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1. 发明申请

US20050004163A1 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives 审中-公开
标题翻译： 3-（二芳基亚甲基）-8-氮杂双环[3.2.1]辛烷衍生物
公开(公告)号：US20050004163A1
公开(公告)日：2005-01-06
申请号：US10767712
申请日：2004-01-29
申请人： Steven Coats , John Carson , Lou Neilson , Philip Pitis , Mark Schulz
发明人： Steven Coats , John Carson , Lou Neilson , Philip Pitis , Mark Schulz
IPC分类号： A61K31/439 , C07D451/02 , A61K31/46
CPC分类号： C07D451/02 , A61K31/439
摘要： This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as δ-opioid or μ-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
摘要翻译：本发明涉及可用作δ-阿片样物质或μ-阿片受体调节剂的3-（二芳基亚甲基）-8-氮杂双环[3.2.1]辛烷衍生物。根据其激动剂或拮抗剂的作用，化合物是有用的止痛剂，免疫抑制剂，抗炎剂，用于治疗神经和精神病症的药剂，用于药物和酒精滥用的药物，用于治疗胃炎和腹泻的药剂，用于治疗的心血管药剂和药剂的呼吸系统疾病。

2. 发明申请

US20050148636A1 Useful aroyl pyrrole heteroaryl methanones and methanols 审中-公开
标题翻译：有用的芳酰基吡咯杂芳基甲酮和甲醇
公开(公告)号：US20050148636A1
公开(公告)日：2005-07-07
申请号：US11065914
申请日：2005-02-25
申请人： John Carson , Ellen Codd , Philip Pitis
发明人： John Carson , Ellen Codd , Philip Pitis
IPC分类号： A61K31/4178 , A61K31/4439 , A61P1/06 , A61P1/08 , A61P1/12 , A61P1/14 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/00 , A61P17/02 , A61P17/04 , A61P19/02 , A61P19/08 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P31/18 , A61P35/00 , A61P43/00 , C07D401/06 , C07D403/06 , C07D409/14 , C07D43/02
CPC分类号： C07D401/06 , C07D403/06 , C07D409/14
摘要： This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
摘要翻译：本发明涉及可用作治疗或调节中枢神经系统疾病的药物的芳酰基吡咯杂芳基甲酮和甲醇化合物以及用于治疗或调节中枢神经系统疾病的方法。

3. 发明申请

US20070244194A1 CARBOXAMIDO OPIOID COMPOUNDS 审中-公开
标题翻译： CARBOXAMIDO OPIOID化合物
公开(公告)号：US20070244194A1
公开(公告)日：2007-10-18
申请号：US11766892
申请日：2007-06-22
申请人： John Carson , Philip Pitis
发明人： John Carson , Philip Pitis
IPC分类号： A61K31/195 , A61P25/00
CPC分类号： A41D27/201 , A45F5/022 , A61K31/195 , Y10T24/1376
摘要： This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
摘要翻译：本发明涉及药物上可用作治疗或调节中枢神经系统障碍的药物的甲酰胺阿片样物质和治疗或调节中枢神经系统疾病的方法。

4. 发明申请

US20050256203A1 Carboxamido opioid compounds 有权
标题翻译：卡马西多阿片类化合物
公开(公告)号：US20050256203A1
公开(公告)日：2005-11-17
申请号：US11126771
申请日：2005-05-11
申请人： John Carson , Philip Pitis
发明人： John Carson , Philip Pitis
IPC分类号： A61K31/165 , C07C237/00 , C07C237/30 , C07C237/32 , C07C237/38
CPC分类号： C07C237/30 , C07C237/38 , C07C2601/02 , C07C2601/14
摘要： This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.
摘要翻译：本发明涉及药物上可用作治疗或调节中枢神经系统障碍的药物的甲酰胺阿片样物质和治疗或调节中枢神经系统疾病的方法。

5. 发明申请

US20060135524A1 Tricyclic delta-opioid modulators 失效
标题翻译：三环类阿片样物质调节剂
公开(公告)号：US20060135524A1
公开(公告)日：2006-06-22
申请号：US11313704
申请日：2005-12-21
申请人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
发明人： John Carson , Scott Dax , Bart DeCorte , Li Liu , Mark McDonnell , James McNally
IPC分类号： A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4709 , A61K31/445 , C07D403/02
CPC分类号： C07D451/02
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及Δ阿片样物质受体调节剂。更具体地，本发明涉及三环类阿片样物质调节剂。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

