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1. 发明授权

US07517439B2 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US07517439B2
公开(公告)日：2009-04-14
申请号：US10907817
申请日：2005-04-15
申请人： Ian Harding , Richard Williams , Steven Diamond
发明人： Ian Harding , Richard Williams , Steven Diamond
IPC分类号： G01F1/64
CPC分类号： C12Q1/006 , G01N27/3273
摘要： Measurement of the series resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中对工作电极对和对电极对的串联电阻的测量提供了测试条质量的多种变化以及测试仪中条带的操作的错误检测。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

2. 发明申请

US20080093230A1 Electrochemical determination of analytes 有权
标题翻译：分析物的电化学测定
公开(公告)号：US20080093230A1
公开(公告)日：2008-04-24
申请号：US11874772
申请日：2007-10-18
申请人： Steven Diamond , Ian Harding , Sridhar Iyengar , Richard Williams
发明人： Steven Diamond , Ian Harding , Sridhar Iyengar , Richard Williams
IPC分类号： G01N33/66 , G01N27/26
CPC分类号： G01N27/3274
摘要： Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.
摘要翻译：通过电化学测定初始分析物浓度，执行多个电流/电位开关周期，观察多个开关周期中的每一个期间的信号特性，确定分析物的特性的平均值，信号，并且校正初始测量值以获得分析物浓度的最终测量值或者根据信号的特性的平均值来拒绝初始测量值。观察到的信号的特征本身并不表示样品中存在的分析物的量。相反，它是反映电极质量，电化学电池的填充程度或样品的特征的信号的特征，而不是诸如氧水平或血细胞比容的分析物浓度。

3. 发明申请

US20080093227A1 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US20080093227A1
公开(公告)日：2008-04-24
申请号：US11874766
申请日：2007-10-18
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： G01N27/26 , G01N27/28
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

4. 发明授权

US08192610B2 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US08192610B2
公开(公告)日：2012-06-05
申请号：US12961654
申请日：2010-12-07
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

5. 发明授权

US07846321B2 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US07846321B2
公开(公告)日：2010-12-07
申请号：US11874766
申请日：2007-10-18
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： C12Q1/00 , C12M1/00
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

6. 发明申请

US20110073496A1 Error detection in analyte measurements based on measurement of system resistance 有权
标题翻译：基于测量系统电阻的分析物测量中的误差检测
公开(公告)号：US20110073496A1
公开(公告)日：2011-03-31
申请号：US12961654
申请日：2010-12-07
申请人： Steven Diamond , Ian Harding , Richard Williams
发明人： Steven Diamond , Ian Harding , Richard Williams
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：在电化学测试条中测量工作电极对和对电极对的串联轨道电阻可以提供测试条质量的多种变化的错误检测以及测试仪中条带的操作。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3））导致不正确的读数时，可以使用串联电阻的单次测量来检测并产生错误信息，或（4）电极之间的短路。

7. 发明授权

US07771583B2 Electrochemical determination of analytes 有权
标题翻译：分析物的电化学测定
公开(公告)号：US07771583B2
公开(公告)日：2010-08-10
申请号：US11874772
申请日：2007-10-18
申请人： Steven Diamond , Ian Harding , Sridhar Iyengar , Richard Williams
发明人： Steven Diamond , Ian Harding , Sridhar Iyengar , Richard Williams
IPC分类号： G01N33/66 , G01N27/26
CPC分类号： G01N27/3274
摘要： Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.
摘要翻译：通过电化学测定初始分析物浓度，执行多个电流/电位开关周期，观察多个开关周期中的每一个期间的信号特性，确定分析物的特性的平均值，信号，并且校正初始测量值以获得分析物浓度的最终测量值或者根据信号的特性的平均值来拒绝初始测量值。观察到的信号的特征本身并不表示样品中存在的分析物的量。相反，它是反映电极质量，电化学电池的填充程度或样品的特征的信号的特征，而不是诸如氧水平或血细胞比容的分析物浓度。

8. 发明授权

US07547382B2 Determination of partial fill in electrochemical strips 有权
标题翻译：电化学条中局部填充的测定
公开(公告)号：US07547382B2
公开(公告)日：2009-06-16
申请号：US10907813
申请日：2005-04-15
申请人： Ian Harding , Steven Diamond , Richard Williams , Sridhar G. Iyengar
发明人： Ian Harding , Steven Diamond , Richard Williams , Sridhar G. Iyengar
IPC分类号： G01N1/00 , G01N27/26 , G01N31/00 , G01N33/50 , G01N17/00 , G01F1/64
CPC分类号： G01N27/327
摘要： Partial fill of an electrochemical test strip is determined by making a DC determination of double layer capacitance from charging or discharging charge on a test strip containing sample, for example a blood sample to be tested for glucose. The measured double layer capacitance is compared to a reference value. The double layer capacitance may be determined as an integral or differential capacitance. Double layer capacitance may also be used for quality control to monitor the quality of electrode formation, particularly in strips using screen printed electrodes.
摘要翻译：电化学测试条的部分填充通过在含有样品的测试条（例如要测试葡萄糖的血液样品）上进行充电或放电电荷的双层电容的DC测定来确定。将测量的双层电容与参考值进行比较。双层电容可以被确定为积分或差分电容。双层电容也可用于质量控制，以监测电极形成的质量，特别是使用丝网印刷电极的条带。

9. 发明申请

US20060231418A1 Determination of Partial Fill in Electrochemical Strips 有权
标题翻译：电化学工业部分填充物的测定
公开(公告)号：US20060231418A1
公开(公告)日：2006-10-19
申请号：US10907813
申请日：2005-04-15
申请人： Ian Harding , Steven Diamond , Richard Williams , Sridhar Iyengar
发明人： Ian Harding , Steven Diamond , Richard Williams , Sridhar Iyengar
IPC分类号： G01N27/26
CPC分类号： G01N27/327
摘要： Partial fill of an electrochemical test strip is determined by making a DC determination of double layer capacitance from charging or discharging charge on a test strip containing sample, for example a blood sample to be tested for glucose. The measured double layer capacitance is compared to a reference value. The double layer capacitance may be determined as an integral or differential capacitance. Double layer capacitance may also be used for quality control to monitor the quality of electrode formation, particularly in strips using screen printed electrodes.
摘要翻译：电化学测试条的部分填充通过在含有样品的测试条（例如要测试葡萄糖的血液样品）上进行充电或放电电荷的双层电容的DC测定来确定。将测量的双层电容与参考值进行比较。双层电容可以被确定为积分或差分电容。双层电容也可用于质量控制，以监测电极形成的质量，特别是使用丝网印刷电极的条带。

10. 发明申请

US20110267028A1 Measuring device and methods for use therewith 有权
标题翻译：测量装置及其使用方法
公开(公告)号：US20110267028A1
公开(公告)日：2011-11-03
申请号：US13108621
申请日：2011-05-16
申请人： Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
发明人： Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
IPC分类号： G01R19/00
CPC分类号： G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要： The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
摘要翻译：在电流测量和电位测量之间切换的能力在执行未知数的分析方面提供了极大的灵活性。装置和方法可以提供这种切换以从电化学电池收集数据。细胞可以含有用于测量人血液中的葡萄糖的试剂。

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