专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140274766A1 METHODS OF USING F-SPONDIN AS A BIOMARKER FOR CARTILAGE DEGENERATIVE CONDITIONS AND BONE DISEASES 审中-公开
标题翻译：使用F-SPONDIN作为生物标记物用于治疗退行性疾病和骨髓疾病的方法
公开(公告)号：US20140274766A1
公开(公告)日：2014-09-18
申请号：US14155491
申请日：2014-01-15
申请人： Steven B. Abramson , Mukundan Attur , Glyn Palmer , Ashok Amin
发明人： Steven B. Abramson , Mukundan Attur , Glyn Palmer , Ashok Amin
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5041 , G01N33/6887 , G01N33/6893
摘要： Methods for identifying subjects having, or at risk for developing, osteoarthritis or other cartilage degenerative conditions by measuring levels of expression of F-spondin are provided. Assays, kits and methods for determining and assaying the presence of F-spondin in individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods are disclosed for identifying candidate compounds that modulate F-spondin levels of expression and/or function or for determining and evaluating an individual's response to drugs and therapeutic agents, are provided. The invention further relates to the modulation of F-spondin, particularly the inhibition of F-spondin, for increasing or stimulating bone formation and/or growth and mediating the alleviation of bone disease, disorders or conditions. The use of F-spondin, an active fragment thereof, or a modulator thereof for enhancing cartilage repair or preventing or treating cartilage degeneration, degenerative diseases or arthritic conditions is also provided.
摘要翻译：提供了通过测量F-spondin的表达水平来鉴定具有或具有发展为骨关节炎或其它软骨退行性疾病风险的受试者的方法。公开了用于确定和测定个体患者中F-spondin的存在的测定，试剂盒和方法。描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。公开了用于鉴定调节F-spondin水平的表达和/或功能或用于确定和评估个体对药物和治疗剂的反应的候选化合物的测定和方法。本发明还涉及F-spondin的调节，特别是F-spondin的抑制，用于增加或刺激骨形成和/或生长并介导骨疾病，病症或病症的缓解。还提供了用于增强软骨修复或预防或治疗软骨变性，退行性疾病或关节炎病症的F-斯朋素，其活性片段或其调节剂的用途。

2. 发明申请

US20100015129A1 Methods of using F-spondin as a biomarker for cartilage degenerative conditions and bone diseases 审中-公开
标题翻译：使用F-spondin作为软骨退行性疾病和骨病的生物标志物的方法
公开(公告)号：US20100015129A1
公开(公告)日：2010-01-21
申请号：US12455296
申请日：2009-05-29
申请人： Steven B. Abramson , Mukundan Attur , Ashok Amin , Glyn Palmer
发明人： Steven B. Abramson , Mukundan Attur , Ashok Amin , Glyn Palmer
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/00 , G01N33/53 , A61K31/7088
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5041 , G01N33/6887 , G01N33/6893
摘要： Methods for identifying subjects having, or at risk for developing, osteoarthritis or other cartilage degenerative conditions by measuring levels of expression of F-spondin are provided. Assays, kits and methods for determining and assaying the presence of F-spondin in individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods are disclosed for identifying candidate compounds that modulate F-spondin levels of expression and/or function or for determining and evaluating an individual's response to drugs and therapeutic agents, are provided. The invention further relates to the modulation of F-spondin, particularly the inhibition of F-spondin, for increasing or stimulating bone formation and/or growth and mediating the alleviation of bone disease, disorders or conditions. The use of F-spondin, an active fragment thereof, or a modulator thereof for enhancing cartilage repair or preventing or treating cartilage degeneration, degenerative diseases or arthritic conditions is also provided.
摘要翻译：提供了通过测量F-spondin的表达水平来鉴定具有或具有发展为骨关节炎或其它软骨退行性疾病风险的受试者的方法。公开了用于确定和测定个体患者中F-spondin的存在的测定，试剂盒和方法。描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。公开了用于鉴定调节F-spondin水平的表达和/或功能或用于确定和评估个体对药物和治疗剂的反应的候选化合物的测定和方法。本发明还涉及F-spondin的调节，特别是F-spondin的抑制，用于增加或刺激骨形成和/或生长并介导骨疾病，病症或病症的缓解。还提供了用于增强软骨修复或预防或治疗软骨变性，退行性疾病或关节炎病症的F-斯朋素，其活性片段或其调节剂的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式