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    • 1. 发明授权
    • Covered microchannels and the microfabrication thereof
    • 覆盖微通道及其微细加工
    • US5783452A
    • 1998-07-21
    • US595683
    • 1996-02-02
    • Steve D. JonsPaul J. O'ConnorIng-Fen Hu
    • Steve D. JonsPaul J. O'ConnorIng-Fen Hu
    • G01N27/447G01N30/60G03F7/00G01N33/00G01N30/02G03C5/00
    • G01N30/6095G01N27/44791G03F7/0035
    • The present invention is a covered microchannel comprising: a) a substrate; b) an etched material adhered to the substrate; and c) a silicon-carbon material adhered to the etched material in such a manner to form a covered microchannel; wherein the silicon-carbon material comprises SiO.sub.1.8-2.4 C.sub.0.3-1.0 and H.sub.0.7-4.0 containing at least one of the following functional groups: --Si--O--Si--, --Si--CH.sub.2 --, --Si--H, or --Si--OH. The covered microchannel can be prepared by the steps of: a) coating a filler material onto a substrate having a groove, wherein the filler material covering the substrate fills the groove; b) removing filler material from the substrate but not from the groove; c) coating the substrate and the filler with an adhering, formable, capping material; and d) removing the filler from the groove. An etched laminate can also be used to prepare the covered microchannel. The present invention provides a covered microchannel that can be prepared under milder conditions than those previously contemplated, thereby allowing greater flexibility in the choice of material of the substrate. The covered microchannel can be used, for example, in micro-liquid or micro-gas chromatographic or electrophoretic applications.
    • 本发明是一种覆盖的微通道,其包括:a)基底; b)粘附到基底上的蚀刻材料; 和c)以形成覆盖微通道的方式粘附到蚀刻材料上的硅 - 碳材料; 其中所述硅 - 碳材料包含含有至少一个以下官能团的SiO:1.8-2.4 C0.3-1.0和H0.7-4.0:-Si-O-Si-,-Si-CH2-,-Si- H或-Si-OH。 覆盖的微通道可以通过以下步骤制备:a)将填料材料涂覆到具有凹槽的基底上,其中覆盖基底的填充材料填充凹槽; b)从衬底移除填料,但不从槽中取出; c)用粘合的可成形的封盖材料涂覆基材和填料; 和d)从槽中去除填料。 蚀刻的层压板也可用于制备被覆盖的微通道。 本发明提供了一种覆盖的微通道,其可以在比先前考虑的条件更温和的条件下制备,从而在选择基材的材料方面具有更大的灵活性。 被覆微通道可用于例如微液体或微气相色谱或电泳应用。
    • 4. 发明授权
    • Apparatus and method for reversed permeation membrane extraction of
compounds from sample solutions
    • 从样品溶液中反渗透膜提取化合物的装置和方法
    • US5221477A
    • 1993-06-22
    • US893874
    • 1992-06-05
    • Richard G. MelcherPaul J. O'Connor
    • Richard G. MelcherPaul J. O'Connor
    • B01J20/281B01D11/04B01D61/00B01D61/08B01D63/00B01D63/06G01N1/34G01N30/06G01N30/08G01N30/14G01N30/88G01N33/18
    • B01D61/00B01D11/0415G01N1/34G01N30/08G01N2001/4016G01N2030/062G01N2030/146G01N33/1826
    • A reversed permeation membrane assembly and method for collecting one or more compounds of interest from a sample solution. The membrane assembly includes a semi-permeable membrane of predetermined thickness and length, and having inner and outer surfaces. The membrane is attached adjacent its outer surface to a substantially rigid membrane support, and a non-porous barrier contacts the outer surface of the membrane to prevent permeation of compounds beyond the outer surface in use. In a preferred embodiment, the semi-permeable membrane assumes a substantially tubular conformation through which sample solution may be passed. The membrane support also preferably features a tubular conformation within which the semi-permeable membrane is mounted. Because of its unique structure and improved efficiency, the assembly of the present invention may be incorporated for in-line use with liquid and gas chromatography devices and GC/MS units. In some applications, the extractant can even be flowed through the membrane cell to collect analytes and directly to an LC column for analysis in a substantially non-stop manner.
    • 用于从样品溶液中收集一种或多种感兴趣化合物的反渗透膜组件和方法。 膜组件包括具有预定厚度和长度的半透膜,并且具有内表面和外表面。 膜邻近其外表面附接到基本上刚性的膜支撑件,并且非多孔屏障接触膜的外表面以防止化合物在使用中超过外表面渗透。 在优选的实施方案中,半透膜呈现出可以通过样品溶液的基本上管状的构型。 膜支撑体还优选地具有管状构型,半透膜被安装在该构造内。 由于其独特的结构和改进的效率,本发明的组装可以并入用于与液相和气相色谱装置和GC / MS装置的在线使用。 在一些应用中,萃取剂甚至可以流过膜细胞以收集分析物并直接进入LC柱以便以基本不间断的方式进行分析。