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1. 发明申请

US20050026251A1 Transmembrane protein 审中-公开
标题翻译：跨膜蛋白
公开(公告)号：US20050026251A1
公开(公告)日：2005-02-03
申请号：US10872681
申请日：2004-06-21
申请人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Melanie Yorke
发明人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Melanie Yorke
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/43 , A61K39/00 , A61K45/00 , A61K48/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P19/08 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07K14/705 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K39/00
摘要： The invention is based on the discovery that the INSP017 protein functions as a trans-membrane protein molecule, preferably as a trans-membrane protein molecule of the netrin receptor family.
摘要翻译：本发明基于以下发现：INSP017蛋白质作为跨膜蛋白分子，优选作为netrin受体家族的跨膜蛋白分子。

2. 发明申请

US20070155958A1 Tnf-like secreted protein 失效
标题翻译： Tnf样分泌蛋白
公开(公告)号：US20070155958A1
公开(公告)日：2007-07-05
申请号：US10557400
申请日：2003-05-21
申请人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Mark Ibberson , Melanie Yorke
发明人： Stephen Fitzgerald , Richard Fagan , Christopher Phelps , Christine Power , Mark Ibberson , Melanie Yorke
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/02 , C07K14/52
CPC分类号： A01K2217/075 , A61K38/00 , C07K14/472 , C07K14/525
摘要： This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.
摘要翻译：本发明涉及本文鉴定为TNF-样分泌蛋白的新型蛋白质INSP058，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。

3. 发明申请

US20060121475A1 Protein kinases 审中-公开
标题翻译：蛋白激酶
公开(公告)号：US20060121475A1
公开(公告)日：2006-06-08
申请号：US10526722
申请日：2003-09-05
申请人： Andrew Davids , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke
发明人： Andrew Davids , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , A01K2217/05 , A01K2217/075
摘要： The present invention relates to novel proteins, termed INSP081, INSP082, and INSP091, herein identified as members of the Germinal Center Kinase (GCK) subfamily of the STE20 family of protein kinases, preferably as NCK-interacting kinases (NIKs) and more preferably as NIK-like embryo specific kinases (NESKs), and to the use of these and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译：本发明涉及称为INSP081，INSP082和INSP091的新蛋白质，其在本文中被鉴定为STE20家族蛋白激酶的生发中心激酶（GCK）亚家族的成员，优选作为NCK相互作用的激酶（NIK），更优选为 NIK样胚胎特异性激酶（NESKs），以及来自编码基因的这些和核酸序列在疾病的诊断，预防和治疗中的应用。

4. 发明申请

US20050186663A1 Cystine-knot fold protein 失效
标题翻译：胱氨酸结折叠蛋白
公开(公告)号：US20050186663A1
公开(公告)日：2005-08-25
申请号：US10872898
申请日：2004-06-21
申请人： Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人： Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , C07H21/04 , C07K14/475 , C07K14/52 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00
摘要： This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及一种新型蛋白质（INSP002），其被鉴定为分泌型蛋白质，其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员，并且使用该蛋白质和来自编码基因的核酸序列诊断，预防和治疗疾病。

5. 发明申请

US20060275293A1 Splice variant of the human pituitary growth hormone 失效
公开(公告)号：US20060275293A1
公开(公告)日：2006-12-07
申请号：US10537142
申请日：2003-12-05
申请人： Richard Fagan , Christopher Phelps , Tania Rodrigues , Melanie Yorke , Mariastella De Tiani
发明人： Richard Fagan , Christopher Phelps , Tania Rodrigues , Melanie Yorke , Mariastella De Tiani
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/09 , A61K39/395 , C07K14/61 , A61K38/27
CPC分类号： C07K14/61 , A01K2217/05 , A01K2217/075
摘要： This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.

