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1. 发明申请

US20050022429A1 Integrated footwear construction and related method of manufacture 有权
标题翻译：综合鞋类建设及相关制造方法
公开(公告)号：US20050022429A1
公开(公告)日：2005-02-03
申请号：US10848670
申请日：2004-05-19
申请人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
发明人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
IPC分类号： A43B7/06 , A43B7/12 , A43B9/00 , A43B9/18 , A43B13/12 , A43B23/07 , B29D35/12
CPC分类号： B29D35/122 , A43B7/12 , A43B9/00 , A43B9/18 , A43B13/12
摘要： An integrated article of footwear including a waterproofing membrane direct attached to an upper of the footwear. An outsole is further secured to the membrane and/or the upper. In one embodiment, the membrane includes a visible aesthetic bead in the footwear forefoot region, but not the heel region. The membrane may be of greater thickness in the forefoot region to provide added rigidity. A heel cradle is positioned in the footwear heel region between the upper and the outsole. The footwear provides the durability of a direct attach construction in the forefoot and the comfort and cushion of an athletic construction in the heel of the shoe. A method for constructing the footwear includes direct attaching the membrane to an upper of the shoe. Optionally, a heel cradle is disposed in the heel region of the shoe, and the outsole is secured to the heel cradle and/or upper there.
摘要翻译：包括直接连接到鞋的鞋面的防水膜的整体鞋类物品。外底进一步固定在膜和/或鞋面上。在一个实施例中，膜包括鞋类前脚掌区域中的可见的美观珠，但不包括鞋跟区域。在前足区域中膜可以具有更大的厚度以提供附加的刚性。脚跟支架位于鞋帮和鞋底之间的鞋跟跟部区域中。该鞋类提供了前脚掌中的直接附接结构的耐久性以及鞋跟中运动结构的舒适性和缓冲性。用于构造鞋类的方法包括将膜直接附接到鞋的鞋面。任选地，脚跟支架设置在鞋的跟部区域中，并且外底固定到脚跟支架和/或上方。

2. 发明申请

US20060265908A1 INTEGRATED FOOTWEAR CONSTRUCTION AND RELATED METHOD OF MANUFACTURE 审中-公开
标题翻译：一体化鞋类结构及相关制造方法
公开(公告)号：US20060265908A1
公开(公告)日：2006-11-30
申请号：US11426181
申请日：2006-06-23
申请人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
发明人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
IPC分类号： A43B13/20
CPC分类号： B29D35/122 , A43B7/12 , A43B9/00 , A43B9/18 , A43B13/12
摘要： An integrated article of footwear including a waterproofing membrane direct attached to an upper of the footwear. An outsole is further secured to the membrane and/or the upper. In one embodiment, the membrane includes a visible aesthetic bead in the footwear forefoot region, but not the heel region. The membrane may be of greater thickness in the forefoot region to provide added rigidity. A heel cradle is positioned in the footwear heel region between the upper and the outsole. The footwear provides the durability of a direct attach construction in the forefoot and the comfort and cushion of an athletic construction in the heel of the shoe. A method for constructing the footwear includes direct attaching the membrane to an upper of the shoe. Optionally, a heel cradle is disposed in the heel region of the shoe, and the outsole is secured to the heel cradle and/or upper there.
摘要翻译：包括直接连接到鞋的鞋面的防水膜的整体鞋类物品。外底进一步固定在膜和/或鞋面上。在一个实施例中，膜包括鞋类前脚掌区域中的可见的美观珠，但不包括鞋跟区域。在前足区域中膜可以具有更大的厚度以提供附加的刚性。脚跟支架位于鞋帮和鞋底之间的鞋跟跟部区域中。该鞋类提供了前脚掌中的直接附接结构的耐久性以及鞋跟中运动结构的舒适性和缓冲性。用于构造鞋类的方法包括将膜直接附接到鞋的鞋面。任选地，脚跟支架设置在鞋的跟部区域中，并且外底固定到脚跟支架和/或上方。

3. 发明申请

US20050086836A1 Integrated footwear construction and related method of manufacture 有权
公开(公告)号：US20050086836A1
公开(公告)日：2005-04-28
申请号：US10996198
申请日：2004-11-23
申请人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
发明人： Stephen Palmer , Chao Chin , Peter Ruston , Chen Shan , William Brown
IPC分类号： A43B7/06 , A43B7/12 , A43B9/00 , A43B9/18 , A43B13/12 , A43B23/07 , B29D35/12 , A43B9/10
CPC分类号： B29D35/122 , A43B7/12 , A43B9/00 , A43B9/18 , A43B13/12
摘要： An integrated article of footwear including a waterproofing membrane direct attached to an upper of the footwear. An outsole is further secured to the membrane and/or the upper. In one embodiment, the membrane includes a visible aesthetic bead in the footwear forefoot region, but not the heel region. The membrane may be of greater thickness in the forefoot region to provide added rigidity. A heel cradle is positioned in the footwear heel region between the upper and the outsole. The footwear provides the durability of a direct attach construction in the forefoot and the comfort and cushion of an athletic construction in the heel of the shoe. A method for constructing the footwear includes direct attaching the membrane to an upper of the shoe. Optionally, a heel cradle is disposed in the heel region of the shoe, and the outsole is secured to the heel cradle and/or upper there.

