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1. 发明授权

US5830207A Electromagnetically triggered, responsive gel based drug delivery device 失效
标题翻译：电磁触发，基于凝胶的药物输送装置
公开(公告)号：US5830207A
公开(公告)日：1998-11-03
申请号：US791368
申请日：1997-01-30
申请人： Steven B. Leeb , Elmer C. Lupton , Xiaohong Yu , George Hovorka
发明人： Steven B. Leeb , Elmer C. Lupton , Xiaohong Yu , George Hovorka
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0009
摘要： A system for remotely inducing a phase transition in a gel is provided. The system includes a gel capable of volume change in response to an environmental stimulus, a seed material in contact with the gel, and generating a time-varying magnetic or a time-varying electric or electromagnetic field in the proximity of the gel to produce the environmental stimulus. In a preferred embodiment, the environmental stimulus is temperature.
摘要翻译：提供了用于远程诱导凝胶中的相变的系统。该系统包括能够响应于环境刺激而体积变化的凝胶，与凝胶接触的种子材料，以及在凝胶附近产生随时间变化的磁性或时变电场或电磁场以产生环境刺激。在优选实施例中，环境刺激是温度。

2. 发明授权

US5643246A Electromagnetically triggered, responsive gel based drug delivery device 失效
标题翻译：电磁触发，基于凝胶的药物输送装置
公开(公告)号：US5643246A
公开(公告)日：1997-07-01
申请号：US393971
申请日：1995-02-24
申请人： Steven B. Leeb , E. C. Lupton , Xiaohong Yu , George Hovorka
发明人： Steven B. Leeb , E. C. Lupton , Xiaohong Yu , George Hovorka
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0009
摘要： A system for remotely inducing a phase transition in a gel is provided. The system includes a gel capable of volume change in response to an environmental stimulus, a seed material in contact with the gel, and generating a time-varying magnetic or a time-varying electric or electromagnetic field in the proximity of the gel to produce the environmental stimulus. In a preferred embodiment, the environmental stimulus is temperature.
摘要翻译：提供了用于远程诱导凝胶中的相变的系统。该系统包括能够响应于环境刺激而体积变化的凝胶，与凝胶接触的种子材料，以及在凝胶附近产生随时间变化的磁性或时变电场或电磁场以产生环境刺激。在优选实施例中，环境刺激是温度。

3. 发明申请

US20090143751A1 Adaptable topical hyperbaric device 有权
标题翻译：适应性局部高压装置
公开(公告)号：US20090143751A1
公开(公告)日：2009-06-04
申请号：US12291317
申请日：2008-11-06
申请人： Phillip Loori , George Hovorka
发明人： Phillip Loori , George Hovorka
IPC分类号： A61F13/00 , B23P11/00
CPC分类号： A61M35/00 , Y10T29/49826
摘要： A wound treatment device includes a seal of variable size for attaching the device to various locations on a patient for treatment of wounds or lesions. The seal has a plurality of weakened areas which allow portions of the seal to be removed for increasing the size of the seal opening to accommodate wounds or lesions of different size.
摘要翻译：伤口治疗装置包括可变尺寸的密封件，用于将装置附接到患者的各个位置以治疗伤口或损伤。密封件具有多个弱化区域，其允许去除密封件的部分以增加密封开口的尺寸以适应不同大小的伤口或损伤。

4. 发明申请

US20090143721A1 Wound treatment device 有权
标题翻译：伤口治疗装置
公开(公告)号：US20090143721A1
公开(公告)日：2009-06-04
申请号：US12291342
申请日：2008-11-07
申请人： George Hovorka
发明人： George Hovorka
IPC分类号： A61M37/00 , A61F13/00 , B32B37/00
CPC分类号： A61H9/0078 , A61G10/00 , A61G10/04
摘要： A limb wound treatment device is described having a first end, a second end and an interior therebetween for accommodating a treatment gas. The device can include a flexible housing that can be inflated or a rigid housing. The first end can include an inflatable cuff seal for hermetically sealing against the limb being treated. The second end can include a closed end or an access port that is releasably sealed with a clamping mechanism. Further, the device can include a controller that can inflate that housing, inflate the cuff seal and provide treatment gas to the interior, in response to pressures within the cuff seal and the housing. Further, the device can accommodate different types of wound treatments, such as hyperbaric therapy, compression therapy or negative pressure therapy.
摘要翻译：描述了一种肢体伤口治疗装置，其具有用于容纳治疗气体的第一端，第二端和内部。该装置可以包括可膨胀的柔性壳体或刚性壳体。第一端可以包括用于气密地密封待处理的肢体的可充气的袖带密封件。第二端可以包括用夹紧机构可释放地密封的封闭端或进入口。此外，该装置可以包括控制器，该控制器可响应于袖带密封件和外壳内的压力而膨胀该壳体，使袖带密封件膨胀并且向内部提供治疗气体。此外，该装置可以适应不同类型的伤口治疗，例如高压治疗，压迫治疗或负压治疗。

