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1. 发明申请

US20090209554A1 Thiazoliums as transketolase inhibitors 审中-公开
标题翻译：噻唑鎓作为转酮酶抑制剂
公开(公告)号：US20090209554A1
公开(公告)日：2009-08-20
申请号：US10593910
申请日：2005-03-23
申请人： Steven A. Boyd , Kevin R. Condroski , Jason De Meese , Stephen S. Gonzales , Indrani W. Gunawardana , Tomas Kaplan , Yvan Le Huerou , Joseph Lyssikatos , Todd T. Romoff , Francis X. Sullivan , Allen Thomas
发明人： Steven A. Boyd , Kevin R. Condroski , Jason De Meese , Stephen S. Gonzales , Indrani W. Gunawardana , Tomas Kaplan , Yvan Le Huerou , Joseph Lyssikatos , Todd T. Romoff , Francis X. Sullivan , Allen Thomas
IPC分类号： A61K31/497 , C12N9/99 , C12N5/06 , A61K31/4439 , A61P35/00 , C07D417/06
CPC分类号： C07D417/06 , C07D417/14
摘要： The present invention provides N-3′-pyridyl-methyl or N-2′-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X− are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
摘要翻译：本发明提供了可用作转酮酶抑制剂的式（I）的N-3'-吡啶基 - 甲基或N-2'-吡嗪基甲基噻唑鎓衍生物，其中R1，R2，R3，Y，R5-R9，Ra-Rd，n 和X-如本文所定义。本发明还提供包含式（I）化合物的药物组合物。本发明提供了抑制转酮醇酶活性，减少细胞核糖-5-磷酸水平，抑制核酸合成，抑制体外和体内细胞增殖和肿瘤细胞生长，刺激肿瘤细胞凋亡和通过给予式（I）化合物或其药物组合物。

2. 发明授权

US07879885B2 Thioalkeneamides as transketolase inhibitors 失效
标题翻译：硫代烯酰胺作为转酮酶抑制剂
公开(公告)号：US07879885B2
公开(公告)日：2011-02-01
申请号：US10593911
申请日：2005-03-23
申请人： Steven A. Boyd , Kevin R. Condroski , Allen Thomas , Stephen S. Gonzales , Indrani W. Gunawardana , Yvan Le Huerou , Todd T. Romoff , Francis X. Sullivan
发明人： Steven A. Boyd , Kevin R. Condroski , Allen Thomas , Stephen S. Gonzales , Indrani W. Gunawardana , Yvan Le Huerou , Todd T. Romoff , Francis X. Sullivan
IPC分类号： A61K31/44
CPC分类号： C07D213/73 , C07D405/12 , C07D411/12
摘要： The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
摘要翻译：本发明提供了可用作转酮酶抑制剂的式（I）的硫代链烯酰胺：其中R1，R2，R3，R4，R5，R6，Ra-Rd，n和环A如本文所定义。本发明还提供包含式（I）化合物的药物组合物。本发明提供了抑制转酮醇酶活性，减少细胞核糖-5-磷酸水平，抑制核酸合成，抑制体外和体内细胞增殖和肿瘤细胞生长，刺激肿瘤细胞凋亡和通过给予式（I）化合物或其药物组合物。

3. 发明授权

US07536290B1 Model-based management of an existing information processing system 有权
标题翻译：现有信息处理系统的模型管理
公开(公告)号：US07536290B1
公开(公告)日：2009-05-19
申请号：US10954775
申请日：2004-09-30
申请人： Duke P. Browning , Francis X. Sullivan
发明人： Duke P. Browning , Francis X. Sullivan
IPC分类号： G06F13/10
CPC分类号： G06F13/10
摘要： A method, system, computer system, and computer-readable medium to create a snapshot of an existing information system using a model of an information processing system. The model defines a set of instructions that is operable to discover data about a resource in the existing information processing system, and the snapshot is created by executing the set of instructions. An analysis of the snapshot is performed to identify a set of actions needed to make a change to the existing information processing system. Changes to the existing information processing system may include, for example, upgrading the existing information processing system, deploying a new instance of the existing information processing system, and optimizing performance of the existing information processing system.
摘要翻译：一种使用信息处理系统的模型创建现有信息系统的快照的方法，系统，计算机系统和计算机可读介质。该模型定义了一组可用于发现关于现有信息处理系统中的资源的数据的指令，并且通过执行该指令集创建快照。执行快照的分析以识别对现有信息处理系统进行改变所需的一组动作。对现有信息处理系统的改变可以包括例如升级现有信息处理系统，部署现有信息处理系统的新实例以及优化现有信息处理系统的性能。

