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1. 发明申请

US20060217417A1 PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA 有权
标题翻译：吡啶衍生物作为PKC-THETA的抑制剂有用
公开(公告)号：US20060217417A1
公开(公告)日：2006-09-28
申请号：US11277536
申请日：2006-03-27
申请人： Steven Brunette , Jin Kim , Rene Lemieux , Matt Tschantz
发明人： Steven Brunette , Jin Kim , Rene Lemieux , Matt Tschantz
IPC分类号： A61K31/445
CPC分类号： C07D213/74 , C07D213/82 , C07D213/85 , C07D401/12
摘要： Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：公开了式（I）的新化合物：其中R 1，R 2和R 3 3如本文所定义，其可用作抑制剂的PKC-θ，因此可用于治疗通过PKC-θ的活性介导或持续的各种疾病和病症，包括免疫学障碍和II型糖尿病。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

2. 发明申请

US20060025433A1 Pyrimidine derivatives useful as inhibitors of PKC-theta 有权
标题翻译：可用作PKC-θ抑制剂的嘧啶衍生物
公开(公告)号：US20060025433A1
公开(公告)日：2006-02-02
申请号：US11175476
申请日：2005-07-06
申请人： Antonio Barbosa , Steven Brunette , Eugene Hickey , Jin Kim , Michael Lawlor , Rene Lemieux , Bryan McKibben , Matt Tschantz , Hui Yu
发明人： Antonio Barbosa , Steven Brunette , Eugene Hickey , Jin Kim , Michael Lawlor , Rene Lemieux , Bryan McKibben , Matt Tschantz , Hui Yu
IPC分类号： A61K31/513 , A61K31/506 , C07D405/02 , C07D239/47
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：公开了式（I）的新化合物：其中X，Y，R 1，R 2和R 3 3如本文所定义，其中可用作PKC-θ的抑制剂，因此可用于治疗通过PKC-θ的活性介导或维持的多种疾病和病症，包括免疫学障碍和II型糖尿病。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

3. 发明申请

US20050054704A1 Derivatives of [6,7-dihydro-5H- Imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide 有权
标题翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物
公开(公告)号：US20050054704A1
公开(公告)日：2005-03-10
申请号：US10969698
申请日：2004-10-20
申请人： Terence Kelly , Jin Kim , Rene Lemieux , Matt Tschantz
发明人： Terence Kelly , Jin Kim , Rene Lemieux , Matt Tschantz
IPC分类号： A61K31/4166 , A61K31/4188 , A61K31/5375 , A61P29/00 , C07D235/02 , C07D403/12 , C07D413/02 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4188
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基]吡咯烷-2-甲酸酰胺的衍生物，其对CAM和白血球素蛋白的相互作用具有良好的抑制作用，因此可用于治疗炎症性疾病。

4. 发明申请

US20060252811A1 SUBSTITUTED BENZYLIMIDAZOLES USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权
标题翻译：用于治疗炎症性疾病的替代苄基咪唑
公开(公告)号：US20060252811A1
公开(公告)日：2006-11-09
申请号：US11278558
申请日：2006-04-04
申请人： Jin Kim , Rene Lemieux , Bryan McKibben , Matt Tschantz , Hui Yu
发明人： Jin Kim , Rene Lemieux , Bryan McKibben , Matt Tschantz , Hui Yu
IPC分类号： C07D233/34 , A61K31/4166
CPC分类号： C07D233/64 , C07D233/70 , C07D233/88 , C07D401/12 , C07D401/14
摘要： The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.
摘要翻译：本发明包括一类式（I）的取代苄基咪唑衍生物及其制备方法。这些化合物可用于治疗炎性病症。

5. 发明申请

US20050054703A1 Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权
公开(公告)号：US20050054703A1
公开(公告)日：2005-03-10
申请号：US10969105
申请日：2004-10-20
申请人： Terence Kelly , Jin Kim , Rene Lemieux
发明人： Terence Kelly , Jin Kim , Rene Lemieux
IPC分类号： A61P37/00 , C07D487/04 , A61K31/4188
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

6. 发明申请

US20080090819A1 DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE 有权
标题翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基]丙酰胺的衍生物
公开(公告)号：US20080090819A1
公开(公告)日：2008-04-17
申请号：US11872276
申请日：2007-10-15
申请人： Terence Kelly , Jin Kim , Rene Lemieux
发明人： Terence Kelly , Jin Kim , Rene Lemieux
IPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , A61P1/00 , A61P17/00 , A61P29/00 , A61P9/00
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。

