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1. 发明申请

US20080119569A1 Polymer-based sustained release device 审中-公开
公开(公告)号：US20080119569A1
公开(公告)日：2008-05-22
申请号：US11878160
申请日：2007-07-20
申请人： Steven G. Wright , Troy Christensen , Thean Yeoh , Michael E. Rickey , Joyce M. Hotz , Rajesh Kumar , Mark Fineman , Christine Smith , John Ong , David M. Lokensgard , Henry R. Costantino
发明人： Steven G. Wright , Troy Christensen , Thean Yeoh , Michael E. Rickey , Joyce M. Hotz , Rajesh Kumar , Mark Fineman , Christine Smith , John Ong , David M. Lokensgard , Henry R. Costantino
IPC分类号： A61K47/00
CPC分类号： A61K47/34 , A61K9/0002 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/573 , A61K38/2278 , A61K38/26
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

2. 发明授权

US08293871B2 Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar 有权
标题翻译：包含多肽和糖的聚（丙交酯 - 共 - 乙交酯）基持续释放微胶囊
公开(公告)号：US08293871B2
公开(公告)日：2012-10-23
申请号：US11578712
申请日：2005-04-15
申请人： Steven G. Wright , Troy Christensen , Thean Yeoh , Michael E. Rickey , Joyce M. Hotz , Rajesh Kumar , Henry R. Costantino , Christine Smith , David M. Lokensgard , Mark Fineman , John Ong
发明人： Steven G. Wright , Troy Christensen , Thean Yeoh , Michael E. Rickey , Joyce M. Hotz , Rajesh Kumar , Henry R. Costantino , Christine Smith , David M. Lokensgard , Mark Fineman , John Ong
IPC分类号： A61K38/00
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/1623 , A61K9/1647 , A61K9/1694 , A61K38/2278 , A61K38/26 , A61K47/26 , A61K47/38
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
摘要翻译：本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

3. 发明授权

US5232707A Solvent extraction process 失效
标题翻译：溶剂萃取工艺
公开(公告)号：US5232707A
公开(公告)日：1993-08-03
申请号：US759803
申请日：1991-09-13
申请人： David M. Lokensgard
发明人： David M. Lokensgard
IPC分类号： A61K9/16 , B01J13/20
CPC分类号： B01J13/206 , A61K9/1694
摘要： There is disclosed a process for the extraction of volatile solvents entrained in a polymer-based pharmaceutical composition designed for sustained release of drug over an extended period of time prepared in microcapsule form wherein the composition comprises at least one hormonally active water-soluble polypeptide in an effective amount greater than a conventional single dose and a biocompatible, bioerodable encapsulating polymer, which process comprises the steps of contacting the composition to a stream of dense gas, that is, pressurized gas and then removing the dense gas, and volatile solvents contained therein, extracted from the pharmaceutical composition.
摘要翻译：公开了一种方法，用于提取夹带在基于聚合物的药物组合物中的挥发性溶剂，所述药物组合物设计用于在微胶囊形式制备的延长的时间段内持续释放药物，其中组合物包含至少一种激素活性水溶性多肽有效量大于常规单剂量和生物相容的可生物侵蚀的包封聚合物，该方法包括以下步骤：将组合物与致密气体流（即加压气体，然后除去致密气体，以及其中所含的挥发性溶剂）接触，从药物组合物中提取。

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