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1. 发明申请

US20100203551A1 MONOCYTE ACTIVATION TEST BETTER ABLE TO DETECT NON-ENDOTOXIN PYROGENIC CONTAMINANTS IN MEDIAL PRODUCTS 有权
公开(公告)号：US20100203551A1
公开(公告)日：2010-08-12
申请号：US12767537
申请日：2010-04-26
申请人： Stephen Poole , Mehul Patel
发明人： Stephen Poole , Mehul Patel
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/5047 , G01N33/5055 , G01N33/5091 , G01N33/6863 , G01N2333/5412 , G01N2800/7095
摘要： An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

2. 发明授权

US07464081B2 Web based dynamic data translation service and method 有权
标题翻译：基于Web的动态数据翻译服务和方法
公开(公告)号：US07464081B2
公开(公告)日：2008-12-09
申请号：US10823370
申请日：2004-04-12
申请人： James Michael McKinley , Timothy Joseph Kane , Stephen Poole , Tammy Nguyen , Wahome Muchiri
发明人： James Michael McKinley , Timothy Joseph Kane , Stephen Poole , Tammy Nguyen , Wahome Muchiri
IPC分类号： G06F17/30
CPC分类号： H04L67/02 , H04L69/08 , Y10S707/99934
摘要： A method and system of translating data from a first format into one or more translated formats includes initiating a translation request on one of plurality of client systems. The translation request includes source data to be translated from the first format into desired translated formats and configuration data defining each type of translation to be performed on the source data. The translation request is communicated to a server system and is processed on the server system to determine from the configuration data the type of each data translation to be performed on the data. The data is provided to an appropriate translation service on the server system and is translated to the appropriate translated format via the corresponding translation service. A return translation request is communicated to the client system, the return translation request including the data in each translated format.
摘要翻译：将数据从第一格式转换为一个或多个翻译格式的方法和系统包括在多个客户端系统之一上发起翻译请求。翻译请求包括要从第一格式转换为期望的翻译格式的源数据和定义要对源数据执行的每种类型的翻译的配置数据。将翻译请求传送到服务器系统，并在服务器系统上进行处理，从配置数据中确定要对数据执行的每个数据转换的类型。将数据提供给服务器系统上的适当的翻译服务，并通过相应的翻译服务转换为适当的翻译格式。返回翻译请求被传送到客户端系统，返回翻译请求包括每种转换格式的数据。

3. 发明申请

US20060101414A1 System and method for automatically generating self-checking software 审中-公开
标题翻译：自动生成自检软件的系统和方法
公开(公告)号：US20060101414A1
公开(公告)日：2006-05-11
申请号：US11247790
申请日：2005-10-11
申请人： Stephen Poole
发明人： Stephen Poole
IPC分类号： G06F9/44 , G06F11/00
CPC分类号： G06F11/3684 , G06F9/44589
摘要： Generates self-checking software by providing characteristics of a specification; traversing points in state space defined by the characteristics to generate stand-alone test code; determining if the generated code is deterministic; and forming expected results of the test code into a standalone, self-checking body of test cases. The expected results may be merged back into randomly generated test cases to form the standalone, self-checking body of test cases.
摘要翻译：通过提供规格的特征生成自检软件; 通过由特征定义的状态空间中的遍历点来生成独立测试代码; 确定所生成的代码是否是确定性的; 并将测试代码的预期结果形成为独立的自检单元的测试用例。预期的结果可能会被并入随机生成的测试用例中，形成独立的自检实体。