4. 发明授权

US06999990B1 Technical support chain automation with guided self-help capability, escalation to live help, and active journaling 有权
标题翻译：技术支持链自动化，引导自助能力，升级到现场帮助，以及积极的日志记录
公开(公告)号：US06999990B1
公开(公告)日：2006-02-14
申请号：US09310795
申请日：1999-05-12
申请人： Francis X. Sullivan , Brian Jay Vetter
发明人： Francis X. Sullivan , Brian Jay Vetter
IPC分类号： G06F15/16
CPC分类号： H04L67/36 , G06F9/453 , G06Q30/02 , H04L29/06 , H04L67/02 , H04L69/329
摘要： A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins initiates a guided self-help session in response to entry by a user of a problem area and description. During the self-help session, the user is provided with an option to escalate to live help. If the user exercises that option, the system automatically provides a support engineer at the server with a data stream summarizing the self-help session. During the live help, the support engineer may then repeat a portion of the user's self-help session, view information generated during that session, and/or execute certain actions with respect to the user's machine, all from the engineer's desktop. An active journal is maintained for each problem incident, and active journals may be used by other analysts to facilitate problem resolutions for new incidents.
摘要翻译：一种用于具有客户端机器的计算机网络中的自动化技术支持的方法，以及至少一个从其提供现场帮助的服务器。该方法开始响应于用户输入问题区域和描述而启动指导的自助会话。在自助会议期间，向用户提供了升级到实时帮助的选项。如果用户练习该选项，系统会自动向服务器提供一个支持工程师，并提供汇总自助会话的数据流。在实时帮助期间，支持工程师可以重复用户的自助会话的一部分，查看在该会话期间生成的信息，和/或执行关于用户机器的某些动作，全部来自工程师的桌面。为每个问题事件维护一份活跃的期刊，其他分析师也可以使用活跃的期刊来促进新事件的问题解决。

5. 发明授权

US06542898B1 Technical support chain automation with guided self-help capability using active content developed for specific audiences 有权
标题翻译：技术支持链自动化，使用针对特定受众开发的活动内容的指导自助功能
公开(公告)号：US06542898B1
公开(公告)日：2003-04-01
申请号：US09310399
申请日：1999-05-12
申请人： Francis X. Sullivan , Brian Jay Vetter
发明人： Francis X. Sullivan , Brian Jay Vetter
IPC分类号： G06F1700
CPC分类号： G06Q30/02 , Y10S707/956 , Y10S707/966 , Y10S707/99939 , Y10S707/99943
摘要： Guided self-help is facilitated through use of so-called “active content” pages that are selectively viewable by given “audiences” within a technical support chain automation system. Active content is Web-based content (e.g., content viewable by a Web browser) that has one or more diagnostic maps initiated when certain actions are taken According to the invention, users are assigned to a hierarchy of audiences. A given audience within the hierarchy has the right to view active content written for that audience and active content written for any audience within the hierarchy at a lower level in the hierarchy. Given segments or portions of an active content database are associated with given audiences in the hierarchy. Thus, during a guided technical support session initiated by a user, given active content is served to the user as a function of the audience to which the user has been assigned.
摘要翻译：通过使用技术支持链自动化系统中由给定“受众”选择性查看的所谓“活动内容”页面，便于引导自助。活动内容是基于Web的内容（例如，可由Web浏览器查看的内容），其具有在采取某些动作时启动的一个或多个诊断图。根据本发明，将用户分配给观众的层次结构。层级中的给定受众有权查看针对该受众群体编写的活动内容，并为层次结构中层次结构中的所有受众编写的活动内容位于层次结构中的较低级别。给定活动内容数据库的段或部分与层次结构中的给定受众相关联。因此，在由用户发起的指导技术支持会话期间，根据用户已经被分配到的受众，给予活动内容给予用户。

6. 发明授权

US06615240B1 Technical support chain automation with guided self-help capability and option to escalate to live help 有权
标题翻译：技术支持链自动化，具有指导的自助功能和选项，升级到实时帮助
公开(公告)号：US06615240B1
公开(公告)日：2003-09-02
申请号：US09215873
申请日：1998-12-18
申请人： Francis X. Sullivan , Thomas William Bereiter , Brian Jay Vetter
发明人： Francis X. Sullivan , Thomas William Bereiter , Brian Jay Vetter
IPC分类号： G06F1516
CPC分类号： H04L67/36 , G06F9/453 , G06Q30/02 , H04L29/06 , H04L67/02 , H04L69/329
摘要： A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins initiates a guided self-help session in response to entry by a user of a problem area and description. During the self-help session, the user is provided with an option to escalate to live help. If the user exercises that option, the system automatically provides a support engineer at the server with a data stream summarizing the self-help session. During the live help, the support engineer may then repeat a portion of the user's self-help session, view information generated during that session, and/or execute certain actions with respect to the user's machine, all from the engineer's desktop.
摘要翻译：一种用于具有客户端机器的计算机网络中的自动化技术支持的方法，以及至少一个从其提供现场帮助的服务器。该方法开始响应于用户输入问题区域和描述而启动指导的自助会话。在自助会议期间，向用户提供了升级到实时帮助的选项。如果用户练习该选项，系统会自动向服务器提供一个支持工程师，并提供汇总自助会话的数据流。在实时帮助期间，支持工程师可以重复用户的自助会话的一部分，查看在该会话期间生成的信息，和/或执行关于用户机器的某些动作，全部来自工程师的桌面。

