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1. 发明授权

US5947953A Splittable multiple catheter assembly and methods of inserting the same 失效
标题翻译：可分离多导管组件及其插入方法
公开(公告)号：US5947953A
公开(公告)日：1999-09-07
申请号：US907311
申请日：1997-08-06
申请人： Stephen R. Ash , Anthony J. Madison , Timothy M. Schweikert
发明人： Stephen R. Ash , Anthony J. Madison , Timothy M. Schweikert
IPC分类号： A61M25/00 , A61M25/14 , A61M31/00
CPC分类号： A61M25/0021 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037 , A61M2025/004 , A61M25/0043
摘要： A multiple lumen catheter assembly and methods for inserting the same are provided. The assembly includes a splittable membrane joining a first catheter and a second catheter for allowing the catheters to be at least partially longitudinally split from each other. Each catheter has at least one lumen extending longitudinally through the catheter. One method for inserting the assembly includes making an incision near the area to be catheterized, at least partially splitting the distal end regions of the catheters from each other by splitting apart the splittable membrane, and inserting the distal end regions of the catheters in a juxtaposed relation through the incision and into the area to be catheterized. In another method, the catheters are first tunnelled subcutaneously by pulling the distal end regions of the catheters in the assembly through a tunnel and outwardly from the tunnel near the area to be catheterized, leaving proximal end regions at least partially within the tunnel. An incision is made near the area to be catheterized, the distal end regions of the catheters are at least partially split from each other by splitting the splittable membrane, and the distal end regions of the catheters are inserted in a juxtaposed relation through the incision and into the area to be catheterized.
摘要翻译：提供了一种多腔导管组件及其插入方法。该组件包括接合第一导管和第二导管的可分离膜，用于允许导管至少部分地彼此纵向分开。每个导管具有至少一个沿着导管纵向延伸的内腔。用于插入组件的一种方法包括在待导管的区域附近形成切口，至少部分地将导管的远端区域彼此分开，通过分开可分离的膜并将导管的远端区域并列插入通过切口和进入导管区域的关系。在另一种方法中，导管首先通过穿过隧道拉动组件中的导管的远端区域并从导管区域附近的隧道向外拉动皮下，使得近端区域至少部分地在隧道内。在待导管的区域附近进行切口，通过分裂可分离的膜，导管的远端区域至少部分地彼此分开，并且导管的远端区域通过切口以并置的关系插入，并且进入导管区域。

2. 发明授权

US06190349B1 Splittable multiple catheter assembly and methods for inserting the same 有权
标题翻译：可分离多导管组件及其插入方法
公开(公告)号：US06190349B1
公开(公告)日：2001-02-20
申请号：US09365698
申请日：1999-08-02
申请人： Stephen R. Ash , Anthony J. Madison , Timothy M. Schweikert
发明人： Stephen R. Ash , Anthony J. Madison , Timothy M. Schweikert
IPC分类号： A61M300
CPC分类号： A61M25/0021 , A61M25/0043 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037 , A61M2025/004
摘要： A multiple lumen catheter assembly and methods for inserting the same are provided. The assembly includes a splittable membrane joining a first catheter and a second catheter for allowing the catheters to be at least partially longitudinally split from each other. Each catheter has at least one lumen extending longitudinally through the catheter. One method for inserting the assembly includes making an incision near the area to be catheterized, at least partially splitting the distal end regions of the catheters from each other by splitting apart the splittable membrane, and inserting the distal end regions of the catheters in a juxtaposed relation through the incision and into the area to be catheterized. In another method, the catheters are first tunnelled subcutaneously by pulling the distal end regions of the catheters in the assembly through a tunnel and outwardly from the tunnel near the area to be catheterized, leaving proximal end regions at least partially within the tunnel. An incision is made near the area to be catheterized, the distal end regions of the catheters are at least partially split from each other by splitting the splittable membrane, and the distal end regions of the catheters are inserted in a juxtaposed relation through the incision and into the area to be catheterized.
摘要翻译：提供了一种多腔导管组件及其插入方法。该组件包括接合第一导管和第二导管的可分离膜，用于允许导管至少部分地彼此纵向分开。每个导管具有至少一个沿着导管纵向延伸的内腔。用于插入组件的一种方法包括在待导管的区域附近形成切口，至少部分地将导管的远端区域彼此分开，通过分开可分离的膜并将导管的远端区域并列插入通过切口和进入导管区域的关系。在另一种方法中，导管首先通过穿过隧道拉动组件中的导管的远端区域并从导管区域附近的隧道向外拉动皮下，使得近端区域至少部分地在隧道内。在待导管的区域附近进行切口，通过分裂可分离的膜，导管的远端区域至少部分地彼此分开，并且导管的远端区域通过切口以并置的关系插入，并且进入导管区域。