4. 发明授权

US09023647B2 Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products 有权
标题翻译：单核细胞活化测试能更好地检测医疗产品中的非内毒素致热原性污染物
公开(公告)号：US09023647B2
公开(公告)日：2015-05-05
申请号：US13293868
申请日：2011-11-10
申请人： Stephen Poole , Mehul Patel
发明人： Stephen Poole , Mehul Patel
IPC分类号： C12N5/00 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6869 , G01N33/5047 , G01N33/5055 , G01N33/5091 , G01N33/6863 , G01N2333/5412 , G01N2800/7095
摘要： An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
摘要翻译：描述了改进的单核细胞活化试验，其更能够检测医疗产品中的非内毒素热原，其中将样品与包含至少一个包含聚丙烯的表面的测定系统中的含单核细胞的试剂一起温育。本发明还涉及用于这些测试的测定系统，其包括至少一个微量滴定孔，其具有至少一个包含聚丙烯的内表面，并且具有使含单核细胞的试剂在孔中浓缩以提供更大的细胞与细胞接触的形状。本发明还涉及可用于测试样品中非内毒素热原的存在的诊断试剂盒。

5. 发明申请

US20070184496A1 MONOCYTE ACTIVATION TEST BETTER ABLE TO DETECT NON-ENDOTOXIN PYROGENIC CONTAMINANTS IN MEDICAL PRODUCTS 有权
标题翻译：在医药产品中检测非内毒素有毒污染物的单克隆抗体活性测定
公开(公告)号：US20070184496A1
公开(公告)日：2007-08-09
申请号：US11613866
申请日：2006-12-20
申请人： Stephen Poole , Mehul Patel
发明人： Stephen Poole , Mehul Patel
IPC分类号： G01N33/567 , C12M3/00
CPC分类号： G01N33/6869 , G01N33/5047 , G01N33/5055 , G01N33/5091 , G01N33/6863 , G01N2333/5412 , G01N2800/7095
摘要： An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
摘要翻译：描述了改进的单核细胞活化试验，其更能够检测医疗产品中的非内毒素热原，其中将样品与包含至少一个包含聚丙烯的表面的测定系统中的含单核细胞的试剂一起温育。本发明还涉及用于这些测试的测定系统，其包括至少一个微量滴定孔，其具有至少一个包含聚丙烯的内表面，并且具有使含单核细胞的试剂在孔中浓缩以提供更大的细胞与细胞接触的形状。本发明还涉及可用于测试样品中非内毒素热原的存在的诊断试剂盒。

6. 发明授权

US06314445B1 Native function calling 失效
标题翻译：本地函数调用
公开(公告)号：US06314445B1
公开(公告)日：2001-11-06
申请号：US09128082
申请日：1998-08-03
申请人： Stephen Poole
发明人： Stephen Poole
IPC分类号： G06F1700
CPC分类号： G06F9/4484
摘要： A method and system of processing within a Java Virtual Machine on a computer system, a native function call instruction of a dynamic parameter set type and contained in a Java byte code application. The method comprises the steps of; interpreting the byte code representing a native function call instruction of the dynamic parameter set type; storing the parameters of the variable parameter set in an array; using the computer system to process the native function call as a fixed parameter set type using the array as the fixed parameter set. Before the function is called the computer system transfers the parameters from the array to a stack used by the native function.
摘要翻译：在计算机系统上的Java虚拟机内的处理方法和系统，动态参数集类型的本机函数调用指令，并包含在Java字节码应用程序中。该方法包括以下步骤：解释表示动态参数集类型的本地函数调用指令的字节码; 将变量参数集的参数存储在数组中; 使用计算机系统将本机函数调用作为固定参数集类型，使用数组作为固定参数集。在调用函数之前，计算机系统将参数从数组传递给本机函数使用的堆栈。

7. 发明授权

US07736863B2 Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products 有权
标题翻译：单核细胞活化测试能更好地检测医疗产品中的非内毒素致热原性污染物
公开(公告)号：US07736863B2
公开(公告)日：2010-06-15
申请号：US11613866
申请日：2006-12-20
申请人： Stephen Poole , Mehul Patel
发明人： Stephen Poole , Mehul Patel
IPC分类号： G01N33/567 , C12M1/34
CPC分类号： G01N33/6869 , G01N33/5047 , G01N33/5055 , G01N33/5091 , G01N33/6863 , G01N2333/5412 , G01N2800/7095
摘要： An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.
摘要翻译：描述了改进的单核细胞活化试验，其更能够检测医疗产品中的非内毒素热原，其中将样品与包含至少一个包含聚丙烯的表面的测定系统中的含单核细胞的试剂一起温育。本发明还涉及用于这些测试的测定系统，其包括至少一个微量滴定孔，其具有至少一个包含聚丙烯的内表面，并且具有使含单核细胞的试剂在孔中浓缩以提供更大的细胞与细胞接触的形状。本发明还涉及可用于测试样品中非内毒素热原的存在的诊断试剂盒。

