species) is administered to an animal possibly developing or already having induced systemic hypotension. The arginine derivatives are preferably of the L configuration and include pharmaceutically acceptable addition salts. Prophylaxis or treatment or systemic hypotension in a patient which has been induced by chemotherapeutic treatment with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, i.e., septic shock may also be accomplished by treatment with the arginine derivatives.
摘要翻译：一种用于预防由内部氮氧化物产生引起的全身性低血压的动物治疗的方法。该方法包括施用治疗有效量的某些精氨酸衍生物以抑制由精氨酸形成的氮氧化物。优选NG取代的精氨酸或NG，NG-二取代精氨酸（在由另一种原子物质取代的末端胍基氨基上具有至少一个氢）向可能发展或已经具有诱导的全身性低血压的动物施用。精氨酸衍生物优选为L构型，并且包括药学上可接受的加成盐。可以通过用生物反应调节剂如肿瘤坏死因子或白细胞介素-2进行化学治疗诱导的患者中的预防或治疗或全身性低血压。由内毒素引起的系统性低血压的治疗，即败血性休克也可以通过用精氨酸衍生物进行治疗来实现。

8. 发明申请

US20120291559A1 Integrated Pressure Sensor Seal 有权
标题翻译：集成压力传感器密封
公开(公告)号：US20120291559A1
公开(公告)日：2012-11-22
申请号：US13111362
申请日：2011-05-19
申请人： James William Sterling , Steven Gross
发明人： James William Sterling , Steven Gross
IPC分类号： G01L9/00
CPC分类号： H01L23/057 , B81B7/0058 , B81B2201/0264 , G01L19/0636 , H01L23/04 , H01L2224/48091 , H01L2224/48247 , H01L2924/1461 , H01L2924/00014 , H01L2924/00
摘要： Some embodiments of the present disclosure relate to improved package assemblies for pressure sensing elements. Rather than leaving a pressure sensing element unabashedly exposed to the ambient environment in a manner that makes it susceptible to damage from stray wires, dirt, and the like; the improved package assemblies disclosed herein include a cover that helps form an enclosure around the pressure sensing element. The cover includes a fluid-flow channel with a blocking member arranged therein. The fluid-flow channel puts the pressure sensing element in fluid communication with the external environment so pressure measurements can be taken, while the blocking member helps protect the pressure sensing element from the external environment (e.g., stray wires and dirt to some extent). In this way, the package assemblies disclosed herein help promote more accurate and reliable pressure measurements than previous implementations.
摘要翻译：本公开的一些实施例涉及用于压力感测元件的改进的包装组件。而不是以使得它容易受到杂散电线，污垢等的损害的方式离开压力感测元件而暴露于周围环境中; 本文公开的改进的包装组件包括有助于形成围绕压力感测元件的外壳的盖。所述盖包括其中布置有阻挡构件的流体流动通道。流体流动通道将压力感测元件与外部环境流体连通，从而可以采取压力测量，同时阻挡构件有助于保护压力感测元件免受外部环境（例如，杂散电线和污垢在一定程度上的影响）。以这种方式，本文公开的封装组件有助于促进比先前的实施更准确和可靠的压力测量。

9. 发明申请

US20100310672A1 DISINFECTANT BASED ON AQUEOUS; HYPOCHLOROUS ACID (HOCI)-CONTAINING SOLUTIONS; METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF 审中-公开
标题翻译：基于水分的消毒剂; 高氯酸（HOCI） - 解决方案; 其生产方法及其用途
公开(公告)号：US20100310672A1
公开(公告)日：2010-12-09
申请号：US12599509
申请日：2008-05-14
申请人： Alfons Beltrup , Lars Füchtjohann , Steven Gross , Bernd Jöst
发明人： Alfons Beltrup , Lars Füchtjohann , Steven Gross , Bernd Jöst
IPC分类号： A01N59/00 , A01P1/00
CPC分类号： A61L2/186 , A01N59/00 , A61L2202/11 , C02F1/441 , C02F1/444 , C02F1/4618 , C02F1/4672 , C02F2001/46142 , C02F2001/46152 , C02F2001/46185 , C02F2001/4619 , C02F2001/46195 , C02F2103/026 , C02F2201/46115 , C02F2201/46125 , C02F2201/4618 , C02F2209/05 , C02F2209/06 , A01N25/00 , A01N25/02 , A01N25/04 , A01N2300/00
摘要： Disclosed are a disinfectant based on an aqueous, hypochlorous acid-containing solution, especially in the form of an electrochemically activated, diluted water/electrolyte solution, as well as a method for producing such a disinfectant. In order to increase the stability of such a disinfectant also in case the disinfectant has a large surface, e.g. when the disinfectant is applied to surfaces, the disinfectant further contains a certain percentage of amorphous silica (SiO2), particularly in the form of amorphous silicic acids and/or amorphous silicic anhydrides. Said percentage can be selected especially in such a way as to increase the viscosity of the aqueous solution to the point where the solution gels. The invention further relates to the use of such a disinfectant.
摘要翻译：公开了一种基于含有次氯酸的溶液的消毒剂，特别是以电化学活化的稀释水/电解质溶液的形式，以及生产这种消毒剂的方法。为了在消毒剂具有大的表面的情况下也增加这种消毒剂的稳定性，例如，当消毒剂施用于表面时，消毒剂还含有一定百分比的无定形二氧化硅（SiO 2），特别是无定形硅酸和/或无定形硅酸酐的形式。所述百分比可以特别是以增加水溶液粘度至溶液凝固点的方式进行选择。本发明还涉及这种消毒剂的用途。

10. 发明授权

US08671766B2 Integrated pressure sensor seal 有权
标题翻译：集成压力传感器密封
公开(公告)号：US08671766B2
公开(公告)日：2014-03-18
申请号：US13111362
申请日：2011-05-19
申请人： James William Sterling , Steven Gross
发明人： James William Sterling , Steven Gross
IPC分类号： G01L9/00
CPC分类号： H01L23/057 , B81B7/0058 , B81B2201/0264 , G01L19/0636 , H01L23/04 , H01L2224/48091 , H01L2224/48247 , H01L2924/1461 , H01L2924/00014 , H01L2924/00
摘要： Some embodiments of the present disclosure relate to improved package assemblies for pressure sensing elements. Rather than leaving a pressure sensing element unabashedly exposed to the ambient environment in a manner that makes it susceptible to damage from stray wires, dirt, and the like; the improved package assemblies disclosed herein include a cover that helps form an enclosure around the pressure sensing element. The cover includes a fluid-flow channel with a blocking member arranged therein. The fluid-flow channel puts the pressure sensing element in fluid communication with the external environment so pressure measurements can be taken, while the blocking member helps protect the pressure sensing element from the external environment (e.g., stray wires and dirt to some extent). In this way, the package assemblies disclosed herein help promote more accurate and reliable pressure measurements than previous implementations.
摘要翻译：本公开的一些实施例涉及用于压力感测元件的改进的包装组件。而不是以使得它容易受到杂散电线，污垢等的损害的方式离开压力感测元件而暴露于周围环境中; 本文公开的改进的包装组件包括有助于形成围绕压力感测元件的外壳的盖。所述盖包括其中布置有阻挡构件的流体流动通道。流体流动通道将压力感测元件与外部环境流体连通，从而可以采取压力测量，同时阻挡构件有助于保护压力感测元件免受外部环境（例如，杂散电线和污垢在一定程度上的影响）。以这种方式，本文公开的封装组件有助于促进比先前的实施更准确和可靠的压力测量。

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