6. 发明申请

US20070032416A1 Chorionic somatomammotropin hormone splice variants 审中-公开
标题翻译：绒毛膜促生长激素拼接变体
公开(公告)号：US20070032416A1
公开(公告)日：2007-02-08
申请号：US10540179
申请日：2003-12-22
申请人： Tania Rodrigues , Richard Fagan , Christopher Phelps , Melanie Yorke , Mariastella De Tiani
发明人： Tania Rodrigues , Richard Fagan , Christopher Phelps , Melanie Yorke , Mariastella De Tiani
IPC分类号： A61K38/22 , A61K48/00 , C07K14/61 , C07K16/26
CPC分类号： C07K14/57518
摘要： The invention is based on the discovery that INSP100 is a splice variant of human chorionic somatomammotropin hormone 2 (HCS-B; Q14407) and that INSP104 is a splice variant of human chorionic somatomammotropin hormone 1 (hCS-A;P01243). The invention relates to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. This invention relates to novel proteins, termed INSP100 and INSP104, herein identified as novel splice variants of human Chorionic somatomammotropin hormone 2 (hCS-B; Q14407) and human Chorionic somatomammotropin hormone 1 (hCS-A; P01243) respectively and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. The variants have an altered A-B loop and are therefore predicted to possess altered receptor binding properties. All publications, patents and patent applications cited herein are incorporated in full by reference.
摘要翻译：本发明基于以下发现：INSP100是人绒毛膜促生长激素激素2（HCS-B; Q14407）的剪接变体，INSP104是人绒毛膜促生长激素1（hCS-A; P01243）的剪接变体。本发明涉及来自编码基因的这些蛋白质和核酸序列在疾病的诊断，预防和治疗中的用途。本发明涉及分别命名为INSP 100和INSP 104的新型蛋白质，其分别被鉴定为人绒毛膜促生长激素激素2（hCS-B; Q14407）和人绒毛膜促生长激素1（hCS-A; P 01243）的新型剪接变体，使用这些蛋白质和核酸序列从编码基因中诊断，预防和治疗疾病。变体具有改变的A-B环，因此预测具有改变的受体结合性质。本文引用的所有出版物，专利和专利申请通过引用全部并入。

7. 发明申请

US20060275259A1 Il-8-like proteins 审中-公开
标题翻译： II-8样蛋白
公开(公告)号：US20060275259A1
公开(公告)日：2006-12-07
申请号：US10540180
申请日：2003-12-19
申请人： Richard Fagan , Christopher Phelps , Mark Davies , Melanie Yorke
发明人： Richard Fagan , Christopher Phelps , Mark Davies , Melanie Yorke
IPC分类号： A61K38/20 , C07K14/54
CPC分类号： C07K14/5421
摘要： This invention relates to proteins, termed INSP093, herein identified as secreted proteins, in particular, as members of the Interleukin (IL) 8-like chemokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及称为INSP093的蛋白质，本文鉴定为分泌蛋白质，特别是作为白细胞介素（IL）8样趋化因子家族的成员，以及来自编码基因的这些蛋白质和核酸序列在诊断中的应用，预防和治疗疾病。

8. 发明申请

US20060252117A1 Metalloprotease proteins 失效
标题翻译：金属蛋白酶蛋白
公开(公告)号：US20060252117A1
公开(公告)日：2006-11-09
申请号：US10539847
申请日：2003-12-23
申请人： Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
发明人： Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
IPC分类号： C12N9/64 , C07H21/04 , C12P21/06
CPC分类号： C12N9/6489 , C12N15/52
摘要： This invention relates to proteins termed INSPOO5a and INSPOO5b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译：本发明涉及称为INSPOO5a和INSPOO5b的蛋白质，这里鉴定为分泌蛋白质，特别是金属蛋白酶家族的成员，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。

9. 发明申请

US20050042731A1 Secreted proteins 审中-公开
标题翻译：分泌蛋白
公开(公告)号：US20050042731A1
公开(公告)日：2005-02-24
申请号：US10873332
申请日：2004-06-21
申请人： Richard Fagan , Christopher Phelps , Alex Gutteridge , Christine Power
发明人： Richard Fagan , Christopher Phelps , Alex Gutteridge , Christine Power
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/57 , C07K14/575 , C07K14/705 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C07K14/52 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/5759 , Y02A50/412
摘要： This invention relates to novel proteins (INSP032, INSP033, INSP034, INSP036, INSP038), herein identified as members of the four helical bundle cytokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及本文鉴定为四螺旋束细胞因子家族的成员的新型蛋白质（INSP032，INSP033，INSP034，INSP036，INSP038）以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病。

10. 发明申请

US20070141569A1 Splice variant of human placental growth hormone 失效
标题翻译：人胎盘生长激素的接头变体
公开(公告)号：US20070141569A1
公开(公告)日：2007-06-21
申请号：US10539962
申请日：2003-12-19
申请人： Richard Fagan , Christopher Phelps , Tania Rodrigues , Christine Power , Mariastella Tiani
发明人： Richard Fagan , Christopher Phelps , Tania Rodrigues , Christine Power , Mariastella Tiani
IPC分类号： C12Q1/68 , A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/61
摘要： This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及一种称为INSP105的蛋白质，在本文中被鉴定为人胎盘生长激素的剪接变体，以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。

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