4. 发明申请

US20080014172A1 Use of Il-17 in the Treatment of Fertility-Related Disorders 审中-公开
标题翻译：使用Il-17治疗与生育相关的疾病
公开(公告)号：US20080014172A1
公开(公告)日：2008-01-17
申请号：US11596416
申请日：2005-05-31
申请人： Ann Clark , David Kagan , Stephen Palmer
发明人： Ann Clark , David Kagan , Stephen Palmer
IPC分类号： A61K38/20 , A61P15/00 , C12Q1/02
CPC分类号： G01N33/6863 , A61K38/09 , A61K38/20 , A61K45/06 , C07K16/241 , G01N33/543 , G01N33/56966 , G01N33/6869 , G01N2333/495 , G01N2500/00 , G01N2800/364 , A61K2300/00
摘要： The present invention is directed to methods for ameliorating reproductive disorders. More specifically, the present invention describes methods and compositions for using IL-17 in the treatment of various infertility-related defects.
摘要翻译：本发明涉及改善生殖障碍的方法。更具体地，本发明描述了用于治疗各种不育症相关缺陷的用于使用IL-17的方法和组合物。

5. 发明授权

US07507707B2 Methods of inducing ovulation using a non-polypeptide camp level modulator 有权
标题翻译：使用非多肽血浆调节剂诱导排卵的方法
公开(公告)号：US07507707B2
公开(公告)日：2009-03-24
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

6. 发明申请

US20080293622A1 METHODS OF INDUCING OVULATION 有权
标题翻译：诱导卵泡的方法
公开(公告)号：US20080293622A1
公开(公告)日：2008-11-27
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
IPC分类号： A61K38/24 , A61K31/4196 , A61P15/00
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

7. 发明授权

US07078236B2 Methods of inducing ovulation 失效
标题翻译：诱导排卵的方法
公开(公告)号：US07078236B2
公开(公告)日：2006-07-18
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K38/24 , C12N15/15
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

8. 发明授权

US06953774B2 Methods of inducing ovulation 失效
标题翻译：诱导排卵的方法
公开(公告)号：US06953774B2
公开(公告)日：2005-10-11
申请号：US10014812
申请日：2001-12-14
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00 , A61K31/137 , A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase type 4.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是4型磷酸二酯酶抑制剂。

9. 发明申请

US20210317019A1 System and Method for Collecting and Utilizing Heat from an Effluent Disposal System 有权
公开(公告)号：US20210317019A1
公开(公告)日：2021-10-14
申请号：US17272687
申请日：2020-10-02
申请人： Stephen Palmer
发明人： Stephen Palmer
IPC分类号： C02F3/04 , C02F3/10
摘要： A system and method for collecting heat generated by the microbial action in a septic system effluent disposal area that is then transferred to a building structure where it may provide, for example, the temperature differential for a heat exchanger in a heat pump, thereby being the energy source for heating and cooling buildings.

10. 发明申请

US20070282162A1 USE OF PREGNANCY SPECIFIC GLYCOPROTEIN FOR MATURATION OF OOCYTES 审中-公开
标题翻译：使用特异性糖蛋白对卵磷脂的成熟
公开(公告)号：US20070282162A1
公开(公告)日：2007-12-06
申请号：US11575398
申请日：2005-09-30
申请人： Daniel De Matos , Cam Tran , Ann Clark , Stephen Palmer
发明人： Daniel De Matos , Cam Tran , Ann Clark , Stephen Palmer
IPC分类号： A61B17/435 , C12N5/06
CPC分类号： C07K14/4715 , C12N5/0609 , C12N2501/11 , C12N2501/998 , C12N2517/10
摘要： The use of PSG for the in vitro maturation of mammalian oocytes is described. The in vitro matured oocytes may be used for in vitro fertilization protocols.
摘要翻译：描述了PSG用于哺乳动物卵母细胞体外成熟的用途。体外成熟卵母细胞可用于体外受精方案。

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