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1. 发明授权

US06110907A Synthesis of platinum complexes and uses thereof 失效
标题翻译：铂络合物的合成及其用途
公开(公告)号：US06110907A
公开(公告)日：2000-08-29
申请号：US69562
申请日：1998-04-29
申请人： Steve C. F. Au-Yeung , Yee Ping Ho , Lin Ge , Han Xiuwen , Wang Xinning , Lu Shiwei , Jiang Tao
发明人： Steve C. F. Au-Yeung , Yee Ping Ho , Lin Ge , Han Xiuwen , Wang Xinning , Lu Shiwei , Jiang Tao
IPC分类号： C07F15/00 , A61K31/555
CPC分类号： C07F15/0093
摘要： This invention provides novel antitumor demethylcantharidin platinum complexes. This invention also provides a composition comprising at least one of said demethylcantharidin platinum complexes and a suitable carrier. This invention provides a pharmaceutical composition comprising effective amount of at least one of the said demethylcantharidin platinum complexes and a pharmaceutically acceptable carrier. This invention provides a method of inhibiting the growth of tumorous cells comprising contacting the cells with an amount of said demethylcantharidin platinum complex effective to inhibit the growth of said tumorous cells. This invention provides a method of inhibiting the growth of tumorous cells in a subject comprising administering to the subject with an amount of the said demethylcantharidin platinum complexes effective to inhibit the growth of said tumorous cells in the subject. Finally, this invention provides methods for producing said demethylcantharidin platinum complexes.
摘要翻译：本发明提供新的抗肿瘤去甲基杀青霉素铂络合物。本发明还提供了包含至少一种所述去甲基青霉素铂络合物和合适的载体的组合物。本发明提供一种药物组合物，其包含有效量的至少一种所述去甲基杀青霉素铂络合物和药学上可接受的载体。本发明提供抑制肿瘤细胞生长的方法，包括使细胞与一定量的有效抑制所述肿瘤细胞生长的去甲基角叉菜碱铂络合物接触。本发明提供一种抑制受试者中肿瘤细胞生长的方法，其包括向受试者施用一定量的有效抑制受试者中所述肿瘤细胞生长的所述去甲基杀青霉素铂配合物。最后，本发明提供了制备所述去甲基杀青霉素铂络合物的方法。

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