6. 发明申请

US20050288323A1 Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine 审中-公开
标题翻译：八氢 - 中氮茚和喹嗪和六氢吡咯嗪
公开(公告)号：US20050288323A1
公开(公告)日：2005-12-29
申请号：US11205958
申请日：2005-08-17
申请人： Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
发明人： Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/00 , A61K49/00 , A61K51/04 , A61P1/08 , A61P1/14 , A61P11/02 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D487/04 , A61K31/4745
CPC分类号： C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要： The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译：本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。

7. 发明申请

US20050159443A1 Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators 有权
标题翻译：用作缓激肽受体调节剂的新型杂芳基烷基酰胺衍生物
公开(公告)号：US20050159443A1
公开(公告)日：2005-07-21
申请号：US11014471
申请日：2004-12-16
申请人： John Carson , Michele Jetter , Jung Lee , Mark Youngman
发明人： John Carson , Michele Jetter , Jung Lee , Mark Youngman
IPC分类号： A61K31/4375 , A61K31/4709 , A61K31/4745 , A61P1/04 , A61P1/18 , A61P11/06 , A61P17/02 , A61P19/02 , A61P25/04 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D471/04 , C07D471/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/4709 , A61K31/4745 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.
摘要翻译：本发明涉及作为缓激肽受体拮抗剂的新型烷基酰胺衍生物，其用于治疗缓激肽调节障碍如疼痛，炎症，哮喘和过敏。此外，本发明涉及作为可用于治疗缓激肽调节障碍如高血压等的缓激肽受体激动剂的新型烷基酰胺衍生物。

8. 发明申请

US20050058128A1 High speed switching module comprised of stacked layers incorporating T-connect structures 有权
标题翻译：高速切换模块由包含T形连接结构的堆叠层组成
公开(公告)号：US20050058128A1
公开(公告)日：2005-03-17
申请号：US10960712
申请日：2004-10-06
申请人： John Carson , Volkan Orguz
发明人： John Carson , Volkan Orguz
IPC分类号： G06T7/20 , G06T9/00 , H04L12/56 , H04L12/50
CPC分类号： G06T7/20 , G06T9/004 , H04L45/583 , H04L49/101 , H04L49/1507 , H04L49/25 , H04L49/3018 , H04L49/3027 , H04L49/357 , Y10S257/93
摘要： A compact multi-stage switching network (100), and a router (510) incorporating such multi-stage switching network, adapted for simultaneously routing a plurality of data packets from a first plurality of input ports (110) to selected ones of a second plurality of output ports (190) comprising: a first stack (140) of IC switching layers (113) that are stacked in physical contact with one another, each IC switching layer containing at least one switching element circuit (142); a second stack (160) of IC switching layers (113) that are stacked in physical contact with one another, each IC switching layer (113) containing at least one switching element circuit (162); and interconnecting circuitry (150) that connects the first stack (140) of IC layers to the second stack (160) of IC layers to form the compact multi-stage switching network. The stacks (140, 160) are preferably mated to one another in a transverse fashion in order to achieve a natural full-mesh connection. Also contemplated are the use of superconducting IC switching circuits (142) and a suitable superconducting cooling housing (730), as permitted by the compact nature of the multi-stage switching network (100), in order to operate at high speed and low power.
摘要翻译：紧凑型多级交换网络（100）以及包含这种多级交换网络的路由器（510），适用于将多个数据分组从第一多个输入端口（110）同时路由到第二个多个输出端口（190）包括：彼此物理接触堆叠的IC开关层（113）的第一堆叠（140），每个IC开关层包含至少一个开关元件电路（142）; 叠层物理接触的IC开关层（113）的第二堆叠（160），每个IC开关层（113）包含至少一个开关元件电路（162）; 以及将IC层的第一堆叠（140）连接到IC层的第二堆叠（160）的互连电路（150），以形成紧凑的多级交换网络。堆叠（140,160）优选以横向方式彼此配合，以便实现自然的全网状连接。还考虑了如多级开关网络（100）的紧凑特性所允许的超导IC开关电路（142）和合适的超导冷却壳体（730）的使用，以便以高速和低功率运行。