7. 发明申请

US20050165027A1 Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权
标题翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物
公开(公告)号：US20050165027A1
公开(公告)日：2005-07-28
申请号：US11034701
申请日：2005-01-13
申请人： Terence Kelly , Jin Kim , Rene Lemieux
发明人： Terence Kelly , Jin Kim , Rene Lemieux
IPC分类号： A61P37/00 , C07D487/04 , A61K31/506
CPC分类号： A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04
摘要： Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。

8. 发明申请

US20080031006A1 Light guide plate and liquid crystal display device having the same 有权
标题翻译：导光板及具有该导光板的液晶显示装置
公开(公告)号：US20080031006A1
公开(公告)日：2008-02-07
申请号：US11730802
申请日：2007-04-04
申请人： Hee Kim , Jin Kim , Jin Kim
发明人： Hee Kim , Jin Kim , Jin Kim
IPC分类号： F21V8/00
CPC分类号： G02B6/0036 , G02B6/0051 , G02B6/0053 , G02B6/0061
摘要： A light guide plate and a liquid crystal display device having the same. The light guide plate is disposed upstream of a liquid crystal panel to refract light supplied through an edge thereof, toward the liquid crystal panel. In the light guide plate, a plate body is disposed at a side of a light source for supplying light when a supply voltage is applied. A plurality of pyramidal diffusing elements are arrayed in a predetermined pattern on a surface of the plate body. Each of the diffusing elements is rotated clockwise or counterclockwise about an axis extending through a vertex of the diffusing element perpendicularly to the surface of the plate body so that an edge of the diffusing element facing a reference line connecting a central point of the light source to a central point of the plate body is angled 10° to 35° about the reference line.
摘要翻译：导光板和具有该导光板的液晶显示装置。导光板配置在液晶面板的上游侧，将通过其边缘供给的光折射到液晶面板。在导光板中，当施加电源电压时，板体设置在用于供应光的光源的一侧。多个金字塔形扩散元件以预定图案排列在板体的表面上。每个扩散元件围绕延伸穿过漫射元件的顶点的轴线顺时针或逆时针旋转，垂直于板体的表面，使得漫射元件的边缘面向连接光源的中心点的参考线，板体的中心点围绕参考线倾斜10°至35°。

9. 发明申请

US20070076721A1 Method of processing traffic information and digital braodcast system 有权
标题翻译：处理交通信息和数字编织系统的方法
公开(公告)号：US20070076721A1
公开(公告)日：2007-04-05
申请号：US11541564
申请日：2006-10-03
申请人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
发明人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
IPC分类号： H04L12/56
CPC分类号： H04N21/435 , H04H20/30 , H04H20/55 , H04H20/72 , H04H40/27 , H04N21/235 , H04N21/23614 , H04N21/2362 , H04N21/2383 , H04N21/41422 , H04N21/4345 , H04N21/4348 , H04N21/4382 , H04N21/64315 , H04N21/8126
摘要： A digital broadcast transmitting/receiving system and a method for processing data are disclosed. The method for processing data may enhance the receiving performance of the receiving system by performing additional coding and multiplexing processes on the traffic information data and transmitting the processed data. Thus, robustness is provided to the traffic information data, thereby enabling the data to respond strongly against the channel environment which is always under constant and vast change.
摘要翻译：公开了数字广播发送/接收系统和数据处理方法。处理数据的方法可以通过对交通信息数据执行额外的编码和复用处理并发送处理的数据来增强接收系统的接收性能。因此，提供了对交通信息数据的鲁棒性，从而使得数据能够对始终处于不断变化和巨大变化的信道环境产生强烈反应。

10. 发明申请

US20070076585A1 Method of processing traffic information and digital broadcast system 有权
公开(公告)号：US20070076585A1
公开(公告)日：2007-04-05
申请号：US11542160
申请日：2006-10-04
申请人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
发明人： Jin Kim , Young Kim , Ho Hong , In Choi , Kook Kwak , Hyoung Lee , Byoung Kim , Jin Kim , Jong Kim , Won Song
IPC分类号： H04J11/00
CPC分类号： H04H20/44 , H04B1/0475 , H04B1/10 , H04H20/55 , H04L1/0065 , H04L1/0071 , H04L1/0083 , H04L2001/0093
摘要： A digital broadcast transmitting/receiving system and a method for processing data are disclosed. The method for processing data may enhance the receiving performance of the receiving system by performing additional coding and multiplexing processes on the traffic information data and transmitting the processed data. Thus, robustness is provided to the traffic information data, thereby enabling the data to respond strongly against the channel environment which is always under constant and vast change.

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