3. 发明授权

US07749529B2 Catheter lock solution comprising citrate and a paraben 有权
标题翻译：导管锁定溶液，其包含柠檬酸盐和对羟基苯甲酸酯
公开(公告)号：US07749529B2
公开(公告)日：2010-07-06
申请号：US11053130
申请日：2005-02-08
申请人： Stephen R. Ash , Janusz Steczko , Gary L. Swanson
发明人： Stephen R. Ash , Janusz Steczko , Gary L. Swanson
IPC分类号： A61K31/5415 , A61K31/235 , A61K31/19 , A61F2/00
CPC分类号： A01N37/10 , A01N37/04 , A61L29/14 , A61L29/16 , A61L2300/404 , A61L2300/42 , A61M25/0017
摘要： This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.
摘要翻译：本发明涉及将导管锁定溶液输注到留置导管中的组合物，方法，装置和试剂盒。本发明的组合物，方法，装置和试剂盒有助于减少导管中的微生物感染和导管闭塞的影响。本发明提供的锁定溶液包括柠檬酸盐和对羟基苯甲酸酯。溶液优选具有适于在锁定期间将溶液保留在导管中的密度。本发明提供的另一种锁定溶液包括柠檬酸盐，对羟基苯甲酸酯和光氧化剂，例如亚甲基蓝。

4. 发明申请

US20100010086A1 ANTIMICROBIAL THERAPY FOR INDWELLING CATHETERS AND FOR SANITIZING SURFACES 审中-公开
标题翻译：用于保护导管和消毒表面的抗微生物治疗
公开(公告)号：US20100010086A1
公开(公告)日：2010-01-14
申请号：US12309146
申请日：2007-08-03
申请人： Stephen R. Ash , Janusz Steczko
发明人： Stephen R. Ash , Janusz Steczko
IPC分类号： A01N37/10 , A01P1/00
CPC分类号： A61L29/14 , A01N37/40 , A61L29/16 , A61L2300/216 , A61L2300/406 , A61L2300/42 , A01N37/36 , A01N37/44 , A01N2300/00
摘要： The invention relates to compositions that provide antimicrobial therapy for indwelling catheters and as topical disinfectants, and methods, devices and kits relating thereto. In one aspect, the invention relates to the infusion of a catheter lock solution into an indwelling catheter. Use of inventive compositions as catheter lock solutions advantageously aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or other surfaces. An antimicrobial composition provided by the invention includes EDTA, a paraben, and optionally one or both of citrate and a photo-oxidant.
摘要翻译：本发明涉及提供用于留置导管和局部消毒剂的抗微生物治疗的组合物，以及与其相关的方法，装置和试剂盒。一方面，本发明涉及将导管锁定溶液输注到留置导管中。使用本发明的组合物作为导管锁定溶液有利地有助于减少导管中的微生物感染和导管闭塞的影响。在其他方面，抗微生物组合物用于对伤口，皮肤区域和/或其它表面进行局部消毒。本发明提供的抗微生物组合物包括EDTA，对羟基苯甲酸酯和任选的一种或两种柠檬酸盐和光氧化剂。

5. 发明申请

US20090291944A1 Antimicrobial compositions and methods of use 有权
标题翻译：抗微生物组合物和使用方法
公开(公告)号：US20090291944A1
公开(公告)日：2009-11-26
申请号：US12154557
申请日：2008-05-23
申请人： Stephen R. Ash , Janusz Steczko
发明人： Stephen R. Ash , Janusz Steczko
IPC分类号： A61K31/5415 , A61K31/045 , A61K31/194
CPC分类号： A01N43/84 , A01N31/02 , A01N37/02 , A01N37/10 , A61L2/0088 , A61L2/18 , A01N25/34 , A01N37/36 , A01N37/40 , A01N2300/00
摘要： In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one paraben, a redox compound and an organic acid at a concentration of from about 1.5 percent to about 10 percent by weight, based on the total weight of the composition. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or to disinfect surgical instruments or other surfaces. Still, in further aspects, methods, devices and kits relating to an antimicrobial composition are provided.
摘要翻译：在一个方面，组合物提供抗微生物治疗作为局部消毒剂。特别地，一个方面涉及含醇的抗微生物组合物，其包含至少一种对羟基苯甲酸酯，氧化还原化合物和浓度为组合物总重量的约1.5重量％至约10重量％的有机酸。在其他方面，抗微生物组合物用于对伤口，皮肤区域进行局部消毒和/或消毒外科器械或其它表面。然而，在另外的方面，提供了与抗微生物组合物有关的方法，装置和试剂盒。

6. 发明授权

US06958049B1 Method of enhancing catheter patency using a citrate salt catheter lock solution 有权
公开(公告)号：US06958049B1
公开(公告)日：2005-10-25
申请号：US09763666
申请日：1999-08-25
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： A61M1/00 , A61M25/00
CPC分类号： A61L29/14 , A61M25/0017
摘要： This invention relates to an infusion device for a catheter lock solution, to a method of enhancing the patency of catheters in animals and to a catheter lock solution. The device includes a syringe (34) containing a lock solution comprising a citrate salt. The method for enhancing the patency of catheters includes infusing a lumen (14, 16) of an indwelling catheter (10) with a lock solution comprising a citrate salt. In one aspect of the invention, the catheter lock solution includes a citrate salt and a viscosifying agent. The lock solution is prepared to have sufficient viscosity and density to remain in the lumen for a desired amount of time.