7. 发明授权

US07155346B2 Crystal structure of yqeJ and uses thereof 失效
公开(公告)号：US07155346B2
公开(公告)日：2006-12-26
申请号：US10209041
申请日：2002-07-31
申请人： Andrea M. Olland , Mark L. Stahl , Francis X. Sullivan , Kathryn W. Underwood , Rajiv Chopra
发明人： Andrea M. Olland , Mark L. Stahl , Francis X. Sullivan , Kathryn W. Underwood , Rajiv Chopra
IPC分类号： G01N33/48 , C12Q1/48
CPC分类号： G01N25/147 , G06F19/70
摘要： This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.

8. 发明授权

US06694314B1 Technical support chain automation with guided self-help capability via a system-supplied search string 有权
标题翻译：技术支持链自动化，通过系统提供的搜索字符串引导自助功能
公开(公告)号：US06694314B1
公开(公告)日：2004-02-17
申请号：US09215880
申请日：1998-12-18
申请人： Francis X. Sullivan , Thomas William Bereiter , Brian Jay Vetter
发明人： Francis X. Sullivan , Thomas William Bereiter , Brian Jay Vetter
IPC分类号： G06F1730
CPC分类号： G06F17/30985 , Y10S707/99942
摘要： A method for automated technical support in a computer network having a client machine, and at least one server from which live help is available. The method begins in response to entry by a user of a problem area and description. In response, a diagnostic map is executed to explore the user's machine and the problem description. The map returns a self-help search string that, upon execution in a search engine, is expected to return relevant search results. The search string may then be executed to facilitate a guided self-help session.
摘要翻译：一种用于具有客户端机器的计算机网络中的自动化技术支持的方法，以及至少一个从其提供现场帮助的服务器。该方法响应于用户输入问题区域和描述而开始。作为响应，执行诊断图以探索用户的机器和问题描述。该地图返回一个自助搜索字符串，在搜索引擎中执行时，可以返回相关的搜索结果。然后可以执行搜索字符串以便于指导的自助会话。

9. 发明授权

US06477531B1 Technical support chain automation with guided self-help capability using active content 有权
标题翻译：技术支持链自动化，使用活动内容引导自助功能
公开(公告)号：US06477531B1
公开(公告)日：2002-11-05
申请号：US09216212
申请日：1998-12-18
申请人： Francis X. Sullivan , Brian Jay Vetter
发明人： Francis X. Sullivan , Brian Jay Vetter
IPC分类号： G06F1730
CPC分类号： G06F17/30873
摘要： A method for automated technical support in a computer network having a client machine, and at least one server. The method begins in response to entry by a user of a problem areas and description. During a guided self-help session, the user is presented with active content, for example, technical support information that may be “activated” via a diagnostic map. A given diagnostic map encapsulates a set of one or more methods that, upon execution, explore the user's machine and gathers diagnostic data. The active content is useful to facilitate diagnosis or self-repair during the self-help session.
摘要翻译：一种用于具有客户端机器的计算机网络中的自动技术支持的方法，以及至少一个服务器。该方法响应于用户输入问题区域和描述而开始。在指导的自助会话期间，向用户呈现活动内容，例如可以通过诊断图“激活”的技术支持信息。给定的诊断图封装了一组一个或多个方法，在执行时，可以探索用户的机器并收集诊断数据。活动内容有助于在自助会议期间促进诊断或自我修复。

10. 发明授权

US07809536B1 Model-building interface 有权
标题翻译：模型建立界面
公开(公告)号：US07809536B1
公开(公告)日：2010-10-05
申请号：US10955350
申请日：2004-09-30
申请人： Duke P. Browning , Francis X. Sullivan
发明人： Duke P. Browning , Francis X. Sullivan
IPC分类号： G06G7/48 , G06F11/00
CPC分类号： G06N5/02
摘要： A method, system, computer system, and computer-readable medium to provide an interface for defining a model of a particular functionality of an information processing system. Intelligent models can be defined that can be used by an application to discover actual relationship, dependency, or configuration data for components of an information processing system. Models can be defined to include a set of one or more instructions to discover data about an existing information system, where the data are related to the specific information processing function being modeled. Models provide a context for analyzing and evaluating the functionality of an information processing system. The interface can also be used to define the model itself, including components of the model, properties of the components, and relationships between components.
摘要翻译：一种方法，系统，计算机系统和计算机可读介质，以提供用于定义信息处理系统的特定功能的模型的接口。可以定义智能模型，可以由应用程序使用它来发现信息处理系统的组件的实际关系，依赖关系或配置数据。可以将模型定义为包括一组一个或多个指令以发现关于现有信息系统的数据，其中数据与被建模的特定信息处理功能相关。模型提供了分析和评估信息处理系统功能的上下文。该界面还可用于定义模型本身，包括模型的组件，组件的属性以及组件之间的关系。

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