5. 发明授权

US07540283B2 Hyperbaric oxygen devices and delivery methods 有权
标题翻译：高压氧气装置及配送方法
公开(公告)号：US07540283B2
公开(公告)日：2009-06-02
申请号：US11064581
申请日：2005-02-24
申请人： Phillip Loori , George Hovorka
发明人： Phillip Loori , George Hovorka
IPC分类号： A61F13/00
CPC分类号： A61G10/026 , A61H33/14 , A61H2033/143 , A61M35/00
摘要： A hyperbaric oxygen device and methods of applying hyperbaric oxygen are disclosed. The device comprises an enclosure including a collapsible bag defined by two sheets of fluid impervious material sealed together at both ends such that gas can be delivered between the sheets to inflate the enclosure to a rigid state and maintain the enclosure in the rigid state when oxygen pressure in the interior of the enclosure is cycled between ambient pressure and above ambient pressure.
摘要翻译：公开了一种高压氧装置和施加高压氧的方法。该装置包括外壳，其包括由在两端密封在一起的两片流体不可渗透材料限定的可折叠袋，使得气体可在片材之间输送以将外壳充气至刚性状态，并且当氧气压力在外壳的内部在环境压力和高于环境压力之间循环。

6. 发明授权

US5179288A Apparatus and method for measuring a bodily constituent 失效
标题翻译：用于测量身体成分的装置和方法
公开(公告)号：US5179288A
公开(公告)日：1993-01-12
申请号：US769031
申请日：1991-09-30
申请人： Donald Miffitt , Edward Poto , George Hovorka , Arthur Costaris
发明人： Donald Miffitt , Edward Poto , George Hovorka , Arthur Costaris
IPC分类号： G01N33/52 , B64D17/78 , G01J1/44 , G01N21/27 , G01N21/86 , G01N33/487 , G01N33/92
CPC分类号： G01N21/27 , G01J2001/4406 , G01N2021/8494 , G01N21/8483 , G01N2201/126 , G01N2201/12753
摘要： An apparatus and method for measuring a bodily constituent such as glucose or cholesterol by analyzing a sample taken from the body such as blood, saliva or urine. The sample is placed on a test strip inserted into the test block portion of the apparatus where the portion of the sample containing the constituent desired to be measured reacts with a chemical reagent. Products of this reaction have an absorbance/reflectance characteristic which is mathematically related to the concentration of the constituent in the bodily sample. The reflected light is absorbed by a photodiode and the output of the photodiode converted to a digital form where a microprocessor can calculate the concentration of the constituent using the mathematical relationship between the reflected light and concentration stored in memory means of the apparatus.
摘要翻译：一种用于通过摄取来自身体如血液，唾液或尿液的样品来测量身体成分如葡萄糖或胆固醇的装置和方法。将样品放置在插入装置的测试块部分的测试条上，其中含有待测量的成分的样品的一部分与化学试剂反应。该反应的产物具有在数学上与身体样品中成分浓度相关的吸光度/反射特性。反射光被光电二极管吸收，并且光电二极管的输出转换成数字形式，其中微处理器可以使用存储在设备的存储器装置中的反射光和浓度之间的数学关系来计算组分的浓度。

7. 发明授权

US07922678B2 Wound treatment device 有权
标题翻译：伤口治疗装置
公开(公告)号：US07922678B2
公开(公告)日：2011-04-12
申请号：US12291342
申请日：2008-11-07
申请人： George Hovorka
发明人： George Hovorka
IPC分类号： A61F5/00
CPC分类号： A61H9/0078 , A61G10/00 , A61G10/04
摘要： A limb wound treatment device is described having a first end, a second end and an interior therebetween for accommodating a treatment gas. The device can include a flexible housing that can be inflated or a rigid housing. The first end can include an inflatable cuff seal for hermetically sealing against the limb being treated. The second end can include a closed end or an access port that is releasably sealed with a clamping mechanism. Further, the device can include a controller that can inflate that housing, inflate the cuff seal and provide treatment gas to the interior, in response to pressures within the cuff seal and the housing. Further, the device can accommodate different types of wound treatments, such as hyperbaric therapy, compression therapy or negative pressure therapy.
摘要翻译：描述了一种肢体伤口治疗装置，其具有用于容纳治疗气体的第一端，第二端和内部。该装置可以包括可膨胀的柔性壳体或刚性壳体。第一端可以包括用于气密地密封待处理的肢体的可充气的袖带密封件。第二端可以包括用夹紧机构可释放地密封的封闭端或进入口。此外，该装置可以包括控制器，该控制器可响应于袖带密封件和外壳内的压力而膨胀该壳体，使袖带密封件膨胀并且向内部提供治疗气体。此外，该装置可以适应不同类型的伤口治疗，例如高压治疗，压迫治疗或负压治疗。