7. 发明授权

US06264680B1 Apparatuses and processes for whole-body hyperthermia 有权
标题翻译：全身热疗的设备和方法
公开(公告)号：US06264680B1
公开(公告)日：2001-07-24
申请号：US09235449
申请日：1999-01-22
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： A61F700
CPC分类号： A61M1/369 , A61M1/166 , A61M1/26 , A61M1/3437 , A61M1/3458 , A61M1/3493 , A61M1/3621 , A61M2205/12
摘要： Apparatuses for use in whole body hypothermia include a high-flow hyperthermia circuit coupled to a low-flow dialysis circuit in a manner which reduces tensioning of membranes in the dialyzer of the dialysis circuit. The arrangement thereby allows proper membrane movement to assist in mixing a sorbent suspension circulated on the sorbent side of the dialyzer. Additional dialysis apparatuses include advantageous disposable packs including the dialyzer, sorbent heat exchangers arranged to cooperate with heating elements on base units of the apparatuses, and adaptations for very high flow rates useful in the hyperthermic treatment of cancers.
摘要翻译：用于全身低体温的装置包括以降低透析回路的透析器中的膜张力的方式耦合到低流量透析回路的高流量热疗回路。因此，该装置允许适当的膜移动以帮助混合在透析器的吸附剂侧上循环的吸附剂悬浮液。附加的透析设备包括有利的一次性包装，包括透析器，布置成与装置的基本单元上的加热元件配合的吸附剂热交换器，以及适用于在癌症的高热处理中有用的非常高的流速。

8. 发明授权

US06042561A Non-intravascular infusion access device 失效
标题翻译：非血管内输液器械
公开(公告)号：US06042561A
公开(公告)日：2000-03-28
申请号：US956001
申请日：1997-10-22
申请人： Stephen R. Ash , Elsa M. Janle
发明人： Stephen R. Ash , Elsa M. Janle
IPC分类号： A61K9/22 , A61M1/00 , A61M11/00
CPC分类号： A61M39/0247
摘要： A non-intravascular infusion access device and method for long-term continuous infusion of drugs. The infusion access device includes a porous membrane made of a material which is biocompatible for long-term patency inside the body. The porous membrane is connected to a conducting tubing which exits from the body and is connected to a drug infusion system. At the exit site is a cuff of porous material. The cuff serves to anchor the access device in position as the surrounding body tissue grows back around the cuff. There are also two small suture retainers for stabilizing the position of the access device relative until tissue ingrowth occurs in and around the cuff.
摘要翻译：一种用于长期连续输注药物的非血管内输液装置和方法。输液进入装置包括由在体内长期通畅生物相容的材料制成的多孔膜。多孔膜连接到从身体离开并连接到药物输注系统的导管。在出口处是多孔材料的袖口。袖带用于在周围的身体组织围绕袖带增长时将访问装置锚定在适当的位置。还有两个小的缝线保持器，用于稳定进入装置的位置，直到组织向内生长发生在袖带内和周围。

9. 发明授权

US5322519A Foldable catheter for peritoneal dialysis 失效
标题翻译：用于腹膜透析的可折叠导管
公开(公告)号：US5322519A
公开(公告)日：1994-06-21
申请号：US19367
申请日：1993-02-17
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： A61M25/00 , A61M1/00 , A61M1/14 , A61M1/28
CPC分类号： A61M1/285 , A61M1/284
摘要： A foldable peritoneal catheter is provided with a flexible central plenum chamber and flexible fluted wands or rods that extend outwardly from the plenum chamber and serve as liquid transport means for a dialysate fluid or the like. This type of peritoneal catheter is well suited for chronic peritoneal dialysis.
摘要翻译：可折叠的腹膜导管设置有柔性中央增压室和从充气室向外延伸并用作透析液或类似物的液体输送装置的柔性槽纹棒或杆。这种类型的腹膜导管非常适合慢性腹膜透析。

10. 发明授权

US5277820A Device and method for extracorporeal blood treatment 失效
标题翻译：体外血液治疗的装置和方法
公开(公告)号：US5277820A
公开(公告)日：1994-01-11
申请号：US832080
申请日：1992-02-06
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： A61M1/14 , A61M1/10 , A61M1/16 , A61M1/26 , A61M1/30 , A61M1/34 , B01D61/00 , B01D61/14 , B01D61/24 , B01D61/26 , B01D61/58 , B01D63/16 , B01D65/08
CPC分类号： B01D65/08 , A61M1/1005 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1696 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3431 , A61M1/3475 , A61M1/3493 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D63/16 , A61M1/1692 , A61M1/26 , A61M1/3472 , A61M2205/12 , A61M2205/7563 , B01D2321/2083 , Y10T436/255
摘要： Disclosed are preferred devices and methods which provide extracorporeal treatment of blood to effectively and consistently remove toxins therefrom and from patients over extended periods of time.
摘要翻译：公开了优选的装置和方法，其提供血液的体外治疗以有效且一致地从其中长时间地从患者中去除毒素。

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