8. 发明申请

US20070191307A1 Nanosized Carotenoid Cyclodextrin Complexes 有权
标题翻译：纳米级类胡萝卜素环糊精复合物
公开(公告)号：US20070191307A1
公开(公告)日：2007-08-16
申请号：US11538766
申请日：2006-10-04
申请人： Mark Bartlett , Angela Mastaloudis , Carsten Smidt , Stephen Poole
发明人： Mark Bartlett , Angela Mastaloudis , Carsten Smidt , Stephen Poole
IPC分类号： A61K31/702
CPC分类号： A61K47/48969 , A23L33/115 , A23L33/12 , A23L33/155 , A23V2002/00 , A61K9/4866 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/122 , A61K31/355 , A61K31/724 , A61K47/40 , A61K47/44 , A61K47/6951 , A23V2200/224 , A23V2250/5112 , A23V2250/211 , A23V2250/1882 , A23V2250/702 , A23V2250/712
摘要： Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.
摘要翻译：制备纳米营养配方以增强营养剂吸收的方法。这些方法包括环糊精与类胡萝卜素的络合，并将复合物掺入营养补充剂中，而无需中间收集，分离和干燥步骤。

9. 发明授权

US06790832B2 Pharmaceutical preparation for the treatment of inflammatory processes 失效
标题翻译：用于治疗炎症过程的药物制剂
公开(公告)号：US06790832B2
公开(公告)日：2004-09-14
申请号：US10127572
申请日：2002-04-23
申请人： Jürgen Römisch , Gerhard Dickneite , Peter Gronski , Bernhard Vohwinkel , Harald Stauss , Elaine Gray , Pauline Sxouter , Stephen Poole
发明人： Jürgen Römisch , Gerhard Dickneite , Peter Gronski , Bernhard Vohwinkel , Harald Stauss , Elaine Gray , Pauline Sxouter , Stephen Poole
IPC分类号： A61K3800
CPC分类号： A61K38/57 , Y10S514/825
摘要： A pharmaceutical preparation is described while is useful for the treatment of inflammatory processes being accompanied by an increased distribution of cytokines and/or tissue factor in the human body, which preparation contains Antithrombin III as active ingredient.
摘要翻译：描述了药物制剂，同时可用于治疗炎性过程，伴随着人体中细胞因子和/或组织因子的分布增加，该制剂含有抗凝血酶III作为活性成分。

10. 发明授权

US06399572B1 Pharmaceutical preparation for the treatment of inflammatory processes 失效
标题翻译：用于治疗炎症过程的药物制剂
公开(公告)号：US06399572B1
公开(公告)日：2002-06-04
申请号：US09492790
申请日：2000-01-28
申请人： Jürgen Römisch , Gerhard Dickneite , Peter Gronski , Bernhard Vohwinkel , Harald Stauss , Elaine Gray , Pauline Sxouter , Stephen Poole
发明人： Jürgen Römisch , Gerhard Dickneite , Peter Gronski , Bernhard Vohwinkel , Harald Stauss , Elaine Gray , Pauline Sxouter , Stephen Poole
IPC分类号： A61K3800
CPC分类号： A61K38/57 , Y10S514/825
摘要： A pharmaceutical preparation is described while is useful for the treatment of inflammatory processes being accompanied by an increased distribution of cytokines and/or tissue factor in the human body, which preparation contains Antithrombin III as active ingredient.
摘要翻译：描述了药物制剂，同时可用于治疗炎性过程，伴随着人体中细胞因子和/或组织因子的分布增加，该制剂含有抗凝血酶III作为活性成分。

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