8. 发明申请

US20090120433A1 Controller for an extremity hyperbaric device 有权
标题翻译：控制器用于肢体高压装置
公开(公告)号：US20090120433A1
公开(公告)日：2009-05-14
申请号：US12156465
申请日：2008-05-30
申请人： Phillip Loori , George Hovorka
发明人： Phillip Loori , George Hovorka
IPC分类号： A61M37/00
CPC分类号： A61H9/0057 , A61G10/02 , A61G10/023 , A61G10/026 , A61H9/0078 , A61M37/00 , A61M2202/0208
摘要： A controller is operable to selectively supply gas to, and evacuate gas from, regions of a hyperbaric wound treatment chamber. The controller operates to inflate a passage or rib of the device to provide that the device is made sufficiently rigid for inserting a limb therethrough, and inflate an inflatable cuff to create a seal against the limb. The controller also operates to evacuate ambient air trapped within the chamber, and optionally partially evacuate the passage or rib, after the seal is created by the inflatable cuff, and then introduce oxygen into the chamber, and optionally inflate the passage or rib. The cuff, when inflated and creating a seal against a limb, optionally is at least partially within the chamber, and the treatment gas is supplied to the chamber to maintain the seal of the cuff against the limb.
摘要翻译：控制器可操作以选择性地向高压伤口处理室的区域供应气体并从其排出气体。控制器操作以使装置的通道或肋膨胀，以使得该装置被制成足够刚性的用于将肢体插入其中，并且使可膨胀的袖带膨胀以产生抵靠肢体的密封。控制器还操作以在由可膨胀的袖带产生密封之后，抽空室内被捕获的环境空气，并且可选地部分地抽空通道或肋，然后将氧气引入室中，并且可选地使通道或肋膨胀。袖带在膨胀并且对肢体产生密封时可选地至少部分地在腔室内，并且处理气体被供应到腔室以将袖带的密封保持抵靠肢体。

9. 发明申请

US20060185670A1 Hyperbaric oxygen devices and delivery methods 有权
公开(公告)号：US20060185670A1
公开(公告)日：2006-08-24
申请号：US11064581
申请日：2005-02-24
申请人： Phillip Loori , George Hovorka
发明人： Phillip Loori , George Hovorka
IPC分类号： A61G10/00 , A62B31/00
CPC分类号： A61G10/026 , A61H33/14 , A61H2033/143 , A61M35/00
摘要： A hyperbaric oxygen device and methods of applying hyperbaric oxygen are disclosed. The device comprises an enclosure including a collapsible bag defined by two sheets of fluid impervious material sealed together at both ends such that gas can be delivered between the sheets to inflate the enclosure to a rigid state and maintain the enclosure in the rigid state when oxygen pressure in the interior of the enclosure is cycled between ambient pressure and above ambient pressure.

10. 发明授权

US08939961B2 Controller for an extremity hyperbaric device 有权
公开(公告)号：US08939961B2
公开(公告)日：2015-01-27
申请号：US12156465
申请日：2008-05-30
申请人： Phillip Loori , George Hovorka
发明人： Phillip Loori , George Hovorka
IPC分类号： A61M1/00 , A61M37/00 , A61H9/00 , A61G10/02
CPC分类号： A61H9/0057 , A61G10/02 , A61G10/023 , A61G10/026 , A61H9/0078 , A61M37/00 , A61M2202/0208
摘要： A controller is operable to selectively supply gas to, and evacuate gas from, regions of a hyperbaric wound treatment chamber. The controller operates to inflate a passage or rib of the device to provide that the device is made sufficiently rigid for inserting a limb therethrough, and inflate an inflatable cuff to create a seal against the limb. The controller also operates to evacuate ambient air trapped within the chamber, and optionally partially evacuate the passage or rib, after the seal is created by the inflatable cuff, and then introduce oxygen into the chamber, and optionally inflate the passage or rib. The cuff, when inflated and creating a seal against a limb, optionally is at least partially within the chamber, and the treatment gas is supplied to the chamber to maintain the seal of the cuff against the limb.

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