9. 发明授权

US06649177B2 Formulations including hydrolyzed jojoba protein 有权
标题翻译：制剂包括水解霍霍巴蛋白
公开(公告)号：US06649177B2
公开(公告)日：2003-11-18
申请号：US09841544
申请日：2001-04-23
申请人： Mark A. Howard , Clodualdo C. Maningat , Sukh Bassi , Dharmen Makwana , Soraya Rohde , John Carson
发明人： Mark A. Howard , Clodualdo C. Maningat , Sukh Bassi , Dharmen Makwana , Soraya Rohde , John Carson
IPC分类号： A61K600
CPC分类号： A61Q1/02 , A61K8/0208 , A61K8/0212 , A61K8/645 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q9/02 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/88
摘要： Hydrolyzed jojoba protein is provided which can be used in a variety of cosmetic formulations to enhance the desirable properties thereof. The preferred hydrolyzed jojoba protein is in the form of an aqueous dispersion containing a mixture of amino acids, peptides and/or protein fractions derived from the hydrolysis of naturally occurring jojoba protein. Cosmetic formulations such as shampoos, shampoo conditioners, hair styling gels, hair conditioners, hair reparatives, hair tonics, hair fixatives, hair mousses, bath and shower gels, liquid soaps, moisturizing sprays, makeup, pressed powder formulations, lip products, bath additives, sanitizing wipes, hand sanitizers, premoistened towelettes, skin lotions and creams, shaving creams, and sunscreens can be improved by incorporation of hydrolyzed jojoba protein therein.
摘要翻译：提供了水解霍霍巴蛋白，其可用于各种化妆品制剂中以增强其期望的性质。优选的水解霍霍巴蛋白是含有衍生自天然存在的霍霍巴蛋白水解的氨基酸，肽和/或蛋白质级分的混合物的水性分散体的形式。化妆品配方如洗发剂，洗发水调理剂，发型凝胶，头发调理剂，头发修复剂，发用滋补剂，头发固定剂，毛发摩丝，浴和沐浴露，液体皂，保湿喷雾剂，化妆品，压粉配方，唇膏产品，浴液添加剂可以通过在其中掺入水解的霍霍巴蛋白来改善消毒湿巾，手部消毒剂，预润湿毛巾，皮肤洗剂和霜剂，剃须膏和防晒剂。

10. 发明申请

US20120107499A1 Ceramic Encapsulation With Controlled Layering By Use of Functionalized Silanes 有权
标题翻译：通过使用功能化硅烷控制分层的陶瓷封装
公开(公告)号：US20120107499A1
公开(公告)日：2012-05-03
申请号：US13168715
申请日：2011-06-24
申请人： Daniel H. Traynor , Hao Xu , Henry G. Traynor , Daniel H. Traynor , John Carson , Martin S. Flacks , Rachel Sullivan
发明人： Daniel H. Traynor , Hao Xu , Henry G. Traynor , Daniel H. Traynor , John Carson , Martin S. Flacks , Rachel Sullivan
IPC分类号： B29B9/12
CPC分类号： A61K8/11 , A61K8/0279 , A61K8/585 , A61Q19/00
摘要： This invention relates to a method for forming hollow silica-based particles suitable for containing one or more active ingredients or for containing other smaller particles which may include one or more active ingredients. The method comprises preparing an emulsion including a continuous phase that is polar or non-polar and a dispersed phase comprising droplets including (i) a polar active ingredient when the continuous phase is non-polar or (ii) a non-polar active ingredient when the continuous phase is polar; and adding a silica precursor to the emulsion such that the silica precursor can be emulsion templated on the droplets to form hollow silica-based particles. The silica precursor has the general formula (I): R1x—Si—(OR2)y, wherein R1 is selected from substituted and unsubstituted alkyl, substituted and unsubstituted aryl, alcohols, amines, amides, aldehydes, acids, esters, and functional groups having an unsaturated carbon-carbon bond, R2 is an alkyl group, x+y=4, and y=1, 2 or 3. The —OR2 group is a hydrolyzable organic group that exhibits an ability to form a silicon-oxygen bond chain as a result of hydrolysis and condensation.
摘要翻译：本发明涉及一种形成中空二氧化硅基颗粒的方法，该方法适于含有一种或多种活性成分或含有其它可包含一种或多种活性成分的较小颗粒。该方法包括制备包含极性或非极性的连续相的乳液和包含液滴的分散相，包括（i）连续相为非极性时的极性活性成分或（ii）非极性活性成分，连续相为极性; 并将二氧化硅前体添加到乳液中，使得二氧化硅前体可以在液滴上乳液模板化以形成中空二氧化硅基颗粒。二氧化硅前体具有通式（I）：R1x-Si-（OR2）y，其中R1选自取代和未取代的烷基，取代和未取代的芳基，醇，胺，酰胺，醛，酸，酯和官能团具有不饱和碳 - 碳键，R2是烷基，x + y = 4，y = 1,2或3. -OR2基团是表现出形成硅 - 氧键键的能力的可水解的有机基团作为水解和缩合的结果。

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